Population Council Research that makes a difference

Dolores D. Mruk, Ph.D.

Scientist

Actin cross-linking protein palladin and spermatogenesis  (abstract) (PDF) 
Qian,Xiao-jing; Mruk,Dolores D.; Cheng,Yan Ho; Cheng,Chuen-yan
Spermatogenesis 3(1)
Publication date: 2013

Adjudin attenuates lipopolysaccharide (LPS)- and ischemia-induced microglial activation  (abstract) (HTML) 
Shao,Jiaxiang; Liu,Tengyuan; Xie,Qian Reuben; Zhang,Tingting; Yu,Hemei; Wang,Boshi; Ying,Weihai; Mruk,Dolores D.; Silvestrini,Bruno; Cheng,Chuen-yan; Xia,Weiliang
Journal of Neuroimmunology 254(1): 83-90
Publication date: 2013

c-Yes regulates cell adhesion at the apical ectoplasmic specialization-blood-testis barrier axis via its effects on protein recruitment and distribution  (abstract) (HTML) 
Xiao,Xiang; Mruk,Dolores D.; Cheng,Chuen-yan
American Journal of Physiology: Endocrinology and Metabolism (Translational Series) 304(2): E145-E159
Publication date: 2013

Intercellular adhesion molecule-2 is involved in apical ectoplasmic specialization dynamics during spermatogenesis in the rat  (abstract) (HTML) 
Xiao,Xiang; Cheng,Chuen-yan; Mruk,Dolores D.
Journal of Endocrinology 216(1): 73-86
Publication date: 2013

Intercellular adhesion molecules (ICAMs) and spermatogenesis  (abstract) (HTML) 
Xiao,Xiang; Mruk,Dolores D.; Cheng,Chuen-yan
Human Reproduction Update Published online ahead of print, 3 January
Publication date: 2013

Regulation of actin dynamics and protein trafficking during spermatogenesis--Insights into a complex process  (abstract) (HTML) 
Su,Wenhui; Mruk,Dolores D.; Cheng,Chuen-yan
Critical Reviews in Biochemistry and Molecular Biology Published online ahead of print, 23 January
Publication date: 2013

Regulation of blood-testis barrier (BTB) dynamics during spermatogenesis via the "yin" and "yang" effects of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2  (abstract) (HTML) 
Mok,Ka-Wai; Mruk,Dolores D.; Cheng,Chuen-yan
International Review of Cell and Molecular Biology 301: 291-358
Publication date: 2013

Rictor/mTORC2 regulates blood-testis barrier dynamics via its effects on gap junction communications and actin filament network  (abstract) (HTML) 
Mok,Ka-Wai; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
FASEB Journal Published online ahead of print, 3 January
Publication date: 2013

A peptide derived from laminin-y3 reversibly impairs spermatogenesis in rats  (abstract) (HTML) 
Su,Linlin; Mruk,Dolores D.; Lie,Pearl P.Y.; Silvestrini,Bruno; Cheng,Chuen-yan
Nature Communications 3(1185): doi:10.1038/ncomms2171-
Publication date: 2012

Drug transporters in spermatogenesis: A re-evaluation of recent data on P-glycoprotein  (abstract) (PDF) (HTML) 
Mruk,Dolores D.; Cheng,Chuen-yan
Spermatogenesis 2(2): 70-72
Publication date: 2012

Filamin A is a regulator of blood-testis barrier assembly during postnatal development in the rat testis  (abstract) (HTML) 
Su,Wenhui; Mruk,Dolores D.; Lie,Pearl P.Y.; Lui,Wing-Yee; Cheng,Chuen-yan
Endocrinology 153(10): 5023-5035
Publication date: 2012

Filamin A: A regulator of blood-testis barrier assembly during post-natal development  (abstract) (PDF) (HTML) 
Su,Wenhui; Mruk,Dolores D.; Cheng,Chuen-yan
Spermatogenesis 2(2): 73-78
Publication date: 2012

Focal adhesion kinase-Tyr407 and -Tyr397 exhibit antagonistic effects on blood-testis barrier dynamics in the rat  (abstract) (PDF) (HTML) 
Lie,Pearl P.Y.; Mruk,Dolores D.; Mok,Ka-Wai; Su,Linlin; Lee,Will M.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 109(31): 12562-12567
Publication date: 2012

In search of suitable in vitro models to study germ cell movement across the blood-testis barrier  (abstract) (PDF) (HTML) 
Mruk,Dolores D.; Cheng,Chuen-yan
Spermatogenesis 2(1): 6-10
Publication date: 2012

Microtubule affinity-regulating kinase 4 (MARK4) is a component of the ectoplasmic specialization in the rat testis  (abstract) (PDF) (HTML) 
Tang,Elizabeth I.; Xiao,Xiang; Mruk,Dolores D.; Qian,Xiao-jing; Mok,Ka-Wai; Jenardhanan,Pranitha; Lee,Will M.; Mathur,Premendu P.; Cheng,Chuen-yan
Spermatogenesis 2(2): 117-126
Publication date: 2012

Regulation of drug transporters in the testis by environmental toxicant cadmium, steroids and cytokines  (abstract) (PDF) (HTML) 
Su,Linlin; Mruk,Dolores D.; Cheng,Chuen-yan
Spermatogenesis 2(4): 285-293
Publication date: 2012

