Population Council Research that makes a difference

Régine Sitruk-Ware, M.D.

Distinguished Scientist

Dual Health Benefits: Nestorone
Council scientists at the Center for Biomedical Research are developing safer and more effective long-acting contraceptives that have dual health benefits, using molecules with selective binding to hormone receptors, such as Nestorone®, a derivative of progesterone.
(1/2010 - ongoing)
Topics: New and improved reproductive technologies; Reproductive health biomedical research; Technologies for women
Countries: France, United States

Emergency Contraceptive Potential of Products Under Development (more)
Many contraceptive products may have utility as emergency contraceptive methods; the Council is evaluating the potential of selected candidate products.
(1/2005 - ongoing)
Topics: Technologies for women
Countries: United States

Female Hormone Therapy (more)
Research at the Center for Biomedical Research is part of the Council's ongoing efforts to evaluate the long-term safety of the progesterone receptor modulator CDB-2914 for hormone therapy.
(1/2001 - ongoing)
Topics: New and improved reproductive technologies; Technologies for women
Countries: United States

MENT® (more)
Council researchers are working to develop methods of contraception for men that contain MENT®, a synthetic steroid that resembles testosterone
(1/2005 - ongoing)
Topics: Technologies for men
Countries: Chile, Dominican Republic, Germany, United Kingdom, United States

Subdermal Implants for Men (more)
Studies have found that men are interested in taking more responsibility for family planning; an implant for men is the Council's lead product in male contraception.
(1/2005 - ongoing)
Topics: Technologies for men
Countries: Chile, Dominican Republic, Germany, United Kingdom, United States

Transdermal Delivery Systems for Women: Contraceptive Gel (more)
Council scientists are developing a contraceptive gel that is absorbed through the skin.
(1/2005 - ongoing)
Topics: Technologies for women
Countries: United States

Transdermal Delivery Systems for Women: Spray-on Contraceptive (more)
Council researchers are developing a transdermal spray-on contraceptive that makes use of the synthetic progestin Nestorone.
(1/2007 - ongoing)
Topics: Technologies for women
Countries: Australia, United States

One-year Combination Vaginal Ring, Phase 3 Study (more)
The NES/EE vaginal ring is a user-controlled method that can be reused for one year.
(9/2005 - 6/2009)
Topics: Technologies for women
Countries: Americas, Australia, Europe, United States

Régine Sitruk-Ware, M.D.

Distinguished Scientist

7a-methyl-19-nortestosterone (MENT®): The Population Council's contribution to research on male contraception and treatment of hypogonadism  (abstract) (HTML) 
Nieschlag,Eberhard; Kumar,Narender; Sitruk-Ware,Regine
Contraception 87(3): 288-295
Publication date: 2013

Contraception technology: Past, present and future  (abstract) (HTML) 
Sitruk-Ware,Regine; Nath,Anita; Mishell,Daniel R.,Jr.
Contraception 87(3): 319-330
Publication date: 2013

New vision for contraceptive research and development  (PDF) 
Sitruk-Ware,Regine; Donaldson,Peter J.
Contraception 87(3): 257-
Publication date: 2013

New vision for contraceptive research and development  (PDF) 
Donaldson,Peter J.; Sitruk-Ware,Regine
Huffington Post 8 March
Publication date: 2013

The neural androgen receptor: A therapeutic target for myelin repair in chronic demyelination  (abstract) (PDF) 
Hussain,Rashad; Ghoumari,Abdel M.; Bielecki,Bartosz; Steibel,Jerome; Boehm,Nelly; Liere,Philippe; Macklin,Wendy B.; Kumar,Narender; Habert,Rene; Mhaouty-Kodja,Sakina; Tronche,Francois; Sitruk-Ware,Regine; Schumacher,Michael; Ghandour,M.Said
Brain 136(1): 132-146
Publication date: 2013

Ulipristal blocks ovulation by inhibiting progesterone receptor-dependent pathways intrinsic to the ovary  (abstract) (HTML) 
Nallasamy,Shanmugasundaram; Kim,Jaeyeon; Sitruk-Ware,Regine; Bagchi,Milan K.; Bagchi,Indrani C.
Reproductive Sciences 20(4): 371-381
Publication date: 2013

