Impact of Antiretroviral Therapy on Mucosal Immunity
Council researchers are investigating the potential influence of long-term antiretroviral therapy on oral immune function.
Dendritic cells, T cells, and epithelial cells play central roles in maintaining healthy oral immune functions. However, oral immune function is perturbed during HIV infection, resulting in the increased susceptibility to infection with organisms that would normally be controlled by a healthy immune system (e.g., oropharyngeal candidiasis). The numbers and function of dendritic cells and T cells are modified during HIV infection and likely contribute to the impaired ability to control normal oral pathogens.
Treating people with antiretroviral therapy (ART) should control virus amplification to limit immune destruction, but also must not interfere with (and, if possible, improve) oral immune function. Therefore, dendritic cells, T cells, and epithelial cells within the outer epithelial layers as well as the mucosal-associated lymphoid tissues of the oral cavity must be studied closely during ART.
Population Council staff members are conducting research in infected and uninfected animals receiving ART (or not) in order to monitor oral immune function under ART and compare it to the immune functions in other mucosal tissues or blood. Understanding changes in immune activities at the body surfaces is critical in advancing strategies to control HIV-induced immune damage, as well as in the development of antiviral approaches.
See also: Robbiani laboratory
Characterization of peripheral and mucosal immune responses in rhesus macaques on long-term tenofovir and emtricitabine combination antiretroviral therapy (abstract)
Jasny,Edith; Geer,Suzanne; Frank,Ines; Vagenas,Panagiotis; Aravantinou,Meropi; Salazar,Andres M.; Lifson,Jeffrey D.; Piatak Jr.,Michael; Gettie,Agegnehu; Blanchard,James L.; Robbiani,Melissa
Journal of Acquired Immune Deficiency Syndromes 61(4): 425-435
Publication date: 2012
Candida albicans-induced DC activation reduces HIV amplification by DCs while increasing DC-to-T-cell spread of HIV (abstract)
Vachot,Laurence; Williams,Vennansha G.; Bess Jr.,Julian W.; Lifson,Jeffrey D.; Robbiani,Melissa
Journal of Acquired Immune Deficiency Syndromes 48(4): 398-407
Publication date: 2008
Current concepts of HIV transmission (abstract)
Morrow,Gavin; Vachot,Laurence; Vagenas,Panagiotis; Robbiani,Melissa
Current HIV/AIDS Reports 4(1): 29-35
Publication date: 2007
CpG-C ISS-ODN activation of blood-derived B cells from healthy and chronic immunodeficiency virus-infected macaques (abstract)
Teleshova,Natalia; Kenney,Jessica; Williams,Vennansha G.; Van Nest,Gary; Marshall,Jason; Lifson,Jeffrey D.; Sivin,Irving; Dufour,Jason; Bohm,Rudolf; Gettie,Agegnehu; Pope,Melissa
Journal of Leukocyte Biology 79(2): 257-267
Publication date: 2006
Local and systemic effects of intranodally injected CpG-C immunostimulatory-oligodeoxyribonucleotides in macaques (abstract)
Teleshova,Natalia; Kenney,Jessica; Van Nest,Gary; Marshall,Jason; Lifson,Jeffrey D.; Sivin,Irving; Dufour,Jason; Bohm,Rudolf; Gettie,Agegnehu; Robbiani,Melissa
Journal of Immunology 177(12): 8531-8541
Publication date: 2006
Lymphocyte-dendritic cell interactions and mucosal acquisition of SIV/HIV infection (abstract)
Turville,Stuart G.; Peretti,Silvia; Pope,Melissa
Current Opinion in HIV and AIDS 1(1): 3-9
Publication date: 2006
