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BIOMEDICINE Product Research and Development Publications/Resources 2007 Sitruk-Ware, Régine. "The levonorgestrel intrauterine system for use in peri- and postmenopausal women," Contraception 75(6S): S155–S160. (abstract) Sitruk-Ware, Régine, Vivian Brache, Robin Maguire, Horacio Croxatto, Narender Kumar, Sushma Kumar, Juan Carlos Montero, Ana Maria Salvatierra, David Phillips, and Anibal Faundes. "Pharmacokinetic study to compare the absorption and tolerability of two doses of levonorgestrel following single vaginal administration of levonorgestrel in Carraguard® gel: A new formulation for 'dual protection' contraception," Contraception 75(6): 454–460. (abstract) Sitruk-Ware, Régine, Joël Menard, Mandana Rad, Jacobus Burggraaf, Marieke L. de Kam, Barbara A. Tokay, Irving Sivin, and Cornelius Kluft. "Comparison of the impact of vaginal and oral administration of combined hormonal contraceptives on hepatic proteins sensitive to estrogen," Contraception 75(6): 430–437. (abstract) 2006 "Building on decades of success: Population Council continues pioneering biomedical research," brochure. New York: Population Council. (PDF) Grunberg, Steven M., Martin H. Weiss, Christy A. Russell, Irving M. Spitz, Jamshid Ahmadi, Alfredo Sadun, and Régine Sitruk-Ware. "Long-term administration of mifepristone (RU486): Clinical tolerance during extended treatment of meningioma," Cancer Investigation 24(8): 727–733. (abstract) "The one-year contraceptive ring: A technology in development," brochure. New York: Population Council. (PDF) Palanisamy, Gopinath S., Yong-Pil Cheon, Jaeyeon Kim, Athilakshmi Kannan, Quanxi Li, Marcey Sato, Srinivasa R. Mantena, Régine L. Sitruk-Ware, Milan K. Bagchi, and Indrani C. Bagchi. "A novel pathway involving progesterone receptor, endothelin-2, and endothelin receptor B controls ovulation in mice," Molecular Endocrinology 20(11): 2784–2795. (abstract) Rad, Mandana, Cornelius Kluft, Joël Menard, Jacobus Burggraaf, Marieke L. de Kam, Piet Meijer, Irving Sivin, and Régine Sitruk-Ware. "Comparative effects of a contraceptive vaginal ring delivering a nonandrogenic progestin and continuous ethinyl estradiol and progestin and continuous ethinyl estradiol and a combined oral contraceptive containing levonorgestrel on hemostasis variables," American Journal of Obstetrics and Gynecology 195(1): 72–77. (abstract) Sitruk-Ware, Régine. "Contraception: An international perspective," Contraception 73(3): 215–222. (abstract) Sitruk-Ware, Régine (guest ed.). "The levonorgestrel-releasing intrauterine system (Mirena®)," Gynaecology Forum 11(2). (PDF) Sitruk-Ware, Régine. "New progestagens for contraceptive use," Human Reproduction Update 12(2): 169–178. (abstract) (offsite PDF)
2005 Fraser, Ian S., Edith Weisberg, Vivian Brache, Francisco Alvarez, Rebeca Massai, Daniel R. Mishell, Jr., D. Apter, J. Gale, Yun-yen Tsong, and Irving Sivin. "Serum Nestorone® and ethinyl estradiol levels, and ovulation inhibition in women using three different dosage combinations of a Nestorone progestogen-ethinyl estradiol contraceptive vaginal ring on a bleeding-signaled regimen," Contraception 72(1): 40–45. (abstract) Lee, Nikki P.Y., Dolores D. Mruk, Ching-hang Wong, and C. Yan Cheng. "Regulation of Sertoli–germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/β-catenin (CATNB) signaling pathway: An in vitro and in vivo study," Biology of Reproduction 73(3): 458–471. (abstract) Lui, Wing-Yee, Yan Ho Cheng, Dolores D. Mruk, Chin Ho Cheng, Meng Yun Mo, Will M. Lee, and C. Yan Cheng. "α2-macroglobulin expression in the liver in response to inflammation is mediated by the testis," Journal of Endocrinology 185(3): 497–505. (abstract) Sitruk-Ware, Régine. "Delivery options for contraceptives," Drug Discovery Today 10(14): 977–985. (abstract) ———. "Pharmacology of different progestogens: The special case of drospirenone," Climacteric 8(suppl 3): 4–12. (abstract) ———. "Vaginal delivery of contraceptives," Expert Opinion on Drug Delivery 2(4): 729–736. (abstract) Sitruk-Ware, Régine and Pirjo Inki. "The levonorgestrel intrauterine system: Long-term contraception and therapeutic effects," Women's Health 1(2): 171–182. (abstract) (PDF posted with permission