A new combination of testosterone and nestorone transdermal gels for male hormonal contraception  (abstract) (HTML) 
Ilani,Niloufar; Roth,Mara Y.; Amory,John K.; Swerdloff,Ronald S.; Dart,Clint; Page,Stephanie T.; Bremner,William J.; Sitruk-Ware,Regine; Kumar,Narender; Blithe,Diana; Wang,Christina
Journal of Clinical Endocrinology and Metabolism 97(10): 3476-3486
Publication date: 2012

Effects of a novel estrogen-free, progesterone receptor modulator-contraceptive vaginal ring on inhibition of ovulation, bleeding patterns and endometrium in normal women  (abstract) (HTML) 
Brache,Vivian; Sitruk-Ware,Regine; Williams,A.; Blithe,Diana; Croxatto,Horacio B.; Kumar,Narender; Kumar,Sushma; Tsong,Yun-yen; Sivin,Irving; Nath,Anita; Sussman,Heather; Cochon,Leila; Miranda,Maria Jose; Reyes,Veronica; Faundes,Anibal; Mishell,Daniel R.,Jr.
Contraception 85(5): 480-488
Publication date: 2012

Increased impact of a contraceptive vaginal ring with ethinyl estradiol and nestorone on C-reactive protein  (abstract) (HTML) 
Rad,Mandana; Burggraaf,Jacobus; Sitruk-Ware,Regine; de Kam,Marieke L.; Cohen,Adam F.; Kluft,Cornelius
Steroids 77(13): 1483-1486
Publication date: 2012

Postpartum unintended pregnancy and contraception practice among rural-to-urban migrant women in Shanghai  (abstract) (HTML) 
Huang,Yong-mei; Merkatz,Ruth B.; Kang,Jian-Zhong; Roberts,Kevin; Hu,Xiao-Yu; Di Donato,Francis; Sitruk-Ware,Regine; Cheng,Li-nan
Contraception 86(6): 731-738
Publication date: 2012

Progesterone receptors: A key for neuroprotection in experimental stroke  (abstract) (PDF) (HTML) 
Liu,Ailing; Margaill,Isabelle; Zhang,Shaodong; Labombarda,Florencia; Coqueran,Berard; Delespierre,Brigitte; Liere,Philippe; Marchand-Leroux,Catherine; O'Malley,Bert W.; Lydon,John P.; De Nicola,Alejandro; Sitruk-Ware,Regine; Mattern,Claudia; Plotkine,Michel; Schumacher,Michael; Guennoun,Rachida
Endocrinology 153(8): 3747-3757
Publication date: 2012

7α-methyl-19-nortestosterone vs. testosterone implants for hypogonadal osteoporosis: A preclinical study in the aged male orchidectomized rat model  (abstract) (HTML) 
Sinnasael,M.; Callewaert,F.; Morreels,M.; Kumar,Narender; Sitruk-Ware,Regine; Van Proeyen,K.; Hespel,P.; Boonen,Steven; Claessens,F.; Vanderschueren,Dirk
International Journal of Andrology 34(6 pt 2): 601-611
Publication date: 2011

Hormonal influences in multiple sclerosis: New therapeutic benefits for steroids  (abstract) (HTML) 
El-Etr,Martine; Ghoumari,Abdel M.; Sitruk-Ware,Regine; Schumacher,Michael
Maturitas 68(1): 47-51
Publication date: 2011

Metabolic effects of contraceptive steroids  (abstract) (HTML) 
Sitruk-Ware,Regine; Nath,Anita
Reviews in Endocrine and Metabolic Disorders 12(2): 63-75
Publication date: 2011

New strategies for providing hormonal contraception in developing countries  (abstract) (HTML) 
Townsend,John W.; Sitruk-Ware,Regine; Williams,Katherine; Askew,Ian; Brill,Klaus
Contraception 83(5): 405-409
Publication date: 2011

Nomegestrol acetate, a novel progestogen for oral contraception  (abstract) (HTML) 
Mueck,Alfred O.; Sitruk-Ware,Regine
Steroids 76(6): 531-539
Publication date: 2011