Regulation of the blood-testis barrier by coxsackievirus and adenovirus receptor  (abstract) (HTML) 
Su,Linlin; Mruk,Dolores D.; Cheng,Chuen-yan
American Journal of Physiology: Cell Physiology 303(8): C843-C853
Publication date: 2012

rpS6 regulates blood-testis barrier dynamics by affecting F-actin organization and protein recruitment  (abstract) (HTML) 
Mok,Ka-Wai; Mruk,Dolores D.; Silvestrini,Bruno; Cheng,Chuen-yan
Endocrinology 153(10): 5036-5048
Publication date: 2012

Spermatogonial stem cells alone are not sufficient to re-initiate spermatogenesis in the rat testis following adjudin-induced infertility  (abstract) (PDF) (HTML) 
Mok,Ka-Wai; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
International Journal of Andrology 35(1): 86-101
Publication date: 2012

The biology of interleukin-1: Emerging concepts in the regulation of the actin cytoskeleton and cell junction dynamics  (abstract) (HTML) 
Lie,Pearl P.Y.; Cheng,Chuen-yan; Mruk,Dolores D.
Cellular and Molecular Life Sciences 69(4): 487-500
Publication date: 2012

The blood-testis barrier and its implications for male contraception  (abstract) (PDF) (HTML) 
Cheng,Chuen-yan; Mruk,Dolores D.
Pharmacological Reviews 64(1): 16-64
Publication date: 2012

The Scribble/Lgl/Dlg polarity protein complex is a regulator of blood-testis barrier dynamics and spermatid polarity during spermatogenesis  (abstract) (HTML) 
Su,Wenhui; Wong,Elissa W.P.; Mruk,Dolores D.; Cheng,Chuen-yan
Endocrinology 153(12): 6041-6053
Publication date: 2012

Tumor necrosis factor α-mediated restructuring of the Sertoli cell barrier in vitro involves matrix metalloprotease 9 (MMP9), membrane-bound intercellular adhesion molecule-1 (ICAM-1) and the actin cytoskeleton  (abstract) (PDF) (HTML) 
Lydka,Marta; Bilinska,Barbara; Cheng,Chuen-yan; Mruk,Dolores D.
Spermatogenesis 2(4): 294-303
Publication date: 2012

A study to assess the assembly of a functional blood-testis barrier in developing rat testes  (abstract) (PDF) 
Mok,Ka-Wai; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Spermatogenesis 1(3): 270-280
Publication date: 2011

Actin-binding protein drebrin E is involved in junction dynamics during spermatogenesis  (abstract) (PDF) 
Li,Michelle W.M.; Xiao,Xiang; Mruk,Dolores D.; Lam,Yee-ling; Lee,Will M.; Lui,Wing-Yee; Bonanomi,Michele; Silvestrini,Bruno; Cheng,Chuen-yan
Spermatogenesis 1(2): 123-136
Publication date: 2011

Adjudin disrupts spermatogenesis via the action of some unlikely partners: Eps8, Arp2/3 complex, drebrin E, PAR6 and 14-3-3  (abstract) (PDF) 
Cheng,Chuen-yan; Lie,Pearl P.Y.; Wong,Elissa W.P.; Mruk,Dolores D.; Silvestrini,Bruno
Spermatogenesis 1(4): 291-291
Publication date: 2011

Adjudin, a potential male contraceptive, exerts its effects locally in the seminiferous epithelium of mammalian testes  (abstract) (HTML) 
Mok,Ka-Wai; Mruk,Dolores D.; Lie,Pearl P.Y.; Lui,Wing-Yee; Cheng,Chuen-yan
Reproduction 141(5): 571-580
Publication date: 2011

An in vitro system to study Sertoli cell blood-testis barrier dynamics  (abstract) (HTML) 
Mruk,Dolores D.; Cheng,Chuen-yan
Methods in Molecular Biology 763: 237-252
Publication date: 2011

c-Yes regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization in the seminiferous epithelium of rat testes  (abstract) (HTML) 
Xiao,Xiang; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
International Journal of Biochemistry and Cell Biology 43(4): 651-665
Publication date: 2011

Desmosomes in the testis: Moving into an unchartered territory  (abstract) (HTML) 
Mruk,Dolores D.; Cheng,Chuen-yan
Spermatogenesis 1(1): 47-51
Publication date: 2011

Drug transporters and blood-testis barrier function  (abstract) (PDF) (HTML) 
Su,Linlin; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Journal of Endocrinology 209(3): 337-351
Publication date: 2011

Drug transporters, the blood-testis barrier, and spermatogenesis  (abstract) (HTML) 
Su,Linlin; Mruk,Dolores D.; Cheng,Chuen-yan
Journal of Endocrinology 208(3): 207-223
Publication date: 2011

Emerging role for drug transporters at the blood-testis barrier  (abstract) (HTML) 
Mruk,Dolores D.; Su,Linlin; Cheng,Chuen-yan
Trends in Pharmacological Science 32(2): 99-106
Publication date: 2011

Enhanced chemiluminescence (ECL) for routine immunoblotting. An inexpensive alternative to commercially available kits  (abstract) (PDF) 
Mruk,Dolores D.; Cheng,Chuen-yan
Spermatogenesis 1(2): 121-122
Publication date: 2011

