Norplant® implants and progesterone vaginal rings do not affect maternal bone turnover and density during lactation and after weaning (PDF)
Diaz,Soledad; Reyes,M.V.; Zepeda,Ana; Gonzalez,G.B.; Lopez,J.M.; Campino,C.; Croxatto,Horacio B.
Human Reproduction 14(10): 2499-2505
Publication date: 1999
Bone density and turnover was assessed in a longitudinal studyof healthy lactating women who initiated use of Norplantimplants (NOR, n = 29), progesterone vaginal rings (PVR, n =28) or Copper T 380A intrauterine devices (T-Cu, n = 51, controlgroup) around day 60 postpartum. Bone density, serum calcium,phosphorus, alkaline phosphatases, parathyroid hormone (PTH),follicle stimulating hormone (FSH), oestradiol and prolactin,and urinary hydroxyproline and creatinine were measured at postpartummonths 1 (PM1), and 12 (PM12) and 6 or 12 months after weaning;at month 6 postpartum (PM6) serum and urine tests alone wereperformed. Baseline characteristics and lactation performancewere similar between groups. Biochemical markers of bone turnoverwere higher at PM1, PM6 and PM12 than after weaning, with nodifferences between groups. Bone density in the lumbar spine(L2-L4) and femoral neck at PM1 and PM12 (~1.11 g/cm)was similar in three groups. Lumbar spine values were foundto be lower in lactating women than those present in non-lactatingwomen, but increased after weaning to similar values. The twoprogestin-only contraceptives studied appear to have no deleteriouseffect upon bone density and metabolism in healthy lactatingwomen.