PROJECT 
Activating Dendritic Cells to Improve Anti-HIV Vaccines

Publications/Resources
Council researchers' names appear in boldface type.

Submitted
Trapp, Susanna, Nina Derby, Rachel Singer, Andrew Shaw, Vennansha G. Williams, Stuart G. Turville, Julian W. Bess Jr., Jeffrey D. Lifson, and Melissa Robbiani. “The double stranded RNA analog poly(I:C) inhibits HIV amplification in dendritic cells,” submitted.

2007
Morrow, Gavin, Laurence Vachot, Panagiotis Vagenas, and Melissa Robbiani. “Current concepts of HIV transmission,” Current HIV/AIDS Reports 4(1): 29–35. (abstract)

2006
Teleshova, Natalia, Jessica Kenney, Gary Van Nest, Jason Marshall, Jeffrey D. Lifson, Irving Sivin, Jason Dufour, Rudolph Bohm, Agegnehu Gettie, and Melissa Robbiani. “Local and systemic effects of intranodally injected CpG-C immunostimulatory-oligodeoxyribonucleotides in macaques,” Journal of Immunology 177(12): 8531–8541. (abstract)

Teleshova, Natalia,* Jessica Kenney,* Vennansha Williams, Gary Van Nest, Jason Marshall, Jeffrey D. Lifson, Irving Sivin, Jason Dufour, Rudolf Bohm, Agegnehu Gettie, and Melissa Pope. "CpG-C ISS-ODN activation of blood-derived B cells from healthy and chronic immunodeficiency virus-infected macaques," Journal of Leukocyte Biology 79(2): 257–267. (abstract) (*authors contributed equally)

Trapp, Susanna, Stuart G. Turville, and Melissa Robbiani. “Slamming the door on unwanted guests: Why preemptive strikes at the mucosa may be the best-case strategy against HIV,” Journal of Leukocyte Biology 80(5): 1076–1083. (offsite link)

Turville, Stuart G., Silvia Peretti, and Melissa Pope. "Lymphocyte–dendritic cell interactions and mucosal acquisition of SIV/HIV infection," Current Opinion in HIV and AIDS 1(1): 3–9. (abstract)

Vachot, Laurence, Stuart G. Turville, Susanna Trapp, Silvia Peretti, Gavin Morrow, Ines Frank, and Melissa Pope. “Sleeping with the enemy: The insidious relationship between dendritic cells and immunodeficiency viruses,” in Manfred B. Lutz, Nikolaus Romani, and Alexander Steinkasserer (eds.), Handbook of Dendritic Cells: Biology, Diseases and Therapies. Weinheim: Wiley-VCH, pp. 773–797.

2004
Teleshova, Natalia, Jennifer Jones, Jessica Kenney, Jeanette Purcell, Rudolf Bohm, Agegnehu Gettie, and Melissa Pope. “Short-term Flt3L treatment effectively mobilizes functional macaque dendritic cells,” Journal of Leukocyte Biology 75(6): 1102–1110. (abstract)

Teleshova, Natalia, Jessica Kenney, Jennifer Jones, Jason Marshall, Gary Van Nest, Jason Dufour, Rudolf Bohm, Jeffrey D. Lifson, Agegnehu Gettie, and Melissa Pope. “CpG-C ISS-ODN activation of plasmacytoid dendritic cells in rhesus macaques to augment the activation of IFN-γ-secreting SIV-specific T cells,” Journal of Immunology 173(3): 1647–1657. (abstract)

2003
Frank, Ines, John J. Santos, Erin Mehlhop, Loreley Villamide-Herrera, Christine Santisteban, Agegnehu Gettie, Ralf Ignatius, Jeffrey D. Lifson, and Melissa Pope. “Presentation of exogenous whole inactivated simian immunodeficiency virus by mature dendritic cells induces CD4+ and CD8+ T-cell responses,” Journal of Acquired Immune Deficiency Syndromes 34(1): 7–19. (abstract)

Pope, Melissa. “Dendritic cells as a conduit to improve HIV vaccines,” Current Molecular Medicine 3(3): 229–242. (abstract)

Teleshova, Natalia, Ines Frank, and Melissa Pope. “Immunodeficiency virus exploitation of dendritic cells in the early steps of infection,” Journal of Leukocyte Biology 74(5): 683–690. (abstract)

