Population Council Research that makes a difference

Abstract

The biology of interleukin-1: Emerging concepts in the regulation of the actin cytoskeleton and cell junction dynamics (HTML
Lie,Pearl P.Y.; Cheng,Chuen-yan; Mruk,Dolores D.
Cellular and Molecular Life Sciences 69(4): 487-500
Publication date: 2012



Interleukin (IL)-1 is a proinflammatory cytokine with important roles in innate immunity, as well as in normal tissue homeostasis. Interestingly, recent studies have also shown IL-1 to function in the dynamics of the actin cytoskeleton and cell junctions. For example, treatment of different epithelia with IL-1a often results in the restructuring of the actin network and cell junctions, thereby leading to junction disassembly. In this review, we highlight new and interesting findings that show IL-1 to be a critical player of restructuring events in the seminiferous epithelium of the testis during spermatogenesis.




What's New

For 60 years, the Population Council has changed the way the world thinks about important health and development issues. Explore an interactive timeline of the Council's history, learn more about some of our key contributions, and watch a short video about why your support is so important to us.

Get Involved

Connect

  • Visit our Facebook page
  • Follow us on Twitter
  • Visit our Youtube channel