MELBOURNE, AUSTRALIA — While all youth face vulnerability to HIV, adolescent girls face unique challenges in reducing their risk of acquiring HIV due to gender inequalities, but much HIV programming lacks a specific focus on girls and young women. Many of the countries with the highest HIV prevalence are experiencing a massive “youth bulge” in population, so even with decreasing HIV prevalence, the absolute number of young people living with HIV or at risk of acquiring HIV is estimated to grow in the next five years. Young women are especially vulnerable to HIV and have HIV infection rates nearly twice as high as those for young men. At the end of 2012, approximately two-thirds of new HIV infections in adolescents aged 15–19 years were among girls. An AIDS-free generation is not possible without addressing the specific needs of adolescents—especially girls—that put them at risk for HIV acquisition.