Publications/Resources
Council researchers' names appear in boldface type.

2008
Mruk, Dolores D. "New perspectives in non-hormonal male contraception," Trends in Endocrinology and Metabolism 19(2): 57–64. (abstract)

Mruk, Dolores D. and Chuen-yan Cheng. "Delivering non-hormonal contraceptives to men: Advances and obstacles," Trends in Biotechnology 26(2): 90–99. (abstract)

2006
Li, Michelle W.M., Weiliang Xia, Dolores D. Mruk, Claire Q.F. Wang, Helen H.N. Yan, Michelle K.Y. Siu, Wing-Yee Lui, Will M. Lee, and Chuen-yan Cheng. "Tumor necrosis factor α reversibly disrupts the blood–testis barrier and impairs Sertoli–germ cell adhesion in the seminiferous epithelium of adult rat testes," Journal of Endocrinology 190(2): 313–329. (abstract)

Mruk, Dolores D., Ching-Hang Wong, Bruno Silvestrini, and C. Yan Cheng. "A male contraceptive targeting germ cell adhesion," Nature Medicine 12(11): 1323–1328. (abstract)

Wolski, Katja M., Dolores D. Mruk, and Don F. Cameron. "The Sertoli–spermatid junctional complex adhesion strength is affected in vitro by Adjudin," Journal of Andrology 27(6): 790–794. (abstract)

Xia, Weiliang, Dolores D. Mruk, Will M. Lee, and Chuen-yan Cheng. "Differential interactions between transforming growth factor-β3/TβR1, TAB1, and CD2AP disrupt blood–testis barrier and Sertoli–germ cell adhesion," Journal of Biological Chemistry 281(24): 16799–16813. (abstract)

Yan, Helen H.N. and Chuen-yan Chen. "Laminin α 3 forms a complex with β3 and γ3 chains that serves as the ligand for α 6β1-integrin at the apical ectoplasmic specialization in adult rat testes," Journal of Biological Chemistry 281(25): 17286–17303. (abstract)

2005
Cheng, Chuen-yan, Dolores Mruk, Bruno Silvestrini, Michele Bonanomi, Ching-Hang Wong, Michelle K.Y. Siu, Nikki P.Y. Lee, Wing-Yee Lui, and Meng-Yun Mo. "AF-2364 [1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide] is a potential male contraceptive: A review of recent data," Contraception 72(4): 251–261. (abstract)

Lee, Nikki P.Y. and Chuen-yan Cheng. "Protein kinases and adherens junction dynamics in the seminiferous epithelium of the rat testis," Journal of Cellular Physiology 202(2): 344–360. (abstract)

Lee, Nikki P.Y., Dolores D. Mruk, Ching-hang Wong, and C. Yan Cheng. "Regulation of Sertoli–germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/β-catenin (CATNB) signaling pathway: An in vitro and in vivo study," Biology of Reproduction 73(3): 458–471. (abstract)

Lui, Wing-Yee, Yan Ho Cheng, Dolores D. Mruk, Chin Ho Cheng, Meng Yun Mo, Will M. Lee, and C. Yan Cheng. "α₂-macroglobulin expression in the liver in response to inflammation is mediated by the testis," Journal of Endocrinology 185(3): 497–505. (abstract)

Lui, Wing-Yee, Dolores D. Mruk, and Chuen-yan Cheng. "Interactions among IQGAP1, Cdc42, and the cadherin/catenin protein complex regulate Sertoli–germ cell adherens junction dynamics in the testis," Journal of Cellular Physiology 202(1): 49–66. (abstract)

Siu, Michelle K.Y., Ching-hang Wong, Will M. Lee, and C. Yan Cheng. "Sertoli–germ cell anchoring junction dynamics in the testis are regulated by an interplay of lipid and protein kinases," Journal of Biological Chemistry 280(26): 25029–25047. (abstract)

Wong, Ching-hang, Dolores D. Mruk, Michelle K.Y. Siu, and Chuen-yan Cheng. "Blood–testis barrier dynamics are regulated by α2-macroglobulin via the c-Jun N-terminal protein kinase pathway," Endocrinology 146(4): 1893–1908. (abstract)