Environmental contaminants: Is male reproductive health at risk?  (abstract) (PDF) 
Mruk,Dolores D.; Cheng,Chuen-yan
Spermatogenesis 1(4): 283-290
Publication date: 2011

Environmental toxicants and male reproductive function  (abstract) (HTML) 
Cheng,Chuen-yan; Wong,Elissa W.P.; Lie,Pearl P.Y.; Li,Michelle W.M.; Su,Linlin; Siu,Erica R.; Yan,Helen H.N.; Mannu,J.; Mathur,Premendu P.; Bonanomi,Michele; Silvestrini,Bruno; Mruk,Dolores D.
Spermatogenesis 1(1): 2-13
Publication date: 2011

Interleukin-1α is a regulator of the blood-testis barrier  (abstract) (PDF) (HTML) 
Lie,Pearl P.Y.; Cheng,Chuen-yan; Mruk,Dolores D.
FASEB Journal 25(4): 1244-1253
Publication date: 2011

P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK)  (abstract) (PDF) (HTML) 
Su,Linlin; Mruk,Dolores D.; Lui,Wing-Yee; Lee,William M.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 108(49): 19623-19628
Publication date: 2011

Polarity proteins and actin regulatory proteins are unlikely partners that regulate cell adhesion in the seminiferous epithelium during spermatogenesis  (abstract) (HTML) 
Cheng,Chuen-yan; Wong,Elissa W.P.; Lie,Pearl P.Y.; Mruk,Dolores D.; Xiao,Xiang; Li,Michelle W.M.; Lui,Wing-Yee; Lee,Will M.
Histology and Histopathology 26(11): 1465-1474
Publication date: 2011

Regulation of spermiogenesis, spermiation and blood-testis barrier dynamics: Novel insights from studies on Eps8 and Arp3  (abstract) (HTML) 
Cheng,Chuen-yan; Mruk,Dolores D.
Biochemical Journal 435(3): 553-562
Publication date: 2011

Testin and actin are key molecular targets of adjudin, an anti-spermatogenic agent, in the testis  (abstract) (PDF) 
Mruk,Dolores D.; Cheng,Chuen-yan
Spermatogenesis 1(2): 137-146
Publication date: 2011

The biology of the desmosome-like junction a versatile anchoring junction and signal transducer in the seminiferous epithelium  (abstract) (HTML) 
Lie,Pearl P.Y.; Cheng,Chuen-yan; Mruk,Dolores D.
International Review of Cell and Molecular Biology 286: 223-269
Publication date: 2011

The myotubularin family of lipid phosphatases in disease and in spermatogenesis  (abstract) (PDF) 
Mruk,Dolores D.; Cheng,Chuen-yan
Biochemical Journal 433(2): 253-262
Publication date: 2011

The ß1-integrin-p-FAK-p130Cas-DOCK180-RhoA-vinculin is a novel regulatory protein complex at the apical ectoplasmic specialization in adult rat testes  (abstract) (HTML) 
Siu,Michelle K.Y.; Wong,Ching-hang; Xia,Weiliang; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Spermatogenesis 1(1): 73-86
Publication date: 2011

A local autocrine axis in the testes that regulates spermatogenesis  (HTML) 
Cheng,Chuen-yan; Mruk,Dolores D.
Nature Reviews Endocrinology 6(7): 380-395
Publication date: 2010

Adjudin-mediated Sertoli-germ cell junction disassembly affects, Sertoli cell barrier function in vitro and in vivo  (abstract) (HTML) 
Su,Linlin; Cheng,Chuen-yan; Mruk,Dolores D.
International Journal of Biochemistry and Cell Biology 42(11): 1864-1875
Publication date: 2010

Cell junctions in the testis as targets for toxicants 
Wong,Elissa W.P.; Yan,Helen H.N.; Li,Michelle W.M.; Lie,Pearl P.Y.; Mruk,Dolores D.; Cheng,Chuen-yan; Richburg,J.H.; Hoyer,P.; McQueen,Charlene
Comprehensive Toxicology 11, pp. 167-188
Publication date: 2010

Claudin and occludin expression and function in the seminiferous epithelium  (abstract) (PDF) (HTML) 
Morrow,C.M.; Mruk,Dolores D.; Cheng,Chuen-yan; Hess,R.A.
Philosophical Transactions of the Royal Society of London, Series B, Biological Sciences 365(1546): 1679-1696
Publication date: 2010

Connexin 43 is critical to maintain the homeostasis of the blood-testis barrier via its effects on tight junction reassembly  (abstract) (PDF) (HTML) 
Li,Michelle W.M.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 107(42): 17998-18003
Publication date: 2010

Cytoskeletal dynamics and spermatogenesis  (abstract) (PDF) (HTML) 
Lie,Pearl P.Y.; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Philosophical Transactions of the Royal Society of London, Series B, Biological Sciences 365(1546): 1581-1592
Publication date: 2010

Differential effects of testosterone and TGF-ß3 on endocytic vesicle-mediated protein trafficking events at the blood-testis barrier  (abstract) (HTML) 
Su,Linlin; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Experimental Cell Research 316(17): 2945-2960
Publication date: 2010

New frontiers in nonhormonal male contraception  (abstract) (HTML) 
Cheng,Chuen-yan; Mruk,Dolores D.
Contraception 82(5): 476-482
Publication date: 2010