Progesterone and nestorone facilitate axon remyelination: A role for progesterone receptors  (abstract) (PDF) 
Hussain,Rashad; El-Etr,Martine; Gaci,O.; Rakotomamonjy,J.; Macklin,Wendy B.; Kumar,Narender; Sitruk-Ware,Regine; Schumacher,Michael; Ghoumari,Abdel M.
Endocrinology 152(10): 3820-3831
Publication date: 2011

Clinically relevant progestins regulate neurogenic and neuroprotective responses in vitro and in vivo  (abstract) (PDF) 
Liu,Lifei; Zhao,Ligin; She,Hongyun; Chen,Shuhua; Ming Wang,Jun; Wong,Charisse; McClure,Kelsey; Sitruk-Ware,Regine; Diaz Brinton,Roberta
Endocrinology 151(12): 5782-5794
Publication date: 2010

Endometrial effect of progesterone delivered by vaginal rings in estrogen-treated postmenopausal women  (abstract) (HTML) 
Noe,Gabriela; Sitruk-Ware,Regine; Zegers-Hochschild,F.; Variano,B.; Montero,Juan Carlos; Arriagada,P.; Li,A.; Stanczyk,Frank Z.; Felix,J.C.; Mishell,Daniel R.,Jr.; Croxatto,Horacio B.
Climacteric 13(5): 433-441
Publication date: 2010

Intrauterine administration of CDB-2914 (Ulipristal) suppresses the endometrium of rhesus macaques  (abstract) (HTML) 
Brenner,Robert M.; Slayden,Ov D.; Nath,Anita; Tsong,Yun-yen; Sitruk-Ware,Regine
Contraception 81(4): 336-342
Publication date: 2010

Introduction to Population Council Symposium articles  (HTML) 
Sitruk-Ware,Regine; Mishell,Daniel R.,Jr.
Contraception 82(5): 395-395
Publication date: 2010

Progesterone vaginal ring for contraceptive use during lactation  (abstract) (HTML) 
Nath,Anita; Sitruk-Ware,Regine
Contraception 82(5): 428-434
Publication date: 2010

Single-dose Pharmacokinetics of Nestorone, a potential female-contraceptive  (abstract) (HTML) 
Vishwanath Prasad,Pramod; Bashir,Mohammad; Sitruk-Ware,Regine; Kumar,Narender
Steroids 75(3): 252-264
Publication date: 2010

The use of newer progestins for contraception  (abstract) (HTML) 
Sitruk-Ware,Regine; Nath,Anita
Contraception 82(5): 410-417
Publication date: 2010

Central modifications of allopregnanolone and ß-endorphin following subcutaneous administration of Nestorone  (abstract) (HTML) 
Lenzi,E.; Pluchino,N.; Begliuomini,S.; Casarosa,E.; Merlini,S.; Giannini,A.; Luisi,M.; Kumar,Narender; Sitruk-Ware,Regine; Genazzani,Andrea R.
Journal of Steroid Biochemistry and Molecular Biology 116(1-2): 15-20
Publication date: 2009

Combined transdermal testosterone gel and the progestin Nestorone suppresses serum gonadotropins in men  (abstract) (PDF) 
Mahabadi,Vahid; Amory,John K.; Swerdloff,Ronald S.; Bremner,William J.; Page,Stephanie T.; Sitruk-Ware,Regine; Christensen,Peter D.; Kumar,Narender; Tsong,Yun-yen; Blithe,Diana; Wang,Christina
Journal of Clinical Endocrinology and Metabolism 94(7): 2313-2320
Publication date: 2009

Different cardiovascular effects of progestins according to structure and activity  (abstract) (HTML) 
Nath,Anita; Sitruk-Ware,Regine
Climacteric 12(suppl 1): 96-101
Publication date: 2009

Distribution, metabolism and excretion of a synthetic androgen 7α-methyl-19-nortestosterone, a potential male-contraceptive  (abstract) (HTML) 
Vishwanath Prasad,Pramod; Arumugam,Ramamani; Willman,Mark; Ge,Renshan; Sitruk-Ware,Regine; Kumar,Narender
Steroids 74(1): 121-131
Publication date: 2009

