Population Council Research that makes a difference

Projects

Development and Physiology of Leydig Cells (more)
Testosterone production by Leydig cells in the testis is the critical factor ensuring adequate sperm production and male fertility. Council researchers are identifying components that affect testosterone secretion and may offer new avenues for contraception and male hormone therapy.
(1/1998 - ongoing)
United States

Dual Health Benefits: Nestorone
Council scientists at the Center for Biomedical Research are developing safer and more effective long-acting contraceptives that have dual health benefits, using molecules with selective binding to hormone receptors, such as Nestorone®, a derivative of progesterone.
(1/2010 - ongoing)
France, United States

Dual Health Benefits: Ulipristal (more)
Council scientists at the Center for Biomedical Research are developing safer and more effective long-acting contraceptives that have dual health benefits, using molecules with selective binding to hormone receptors, such as ulipristal, a novel progesterone receptor modulator.
(1/2010 - ongoing)
United States

Emergency Contraceptive Potential of Products Under Development (more)
Many contraceptive products may have utility as emergency contraceptive methods; the Council is evaluating the potential of selected candidate products.
(1/2005 - ongoing)
United States

Female Hormone Therapy (more)
Research at the Center for Biomedical Research is part of the Council's ongoing efforts to evaluate the long-term safety of the progesterone receptor modulator CDB-2914 for hormone therapy.
(1/2001 - ongoing)
United States

MENT® (more)
Council researchers are working to develop methods of contraception for men that contain MENT®, a synthetic steroid that resembles testosterone
(1/2005 - ongoing)
Chile, Dominican Republic, Germany, United Kingdom, United States

Nestorone® (more)
Many of the products under development at the Council employ Nestorone, a versatile synthetic progestin similar to the natural hormone progesterone
(1/2005 - ongoing)
United States

Physiology of Sertoli Cells (more)
The goal of Council research on Sertoli cells is the development of safe, reversible male contraceptives.
(1/1995 - ongoing)
United States

Probing Studies in Male Contraception (more)
Council researchers are undertaking research that may lead to novel contraceptive methods for men.
(1/1995 - ongoing)
United States

Subdermal Implants for Men (more)
Studies have found that men are interested in taking more responsibility for family planning; an implant for men is the Council's lead product in male contraception.
(1/2005 - ongoing)
Chile, Dominican Republic, Germany, United Kingdom, United States

Transdermal Delivery Systems for Men (more)
Council research has demonstrated that MENT permeates the skin significantly better than two other androgens and is safe for further development as a hormone therapy method for men.
(1/2005 - ongoing)
Chile, United States

Transdermal Delivery Systems for Women: Contraceptive Gel (more)
Council scientists are developing a contraceptive gel that is absorbed through the skin.
(1/2005 - ongoing)
United States

Transdermal Delivery Systems for Women: Spray-on Contraceptive (more)
Council researchers are developing a transdermal spray-on contraceptive that makes use of the synthetic progestin Nestorone.
(1/2007 - ongoing)
Australia, United States

Assessing the Acceptability of the Progesterone Vaginal Ring in Sub-Saharan Africa (more)
To expand contraceptive options for women in sub-Saharan Africa we are evaluating the acceptability of the progesterone vaginal ring, a user-controlled contraceptive method for lactating women, and exploring strategies for how to introduce the new technology.
(10/2011 - 9/2014)
Kenya, Nigeria, Senegal

Facilitating Regulatory Approval of Multipurpose Prevention Technologies for Reproductive Health (more)
The Population Council is playing a central role in the US Agency for International Development’s effort to clarify and inform regulatory pathways for multipurpose prevention technologies.
(10/2010 - 9/2013)
United States

One-year Combination Vaginal Ring, Phase 3 Study (more)
The NES/EE vaginal ring is a user-controlled method that can be reused for one year.
(9/2005 - 6/2009)
Americas, Australia, Europe, United States

CDB-2914 Intrauterine Delivery System (more)
Council biomedical researchers are developing an intrauterine contraceptive delivery system that releases a novel progesterone receptor modulator.
(1/2005 - 1/2007)
United States