from Women's Health © Future Medicine Ltd, 2005) Sivin, Irving, Daniel R. Mishell, Jr.; Francisco Alvarez, Vivian Brache, Kaisa Elomaa, Pekka Lähteenmäki, Rebeca Massai, Patricia Miranda, Horacio B. Croxatto, Catherine Dean, Margaret Small, Harold A. Nash, and Theodore M Jackanicz. “Contraceptive vaginal rings releasing Nestorone and ethinylestradiol: A 1-year dose-finding trial,” Contraception 71(2): 122–129. (abstract) Spitz, Irving M., Steven M. Grunberg, Nathalie Chabbert-Buffet, Tzina Lindenberg, Hadassa Gelber, and Régine Sitruk-Ware. "Management of patients receiving long-term treatment with mifepristone," Fertility and Sterility 84(6): 1719–1726. (abstract) Venken, K., S. Boonen, E. Van Herck, L. Vandenput, Narender Kumar, Régine Sitruk-Ware, Kalyan Sundaram, R. Bouillon, and D. Vanderschueren, "Bone and muscle protective potential of 7α-methyl-19-nortestosterone, a selective androgen receptor modulator: Evidence from the aged orchidectomized male rat model," Bone 36: 663–670. Weisberg, Edith, Vivian Brache, Francisco Alvarez, Rebeca Massai, Daniel R. Mishell, Jr., D. Apter, J. Gale, Irving Sivin, Yun-yen Tsong, and Ian S. Fraser. "Clinical performance and menstrual bleeding patterns with three dosage combinations of a Nestorone progestogen/ethinyl estradiol contraceptive vaginal ring used on a bleeding-signaled regimen," Contraception 72(1):46–52. Xu, Qin, Shigeki Takekida, Noriyuki Ohara, Wei Chen, Régine Sitruk-Ware, Elof D.B. Johansson, and Takeshi Maruo. "Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates Caspase-3 and poly (adenosine 5’-Diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells," Journal of Clinical Endocrinology and Metabolism 90(2): 953–961. 2004 "Carraguard may block HIV by adhering to cells," Population Briefs 10(1): 2. (full text) Johansson, Elof D.B. "Future developments in hormonal contraception," American Journal of Obstetrics and Gynecology 190(suppl 1): S69–S71. Johansson, Elof D.B. and Régine Sitruk-Ware. “New delivery systems in contraception: Vaginal rings,” American Journal of Obstetrics and Gynecology 190(suppl 1): S54–S59. (abstract) "Moving a contraceptive vaginal ring closer to market," Population Council Annual Report 2003. New York: Population Council. (full text)Mruk, Dolores D. and Chuen-yan Cheng. "Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis," Endocrine Reviews 25(5):747–806. Nash, Harold A., Dale N. Robertson, and Simone J. Evans. "Release-modulating factors strongly affecting steroid diffusion from silicone elastomer," Journal of Pharmaceutical Sciences 93(10): 2420–2430. Phillips, David M., Kristin M. Sudol, Clark L. Taylor, Laura Guichard, Robert Elsen, and Robin A. Maguire. "Lubricants containing N-9 may enhance rectal transmission of HIV and other STIs," Contraception 70(2): 107–110. (abstract) Sitruk-Ware, Régine. "New progestogens: A review of their effects in perimenopausal and postmenopausal women," Drugs and Aging 21(13): 865–883. ———. "Pharmacological profile of progestins," Maturitas 47(4): 277–283. Sitruk-Ware, Régine and Geneviève Plu-Bureau. "Exogenous progestagens and the human breast," Maturitas 49(1): 58–66. 2003 Laoag-Fernandez, Jovelle B., Takeshi Maruo, Paivi Pakarinen, Irving M. Spitz, and Elof D.B. Johansson. "Effects of levonorgestrel-releasing intra-uterine system on the expression of vascular endothelial growth factor and adrenomedullin in the endometrium in adenomyosis," Human Reproduction 18(4): 694–699. "Long-term contraceptive shown to reduce menstrual flow, " Population Council news release. (full text) Saleh, Saleh I., Sayed H. Khidr, Sayed M. Ahmed, Theodore M. Jackanicz, and Harold A. Nash. "Estradiol-progesterone interaction during the preparation of vaginal rings," Journal of Pharmaceutical Sciences 92(2): 258–265. Sitruk-Ware, Régine and Irving M. Spitz. "Pharmacological properties of mifepristone: Toxicology and safety in animal and human studies," Contraception 68(6): 409–420. Sitruk-Ware, Régine, Margaret Small, Narender Kumar, Yun-Yen Tsong, Kalyan Sundaram, and Theodore M. Jackanicz. “Nestorone: Clinical applications for contraception and HRT,” Steroids 68(10–13): 907–913. Sivin, Irving. "Risks and benefits, advantages and disadvantages of levonorgestrel-releasing contraceptive implants," Drug Safety 26(5): 303–335. von Eckardstein, Sigrid, Gabriela Noe, Vivian Brache, Eberhard Nieschlag, Horacio B. Croxatto, Francisco Alvarez, Alfred J. Moo-Young, Irving Sivin, Narender Kumar, Margaret Small, Kalyan Sundaram, Population Council International Committee for Contraception Research. "A clinical trial of 7 alpha-methyl-19-nortestosterone implants for possible use as a long-acting contraceptive for men," Journal of Clinical Endocrinology and Metabolism 88(11): 5232–5239. Ylänen, Kaija, Timo Laatikainen, Pekka Lähteenmäki, and Alfred