Effect of sexual intercourse on the absorption of levonorgestrel after vaginal administration of 0.75 mg in Carraguard® gel: A randomized, cross-over, pharmacokinetic study  (abstract) (HTML) 
Brache,Vivian; Croxatto,Horacio B.; Kumar,Narender; Sitruk-Ware,Regine; Cochon,Leila; Schiappacasse,Veronica; Sivin,Irving; Munoz,Carla; Maguire,Robin A.; Faundes,Anibal
Contraception 79(2): 150-154
Publication date: 2009

Meta-analysis of 200 or 600 mg mifepristone in association with two prostaglandins for termination of early pregnancy  (abstract) (HTML) 
Lievre,Michel; Sitruk-Ware,Regine
Contraception 80(1): 95-100
Publication date: 2009

Methods for female contraception: A model for innovation in drug delivery systems  (abstract) (HTML) 
Merkatz,Ruth B.; Tokay,Barbara A.; Sitruk-Ware,Regine
Clinical Pharmacology and Therapeutics 85(5): 553-557
Publication date: 2009

Parenteral administration of progestins for hormonal replacement therapy  (abstract) (HTML) 
Nath,Anita; Sitruk-Ware,Regine
European Journal of Contraception and Reproductive Health Care 14(2): 88-96
Publication date: 2009

Pharmacology and clinical applications of selective estrogen receptor modulators  (abstract) (HTML) 
Nath,Anita; Sitruk-Ware,Regine
Climacteric 12(3): 188-205
Publication date: 2009

Comparative actions of progesterone, medroxyprogesterone acetate, drospirenone and nestorone on breast cancer cell migration and invasion  (abstract) (PDF) 
Fu,Xiao-Dong; Giretti,Maria Silva; Goglia,Lorenzo; Flamini,Marina Ines; Matias Sanchez,Angel; Baldacci,Chiara; Garibaldi,Silvia; Sitruk-Ware,Regine; Genazzani,Andrea R.; Simoncini,Tommaso
BMC Cancer 8: 166-
Publication date: 2008

Determinants of the rate and extent of spermatogenic suppression during hormonal male contraception: An integrated analysis  (abstract) (PDF) (HTML) 
Liu,Peter Y.; Swerdloff,Ronald S.; Anawalt,Bradley D.; Anderson,Richard A.; Bremner,William J.; Elliesen,Joerg; Gu,Yi-Qun; Kersemaekers,Wendy M.; McLachlan,Robert I.; Meriggiola,M.Christina; Nieschlag,Eberhard; Sitruk-Ware,Regine; Vogelsong,Kirsten M.; Wang,Xing-Hai; Wu,Frederick C.W.; Zitzmann,Michael; Handelsman,David J.; Wang,Christina
Journal of Clinical Endocrinology and Metabolism 93(5): 1774-1783
Publication date: 2008

Does estrogen therapy reduce coronary artery calcification in postmenopausal women?  (HTML) 
Sitruk-Ware,Regine
Nature Clinical Practice Endocrinology and Metabolism 4(1): 12-13
Publication date: 2008

New vistas in contraceptive technology  (abstract) (PDF) 
RamaRao,Saumya; Sitruk-Ware,Regine; Townsend,John W.
Gender and Development 16(2): 327-344
Publication date: 2008

Progesterone and progestins: Neuroprotection and myelin repair  (abstract) (HTML) 
Schumacher,Michael; Sitruk-Ware,Regine; De Nicola,Alejandro
Current Opinion in Pharmacology 8(6): 740-746
Publication date: 2008

Progesterone receptor modulator CDB-2914 induces extracellular matrix metalloproteinase inducer in cultured human uterine leiomyoma cells  (abstract) (PDF) (HTML) 
Xu,Qin; Ohara,Noriyuki; Liu,Jin; Amano,Mariko; Sitruk-Ware,Regine; Yoshida,Shigeki; Maruo,Takeshi
Molecular Human Reproduction 14(3): 181-191
Publication date: 2008

An initial pharmacokinetic study with a Metered Dose Transdermal System® for delivery of the progestogen Nestorone® as a possible future contraceptive  (abstract) (HTML) 
Fraser,Ian S.; Weisberg,Edith; Kumar,Narender; Kumar,Sushma; Humberstone,Andrew J.; McCrossin,Louise; Shaw,Deborah; Tsong,Yun-yen; Sitruk-Ware,Regine
Contraception 76(6): 432-438
Publication date: 2007