Regulation of blood-testis barrier dynamics by TGF-ß3 is a Cdc42-dependent protein trafficking event  (abstract) (PDF) (HTML) 
Wong,Elissa W.P.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 107(25): 11399-11404
Publication date: 2010

Regulation of spermatogenesis in the microenvironment of the seminiferous epithelium: New insights and advances  (abstract) (HTML) 
Cheng,Chuen-yan; Wong,Elissa W.P.; Yan,Helen H.N.; Mruk,Dolores D.
Molecular and Cellular Endocrinology 315(1-2): 49-56
Publication date: 2010

Restricted Arp3 expression in the testis prevents blood-testis barrier disruption during junction restructuring at spermatogenesis  (abstract) (PDF) (HTML) 
Lie,Pearl P.Y.; Chan,Apple Y.N.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 107(25): 11411-11416
Publication date: 2010

Sertoli-germ cell junctions in the testis: A review of recent data  (abstract) (PDF) (HTML) 
Kopera,Ilona A.; Bilinska,Barbara; Cheng,Chuen-yan; Mruk,Dolores D.
Philosophical Transactions of the Royal Society of London, Series B, Biological Sciences 365(1546): 1593-1605
Publication date: 2010

The biology of spermatogenesis: The past, present and future  (abstract) (HTML) 
Cheng,Chuen-yan; Mruk,Dolores D.
Philosophical Transactions of the Royal Society of London, Series B, Biological Sciences 365(1546): 1459-1463
Publication date: 2010

Tight junctions in the testis: New perspectives  (abstract) (PDF) (HTML) 
Mruk,Dolores D.; Cheng,Chuen-yan
Philosophical Transactions of the Royal Society of London, Series B, Biological Sciences 365(1546): 1621-1635
Publication date: 2010

Adjudin targeting rabbit germ cell adhesion as a male contraceptive: A pharmacokinetics study  (abstract) (PDF) (HTML) 
Hu,Guo-Xin; Hu,Lu-Feng; Yang,Dai-Zheng; Li,Jun-Wei; Chen,Guo-Rong; Chen,Bing-Bing; Mruk,Dolores D.; Bonanomi,Michele; Silvestrini,Bruno; Cheng,Chuen-yan; Ge,Renshan
Journal of Andrology 30(1): 87-93
Publication date: 2009

An in vivo study on adjudin and blood-testis barrier dynamics  (abstract) (PDF) (HTML) 
Kopera,Ilona A.; Su,Linlin; Bilinska,Barbara; Cheng,Chuen-yan; Mruk,Dolores D.
Endocrinology 150(10): 4724-4733
Publication date: 2009

An intracellular trafficking pathway in the seminiferous epithelium regulating spermatogenesis: A biochemical and molecular perspective  (abstract) (PDF) (HTML) 
Cheng,Chuen-yan; Mruk,Dolores D.
Critical Reviews in Biochemistry and Molecular Biology 44(5): 245-263
Publication date: 2009

An occludin-focal adhesion kinase protein complex at the blood-testis barrier: A study using the cadmium model  (abstract) (PDF) (HTML) 
Siu,Erica R.; Wong,Elissa W.P.; Mruk,Dolores D.; Sze,K.L.; Porto,Catarina S.; Cheng,Chuen-yan
Endocrinology 150(7): 3336-3344
Publication date: 2009

Cadmium-induced testicular injury  (abstract) (HTML) 
Siu,Erica R.; Mruk,Dolores D.; Porto,Catarina S.; Cheng,Chuen-yan
Toxicology and Applied Pharmacology 238(3): 240-249
Publication date: 2009

Connexin 43 and plakophilin-2 as a protein complex that regulates blood-testis barrier dynamics  (abstract) (PDF) (HTML) 
Li,Michelle W.M.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 106(25): 10213-10218
Publication date: 2009

Coordinating cellular events during spermatogenesis: A biochemical model  (abstract) (HTML) 
Lie,Pearl P.Y.; Cheng,Chuen-yan; Mruk,Dolores D.
Trends in Biochemical Sciences 34(7): 366-373
Publication date: 2009

Cytokines and junction restructuring events during spermatogenesis in the testis: An emerging concept of regulation  (abstract) (HTML) 
Li,Michelle W.M.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Cytokine and Growth Factor Reviews 20(4): 329-338
Publication date: 2009

Disruption of the blood-testis barrier integrity by bisphenol A in vitro: Is this a suitable model for studying blood-testis barrier dynamics?  (abstract) (HTML) 
Li,Michelle W.M.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
International Journal of Biochemistry and Cell Biology 41(11): 2302-2314
Publication date: 2009

Drug transporter, P-glycoprotein (MDR1), is an integrated component of the mammalian blood-testis barrier  (abstract) (HTML) 
Su,Linlin; Cheng,Chuen-yan; Mruk,Dolores D.
International Journal of Biochemistry and Cell Biology 41(12): 2578-2587
Publication date: 2009

Epidermal growth factor receptor pathway substrate 8 (Eps8) is a novel regulator of cell adhesion and the blood-testis barrier integrity in the seminiferous epithelium  (abstract) (PDF) (HTML) 
Lie,Pearl P.Y.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
FASEB Journal 23(8): 2555-2567
Publication date: 2009

Focal adhesion kinase is a blood-testis barrier regulator  (abstract) (PDF) (HTML) 
Siu,Erica R.; Wong,Elissa W.P.; Mruk,Dolores D.; Porto,Catarina S.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 106(23): 9298-9303
Publication date: 2009