J. Moo-Young. "Subdermal progestin implant (Nestorone®) in the treatment
of endometriosis: Clinical response to various doses," Acta Obstetricia
et Gynecologica Scandinavica 82(2): 2002 Johansson, Elof D.B., Vivian Brache, Francisco Alvarez-Sanchez, Anibal Faundes, Leila Cochon, Sirpa Ranta, Mark Lovern, and Narender Kumar. "Pharmacokinetic study of different dosing regimens of levonorgestrel for emergency contraception in healthy women," Human Reproduction 17(6): 1472–1476. Maruo, Takeshi, Daniel R. Mishell, Jr., Avraham Ben-Chetrit, Drorith
Hochner-Celnikier, Anna L. Hamada, and Harold A. Nash. "Vaginal rings
delivering progesterone and estradiol may be a new method of hormone
replacement therapy," Fertility and Sterility Maruo, Takeshi, Jovelle B. Laoag-Fernandez, Hiroya Matsuo, Takashi Samoto, Osamu Kurachi, S. Takeuchi, Irving M. Spitz, Paivi Pakarinen, Pekka Lähteenmäki, and Elof D.B. Johansson. "Effects of levonorgestrel-releasing intrauterine system on the endometrium and the relevance to the management of menorrhagia caused by uterine myoma and adenomyosis," in Takeshi Maruo, David Barlow, Helen Mardon, and Stephen Kennedy (eds.), Cell and Molecular Biology of Endometrium in Health and Disease. Osaka: Soeisha, pp. 193–207. "Population Council takes a leading role in emerging AIDS-prevention arena," Momentum. New York: Population Council. (PDF) (full text) Ramachandra, S.G., V. Ramesh, H.N. Krishnamurthy, Narender Kumar, Kalyan Sundaram, Matthew P. Hardy, and A.J. Rao. "Effect of chronic administration of 7α-methyl-19-nortestosterone on serum testosterone, number of spermatozoa and fertility in adult male bonnet monkeys (Macaca radiata)," Reproduction 124(2): 301–309. Sitruk-Ware, Régine. "Antiandrogenic progestogens in hormone replacement therapy," Gynaecology Forum 7(2): 8–11. ———. "Hormonal replacement therapy," Reviews in
Endocrine and Metabolic Disorders ———. "Progestogens in hormonal replacement therapy: New molecules, risks, and benefits," Menopause 9(1): 6–15. Sitruk-Ware, Régine and Geneviève Plu-Bureau. "Progestins and breast cancer risk: State of the controversy," in Manuel Neves-e-Castro and Barry G. Wren (eds.), Menopause: Hormones and Cancer. Lancaster, UK: Parthenon Publishers, pp. 123–128. Sitruk-Ware, Régine and Margaret Small. "New methods of progestin delivery," Contemporary Clinical Gynecology and Obstetrics 2(4): 287–298. Sivin, Irving and Alfred J. Moo-Young. "Recent developments in contraceptive implants at the Population Council," Contraception 65(1): 113–119. "Toward the development of a microbicide," Population Briefs 2002 (Spring): HIV/AIDS edition. (PDF) (full text) 2001 Massai, Rebeca, Soledad Diaz, E. Quinteros, Veronica Reyes, C. Herreros, A. Zepeda, Horacio B. Croxatto, and Alfred J. Moo-Young. "Contraceptive efficacy and clinical performance of Nestorone implants in postpartum women," Contraception 64(6): 369–376. Schlegel, Peter N., Petr Kuzma, Julian Frick, Amicur Farkas, Andreas Gomahr, Irving M. Spitz, Boris Chertin, Doris Mack, Andreas Jungwirth, Peggy King, Harold A. Nash, C. Wayne Bardin, and Alfred J. Moo-Young. "Effective long-term androgen suppression in men with prostate cancer using a hydrogel implant with the GnRH agonist histrelin," Urology 58(4): 578–582. Sivin, Irving, Livia Wan, Sirpa Ranta, Francisco Alvarez, Vivian Brache, Daniel R. Mishell, Jr., Philip Darney, Arijit Biswas, Soledad Diaz, Orawan Kiriwat, Manee Piya Anant, Cynthia Klaisle, Margarita Pavez, and Janet Schechter. "Levonorgestrel concentrations during 7 years of continuous use of Jadelle contraceptive implants," Contraception 64(1): 43–49.
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