Comparison of the impact of vaginal and oral administration of combined hormonal contraceptives on hepatic proteins sensitive to estrogen  (abstract) (HTML) 
Sitruk-Ware,Regine; Menard,Joel; Rad,Mandana; Burggraaf,Jacobus; de Kam,Marieke L.; Tokay,Barbara A.; Sivin,Irving; Kluft,Cornelius
Contraception 75(6): 430-437
Publication date: 2007

Effect of a single vaginal administration of levonorgestrel in Carraguard® gel on the ovulatory process: A potential candidate for 'dual protection' emergency contraception  (abstract) (HTML) 
Brache,Vivian; Croxatto,Horacio B.; Sitruk-Ware,Regine; Maguire,Robin A.; Montero,Juan Carlos; Kumar,Narender; Salvatierra,Ana Maria; Tejada,Ana-Sofia; Cochon,Leila; Forcelledo,Maria Luisa; Lahteenmaki,Pekka; Alvarez,Francisco; Faundes,Anibal
Contraception 76(2): 111-116
Publication date: 2007

Effects of estradiol with oral or intravaginal progesterone on risk markers for breast cancer in a postmenopausal monkey model  (abstract) (HTML) 
Wood,Charles E.; Sitruk-Ware,Regine; Tsong,Yun-yen; Register,Thomas C.; Lees,Cynthia J.; Cline,J.Mark
Menopause 14(4): 1-9
Publication date: 2007

Effects of levonorgestrel-releasing IUS and progesterone receptor modulator PRM CDB-2914 on uterine leiomyomas  (abstract) (HTML) 
Maruo,Takeshi; Ohara,Noriyuki; Matsuo,Hiroya; Xu,Qin; Chen,Wei; Sitruk-Ware,Regine; Johansson,Elof D.B.
Contraception 75(6S): S99-S103
Publication date: 2007

Effects of oral and transvaginal ethinyl estradiol on hemostatic factors and hepatic proteins in a randomized, cross-over study  (abstract) (PDF) (HTML) 
Sitruk-Ware,Regine; Plu-Bureau,Genevieve; Menard,Joel; Conard,Jacqueline; Kumar,Sushma; Thalaband,Jean-Christophe; Tokay,Barbara A.; Bouchard,Philippe
Journal of Clinical Endocrinology and Metabolism 92(6): 2074-2079
Publication date: 2007

Hormone therapy effects on social behavior and activity levels of surgically postmenopausal cynomolgus monkeys  (abstract) (HTML) 
Shively,Carol A.; Wood,Charles E.; Register,Thomas C.; Willard,Stephanie L.; Lees,Cynthia J.; Chen,Haiying; Sitruk-Ware,Regine; Tsong,Yun-yen; Cline,J.Mark
Psychoneuroendocrinology 32(8-10): 981-990
Publication date: 2007

Pharmacokinetic study to compare the absorption and tolerability of two doses of levonorgestrel following single vaginal administration of levonorgestrel in Carraguard® gel: A new formulation for 'dual protection' contraception  (abstract) (HTML) 
Sitruk-Ware,Regine; Brache,Vivian; Maguire,Robin A.; Croxatto,Horacio B.; Kumar,Narender; Kumar,Sushma; Montero,Juan Carlos; Salvatierra,Ana Maria; Phillips,David M.; Faundes,Anibal
Contraception 75(6): 454-460
Publication date: 2007

Preclinical and clinical properties of trimegestone: A potent and selective progestin  (abstract) (HTML) 
Sitruk-Ware,Regine; Bossemeyer,Ronald; Bouchard,Philippe
Gynecological Endocrinology 23(6): 310-319
Publication date: 2007

Routes of delivery for progesterone and progestins  (abstract) (HTML) 
Sitruk-Ware,Regine
Maturitas 57(1): 77-80
Publication date: 2007

Special issue on intrauterine devices and systems  (abstract) (HTML) 
Sitruk-Ware,Regine; Donaldson,Peter J.
Contraception 75(6S): S1-
Publication date: 2007

The levonorgestrel intrauterine system for use in peri- and postmenopausal women  (abstract) (HTML) 
Sitruk-Ware,Regine
Contraception 75(6S): S155-S160
Publication date: 2007