Mitogen-activated protein kinases in male reproductive function  (abstract) (HTML) 
Li,Michelle W.M.; Mruk,Dolores D.; Cheng,Chuen-yan
Trends in Molecular Medicine 15(4): 159-168
Publication date: 2009

RAB13 participates in ectoplasmic specialization dynamics in the rat testis  (abstract) (PDF) (HTML) 
Mruk,Dolores D.; Lau,Ann S.N.
Biology of Reproduction 80(3): 590-601
Publication date: 2009

Regulation of blood-testis barrier dynamics by focal adhesion kinase (FAK): An unexpected turn of events  (abstract) (PDF) 
Cheng,Chuen-yan; Mruk,Dolores D.
Cell Cycle 8(21): 3493-3499
Publication date: 2009

Testicular cell junction: A novel target for male contraception   (abstract) (HTML) 
Lee,Nikki P.Y.; Wong,Elissa W.P.; Mruk,Dolores D.; Cheng,Chuen-yan
Current Medicinal Chemistry 16(7): 906-915
Publication date: 2009

TGF-ß3 and TNFα perturb blood-testis barrier (BTB) dynamics by accelerating the clathrin-mediated endocytosis of integral membrane proteins: A new concept of BTB regulation during spermatogenesis  (abstract) (PDF) (HTML) 
Xia,Weiliang; Wong,Elissa W.P.; Mruk,Dolores D.; Cheng,Chuen-yan
Developmental Biology 327(1): 48-61
Publication date: 2009

An autocrine axis in the testis that coordinates spermiation and blood-testis barrier restructuring during spermatogenesis  (abstract) (PDF) (HTML) 
Yan,Helen H.N.; Mruk,Dolores D.; Wong,Elissa W.P.; Lee,Will M.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 105(26): 8950-8955
Publication date: 2008

Anchoring junctions as drug targets: Role in contraceptive development  (abstract) (PDF) (HTML) 
Mruk,Dolores D.; Silvestrini,Bruno; Cheng,Chuen-yan
Pharmacological Reviews 60(2): 146-180
Publication date: 2008

Biology and regulation of ectoplasmic specialization, an atypical adherens junction type, in the testis  (abstract) (HTML) 
Wong,Elissa W.P.; Mruk,Dolores D.; Cheng,Chuen-yan
Biochimica et Biophysica Acta--Biomembranes 1778(3): 692-708
Publication date: 2008

Blood-testis barrier dynamics are regulated by testosterone and cytokines via their differential effects on the kinetics of protein endocytosis and recycling in Sertoli cells  (abstract) (PDF) (HTML) 
Yan,Helen H.N.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
FASEB Journal 22(6): 1945-1959
Publication date: 2008

Cross-talk between tight and anchoring junctions: Lesson from the testis  (abstract) (HTML) 
Yan,Helen H.N.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Advances in Experimental Medicine and Biology 636: 234-254
Publication date: 2008

Delivering non-hormonal contraceptives to men: Advances and obstacles  (abstract) (HTML) 
Mruk,Dolores D.; Cheng,Chuen-yan
Trends in Biotechnology 26(2): 90-99
Publication date: 2008

Interleukin 1 Alpha (IL1A) is a novel regulator of the blood-testis barrier in the rat  (abstract) (PDF) (HTML) 
Sarkar,Oli; Mathur,Premendu P.; Cheng,Chuen-yan; Mruk,Dolores D.
Biology of Reproduction 78(3): 445-454
Publication date: 2008

New perspectives in non-hormonal male contraception  (abstract) (HTML) 
Mruk,Dolores D.
Trends in Endocrinology and Metabolism 19(2): 57-64
Publication date: 2008

Par3/Par6 polarity complex coordinates apical ectoplasmic specialization and blood-testis barrier restructuring during spermatogenesis  (abstract) (PDF) (HTML) 
Wong,Elissa W.P.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 105(28): 9657-9662
Publication date: 2008

Cellular localization of sphingomyelin synthase 2 in the seminiferous epithelium of adult rat testes  (abstract) (PDF) (HTML) 
Lee,Nikki P.Y.; Mruk,Dolores D.; Xia,Weiliang; Cheng,Chuen-yan
Journal of Endocrinology 192(1): 17-32
Publication date: 2007

Coxsackie and adenovirus receptor (CAR) is a product of Sertoli and germ cells in rat testes which is localized at the Sertoli-Sertoli and Sertoli-germ cell interface  (abstract) (HTML) 
Wang,Claire Q.F.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Experimental Cell Research 313(7): 1373-1392
Publication date: 2007

C-type natriuretic peptide regulates blood-testis barrier dynamics in adult rat testes  (abstract) (PDF) (HTML) 
Xia,Weiliang; Mruk,Dolores D.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 104(10): 3841-3846
Publication date: 2007

Ectoplasmic specialization: A friend or a foe of spermatogenesis?  (abstract) (HTML) 
Yan,Helen H.N.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
BioEssays 29(1): 36-48
Publication date: 2007

Junction restructuring and spermatogenesis: The biology, regulation, and implication in male contraceptive development  (abstract) (HTML) 
Yan,Helen H.N.; Mruk,Dolores D.; Cheng,Chuen-yan
Current Topics in Developmental Biology 80: 57-92
Publication date: 2007