Wong, Ching-hang, Weiliang Xia, Nikki P.Y. Lee, Dolores D. Mruk, Will M. Lee, and Chuen-yan Cheng. "Regulation of ectoplasmic specialization dynamics in the seminiferous epithelium by focal adhesion-associated proteins in testosterone-suppressed rat testes," Endocrinology 146(3): 1192–1204. (abstract)

Xia, Weiliang and Chuen-yan. "TGF-β3 regulates anchoring junction dynamics in the seminiferous epithelium of the rat testis via the Ras/ERK signaling pathway: An in vivo study," Developmental Biology 280(2): 321–343. (abstract)

Zhang, Jiayi, Ching-hang Wong, Weiliang Xia, Dolores D. Mruk, Nikki P.Y. Lee, Will M. Lee, and Chuen-yan. "Regulation of Sertoli–germ cell adherens junction dynamics via changes in protein–protein interactions of the N-cadherin-β-catenin protein complex which are possibly mediated by c-Src and myotubularin-related protein 2: An in vivo study using an androgen suppression model," Endocrinology 146(3): 1268–1284. (abstract)

2004
Bolino, Alessandra,  Annalisa Bolis, Stefano Carlo Previtali, Giorgia Dina, Simona Bussini, Gabriele Dati, Stefano Amadio, Ubaldo Del Carro, Dolores D. Mruk, Maria Laura Feltri, C. Yan Cheng, Angelo Quattrini, and Lawrence Wrabetz. "Disruption of Mtmr2 produces CMT4B1-like neuropathy with myelin outfolding and impaired spermatogenesis," Journal of Cell Biology 167(4): 711–721.*

Lee, Nikki P.Y. and Chuen-yan Cheng. "Adaptors, junction dynamics, and spermatogenesis," Biology of Reproduction 71(2): 392–404.*

———. "Ectoplasmic specialization, a testis-specific cell–cell actin-based adherens junction type: Is this a potential target for male contraceptive development?" Human Reproduction Update 10(4): 349–369.*

———. "Nitric oxide/nitric oxide synthase, spermatogenesis, and tight junction dynamics," Biology of Reproduction 70(2): 267–276.*

Lee, Nikki P.Y., Dolores D. Mruk, Anne M. Conway, and Chuen-yan Cheng. "Zyxin, axin, and Wiskott-Aldrich Syndrome protein are adaptors that link the cadherin/catenin protein complex to the cytoskeleton at adherens junctions in the seminiferous epithelium of the rat testis," Journal of Andrology 25(2): 200–215.*

Mruk, Dolores D. and Chuen-yan Cheng. "Cell–cell interactions at the ectoplasmic specialization in the testis," Trends in Endocrinology and Metabolism 15(9): 439–447.*

———. "Sertoli–Sertoli and Sertoli–germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis," Endocrine Reviews 25(5): 747–806.*

Siu, Michelle K.Y. and Chuen-yan Cheng. "Dynamic cross-talk between cells and the extracellular matrix in the testis," BioEssays 26(9): 978–992.*

———. "Extracellular matrix: Recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis," Biology of Reproduction 71(2): 375–391.*

———. "Interactions of proteases, protease inhibitors, and the β1 integrin/laminin γ3 protein complex in the regulation of ectoplasmic specialization dynamics in the rat testis," Biology of Reproduction 70(4): 945–964.*

Wong, Ching-hang, Dolores D. Mruk, Wing-yee Lui, and Chuen-yan Cheng. "Regulation of blood–testis barrier dynamics: An in vivo study," Journal of Cell Science 117(5): 783–798.*

2003
Chen, Yong-Mei, Nikki P.Y. Lee, Dolores D. Mruk, Will M. Lee, and Chuen-yan Cheng. “Fer kinase/FerT and adherens junction dynamics in the testis: An in vitro and in vivo study,” Biology of Reproduction 69(2): 656–672.*

Cheng, Chuen-yan. “Recent advances in male contraceptive research” and “Non-hormonal contraception in males by targeting the ectoplasmic specialization, a testis-specific actin-based adherens junction type, in the seminiferous epithelium,” presentations at the Second International Workshop on Male Contraception, Rome, 24–25 October.