A novel pathway involving progesterone receptor, endothelin-2, and endothelin receptor B controls ovulation in mice  (abstract) (PDF) (HTML) 
Palanisamy,Gopinath S.; Cheon,Yong-Pil; Kim,Jaeyeon; Kannan,Athilakshmi; Li,Quanxi; Sato,Marcey; Mantena,Srinivasa R.; Sitruk-Ware,Regine; Bagchi,Milan K.; Bagchi,Indrani C.
Molecular Endocrinology 20(11): 2784-2795
Publication date: 2006

Comparative effects of a contraceptive vaginal ring delivering a nonandrogenic progestin and continuous ethinyl estradiol and a combined oral contraceptive containing levonorgestrel on hemostasis variables  (abstract) (HTML) 
Rad,Mandana; Kluft,Cornelius; Menard,Joel; Burggraaf,Jacobus; de Kam,Marieke L.; Meijer,Piet; Sivin,Irving; Sitruk-Ware,Regine
American Journal of Obstetrics and Gynecology 195(1): 72-77
Publication date: 2006

Contraception: An international perspective  (abstract) (HTML) 
Sitruk-Ware,Regine
Contraception 73(3): 215-222
Publication date: 2006

Cyclical mastalgia and breast cancer risk: Results of a French cohort study  (abstract) (PDF) (HTML) 
Plu-Bureau,Genevieve; Le,Monique G.; Sitruk-Ware,Regine; Thalaband,Jean-Christophe
Cancer Epidemiology Biomarkers & Prevention 15(6): 1229-1231
Publication date: 2006

Long-term administration of mifepristone (RU486): Clinical tolerance during extended treatment of meningioma  (abstract) (HTML) 
Grunberg,Steven M.; Weiss,Martin H.; Russell,Christy A.; Spitz,Irving M.; Ahmadi,Jamshid; Sadun,Alfredo; Sitruk-Ware,Regine
Cancer Investigation 24(8): 727-733
Publication date: 2006

Mifepristone and misoprostol sequential regimen side effects, complications and safety  (abstract) (HTML) 
Sitruk-Ware,Regine
Contraception 74(1): 48-55
Publication date: 2006

New progestagens for contraceptive use  (abstract) (PDF) 
Sitruk-Ware,Regine
Human Reproduction Update 12(2): 169-178
Publication date: 2006

Progesterone receptor modulator CDB-2914 down-regulates vascular endothelial growth factor, adrenomedullin and their receptors and modulates progesterone receptor content in cultured human uterine leiomyoma cells  (abstract) (PDF) (HTML) 
Xu,Qin; Ohara,Noriyuki; Chen,Wei; Liu,Jin; Sasaki,Hiroko; Morikawa,Akira; Sitruk-Ware,Regine; Johansson,Elof D.B.; Maruo,Takeshi
Human Reproduction 21(9): 2408-2416
Publication date: 2006

Progestins and the brain, affects on sexuality and quality of life 
Sitruk-Ware,Regine; Kumar,Narender
Proceedings of the 6th International Menopause Society (IMS) Workshop, Pisa, Italy
Publication date: 2006

The levonorgestrel-releasing intrauterine system (Mirena®)  (HTML) 
Sitruk-Ware,Regine
Gynaecology Forum 11(2): 1-32
Publication date: 2006

Bone and muscle protective potential of the prostate-sparing synthetic androgen 7α-methyl-19-nortestosterone: Evidence from the aged orchidectomized male rat model  (abstract) (HTML) 
Venken,Katrien; Boonen,Steven; Van Herck,Erik; Vandenput,Liesbeth; Kumar,Narender; Sitruk-Ware,Regine; Sundaram,Kalyan; Bouillon,Roger; Vanderschueren,Dirk
Bone 36(4): 663-670
Publication date: 2005

Delivery options for contraceptives  (abstract) (HTML) 
Sitruk-Ware,Regine
Drug Discovery Today 10(14): 977-985
Publication date: 2005

Estrogen and progestogens: Different routes of administration (editorial)  (HTML) 
Sitruk-Ware,Regine
Climacteric 8(suppl 1): 1-2
Publication date: 2005

