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PROJECT
Microbicides to Prevent
Sexual Transmission of HIV
Publications/Resources
Council researchers' names appear in boldface type.
In press or submitted
Frank, Ines, Hella Stössel, Agegnehu Gettie, Stuart G. Turville, Julian
W. Bess Jr., Jeffrey D. Lifson, Irving Sivin, Nikolaus Romani, and
Melissa Robbiani. “A fusion inhibitor prevents dendritic cell (DC)
spread of immunodeficiency viruses but not DC activation of
virus-specific T cells,” Journal of Virology, in press.
Schweizer, Andreas, Peter Rusert, Livia Berlinger, Claudia Ruprecht, Axel Mann, S. Corthésy, Stuart G. Turville, Meropi Aravantinou, Melissa Robbiani, Patrick Amstutz, and Alexandra Trkola. “CD4-specific designed ankyrin repeat proteins are novel potent HIV entry inhibitors with unique characteristics,” submitted.
2008
Turville, Stuart G., Meropi Aravantinou, Hella Stössel,
Nikolaus Romani, and Melissa Robbiani. “Resolution of de novo
HIV production and trafficking in immature dendritic cells,” Nature
Methods 5(1): 75–85.
(abstract)
2007
Fernández-Romero,
José A., Mitchell Thorn, Stuart G. Turville, Kanani Titchen,
Kristin M. Sudol, Jifan Li, Todd Miller, Melissa
Robbiani, Robin A. Maguire, Robert
W. Buckheit Jr., Tracy L. Hartman, and David M. Phillips. "Carrageenan/MIV-150 (PC-815), a combination microbicide," Sexually Transmitted Diseases
34(1): 9–14. (abstract)
Morrow, Gavin, Laurence Vachot, Panagiotis Vagenas, and Melissa Robbiani. “Current concepts of HIV transmission,” Current HIV/AIDS Reports 4:29–35. (abstract)
2006
Turville, Stuart G., Silvia Peretti, and Melissa Pope. "Lymphocyte–dendritic cell interactions and mucosal acquisition
of SIV/HIV infection," Current Opinion in HIV and AIDS 1(1): 3–9.
(abstract)
Trapp, Susanna, Stuart G. Turville, and Melissa Robbiani. “Slamming the door on unwanted guests: Why preemptive strikes at the mucosa may be the best-case strategy against HIV,” Journal of Leukocyte Biology 80(5): 1076–1083. (offsite link)
2005
Morcock, David R., James A. Thomas, Tracy D. Gagliardi, Robert J. Gorelick,
J. David Roser, Elena N. Chertova, Julian W. Bess, Jr., David E. Ott,
Quentin J. Sattentau, Ines Frank, Melissa Pope, Jeffrey D.
Lifson, Louis E. Henderson, and Bruce J. Crise. "Elimination of retroviral
infectivity by N-ethylmaleimide with preservation of functional
envelope glycoproteins," Journal of Virology 79(3): 1533–1542. (abstract)
Peretti, Silvia, Andrew Shaw, James Blanchard, Rudolf Bohm, Gavin Morrow, Jeffrey D. Lifson, Agegnehu Gettie, and Melissa Pope. “Immunomodulatory effects of HSV-2 infection on immature macaque dendritic cells modify innate and adaptive responses,” Blood 106(4): 1305–1313. (abstract)
2004
Hu, Qinxue, Ines Frank, Vennansha Williams, John J. Santos, Patricia Watts, George E. Griffin, John P. Moore, Melissa Pope, and Robin Shattock. “Blockade of attachment and fusion receptors inhibits HIV-1 infection of human cervical tissue,” Journal of Experimental Medicine 199(8): 1065–1075.
(abstract)
Turville, Stuart G.,* John J. Santos,* Ines Frank, Paul U. Cameron, John Wilkinson, Monica Miranda-Saksena, Joanne Dable, Hella Stössel, Nikolaus Romani, Michael Piatak, Jr., Jeffrey D. Lifson, Melissa Pope,^ and Anthony L. Cunningham.^ “Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells,” Blood 103(6): 2170–2179. (abstract) (*authors contributed equally; ^equal senior contributors)
2003
Ketas, Thomas J., Ines Frank, Per Johan Klasse, Brian M. Sullivan, Jason P. Gardener, Catherine Spenlehauer, Mirjana Nesin, William C. Olson, John P. Moore, and Melissa Pope. “Human immunodeficiency virus type 1 attachment, coreceptor, and fusion inhibitors are active against both direct and
trans infection of primary cells,” Journal of Virology 77(4): 2762–2767.