2002
Frank, Ines and Melissa Pope. "The enigma of dendritic cell–immunodeficiency virus interplay," Current Molecular Medicine 2(3): 229–248. (abstract)

Mehlhop, Erin,* Loreley Villamide,* Ines Frank, Agegnehu Gettie, Christine Santisteban, Davorka Messmer, Ralf Ignatius, Jeffrey D. Lifson, and Melissa Pope. “Enhanced in vitro stimulation of rhesus macaque dendritic cells for activation of SIV-specific T cell responses,” Journal of Immunological Methods 260(1–2): 219–234. (abstract) (*authors contributed equally)

Steinman, Ralph M. and Melissa Pope. "Exploiting dendritic cells to improve vaccine efficacy," Journal of Clinical Investigation 109(12): 1519–1526. (offsite PDF)

Presentations

2007
Morrow, Gavin. “The pros and cons of dendritic cells in HIV transmission,” invited speaker, X International Congress of Reproductive Immunology, Croatia, June.

Robbiani, Melissa. “Biology of transmission: Dendritic cells," plenary speaker, 2nd International Workshop on HIV Transmission: Principles of Intervention, Washington, DC, August.

Trapp, Susanna. “The activation of cellular defense mechanisms by poly(IC) to block DC-driven HIV infection,” poster presentation, Keystone Symposia on HIV Vaccines/HIV Pathogenesis, Whistler, British Columbia, March.

Vagenas, Panagiotis. “CpG C ISS-ODN activates mucosal dendritic cells and B cells: A potent adjuvant for mucosal HIV vaccines,” oral and poster presentation, 13th International Congress of Immunology, Rio de Janeiro, Brazil, August.

2006
Morrow, Gavin. “Innate and adaptive mucosal immune responses in macaques during immunodeficiency virus infection”, poster presentation, Keystone Symposia on HIV Vaccines/HIV Pathogenesis, Keystone, CO, March.

Morrow, Gavin. “Innate mucosal immune responses in macaques during SIV/HSV-2 infection,” poster presentation, 4th International Innate Immunity Conference, Corfu, Greece, June.

2005
Frank, Ines. “Visualizing virus capture and transmission by DCs: Interference with a fusion inhibitor,” oral presentation, 12th Conference on Retroviruses and Opportunistic Infections, Boston, MA, 22–25 February.

Kenney, Jessica. “B cells from naïve and SHIV-infected macaques are activated by CpG-C ISS-ODNs,” poster presentation, 12th Conference on Retroviruses and Opportunistic Infections, Boston, MA, 22–25 February.

Pope, Melissa. “Strategies to prevent dendritic cell–driven infection across the mucosa,” invited speaker, International Meeting of the Institute of Human Virology, Baltimore, MD, August/September.

Williams, Vennansha. “In vivo priming of SIV-specific responses by AT-2 SIV-loaded mature dendritic cells,” poster presentation, 12th Conference on Retroviruses and Opportunistic Infections, Boston, MA, 22–25 February.

2004
Pope, Melissa. “Dendritic cells and HIV infection: Activating DCs to boost mucosal immunity,” plenary speaker, 5th World Workshop on Oral Health and Disease in AIDS, Phuket, Thailand, 6–10 July.

———. “Exploiting dendritic cells for improved vaccines,” invited speaker, Keystone Symposium, Rational Design of Vaccines and Immunotherapeutics, Keystone, CO, 6–11 January.

———. “Overcoming the exploitation of dendritic cells to boost anti-HIV immunity,” invited seminar, Baylor College of Medicine, Houston, May.

2003
Frank, Ines. “T-cell activation versus cell-to-cell spread of virus by virus-bearing dendritic cells,” oral presentation at AIDS Vaccine Meeting, New York, September.

Pope, Melissa. “Aspects of dendritic cells that influence virus spread over immune activation,” invited speaker, International Meeting of the Institute of Human Virology, Baltimore, October.

———. “T-cell activation vs. virus dissemination by virus-bearing dendritic cells,” invited speaker, UCSF-Gladstone Institute of Virology and Immunology Center for AIDS Research Symposium, San Francisco, CA, October.

Villamide-Herrera, Loreley et al. “Macaque dendritic cells infected with SIV-recombinant canarypox ex vivo induce SIV-specific immune responses in vivo,” poster presentation, AIDS Vaccine Meeting, New York, September.

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