Management of patients receiving long-term treatment with mifepristone  (abstract) (HTML) 
Spitz,Irving M.; Grunberg,Steven M.; Chabbert-Buffet,Nathalie; Lindenberg,Tzina; Gelber,Hadassa; Sitruk-Ware,Regine
Fertility and Sterility 84(6): 1719-1726
Publication date: 2005

Pharmacology of different progestogens: The special case of drospirenone  (abstract) (HTML) 
Sitruk-Ware,Regine
Climacteric 8(suppl 3): 4-12
Publication date: 2005

Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells  (abstract) (PDF) (HTML) 
Xu,Qin; Takekida,Shigeki; Ohara,Noriyuki; Chen,Wei; Sitruk-Ware,Regine; Johansson,Elof D.B.; Maruo,Takeshi
Journal of Clinical Endocrinology and Metabolism 90(2): 953-961
Publication date: 2005

The levonorgestrel intrauterine system: Long-term contraception and therapeutic effects  (abstract) (PDF) 
Sitruk-Ware,Regine; Inki,Pirjo
Women's Health 1(2): 171-182
Publication date: 2005

Vaginal delivery of contraceptives  (abstract) (HTML) 
Sitruk-Ware,Regine
Expert Opinion on Drug Delivery 2(4): 729-736
Publication date: 2005

Exogenous progestagens and the human breast  (abstract) (HTML) 
Sitruk-Ware,Regine; Plu-Bureau,Genevieve
Maturitas 49(1): 58-66
Publication date: 2004

Mifepristone does not induce cervical softening in non-pregnant women  (abstract) (HTML) 
Ben-Chetrit,Avraham; Eldar-Geva,Talia; Lindenberg,Tzina; Farhat,Morshed; Shimonovitz,Shlomo; Zacut,David; Gelber,Hadassa; Sitruk-Ware,Regine; Spitz,Irving M.
Human Reproduction 19(10): 2372-2376
Publication date: 2004

New delivery systems in contraception: Vaginal rings  (abstract) (HTML) 
Johansson,Elof D.B.; Sitruk-Ware,Regine
American Journal of Obstetrics and Gynecology 190(suppl 1): S54-S59
Publication date: 2004

New progestogens: A review of their effects in perimenopausal and postmenopausal women  (abstract) (HTML) 
Sitruk-Ware,Regine
Drugs and Aging 21(13): 865-883
Publication date: 2004

Pharmacological profile of progestins  (abstract) (HTML) 
Sitruk-Ware,Regine
Maturitas 47(4): 277-283
Publication date: 2004

Role of progestins with partial antiandrogenic effects  (abstract) (HTML) 
Sitruk-Ware,Regine; Husmann,F.; Skouby,S.O.; Thijssen,J.H.H.; Fruzzetti,F.; Hanker,J.; Huber,J.; Druckmann,R.
Climacteric 7(3): 238-254
Publication date: 2004

Alternatives for optimal hormone replacement therapy  (abstract) 
Sitruk-Ware,Regine
Climacteric 6(suppl 2): 11-16
Publication date: 2003

Hormone therapy and the cardiovascular system: The critical role of progestins  (abstract) 
Sitruk-Ware,Regine
Climacteric 6(suppl 3): 21-28
Publication date: 2003

Nestorone®: Clinical applications for contraception and HRT  (abstract) (HTML) 
Sitruk-Ware,Regine; Small,Margaret; Kumar,Narender; Tsong,Yun-yen; Sundaram,Kalyan; Jackanicz,Theodore M.
Steroids 68(10-13): 907-913
Publication date: 2003

Pharmacological properties of mifepristone: Toxicology and safety in animal and human studies  (abstract) (HTML) 
Sitruk-Ware,Regine; Spitz,Irving M.
Contraception 68(6): 409-420
Publication date: 2003

Progestins in hormonal replacement therapy (HRT): New molecules, risks and benefits 
Sitruk-Ware,Regine
Annales d'Endocrinologie 64(2): 178-178
Publication date: 2003

Progestins in hormonal therapy (HT) today, tomorrow and the next day: A roundtable discussion  (HTML) 
Sitruk-Ware,Regine
Steroids 68(10-13): 973-979
Publication date: 2003