Slamming the door on unwanted guests: Why preemptive strikes at the mucosa may be the best strategy against HIV (abstract)
Trapp,Susanna; Turville,Stuart G.; Robbiani,Melissa
Journal of Leukocyte Biology 80(5): 1076-1083
Publication date: 2006
Sleeping with the enemy: The insidious relationship between dendritic cells and immunodeficiency viruses
Vachot,Laurence; Turville,Stuart G.; Trapp,Susanna; Peretti,Silvia; Morrow,Gavin; Frank,Ines; Pope,Melissa; Lutz,Manfred B.; Romani,Nikolaus; Steinkasserer,Alexander
from Handbook of Dendritic Cells: Biology, Diseases and Therapies, pp. 773-797
Publication date: 2006
CpG-C ISS-ODN activation of plasmacytoid dendritic cells in rhesus macaques to augment the activation of IFN-γ-secreting SIV-specific T cells (abstract)
Teleshova,Natalia; Kenney,Jessica; Jones,Jennifer; Marshall,Jason; Van Nest,Gary; Dufour,Jason; Bohm,Rudolf; Lifson,Jeffrey D.; Gettie,Agegnehu; Pope,Melissa
Journal of Immunology 173(3): 1647-1657
Publication date: 2004
Short-term Flt3L treatment effectively mobilizes functional macaque dendritic cells (abstract)
Teleshova,Natalia; Jones,Jennifer; Kenney,Jessica; Purcell,Jeanette; Bohm,Rudolf; Gettie,Agegnehu; Pope,Melissa
Journal of Leukocyte Biology 75(6): 1102-1110
Publication date: 2004
Dendritic cells as a conduit to improve HIV vaccines (abstract)
Pope,Melissa
Current Molecular Medicine 3(3): 229-242
Publication date: 2003
Immunodeficiency virus exploitation of dendritic cells in the early steps of infection (abstract)
Teleshova,Natalia; Frank,Ines; Pope,Melissa
Journal of Leukocyte Biology 74(5): 683-690
Publication date: 2003
Presentation of exogenous whole inactivated simian immunodeficiency virus by mature dendritic cells induces CD4+ and CD8+ T-cell responses (abstract)
Frank,Ines; Santos,John J.; Mehlhop,Erin; Villamide-Herrera,Loreley; Santisteban,Christine; Gettie,Agegnehu; Ignatius,Ralf; Lifson,Jeffrey D.; Pope,Melissa
Journal of Acquired Immune Deficiency Syndromes 34(1): 7-19
Publication date: 2003
Enhanced in vitro stimulation of rhesus macaque dendritic cells for activation of SIV-specific T cell responses (abstract)
Mehlhop,Erin; Villamide-Herrera,Loreley; Frank,Ines; Gettie,Agegnehu; Santisteban,Christine; Messmer,Davorka; Ignatius,Ralf; Lifson,Jeffrey D.; Pope,Melissa
Journal of Immunological Methods 260(1-2): 219-234
Publication date: 2002
Exploiting dendritic cells to improve vaccine efficacy (PDF) (HTML)
Steinman,Ralph M.; Pope,Melissa
Journal of Clinical Investigation 109(12): 1519-1526
Publication date: 2002
The enigma of dendritic cell-immunodeficiency virus interplay (abstract)
Frank,Ines; Pope,Melissa
Current Molecular Medicine 2(3): 229-248
Publication date: 2002
Project Stats
Location: United States
Program(s):
HIV and AIDS
Topic(s):
HIV biomedical research
Duration: 1/2005 - 6/2012
Population Council researchers:
Meropi Aravantinou
Nina Derby
Ines Frank
Joselin Galvez
Mayla Hsu
Jessica Kenney
Elena Martinelli
Pavel Pugach
Melissa Robbiani
Filippo Veglia
Loreley Villamide-Herrera
Non-Council collaborators:
Agegnehu Gettie (Aaron Diamond AIDS Research Center)
Andres Salazar (Oncovir)
James Blanchard (Tulane National Primate Research Center)
Jeffrey Lifson (National Cancer Institute)
Julian Bess (National Cancer Institute)
Michael Piatak (National Cancer Institute)
Donors:
US National Institutes of Health
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