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PROJECT
Transmission of Immunodeficiency Viruses
Publications/Resources
Council researchers' names appear in boldface type.
In press or submitted
Schweizer, Andreas, Peter Rusert, Livia Berlinger, Claudia Ruprecht,
Axel Mann, S. Corthésy, Stuart G. Turville, Meropi Aravantinou,
Melissa Robbiani, Patrick Amstutz, and Alexandra Trkola. “CD4-specific
designed ankyrin repeat proteins are novel potent HIV entry inhibitors with
unique characteristics,” submitted.
Trapp, Susanna, Nina Derby, Rachel Singer, Andrew Shaw, Vennansha G. Williams, Stuart G. Turville, Julian W. Bess Jr., Jeffrey D. Lifson, and Melissa Robbiani. “The double stranded RNA analog poly(I:C) inhibits HIV amplification in dendritic cells,” submitted.
Vachot, Laurence, Vennansha G. Williams, Julian W. Bess Jr., Jeffrey D. Lifson, and Melissa Robbiani. “Candida albicans–induced DC activation reduces HIV amplification by DCs while increasing DC-to-T-cell spread of HIV,” Journal of Acquired Immune Deficiency Syndromes, in press.
2008
Frank, Ines, Hella Stössel, Agegnehu Gettie, Stuart G. Turville,
Julian W. Bess Jr., Jeffrey D. Lifson, Irving Sivin, Nikolaus
Romani, and Melissa Robbiani. "A fusion inhibitor prevents spread
of immunodeficiency viruses, but not activation of virus-specific T
cells, by dendritic cells," Journal of Virology 82(11):
5329–5339. (abstract)
Sprague, Wendy S., Melissa Robbiani, Paul R. Avery, Kevin P. O'Halloran, and Edward A. Hoover. "Feline immunodeficiency virus dendritic cell infection and transfer," Journal of General Virology 89(3): 709–715. (abstract)
Turville, Stuart G., Meropi Aravantinou, Hella Stössel, Nikolaus Romani, and Melissa Robbiani. “Resolution of de novo HIV production and trafficking in immature dendritic cells,” Nature Methods 5(1): 75–85. (abstract)
2007
Morrow, Gavin, Laurence Vachot, Panagiotis Vagenas, and
Melissa Robbiani. “Current concepts of HIV transmission,” Current
HIV/AIDS Reports 4:29–35. (abstract)
2006
Trapp, Susanna, Stuart G. Turville, and Melissa Robbiani. “Slamming the
door on unwanted guests: Why preemptive strikes at the mucosa may be the
best-case strategy against HIV,” Journal of Leukocyte Biology 80(5): 1076–1083.
(offsite
link)
Turville, Stuart G., Silvia Peretti, and Melissa Pope. "Lymphocyte–dendritic cell interactions and mucosal acquisition of SIV/HIV infection," Current Opinion in HIV and AIDS 1(1): 3–9. (abstract)
2005
Morcock, David R., James A. Thomas, Tracy D. Gagliardi, Robert J. Gorelick,
J. David Roser, Elena N. Chertova, Julian W. Bess, Jr., David E. Ott,
Quentin J. Sattentau, Ines Frank, Melissa Pope, Jeffrey D.
Lifson, Louis E. Henderson, and Bruce J. Crise. "Elimination of retroviral
infectivity by N-ethylmaleimide with preservation of functional
envelope glycoproteins," Journal of Virology 79(3): 1533–1542. (abstract)
Peretti, Silvia, Andrew Shaw, James Blanchard, Rudolf Bohm, Gavin Morrow, Jeffrey D. Lifson, Agegnehu Gettie, and Melissa Pope. “Immunomodulatory effects of HSV-2 infection on immature macaque dendritic cells modify innate and adaptive responses,” Blood 106(4): 1305–1313. (abstract)
Sprague, Wendy S., Melissa Pope, and Edward A. Hoover. 2005. "Culture and characterization of feline myeloid dendritic cells generated from CD14+ monocytes," Journal of Comparative Pathology 133(2–3): 136–145. (abstract)
2004
Hu, Qinxue, Ines Frank, Vennansha Williams, John J. Santos, Patricia Watts, George E. Griffin, John P. Moore, Melissa Pope, and Robin Shattock. “Blockade of attachment and fusion receptors inhibits HIV-1 infection of human cervical tissue,” Journal of Experimental Medicine 199(8): 1065–1075.