Lee, Nikki P.Y. and Chuen-yan Cheng. “Regulation of Sertoli cell tight junction dynamics in the rat testis via the nitric oxide synthase/soluble guanylate cyclase/3’,5’-cyclic guanosine monophosphate/protein kinase G signaling pathway: An in vitro study,” Endocrinology 144(7): 3114–3129.*

Lee, Nikki P.Y., Dolores D. Mruk, William M. Lee, and Chuen-yan Cheng. “Is the cadherin/catenin complex a functional unit of cell–cell actin-based adherens junctions in the rat testis?,” Biology of Reproduction 68(2): 489–508.*

Lui, Wing-Yee, William M. Lee, and Chuen-yan Cheng. “Rho GTPases and spermatogenesis,” Biochimica et Biophysica Acta 1593(2–3): 121–129.*

Lui, Wing-Yee, Dolores D. Mruk, William M. Lee, and Chuen-yan Cheng. “Adherens junction dynamics in the testis and spermatogenesis,” Journal of Andrology 24(1): 1–14.*

Lui, Wing-Yee, Daria C.H. Wong, Dolores D. Mruk, and Chuen-yan Cheng. “TGF-b3 regulates the blood–testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: An in vivo study,” Endocrinology 144(4): 1139–1142.*

Mruk, Dolores D., Michelle K.Y. Siu, Anne M. Conway, Nikki P.Y. Lee, Ann S.N. Lau, and Chuen-yan Cheng. “Role of tissue inhibitor of metalloproteases-1 in junction dynamics in the testis,” Journal of Andrology 24(4): 510–523.*

Lui, Wing-Yee, Will M. Lee, and Chuen-yan Cheng. “Sertoli–germ cell adherens junction dynamics in the testis are regulated by RhoB GTPase via the ROCK/LIMK signaling pathway,” Biology of Reproduction 68(6): 2189–2206.*

———. “TGF-βs: Their role in testicular function and Sertoli cell tight junction dynamics,” International Journal of Andrology 26(3): 147–160.*

———. “Transforming growth factor β3 regulates the dynamics of Sertoli cell tight junctions via the p38 mitogen-activated protein kinase pathway,” Biology of Reproduction 68(5): 1597–1612.*

Lui, Wing-Yee, Dolores D. Mruk, Will M. Lee, and Chuen-yan Cheng. “Sertoli cell tight junction dynamics: Their regulation during spermatogenesis,” Biology of Reproduction 68(4): 1087–1097.*

Siu, Michelle K.Y., Will M. Lee, and Chuen-yan Cheng. “The interplay of collagen IV, tumor necrosis factor-α, gelatinase B (matrix metalloprotease-9), and tissue inhibitor of metalloproteases-1 in the basal lamina regulates Sertoli cell–tight junction dynamics in the rat testis,” Endocrinology 144(1): 371–387.*

Siu, Michelle K.Y., Dolores D. Mruk, Will M. Lee, and Chuen-yan Cheng. “Adhering junction dynamics in the testis are regulated by an interplay of β 1-integrin and focal adhesion complex-associated proteins,” Endocrinology 144(5): 2141–2163.*

2002
Cheng, Chuen-yan, and Dolores D. Mruk.  "Cell junction dynamics in the testis: Sertoli–germ cell interactions and male contraceptive development," Physiological Reviews 82: 825–874.*

Mruk, Dolores D., Bruno Silvestrini, Meng-yun Mo, and Chuen-yan Cheng.  "Antioxidant superoxide dismutase—A review: Its function, regulation in the testis, and role in male fertility," Contraception 65: 305–311.*

2001
Cheng, Chuen-yan, Bruno Silvestrini, Josephine Grima, Meng-yun Mo, LJ Zhu, Elof Johansson, L Saso, MG Leone, M Palmery and Dolores D. Mruk. "Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis," Biology of Reproduction 65: 449–461.*