Progesterone Ring for Lactating Women
Council researchers developed a vaginal ring for lactating women that extends the contraceptive effectiveness of lactation.
The vaginal ring is a drug-delivery system that can be inserted easily into the vagina by the woman herself. It slowly releases natural progesterone that is absorbed into the bloodstream. About 2¼" in diameter and the size of the outer rim of a diaphragm, this soft contraceptive ring is an easy-to-use, reversible method that may have advantages over other methods for women who are breastfeeding.
This ring uses the natural hormone progesterone. While not an effective contraceptive method for women who are not breastfeeding, it can be used by nursing women to extend the contraceptive effectiveness of lactation. The Council developed and has carried out extensive studies with the progesterone ring in more than 1,000 lactating women in eight countries. The method was well accepted and effectively protected women from pregnancy.
Following the registration of the progesterone vaginal ring (Progering®) in several countries in Latin America by Laboratorios Andromaco of Santiago, Chile, the Indian Council of Medical Research (ICMR) has agreed to work with the Population Council and HLL Lifecare Limited to evaluate the progesterone ring’s efficacy, safety, and acceptability in enhancing the contraceptive options for breastfeeding women in diverse cultural contexts of India. With support from the Indo-US Science and Technology Cooperation Program, the Council and ICMR are preparing to conduct a large-scale clinical trial in 20 sites. The long-term goal is to make available in India a new safe and effective contraceptive method for lactating women. This study may also facilitate the transfer of technology for ring production to a qualified manufacturer of pharmaceutical products in India.
Prospective randomized trial to evaluate the efficacy of a vaginal ring releasing progesterone for IVF and oocyte donation (abstract) (PDF)
Zegers-Hochschild,F.; Balmaceda,J.P.; Fabres,C.; Alam,V.; Mackenna,A.; Fernandez,Emilio; Pacheco,I.M.; Sepulveda,M.S.; Chen,S.; Borrero,C.; Borges,E.
Human Reproduction 15(10): 2093-2097
Publication date: 2000
Norplant® implants and progesterone vaginal rings do not affect maternal bone turnover and density during lactation and after weaning (abstract) (PDF)
Diaz,Soledad; Reyes,M.V.; Zepeda,Ana; Gonzalez,G.B.; Lopez,J.M.; Campino,C.; Croxatto,Horacio B.
Human Reproduction 14(10): 2499-2505
Publication date: 1999
Preregistration study on the safety and contraceptive efficacy of a progesterone-releasing vaginal ring in Chilean nursing women (abstract)
Massai,Rebeca; Miranda,Patricia; Valdes,P; Lavin,P.; Zepeda,Ana; Casado,M.E.; Silva,M.A.; Fetis,G.; Bravo,C.; Chandia,O.; Peralta,O.; Croxatto,Horacio B.; Diaz,Soledad
Contraception 60(1): 9-14
Publication date: 1999
Efficacy and acceptability of a vaginal ring releasing progesterone for in vitro fertilization and oocyte donation
Abstract presented at the 14th Annual Meeting of the European Society of Human Reproduction and Embryology, Goteborg, Sweden, 21-24 June
Zegers-Hochschild,F.; Balmaceda,J.P.; Fabres,C.; Alam,V.; Mackenna,A.; Fernandez,Emilio; Pacheco,I.M.; Sepulveda,M.S.
Publication date: 1998
Contraceptives for lactating women: A comparative trial of a progesterone-releasing vaginal ring and the Copper T 380A IUD (abstract)
Sivin,Irving; Diaz,Soledad; Croxatto,Horacio B.; Miranda,Patricia; Shaaban,Mamdouh; Sayed,Ezzat H.; Xiao,Bilian; Wu,Shang-Chun; Du Ming-kun; Alvarez-Sanchez,Francisco; Brache,Vivian; Basnayake,Sriani; McCarthy,Terence; Lacarra,Maria; Mishell,Daniel R.,Jr.; Koetsawang,Suporn; Stern,Janet; Jackanicz,Theodore M.
Contraception 55(4): 225-232
Publication date: 1997
Fertility regulation in nursing women: IX. Contraceptive performance, duration of lactation, infant growth, and bleeding patterns during use of progesterone vaginal rings, progestin-only pills, Norplant implants, and Copper T 380-A intrauterine devices (abstract)
Diaz,Soledad; Zepeda,Ana; Maturana,X.; Reyes,M.V.; Miranda,Patricia; Casado,M.E.; Peralta,O.; Croxatto,Horacio B.
Contraception 56(4): 223-232
Publication date: 1997
Endometrial histology and progesterone concentration in women with ovarian failure supplemented with a progesterone vaginal ring: Report on six pregnancy cycles after oocyte donation
Abstract presented at the 12th Annual Meeting of the European Society of Human Reproduction and Embryology, Maastrict, The Netherlands, 30 June-3 July
Zegers-Hochschild,F.; Croxatto,Horacio B.; Alam,V.; Pacheco,I.M.; Altieri,E.
Publication date: 1996
Contraception in lactating women (abstract)
Diaz,Soledad; Croxatto,Horacio B.
Current Opinion in Obstetrics and Gynecology 5(6): 815-822
Publication date: 1993
Mechanism of action of progesterone as contraceptive for lactating women
Diaz,Soledad; Miranda,Patricia; Brandeis,A.; Cardenas,H.; Croxatto,Horacio B.; Seppala,M.; Hamberger,L.
from Frontiers in Human Reproduction (1st ed.), pp. 11-21
Publication date: 1991
Progesterone vaginal rings for contraception during breastfeeding
Croxatto,Horacio B.; Diaz,Soledad; Runnebaum,B.; Rabe,T.; Kiesel,L.
from Advances in Gynecological and Obstetric Research Series: Vol. 2: Female Contraception and Male Fertility Regulation (1st ed.), pp. 135-142
Publication date: 1991
Fertility regulation in nursing women: VII. Progesterone plasma levels and contraceptive efficacy of a progesterone-releasing vaginal ring (abstract)
Diaz,Soledad; Jackanicz,Theodore M.; Herreros,C.; Juez,G.; Peralta,O.; Miranda,Patricia; Casado,M.E.; Schiappacasse,Veronica; Salvatierra,Ana Maria; Brandeis,A.; Croxatto,Horacio B.
Contraception 32(6): 603-622
Publication date: 1985
Project Stats
Program(s):
Reproductive Health
Topic(s):
Postpartum family planning
Technologies for women
Duration: 1/1985 - 1/2000
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