At the Population Council’s Center for Biomedical Research, scientists are advancing knowledge of the biological mechanisms of HIV transmission, pathogenesis and disease progression. Our research has clarified the role dendritic cells can play in promoting beneficial immune responses, as well as in driving HIV infection. This knowledge allows us to develop effective HIV prevention technologies. In addition, Council scientists study how other sexually transmitted infections (STIs), such as herpes simplex virus (HSV) and human papilloma virus (HPV) are acquired and progress.
Council scientists are determining the role of integrins in HIV transmission across the mucosa. Researchers are also evaluating how herpes viruses augment mucosal HIV transmission. Finally, scientists are evaluating the impct of endogenous and exogenous sex hormones on mucosal HIV transmission.