Rab4A GTPase-catenin interactions are involved in cell junction dynamics in the testis  (abstract) (PDF) (HTML) 
Mruk,Dolores D.; Lau,Ann S.N.; Sarkar,Oli; Xia,Weiliang
Journal of Andrology 28(5): 742-754
Publication date: 2007

Targeted and reversible disruption of the blood-testis barrier by an FSH mutant-occludin peptide conjugate  (abstract) (PDF) (HTML) 
Wong,Ching-hang; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
FASEB Journal 21(2): 438-448
Publication date: 2007

Unraveling the molecular targets pertinent to junction restructuring events during spermatogenesis using the Adjudin-induced germ cell depletion model  (abstract) (PDF) (HTML) 
Xia,Weiliang; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Journal of Endocrinology 192(3): 563-583
Publication date: 2007

A male contraceptive targeting germ cell adhesion  (abstract) (HTML) 
Mruk,Dolores D.; Wong,Ching-hang; Silvestrini,Bruno; Cheng,Chuen-yan
Nature Medicine 12(11): 1323-1328
Publication date: 2006

Adjudin-mediated junction restructuring in the seminiferous epithelium leads to displacement of soluble guanylate cyclase from adherens junctions  (abstract) (HTML) 
Sarkar,Oli; Xia,Weiliang; Mruk,Dolores D.
Journal of Cellular Physiology 208(1): 175-187
Publication date: 2006

Differential interactions between transforming growth factor-β3/TβR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion  (abstract) (PDF) (HTML) 
Xia,Weiliang; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Journal of Biological Chemistry 281(24): 16799-16813
Publication date: 2006

Dynamin II interacts with the cadherin- and occludin-based protein complexes at the blood-testis barrier in adult rat testes  (abstract) (PDF) (HTML) 
Lie,Pearl P.Y.; Xia,Weiliang; Wang,Claire Q.F.; Mruk,Dolores D.; Yan,Helen H.N.; Wong,Ching-hang; Lee,Will M.; Cheng,Chuen-yan
Journal of Endocrinology 191(3): 571-586
Publication date: 2006

The Sertoli-spermatid junctional complex adhesion strength is affected in vitro by adjudin  (abstract) (PDF) (HTML) 
Wolski,Katja M.; Mruk,Dolores D.; Cameron,Don F.
Journal of Andrology 27(6): 790-794
Publication date: 2006

Tumor necrosis factor reversibly disrupts the blood-testis barrier and impairs Sertoli-germ cell adhesion in the seminiferous epithelium of adult rat testes  (abstract) (PDF) (HTML) 
Li,Michelle W.M.; Xia,Weiliang; Mruk,Dolores D.; Wang,Claire Q.F.; Yan,Helen H.N.; Siu,Michelle K.Y.; Lui,Wing-Yee; Lee,Will M.; Cheng,Chuen-yan
Journal of Endocrinology 190(2): 313-329
Publication date: 2006

AF-2364 [1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide] is a potential male contraceptive: A review of recent data  (abstract) (HTML) 
Cheng,Chuen-yan; Mruk,Dolores D.; Silvestrini,Bruno; Bonanomi,Michele; Wong,Ching-hang; Siu,Michelle K.Y.; Lee,Nikki P.Y.; Lui,Wing-Yee; Mo,Meng-Yun
Contraception 72(4): 251-261
Publication date: 2005

Blood-testis barrier dynamics are regulated by α2-macroglobulin via the c-Jun N-terminal protein kinase pathway  (abstract) (PDF) (HTML) 
Wong,Ching-hang; Mruk,Dolores D.; Siu,Michelle K.Y.; Cheng,Chuen-yan
Endocrinology 146(4): 1893-1908
Publication date: 2005

Cytokines and junction restructuring during spermatogenesis: A lesson to learn from the testis  (abstract) (HTML) 
Xia,Weiliang; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Cytokine and Growth Factor Reviews 16(4-5): 469-493
Publication date: 2005

Interactions among IQGAP1, Cdc42, and the cadherin/catenin protein complex regulate Sertoli-germ cell adherens junction dynamics in the testis  (abstract) (HTML) 
Lui,Wing-Yee; Mruk,Dolores D.; Cheng,Chuen-yan
Journal of Cellular Physiology 202(1): 49-66
Publication date: 2005

Myotubularin phosphoinositide phosphatases, protein phosphatases, and kinases: Their roles in junction dynamics and spermatogenesis  (abstract) (HTML) 
Zhang,Jiayi; Mruk,Dolores D.; Cheng,Chuen-yan
Journal of Cellular Physiology 204(2): 470-483
Publication date: 2005

Regulation of ectoplasmic specialization dynamics in the seminiferous epithelium by focal adhesion-associated proteins in testosterone-suppressed rat testes  (abstract) (PDF) (HTML) 
Wong,Ching-hang; Xia,Weiliang; Lee,Nikki P.Y.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Endocrinology 146(3): 1192-1204
Publication date: 2005

Regulation of Sertoli-germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/beta-catenin (CATNB) signaling pathway: An in vitro and in vivo study  (abstract) (PDF) (HTML) 
Lee,Nikki P.Y.; Mruk,Dolores D.; Wong,Ching-hang; Cheng,Chuen-yan
Biology of Reproduction 73(3): 458-471
Publication date: 2005

