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Selected Publications

Mruk, Dolores D, Ching-hang Wong, Bruno Silvestrini and C. Yan Cheng. 2006. "A male contraceptive targeting germ cell adhesion," Nature Medicine 12(11): 1323–1328. (abstract)

Xia, Weiliang, Dolores D. Mruk, Will M. Lee, and C. Yan Cheng. 2006. "Differential interactions between transforming growth factor-β3/TβR1, TAB1, and CD2AP disrupt blood–testis barrier and Sertoli–germ cell adhesion," Journal of Biological Chemistry 281(24): 16799–16813. (abstract)

Yan, Helen H.N. and C. Yan Cheng. 2006. "Laminin α3 forms a complex with β3 and γ3 chains that serves as the ligand for α6β1-integrin at the apical ectoplasmic specialization in adult rat testes," Journal of Biological Chemistry 281(25): 17286–17303. (abstract)

Lee, Nikki P.Y., Dolores D. Mruk, Ching-hang Wong, and C. Yan Cheng. 2005. "Regulation of Sertoli–germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/β-catenin (CATNB) signaling pathway: An in vitro and in vivo study," Biology of Reproduction 73(3): 458–471. (abstract)

Lui, Wing-Yee, Yan Ho Cheng, Dolores D. Mruk, Chin Ho Cheng, Meng Yun Mo, Will M. Lee, and C. Yan Cheng. 2005. "α₂-macroglobulin expression in the liver in response to inflammation is mediated by the testis," Journal of Endocrinology 185(3): 497–505. (abstract)

Siu, Michelle K.Y., Ching-hang Wong, Will M. Lee, and C. Yan Cheng. 2005. "Sertoli–germ cell anchoring junction dynamics in the testis are regulated by an interplay of lipid and protein kinases," Journal of Biological Chemistry 280(26): 25029–25047. (abstract)

Wong, Ching-hang, Dolores D. Mruk, Michelle K.Y. Siu and C. Yan Cheng. 2005. "Blood–testis barrier dynamics are regulated by α2-macroglobulin via the c-Jun N-terminal protein kinase pathway," Endocrinology 146(4): 1893–1908. (abstract)

Xia, Weiliang and C. Yan Cheng. 2005. "TGF-β3 regulates anchoring junction dynamics in the seminiferous epithelium of the rat testis via the Ras/ERK signaling pathway: An in vivo study," Developmental Biology 280(2): 321–343. (abstract)

Yan, Helen H.N. and C. Yan Cheng. 2005. "Blood–testis barrier dynamics are regulated by an engagement/disengagement mechanism between tight and adherens junctions via peripheral adaptors," Proceedings of the National Academy of Sciences of the United States of America 101(33): 11722–11727.

Lee, Nikki P.Y. and C. Yan Cheng. 2004. "Ectoplasmic specialization, a testis-specific cell–cell actin-based adherens junction type: Is this a potential target for male contraceptive development?" Human Reproduction Update 10(4): 349–369.

Mruk, Dolores D. and C. Yan Cheng. 2004. "Cell–cell interactions at the ectoplasmic specialization in the testis," Trends in Endocrinology and Metabolism 15(9):439–447.

Mruk, Dolores D. and C. Yan Cheng. 2004. "Sertoli–Sertoli and Sertoli–germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis," Endocrine Reviews 25(5): 747–806.

Siu, Michelle K.Y. and C. Yan Cheng. 2004. "Interactions of proteases, protease inhibitors, and the β1 integrin/laminin γ3 protein complex in the regulation of ectoplasmic specialization dynamics in the rat testis," Biology of Reproduction 70(4): 945–964.

Wong, Ching-hang, Dolores D. Mruk, Wing-yee Lui, and C. Yan Cheng. 2004. "Regulation of blood–testis barrier dynamics: An in vivo study," Journal of Cell Science 117(5): 783–798.

Cheng, C. Yan and Dolores D. Mruk. 2002. "Cell junction dynamics in the testis: Sertoli–germ cell interactions and male contraceptive development," Physiological Reviews 82(4): 825–874.