(abstract)
Turville, Stuart G.,* John J. Santos,* Ines Frank, Paul U. Cameron, John Wilkinson, Monica Miranda-Saksena, Joanne Dable, Hella Stössel, Nikolaus Romani, Michael Piatak, Jr., Jeffrey D. Lifson, Melissa Pope,^ and Anthony L. Cunningham.^ “Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells,” Blood 103(6): 2170–2179. (abstract) (*authors contributed equally; ^equal senior contributors)
2003
Frank, Ines, John J. Santos, Erin Mehlhop, Loreley Villamide-Herrera, Christine Santisteban, Agegnehu Gettie, Ralf Ignatius, Jeffrey D. Lifson, and Melissa Pope. “Presentation of exogenous whole inactivated simian immunodeficiency virus by mature dendritic cells induces CD4+ and CD8+ T-cell responses,” Journal of Acquired Immune Deficiency Syndromes 34(1): 7–19.
(abstract)
Ketas, Thomas J., Ines Frank, Per Johan Klasse, Brian M. Sullivan, Jason P. Gardener, Catherine Spenlehauer, Mirjana Nesin, William C. Olson, John P. Moore, and Melissa Pope. “Human immunodeficiency virus type 1 attachment, coreceptor, and fusion inhibitors are active against both direct and trans infection of primary cells,” Journal of Virology 77(4): 2762–2767. (abstract)
Ketas, Thomas, Per Johan Klasse, Catherine Spenlehauer, Mirjana Nessin, Ines Frank, Melissa Pope, Julie M. Strizki, Gregory R. Reyes, Bahige M. Baroudy, and John P. Moore. “Entry inhibitors SCH-C, RANTES, and T-20 block HIV type 1 replication in multiple cell types,“ AIDS Research and Human Retroviruses 19(3): 177–186. (abstract)
Pope, Melissa and Ashley T. Haase. “Transmission, acute HIV-1 infection and the quest for strategies to prevent infection,” Nature Medicine 9(7): 847–852. (abstract)
Teleshova, Natalia, Ines Frank, and Melissa Pope. “Immunodeficiency virus exploitation of dendritic cells in the early steps of infection,” Journal of Leukocyte Biology 74(5): 683–690. (abstract)
Veazey, Ronald S., Robin J. Shattock, Melissa Pope, J. Christian Kirijan, Jennifer Jones, Qinxue Hu, Thomas J. Ketas, Preston A. Marx, Per Johan Klasse, Dennis R. Burton, and John P. Moore. “Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120,” Nature Medicine 9(3): 343–346. (abstract)
2002
Frank, Ines, Michael Piatak, Jr., H. Stoessel, Nikolaus Romani, David Bonnyay, Jeffrey D. Lifson, and Melissa Pope. “Infectious and whole inactivated simian immunodeficiency viruses interact similarly with primate dendritic cells (DCs): Differential intracellular fate of virions in mature and immature DCs,” Journal of Virology 76(6): 2936–2951.
(abstract) (offsite
PDF)
Frank, Ines and Melissa Pope. "The enigma of dendritic cell–immunodeficiency virus interplay," Current Molecular Medicine 2(3): 229–248. (abstract)
Ignatius, Ralf, Klara Tenner-Racz, Davorka Messmer, Agegnehu Gettie, Amara Luckay, Christine Russo, Stephen Smith, Preston A. Marx, Ralph M. Steinman, Paul Racz, and Melissa Pope. "Increased macrophage infection upon subcutaneous inoculation of rhesus macaques with simian immunodeficiency virus-loaded dendritic cells or T cells but not with cell-free virus," Journal of Virology 76(19): 9787–9797. (abstract) (offsite PDF)
Messmer, Davorka, Jean-Marc Jacqué, Christine Santisteban, Cynthia Bristow, Seol-Young Han, Loreley Villamide-Herrera, Erin Mehlhop, Preston A. Marx, Ralph M. Steinman, Agegnehu Gettie, and Melissa Pope. “Endogenously expressed nef uncouples cytokine and chemokine production from membrane phenotypic maturation in dendritic cells,” Journal of Immunology 169(8): 4172–4182. (abstract) (offsite PDF)Wu, Li, Arman A. Bashirova, Thomas D. Martin, Loreley Villamide, Erin Mehlhop, Andrei O. Chertov, Derya Unutmaz, Melissa Pope, Mary Carrington, and Vineet N. Kewal Ramani. “Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN,” Proceedings of the National Academy of Sciences of the United States of America 99(3): 1568–1573. (abstract) (offsite PDF)
Presentations
2008
Crostarosa, Federica. “Increased susceptibility of HSV-2-infected
monkeys to SHIV-RT,” poster presentation, Keystone Symposia on HIV
Vaccines/HIV Pathogenesis, Banff, Alberta, Canada, March.
Turville, Stuart. “Discordance of in vitro and in vivo protection using Carraguard-based microbicides,” poster presentation, Keystone Symposia on HIV Vaccines/HIV Pathogenesis, Banff, Alberta, Canada, March.
2007
Crostarosa, Federica. “Carraguard-based microbicides prevent SHIV RT
infection in naïve and HSV-2-infected macaques,” invited speaker, Nonhuman
Primate Models of SIV/HIV Infection Symposium, Penn CFAR, University of
Pennsylvania, Philadelphia, October.