Regulation of Sertoli-germ cell adherens junction dynamics via changes in protein-protein interactions of the N-cadherin-ß-catenin protein complex which are possibly mediated by c-Src and myotubularin-related protein 2: An in vivo study using an androgen suppression model  (abstract) (PDF) (HTML) 
Zhang,Jiayi; Wong,Ching-hang; Xia,Weiliang; Mruk,Dolores D.; Lee,Nikki P.Y.; Lee,Will M.; Cheng,Chuen-yan
Endocrinology 146(3): 1268-1284
Publication date: 2005

α-macroglobulin expression in the liver in response to inflammation is mediated by the testis  (abstract) (PDF) 
Lui,Wing-Yee; Cheng,Yan Ho; Mruk,Dolores D.; Cheng,Chin Ho; Mo,Meng-Yun; Lee,Will M.; Cheng,Chuen-yan
Journal of Endocrinology 185(3): 497-505
Publication date: 2005

Cell-cell interactions at the ectoplasmic specialization in the testis  (abstract) (HTML) 
Mruk,Dolores D.; Cheng,Chuen-yan
Trends in Endocrinology and Metabolism 15(9): 439-447
Publication date: 2004

Disruption of Mtmr2 produces CMT4B1-like neuropathy with myelin outfolding and impaired spermatogenesis  (abstract) (PDF) (HTML) 
Bolino,Alessandra; Bolis,Annalisa; Previtali,Stefano Carlo; Dina,Giorgia; Bussini,Simona; Dati,Gabriele; Amadio,Stefano; Del Carro,Ubaldo; Mruk,Dolores D.; Feltri,Maria Laura; Cheng,Chuen-yan; Quattrini,Angelo; Wrabetz,Lawrence
Journal of Cell Biology 167(4): 711-721
Publication date: 2004

Regulation of blood-testis barrier dynamics: An in vivo study  (abstract) (HTML) 
Wong,Ching-hang; Mruk,Dolores D.; Lui,Wing-Yee; Cheng,Chuen-yan
Journal of Cell Science 117(5): 783-798
Publication date: 2004

Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis  (abstract) (PDF) (HTML) 
Mruk,Dolores D.; Cheng,Chuen-yan
Endocrine Reviews 25(5): 747-806
Publication date: 2004

Zyxin, axin, and Wiskott-Aldrich syndrome protein are adaptors that link the cadherin/catenin protein complex to the cytoskeleton at adherens junctions in the seminiferous epithelium of the rat testis  (abstract) (PDF) (HTML) 
Lee,Nikki P.Y.; Mruk,Dolores D.; Conway,Anne M.; Cheng,Chuen-yan
Journal of Andrology 25(2): 200-215
Publication date: 2004

Adherens junction dynamics in the testis and spermatogenesis  (PDF) (HTML) 
Lui,Wing-Yee; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Journal of Andrology 24(1): 1-14
Publication date: 2003

Adhering junction dynamics in the testis are regulated by an interplay of β 1-integrin and focal adhesion complex-associated proteins  (abstract) (PDF) (HTML) 
Siu,Michelle K.Y.; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Endocrinology 144(5): 2141-2163
Publication date: 2003

Fer kinase/FerT and adherens junction dynamics in the testis: An in vitro and in vivo study  (abstract) (PDF) (HTML) 
Chen,Yong-Mei; Lee,Nikki P.Y.; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Biology of Reproduction 69(2): 656-672
Publication date: 2003

Is the cadherin/catenin complex a functional unit of cell-cell actin-based adherens junctions in the rat testis?  (abstract) (PDF) (HTML) 
Lee,Nikki P.Y.; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Biology of Reproduction 68(2): 489-508
Publication date: 2003

Rab8B GTPase and junction dynamics in the testis  (abstract) (HTML) 
Lau,Ann S.N.; Mruk,Dolores D.
Endocrinology 144(4): 1549-1563
Publication date: 2003

Role of tissue inhibitor of metalloproteases-1 in junction dynamics in the testis  (abstract) (PDF) (HTML) 
Mruk,Dolores D.; Siu,Michelle K.Y.; Conway,Anne M.; Lee,Nikki P.Y.; Lau,Ann S.N.; Cheng,Chuen-yan
Journal of Andrology 24(4): 510-523
Publication date: 2003

Sertoli cell tight junction dynamics: Their regulation during spermatogenesis  (abstract) (PDF) (HTML) 
Lui,Wing-Yee; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Biology of Reproduction 68(4): 1087-1097
Publication date: 2003

TGF-β3 regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: An in vivo study  (abstract) (PDF) (HTML) 
Lui,Wing-Yee; Wong,Daria C.H.; Mruk,Dolores D.; Cheng,Chuen-yan
Endocrinology 144(4): 1139-1142
Publication date: 2003

Antioxidant superoxide dismutase--A review: Its function, regulation in the testis, and role in male fertility  (abstract) (HTML) 
Mruk,Dolores D.; Silvestrini,Bruno; Mo,Meng-Yun; Cheng,Chuen-yan
Contraception 65(4): 305-311
Publication date: 2002

Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development  (abstract) (PDF) (HTML) 
Cheng,Chuen-yan; Mruk,Dolores D.
Physiological Reviews 82(4): 825-874
Publication date: 2002