(abstract)
Ketas, Thomas, Per Johan Klasse, Catherine Spenlehauer, Mirjana Nessin, Ines Frank, Melissa Pope, Julie M. Strizki, Gregory R. Reyes, Bahige M. Baroudy, and John P. Moore. “Entry inhibitors SCH-C, RANTES, and T-20 block HIV type 1 replication in multiple cell types,“ AIDS Research and Human Retroviruses 19(3): 177–186. (abstract)
Pope, Melissa and Ashley T. Haase. “Transmission, acute HIV-1 infection and the quest for strategies to prevent infection,” Nature Medicine 9(7): 847–852. (abstract)
Teleshova, Natalia, Ines Frank, and Melissa Pope. “Immunodeficiency virus exploitation of dendritic cells in the early steps of infection,” Journal of Leukocyte Biology 74(5): 683–690. (abstract)
Veazey, Ronald S., Robin J. Shattock, Melissa Pope, J. Christian Kirijan, Jennifer Jones, Qinxue Hu, Thomas J. Ketas, Preston A. Marx, Per Johan Klasse, Dennis R. Burton, and John P. Moore. “Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120,” Nature Medicine 9(3): 343–346. (abstract)
2002
Frank, Ines, Michael Piatak, Jr., H. Stoessel, Nikolaus Romani, David Bonnyay, Jeffrey D. Lifson, and Melissa Pope. “Infectious and whole inactivated simian immunodeficiency viruses interact similarly with primate dendritic cells (DCs): Differential intracellular fate of virions in mature and immature DCs,” Journal of Virology 76(6): 2936–2951.
(abstract) (offsite
PDF)
Frank, Ines and Melissa Pope. "The enigma of dendritic cell–immunodeficiency virus interplay," Current Molecular Medicine 2(3): 229–248. (abstract)
Presentations
2008
Crostarosa, Federica. “Increased susceptibility of HSV-2-infected
monkeys to SHIV-RT,” poster presentation, Keystone Symposia on HIV
Vaccines/HIV Pathogenesis, Banff, Alberta, Canada, March.
Robbiani, Melissa. “Testing Carraguard-based microbicides,” invited participant, USAID primate workshop, Washington, DC, January.
Turville, Stuart. “Discordance of in vitro and in vivo protection using Carraguard-based microbicides,” poster presentation, Keystone Symposia on HIV Vaccines/HIV Pathogenesis, Banff, Alberta, Canada, March.
2007
Crostarosa, Federica. “Carraguard-based microbicides prevent SHIV RT
infection in naïve and HSV-2-infected macaques,” invited speaker, Nonhuman
Primate Models of SIV/HIV Infection Symposium, Penn CFAR, University of
Pennsylvania, October.
Robbiani, Melissa. “Biology of transmission: Dendritic cells”, plenary speaker, 2nd International Workshop on HIV Transmission: Principles of Intervention, Washington, DC, August.
2006
Frank, Ines. “Impact of a single fusion inhibitor on virus
transmission and antigen presentation by dendritic cells,” poster
presentation, Keystone Symposia on HIV Vaccines/HIV Pathogenesis, Keystone,
CO, March.
Turville, Stuart. “Strategies to prevent dendritic cell–driven infection across the mucosa,” poster presentation, Keystone Symposia on HIV Vaccines/HIV Pathogenesis, Keystone, CO, March.
2005
Frank, Ines. “Visualizing virus capture and transmission by DCs:
Interference with a fusion inhibitor,” oral presentation, 12th Conference on
Retroviruses and Opportunistic Infections, Boston, MA, 22–25 February.
Pope, Melissa. “Strategies to prevent dendritic cell–driven infection across the mucosa,” invited speaker, International Meeting of the Institute of Human Virology, Baltimore, MD, August/September.
2004
Pope, Melissa. “Mechanisms of sexual transmission of HIV,” plenary speaker at Microbicides 2004, London, 28–31 March.
2003
Pope, Melissa. “Aspects of dendritic cells that influence virus spread over immune activation,” invited speaker, International Meeting of the Institute of Human Virology, Baltimore, October.
———. “Factors influencing virus fate in dendritic cells,” invited speaker, HIV Pathogenic Mechanisms and Therapeutics Symposium, Palm Springs, CA, March; invited seminar, UCLA AIDS Institute, Los Angeles, CA, March; invited seminar, Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Beaverton, OR, March.
———. “How HIV exploits dendritic cells to drive infection,” invited seminar, Johns Hopkins School of Medicine, Baltimore, MD, January.
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