Resources

"Safe for mothers and babies," Progesterone Vaginal Ring fact sheet (PDF) 
Publication date: 2013


7a-methyl-19-nortestosterone (MENT®): The Population Council's contribution to research on male contraception and treatment of hypogonadism (abstract) (HTML) 
Nieschlag,Eberhard; Kumar,Narender; Sitruk-Ware,Regine
Contraception 87(3): 288-295
Publication date: 2013


Contraception technology: Past, present and future (abstract) (HTML) 
Sitruk-Ware,Regine; Nath,Anita; Mishell,Daniel R.,Jr.
Contraception 87(3): 319-330
Publication date: 2013


New vision for contraceptive research and development (PDF) 
Sitruk-Ware,Regine; Donaldson,Peter J.
Contraception 87(3): 257-
Publication date: 2013


New vision for contraceptive research and development (PDF) 
Donaldson,Peter J.; Sitruk-Ware,Regine
Huffington Post 8 March
Publication date: 2013


"Anneau vaginal avec progestérone (PVR) : Un nouveau contraceptif contrôlé par l'utilisatrice à l'intention des femmes qui allaient," brochure d'information (PDF) 
Publication date: 2012


"Building on decades of success: Pioneering contraceptive research and products," fact sheet (PDF) 
Publication date: 2012


"Élargir l'accès aux méthodes de contraception réversibles à longue durée d'action," fact sheet (PDF) 
Publication date: 2012


"Expanding access to long-acting reversible contraception," fact sheet (PDF) 
Publication date: 2012


"How does the PVR prevent pregnancy?" Progesterone Vaginal Ring fact sheet (PDF) 
Publication date: 2012


"Progesterone vaginal ring (PVR): A new user-controlled contraceptive for breastfeeding women," informational brochure (PDF) 
Publication date: 2012


A new combination of testosterone and nestorone transdermal gels for male hormonal contraception (abstract) (HTML) 
Ilani,Niloufar; Roth,Mara Y.; Amory,John K.; Swerdloff,Ronald S.; Dart,Clint; Page,Stephanie T.; Bremner,William J.; Sitruk-Ware,Regine; Kumar,Narender; Blithe,Diana; Wang,Christina
Journal of Clinical Endocrinology and Metabolism 97(10): 3476-3486
Publication date: 2012


Bangladesh: A model for national family planning program integration (HTML) 
Hossain,Sharif Mohammed Ismail; Khan,M.E.; Foster,Angel M.; Wynn,L.L.
from Emergency Contraception: The Story of a Global Reproductive Health Technology, pp. 221-237
Publication date: 2012


Bellagio consensus: Recommendations for action to increase access to highly effective, long-acting, reversible contraception (PDF) 
Publication date: 2012


Country mapping: Kenya (PDF) 
Obare,Francis; Liambila,Wilson; Birungi,Harriet; Itombra,Eseoise; Clark,Heather; RamaRao,Saumya
Progesterone Vaginal Ring Technical Report
Publication date: 2012


Country mapping: Nigeria (PDF) 
Ishaku,Salisu Mohammed; RamaRao,Saumya
Progesterone Vaginal Ring Technical Report
Publication date: 2012


Country mapping: Senegal (PDF) 
Mane,Babacar; Diop,Nafissatou; Termini,Nancy; RamaRao,Saumya; Clark,Heather
Progesterone Vaginal Ring Technical Report
Publication date: 2012


Effects of a novel estrogen-free, progesterone receptor modulator-contraceptive vaginal ring on inhibition of ovulation, bleeding patterns and endometrium in normal women (abstract) (HTML) 
Brache,Vivian; Sitruk-Ware,Regine; Williams,A.; Blithe,Diana; Croxatto,Horacio B.; Kumar,Narender; Kumar,Sushma; Tsong,Yun-yen; Sivin,Irving; Nath,Anita; Sussman,Heather; Cochon,Leila; Miranda,Maria Jose; Reyes,Veronica; Faundes,Anibal; Mishell,Daniel R.,Jr.
Contraception 85(5): 480-488
Publication date: 2012