Morrow, Gavin. “The pros and cons of dendritic cells in HIV transmission,” invited speaker, X International Congress of Reproductive Immunology, Croatia, June.
Robbiani, Melissa. “Biology of transmission: Dendritic cells,” plenary speaker, 2nd International Workshop on HIV Transmission—Principles of Intervention, Washington, DC, August.
Trapp, Susanna. “The activation of cellular defense mechanisms by poly(IC) to block DC-driven HIV infection,” poster presentation, Keystone Symposia on HIV Vaccines/HIV Pathogenesis, Whistler, British Columbia, March.
Turville, Stuart. “Dynamic visualization in real time of HIV-1 intracellular production, assembly, and polarized budding in immature dendritic cells,” poster presentation, Keystone Symposia on HIV Vaccines/HIV Pathogenesis, Whistler, British Columbia, March.
Vachot, Laurence. “HIV infection of dendritic cells modulates innate and adaptive responses elicited against Candida albicans,” poster presentation, Keystone Symposia on HIV Vaccines/HIV Pathogenesis, Whistler, British Columbia, March.
2006
Frank, Ines. “Impact of a single fusion inhibitor on virus
transmission and antigen presentation by dendritic cells,” poster
presentation, Keystone Symposia on HIV Vaccines/HIV Pathogenesis, Keystone,
CO, March.
Morrow, Gavin. “Innate and adaptive mucosal immune responses in macaques during immunodeficiency virus infection,” poster presentation, Keystone Symposia on HIV Vaccines/HIV Pathogenesis, Keystone, CO, March.
Morrow, Gavin. “Innate mucosal immune responses in macaques during SIV/HSV-2 infection,” poster presentation, 4th International Innate Immunity Conference, Corfu, Greece, June.
Trapp, Susanna. “Co-pathogens and HIV:TLR3 stimulation dampens HIV replication,” oral and poster presentation, Keystone Symposia on HIV Vaccines/HIV Pathogenesis, Keystone, CO, March.
Turville, Stuart. “Strategies to prevent dendritic cell–driven infection across the mucosa,” poster presentation, Keystone Symposia on HIV Vaccines/HIV Pathogenesis, Keystone, CO, March.
Vachot, Laurence. “AT-2 inactivated HIV-1 does not influence the innate responses elicited by dendritic cells towards Candida albicans,” poster presentation, Keystone Symposia on HIV Vaccines/HIV Pathogenesis, Keystone, CO, March.
Vachot, Laurence. “Innate immune responses against Candida albicans induced in cord blood cells compared to adult blood cells,” poster presentation, 4th International Innate Immunity Conference, Corfu, Greece, June.
2005
Pope, Melissa. “Strategies to prevent dendritic cell–driven infection
across the mucosa,” invited speaker, International Meeting of the Institute
of Human Virology, Baltimore, MD, August/September.
Frank, Ines. “Visualizing virus capture and transmission by DCs: Interference with a fusion inhibitor,” oral presentation, 12th Conference on Retroviruses and Opportunistic Infections, Boston, MA, 22–25 February.
2004
Pope, Melissa. “Dendritic cells and HIV infection: Activating DCs to
boost mucosal immunity,” plenary speaker, 5th World Workshop on Oral Health
and Disease in AIDS, Phuket, Thailand, 6–10 July.
Pope, Melissa. “Mechanisms of sexual transmission of HIV,” plenary speaker at Microbicides 2004, London, 28–31 March.
Pope, Melissa. “Overcoming the exploitation of dendritic cells to boost anti-HIV immunity,” invited seminar, Baylor College of Medicine, Houston, May.
2003
Frank, Ines. “T-cell activation versus cell-to-cell spread of virus by virus-bearing dendritic cells,” oral presentation at AIDS Vaccine Meeting, New York, September.
Pope, Melissa. “Aspects of dendritic cells that influence virus spread over immune activation,” invited speaker, International Meeting of the Institute of Human Virology, Baltimore, October.
Pope, Melissa. “Factors influencing virus fate in dendritic cells,” invited speaker, HIV Pathogenic Mechanisms and Therapeutics Symposium, Palm Springs, CA, March; invited seminar, UCLA AIDS Institute, Los Angeles, CA, March; invited seminar, Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Beaverton, OR, March.
Pope, Melissa. “How HIV exploits dendritic cells to drive infection,” invited seminar, Johns Hopkins School of Medicine, Baltimore, MD, January.
Pope, Melissa. “Selective modulation of dendritic cells by nef,” invited workshop participant and presenter, HIV-1 nef Protein: No End of Conformations and Functions, Praiano, Italy, May.
Pope, Melissa. “T-cell activation vs. virus dissemination by virus-bearing dendritic cells,” invited speaker, UCSF-Gladstone Institute of Virology and Immunology Center for AIDS Research Symposium, San Francisco, CA, October.
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