Abstract
The roles of estrogen and progestin in producing deciduosarcoma and other lesions in the rabbit
Janne,Olli A.; Zook,Bernard C.; Didolkar,Ashok K.; Sundaram,Kalyan; Nash,Harold A.
Toxicologic Pathology 29(4): 417-421
Publication date: 2001
The interactions of estrogens and progestins in producing decidualization,deciduosarcoma, and other lesions in the rabbit were explored.Steroids were delivered by silicone elastomer implants placedsubdermally except for oral dosing in 1 experiment. Varyingdoses of levonorgestre l (LNG) were given with and without estradiol(E) and varying doses of E with and without LNG. LNG alonedelivered at an estimated mean dose of 233 µg/day didnot result in endometrial decidualization or deciduosarcoma.Both conditions occurred when E was added to the regimen andincreased as the dose of E was increased. Sixty µg ofE per day produced endometrial decidualization in all testanimals in a 2-month exposure, but deciduosarcom a occurredonly when LNG was also supplied and increased as the LNG dosewas increased. Progesterone given with E resulted in deciduosarcomain most rabbits. Ethynylestradiol alone at 30 µ g/daydelivered by implants produced splenic and ovarian deciduosarcomas in 1 of 5 test animals. Adding LNG resulted in more numerousand widespread deciduosarcomas. These experiments indicate thatexogenous estrogen is necessary for decidualization of the endometriumand to production of deciduosarcoma in the nonpregnant rabbit.Exogenous progestin promotes the process. Necrosis of the uterinewall tended to increase with increasing dose of estrogens.
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