Le consensus de Bellagio : Recommandations pour améliorer l'accès aux méthodes de contraception efficaces, réversibles à longue durée d'action (PDF) 
Publication date: 2012


Nonclinical development needs and regulatory requirements for multipurpose prevention technologies: A primer (PDF) 
Romano,Joseph W.; Brady,Martha; Manning,Judy
Publication date: 2012


The blood-testis barrier and its implications for male contraception (abstract) (PDF) (HTML) 
Cheng,Chuen-yan; Mruk,Dolores D.
Pharmacological Reviews 64(1): 16-64
Publication date: 2012


Users' and providers' perspectives on MPTs: What do we know, and what do we need to know? (PDF) 
Presentation at Multipurpose Prevention Technologies for Reproductive Health, New Delhi, India, 11-12 December
Brady,Martha
Publication date: 2012


What have we learned from other reproductive health technologies? (PDF) 
Presentation at Multipurpose Prevention Technologies for Reproductive Health, New Delhi, India, 11-12 December
Brady,Martha
Publication date: 2012


An in vitro system to study Sertoli cell blood-testis barrier dynamics (abstract) (HTML) 
Mruk,Dolores D.; Cheng,Chuen-yan
Methods in Molecular Biology 763: 237-252
Publication date: 2011


Day of dialogue on multipurpose prevention technologies: Toward clarity in nomenclature (PDF) 
Brady,Martha; McGrory,C.Elizabeth
Meeting notes
Publication date: 2011


Evaluation of progesterone vaginal ring as a new contraceptive option in India: CRF completion guidelines 
Malabika,Roy; Aruldas,Kumudha; Merkatz,Ruth B.; Huang,Young-mei; Hariprasad,Roopa
Publication date: 2011


Facilitating regulatory approval of multipurpose prevention technologies for sexual and reproductive health (PDF) 
Brady,Martha
Brief
Publication date: 2011


Mifepristone in combination with prostaglandins for termination of 10-16 weeks' gestation: A systematic review (abstract) (HTML) 
Chen,Qiu-ju; Hou,Shu-ping; Meads,Catherine; Huang,Yong-mei; Hong,Qing-qing; Zhu,Hao-ping; Cheng,Li-nan
European Journal of Obstetrics & Gynecology and Reproductive Biology 159(2): 247-254
Publication date: 2011


New strategies for providing hormonal contraception in developing countries (abstract) (HTML) 
Townsend,John W.; Sitruk-Ware,Regine; Williams,Katherine; Askew,Ian; Brill,Klaus
Contraception 83(5): 405-409
Publication date: 2011


Nomegestrol acetate, a novel progestogen for oral contraception (abstract) (HTML) 
Mueck,Alfred O.; Sitruk-Ware,Regine
Steroids 76(6): 531-539
Publication date: 2011


Nursing's influence on drug development and safety 
Merkatz,Ruth B.; Summers,Elyse I.; Mason,Diana J.; Leavitt,Judith K.; Chaffee,Mary W.
from Policy & Politics in Nursing and Health Care, Sixth Edition, pp. 231-239
Publication date: 2011


P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK) (abstract) (PDF) (HTML) 
Su,Linlin; Mruk,Dolores D.; Lui,Wing-Yee; Lee,William M.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 108(49): 19623-19628
Publication date: 2011


Termination of second-trimester pregnancy by mifepristone combined with misoprostol versus intra-amniotic injection of ethacridine lactate (Rivanol®): A systematic review of Chinese trials (abstract) (HTML) 
Hou,Shu-ping; Fang,Ai-hua; Chen,Qin-fang; Huang,Yong-mei; Chen,Qiu-ju; Cheng,Li-nan
Contraception 84(3): 214-223
Publication date: 2011


What regulatory guidance exists for multipurpose prevention technologies (MPTs)? A review of key guidance documents and their applicability to MPTs (PDF) 
Brady,Martha; Park,Heeyoung
Publication date: 2011