Gonadotropins, via cAMP, negatively regulate GATA-1 gene expression in testicular cells  (abstract) (PDF) (HTML) 
Zhang,Zhifang; Wu,Ai Zhen; Feng,Zong-Ming; Mruk,Dolores D.; Cheng,Chuen-yan; Chen,Ching-Ling C.
Endocrinology 143(3): 829-836
Publication date: 2002

Indazole carboxylic acids in male contraception  (abstract) (HTML) 
Cheng,Chuen-yan; Mo,Meng-Yun; Grima,Josephine; Saso,Luciano; Tita,Beatrice; Mruk,Dolores D.; Silvestrini,Bruno
Contraception 65(4): 265-268
Publication date: 2002

Regulation of Sertoli cell myotubularin (rMTM) expression by germ cells in vitro  (abstract) (PDF) (HTML) 
Li,Jonathan C.H.; Lee,William M.; Mruk,Dolores D.; Cheng,Chuen-yan
Journal of Andrology 22(2): 266-277
Publication date: 2001

The inter-Sertoli tight junction permeability barrier is regulated by the interplay of protein phosphatases and kinases: An in vitro study  (abstract) (PDF) (HTML) 
Li,Jonathan C.H.; Mruk,Dolores D.; Cheng,Chuen-yan
Journal of Andrology 22(5): 847-856
Publication date: 2001

Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis  (abstract) (PDF) (HTML) 
Cheng,Chuen-yan; Silvestrini,Bruno; Grima,Josephine; Mo,Meng-Yun; Zhu,Li-Ji; Johansson,Elof D.B.; Saso,Luciano; Leone,Maria Grazia; Palmery,Maura; Mruk,Dolores D.
Biology of Reproduction 65(2): 449-461
Publication date: 2001

In vitro regulation of extracellular superoxide dismutase in Sertoli cells  (abstract) (HTML) 
Mruk,Dolores D.; Cheng,Chuen-yan
Life Sciences 67(2): 133-145
Publication date: 2000

Changes in the expression of junctional and nonjunctional complex component genes when inter-Sertoli tight junctions are formed in vitro  (abstract) (PDF) (HTML) 
Wong,Connie C.S.; Chung,Sanny S.W.; Grima,Josephine; Zhu,Li-Ji; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Journal of Andrology 21(2): 227-237
Publication date: 2000

Rat testicular myotubularin, a protein tyrosine phosphatase expressed by Sertoli and germ cells, is a potential marker for studying cell-cell interactions in the rat testis  (abstract) (HTML) 
Li,Jonathan C.H.; Samy,Eileen T.; Grima,Josephine; Chung,Sanny S.W.; Mruk,Dolores D.; Lee,William M.; Silvestrini,Bruno; Cheng,Chuen-yan
Journal of Cellular Physiology 185(3): 366-385
Publication date: 2000

Sertoli cell proteins in testicular paracriny 
Mruk,Dolores D.; Cheng,Chuen-yan; Jegou,B.; Pineau,C.; Saez,J.
Ernst Schering Research Foundation Workshop Supplement 6, pp. 197-228
Publication date: 2000

Identification and purification of proteins from germ cell-conditioned medium (GCCM)  (abstract) (PDF) (HTML) 
Chung,Sanny S.W.; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Biochemistry and Molecular Biology International 47(3): 479-491
Publication date: 1999

Obstruction of the vas deferens alters protein secretion by the rat caput epididymal epithelium in vivo  (abstract) (PDF) (HTML) 
Turner,Terry T.; Riley,Tina A.; Mruk,Dolores D.; Cheng,Chuen-yan
Journal of Andrology 20(2): 289-297
Publication date: 1999

Sertolin is a novel gene marker of cell-cell interactions in the rat testis  (abstract) (PDF) (HTML) 
Mruk,Dolores D.; Cheng,Chuen-yan
Journal of Biological Chemistry 274(38): 27056-17068
Publication date: 1999

Sertolin: A novel molecule to study Sertoli-germ cell interactions in the testis 
Mruk,Dolores D.; Cheng,Chuen-yan; Coutinho,Elsimar M.; Spinola,Paulo
from Proceedings of the 10th World Congress on Human Reproduction, pp. 99-102
Publication date: 1999

TEMO is a novel testicular gene to study Sertoli-germ cell interactions: Its cDNA cloning and regulation 
Cheng,Chuen-yan; Mo,Meng-Yun; Mruk,Dolores D.; Lee,William M.; Silvestrini,Bruno; Coutinho,Elsimar M.; Spinola,Paulo
from Proceedings of the 10th World Congress on Human Reproduction
Publication date: 1999

Rat testicular extracellular superoxide dismutase (SODEX): Its purification, characterization, and regulation  (abstract) (PDF) (HTML) 
Mruk,Dolores D.; Cheng,Chin Ho; Cheng,Yan Ho; Mo,Meng-Yun; Grima,Josephine; Silvestrini,Bruno; Lee,William M.; Cheng,Chuen-yan
Biology of Reproduction 59: 298-308
Publication date: 1998

Regulation of a2-macroglobulin expression in Sertoli cells and hepatocytes in vitro by germ cells  (abstract) (PDF) (HTML) 
Braghiroli,L.; Silvestrini,Bruno; Sorrentino,J.; Grima,Josephine; Mruk,Dolores D.; Cheng,Chuen-yan
Biology of Reproduction 59: 111-123
Publication date: 1998

Dolores D. Mruk, Ph.D.

Scientist

Curriculum Vitae