Antiandrogenic progestogens in hormone replacement therapy  (HTML) 
Sitruk-Ware,Regine
Gynaecology Forum 7(2): 8-11
Publication date: 2002

Hormonal replacement therapy  (HTML) 
Sitruk-Ware,Regine
Reviews in Endocrine and Metabolic Disorders 3(3): 243-256
Publication date: 2002

New methods of progestin delivery 
Sitruk-Ware,Regine; Small,Margaret
Contemporary Clinical Gynecology and Obstetrics 2(4): 287-298
Publication date: 2002

Progestins and breast cancer risk: State of the controversy 
Sitruk-Ware,Regine; Plu-Bureau,Genevieve; Neves-e-Castro,Manuel; Wren,Barry G.
from Menopause: Hormones and Cancer, pp. 123-128
Publication date: 2002

Progestogens in hormonal replacement therapy: New molecules, risks, and benefits  (abstract) (HTML) 
Sitruk-Ware,Regine
Menopause 9(1): 6-15
Publication date: 2002

Progestins and Antiprogestins in Clinical Practice 
Publication date: 2000

Régine Sitruk-Ware, M.D.

Distinguished Scientist

A dose-finding, cross-over study to evaluate the effect of a transdermal Nestorone®-estradiol (NES/E2) gel on ovulation suppression and assess acceptability in healthy ovulating women (abstract)  
Presentation at American Society for Reproductive Medicine 66th Annual Meeting, Denver, 23-27 October
Merkatz,Ruth B.; Sitruk-Ware,Regine; Mishell,Daniel R.,Jr.; Brache,Vivian; Taylor,DeShawn; Gaete,Cristian Jesam
Publication date: 2010

Delivery routes for hormonal contraception  
Presentation at the 8th Congress of the European Society of Gynecology, Rome, 10-13 September
Sitruk-Ware,Regine
Publication date: 2009

Development and acceptability of the NES/EE CVR: A year-long, user-controlled contraceptive method  
Presentation at the International Conference on Family Planning: Research and Best Practices, Kampala, 16 November
Merkatz,Ruth B.; Sitruk-Ware,Regine; Sivin,Irving; Mensch,Barbara S.; Hewett,Paul C.; Cooney,Michael; Hoskin,Elena
Publication date: 2009

New frontiers in the development of contraceptive methods  
Presentation at the XXI Meeting of the Latin American Association of Human Reproduction Researchers, São Paulo, 22-24 April
Sitruk-Ware,Regine
Publication date: 2009

New strategies for providing hormonal contraception in developing countries (PDF) 
Presentation at the XIX FIGO World Congress of Gynecology & Obstetrics, Cape Town, 5 October
Townsend,John W.; Sitruk-Ware,Regine; Williams,Katherine; Askew,Ian; Brill,Klaus
Publication date: 2009

Non-oral delivery of contraceptive hormones  
Presentation at the 56th Annual Meeting of the Society for Gynecologic Investigation---Science and Women's Health: The Impact of Genes, Hormones and Environment, Glasgow, 19 March
Sitruk-Ware,Regine
Publication date: 2009

Public and private partnership in male contraception  
Presentation at the 9th International Congress of Andrology, Barcelona, 10 March
Sitruk-Ware,Regine
Publication date: 2009

Safety and molecular mechanisms of CDB-2914, a new progesterone receptor modulator, on human breast and endometrium  
Presentation at Contraceptive Development Research Centers Program (U54) Meeting, University of Washington, Seattle, 29 September
Morris,Patricia L.; Hwang,KeumSil; Mitchell,Lyann; Rapelje,Catherine; Sitruk-Ware,Regine
Publication date: 2007

Controversy about hormone therapy: Implications for Population Council research  
Presentation at 115th Meeting of the Board of Trustees, Population Council, New York, 14 January
Sitruk-Ware,Regine; Morris,Patricia L.
Publication date: 2003

Effect of CDB-2914 on breast cells  
Presentation at 83rd meeting of the International Committee for Contraception Research, Santiago, Chile, November
Sitruk-Ware,Regine
Publication date: 2003

Nestorone: Potential use in male contraception  
Oral presentation at the Seventh Summit Meeting on Hormonal Male Contraception, Castle Elmau, Bavaria, Germany, September
Sitruk-Ware,Regine
Publication date: 2003