Population Council Research that makes a difference

MENT® is permeable through animal skin at three times the rate of testosterone and has been shown to readily penetrate the skin and suppress production of the gonadotropins required for spermatogenesis. A transdermal gel formulation of MENT was compared to gel formulations containing two other androgens, 17 methyl testosterone and 17-α methyl testosterone. 

Results indicate that MENT permeates the skin significantly better than the two other androgens. A clinical trial of MENT gel for use in hormone therapy in elderly men was completed, indicating some improvement in well-being among men using the gel. The study shows the gel to be safe for further development as a hormone therapy method.