Prospective randomized trial to evaluate the efficacy of a vaginal ring releasing progesterone for IVF and oocyte donation (PDF)
Zegers-Hochschild,F.; Balmaceda,J.P.; Fabres,C.; Alam,V.; Mackenna,A.; Fernandez,Emilio; Pacheco,I.M.; Sepulveda,M.S.; Chen,S.; Borrero,C.; Borges,E.
Human Reproduction 15(10): 2093-2097
Publication date: 2000
A polysyloxane vaginal ring containing 1g of natural progesteronewas developed as luteal supplementation for women treated withIVF-embryo transfer and for agonadal women participatingin an oocyte donation programme. The ring provides continuousrelease of progesterone (10-20 nmol/l) for 90 days. The efficacyof this form of progesterone supplementation was evaluated intwo multicentre prospective randomized trials. IVF-embryotransfer trial: After oocyte aspiration, 505 women were randomlyallocated to progesterone supplementation with vaginal ringor i.m. progesterone (50 mg/day). The clinical pregnancy ratewas 36.6% in both groups. Implantation rate was 15.9% in thevaginal ring and 16.0% in i.m. progesterone. Oocyte donationtrial: After endometrial proliferation with micronized oestradiol,153 women were allocated to progesterone replacement with avaginal ring or i.m. progesterone (100 mg/day). Clinical pregnancyrate was 39.8 and 28.6% respectively. Implantation rate wassignificantly higher with the vaginal ring compared with i.m.progesterone (19.9 and 11.6% respectively, P = 0.006). The vaginalring is a novel development which provides continuous releaseof progesterone for 90 days. In IVF-embryo transfer, itseffectiveness is similar to daily i.m. injections. In oocytedonation the ring provides a progestative milieu which improvesthe implantation rate and eliminates the discomfort of dailyi.m. injections.
For 60 years, the Population Council has changed the way the world thinks about important health and development issues. Explore an interactive timeline of the Council's history, learn more about some of our key contributions, and watch a short video about why your support is so important to us.