Abstract
Curcumin derivatives inhibit testicular 17ß-hydroxysteroid dehydrogenase 3 (HTML)
Hu,Guo-Xin; Liang,Guang; Chu,Yanhui; Li,Xiao-Kun; Lian,Qing-Quan; Lin,Han; He,Yi; Huang,Yadong; Hardy,Dianne O.; Ge,Renshan
Bioorganic and Medicinal Chemistry Letters 20(8): 2549-2551
Publication date: 2010
Non-steroidal compounds that inhibit 17ß-hydroxysteroid dehydrogenase isoform 3 (17ß-HSD3), an enzyme catalyzing the final step in testosterone biosynthesis in Leydig cells, are under development for male contraceptive or treatment of androgen dependent diseases including prostate cancer. A series of curcumin analogues with more stable chemical structures were compared to curcumin as inhibitors of 17ß-HSD3 in rat intact Leydig cells as well as rat and human testis microsomes.
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