Publications/Resources
Council researchers' names appear in boldface type.

2006
Ge, Renshan, Qiang Dong, Chantal M. Sottas, Vassilios Papadopoulos, Barry R. Zirkin, and Matthew P. Hardy. "In search of rat stem Leydig cells: Identification, isolation, and lineage-specific development," Proceedings of the National Academy of Sciences of the United States of America 103(8): 2719–2724. (abstract)

2005
Ge, Renshan, Qiang Dong, Enmei Niu, Chantal M. Sottas, Dianne O. Hardy, James F. Catterall, Syed A. Latif, David J. Morris, and Matthew P. Hardy. “11β-hydroxysteroid dehydrogenase 2 in rat Leydig cells: Its role in blunting glucocorticoid action at physiological levels of substrate,” Endocrinology 146(6): 2657–2664. (abstract)

Ge Renshan, Qiang Dong, Chantal M. Sottas, Haolin Chen, Barry R. Zirkin, and Matthew P. Hardy. “Gene expression in rat Leydig cells during development from the progenitor to adult stage: A cluster analysis,” Biology of Reproduction 72(6): 1405–1415. (abstract)

Ge, Ren-Shan, Qiang Dong, Chantal M. Sottas, Syed A. Latif, David J. Morris, and Matthew P. Hardy. "Stimulation of testosterone production in rat Leydig cells by aldosterone is mineralocorticoid receptor mediated," Molecular and Cellular Endocrinology 243(1–2): 35–42. (abstract)

Hardy, Matthew P., Hui-Bao Gao, Qiang Dong, Renshan Ge, Qian Wang, Wei Ran Chai, Xing Feng, and Chantal M. Sottas. "Stress hormone and male reproductive function," Cell and Tissue Research 322(1): 147–153. (abstract)

Latif, Syed A., Hector A. Pardo, Matthew P. Hardy, and David J. Morris. "Endogenous selective inhibitors of 11β-hydroxysteroid dehydrogenase isoforms 1 and 2 of adrenal origin," Molecular and Cellular Endocrinology 243(1–2): 43–50. (abstract)

Mukai, Motoko, Qiang Dong, Matthew P. Hardy, Hiroaki Kiyokawa, Richard E. Peterson, and Paul S. Cooke “Altered prostatic epithelial proliferation and apoptosis, prostatic development and serum testosterone in mice lacking cyclin-dependent kinase inhibitors,” Biology of Reproduction 73(5): 951–958. (abstract)

Weissman, Ben-Avi , Enmei Niu, Renshan S. Ge, Chantal M. Sottas, Michael Holmes, James C. Hutson, and Mathew P. Hardy. “Paracrine modulation of androgen synthesis in rat Leydig cells by nitric oxide,” Journal of Andrology 26(3):369–378.

2004
Dong, Qiang, Antonio Salva, Chantal M. Sottas, Enmei Niu, Michael Holmes, and Matthew P. Hardy. “Rapid glucocorticoid mediation of suppressed testosterone biosynthesis in male mice subjected to immobilization stress.” Journal of Andrology 25(6): 973–981.

Salva, Antonio, Matthew P. Hardy, Xiu-feng Wu, Chantal M. Sottas, David T. MacLaughlin, Patricia K. Donahoe, and Mary M. Lee. “Müllerian-inhibiting substance inhibits rat Leydig cell regeneration after ethylene dimethanesulphonate ablation,” Biology of Reproduction 70(3): 600–607.

Wang, Guimin and Matthew P. Hardy. “Development of Leydig cells in the insulin-like growth factor-I (IGF-I) knockout mouse: Effects of IGF-I replacement and gonadotropic stimulation,” Biology of Reproduction 70(3): 632–639.

2003
Gao, Hui-Bao, Ming-Han Tong, Yan-Qin Hu, Hai-Yan You, Qiang-Su Guo, Renshan Ge, and Matthew P. Hardy. “Mechanisms of glucocorticoid-induced Leydig cell apoptosis,” Molecular and Cellular Endocrinology 199(1–2): 153–163.

Hardy, Matthew P. “Diethylhexylphthalate: Action of an endocrine disruptor on the Leydig cell,” presentation to the Department of Pharmacology, McGill University, Montreal, June.

Morris, David J., Arthur S. Brem, Renshan Ge, P. Harry Jellinck, Randall R. Sakai, and Matthew P. Hardy. “The functional roles of 11b-HSD1: Vascular tissue, testis and brain,” Molecular and Cellular Endocrinology 203(1–2): 1–12.

Rothschild, Gerson, Chantal M. Sottas, Holger Kissel, Valter Agosti, Katia Manova, Matthew P. Hardy, and Peter Besmer. “A role for kit receptor signaling in Leydig cell steroidogenesis,” Biology of Reproduction 69(3): 925–932.

Tarka-Leeds, Dana K., Juan D. Suarez, Naomi L. Roberts, John M. Rogers, Matthew P. Hardy, and Gary R. Klinefelter. “Gestational exposure to ethane dimethanesulfonate permanently alters reproductive competence in the CD-1 mouse,” Biology of Reproduction 69(3): 959–967.

Wang, Guimin, Peter J. O’Shaughnessy, Curtis Chubb, Bernard Robaire, and Matthew P. Hardy. “Effects of insulin-like growth factor I on steroidogenic enzyme expression levels in mouse Leydig cells,” Endocrinology 144(11): 5058–5064.