"Nestorone gel: A novel contraceptive gel," fact sheet (PDF) 
Publication date: 2010


A Baby At Last! The Couples' Complete Guide to Getting Pregnant -- from Cutting-Edge Treatments to Commonsense Wisdom (PDF) 
Rosenwaks,Zev R.; Goldstein,Marc; Fuerst,Mark L.
Publication date: 2010


A dose-finding, cross-over study to evaluate the effect of a transdermal Nestorone®-estradiol (NES/E2) gel on ovulation suppression and assess acceptability in healthy ovulating women (abstract) 
Presentation at American Society for Reproductive Medicine 66th Annual Meeting, Denver, 23-27 October
Merkatz,Ruth B.; Sitruk-Ware,Regine; Mishell,Daniel R.,Jr.; Brache,Vivian; Taylor,DeShawn; Gaete,Cristian Jesam
Publication date: 2010


Introduction to Population Council Symposium articles (HTML) 
Sitruk-Ware,Regine; Mishell,Daniel R.,Jr.
Contraception 82(5): 395-395
Publication date: 2010


Mirena® proved useful in women with endometrial cancer and precancer, preserving fertility (PDF) 
Population Briefs 16(2)
Publication date: 2010


New frontiers in nonhormonal male contraception (abstract) (HTML) 
Cheng,Chuen-yan; Mruk,Dolores D.
Contraception 82(5): 476-482
Publication date: 2010


Progesterone vaginal ring for contraceptive use during lactation (abstract) (HTML) 
Nath,Anita; Sitruk-Ware,Regine
Contraception 82(5): 428-434
Publication date: 2010


State-of-the-art of non-hormonal methods of contraception: I. Mechanical barrier contraception (abstract) (HTML) 
Batar,I.; Sivin,Irving
European Journal of Contraception and Reproductive Health Care 15(2): 67-88
Publication date: 2010


State-of-the-art of non-hormonal methods of contraception: III. Intrauterine devices (abstract) (HTML) 
Sivin,Irving; Batar,I.
European Journal of Contraception and Reproductive Health Care 15(2): 96-112
Publication date: 2010


State-of-the-art of non-hormonal methods of contraception: IV. Natural family planning (abstract) (HTML) 
Freundl,G.; Sivin,Irving; Batar,I.
European Journal of Contraception and Reproductive Health Care 15(2): 113-123
Publication date: 2010


The use of newer progestins for contraception (abstract) (HTML) 
Sitruk-Ware,Regine; Nath,Anita
Contraception 82(5): 410-417
Publication date: 2010


Adjudin targeting rabbit germ cell adhesion as a male contraceptive: A pharmacokinetics study (abstract) (PDF) (HTML) 
Hu,Guo-Xin; Hu,Lu-Feng; Yang,Dai-Zheng; Li,Jun-Wei; Chen,Guo-Rong; Chen,Bing-Bing; Mruk,Dolores D.; Bonanomi,Michele; Silvestrini,Bruno; Cheng,Chuen-yan; Ge,Renshan
Journal of Andrology 30(1): 87-93
Publication date: 2009


Cadmium-induced testicular injury (abstract) (HTML) 
Siu,Erica R.; Mruk,Dolores D.; Porto,Catarina S.; Cheng,Chuen-yan
Toxicology and Applied Pharmacology 238(3): 240-249
Publication date: 2009


Central modifications of allopregnanolone and ß-endorphin following subcutaneous administration of Nestorone (abstract) (HTML) 
Lenzi,E.; Pluchino,N.; Begliuomini,S.; Casarosa,E.; Merlini,S.; Giannini,A.; Luisi,M.; Kumar,Narender; Sitruk-Ware,Regine; Genazzani,Andrea R.
Journal of Steroid Biochemistry and Molecular Biology 116(1-2): 15-20
Publication date: 2009


Combined transdermal testosterone gel and the progestin Nestorone suppresses serum gonadotropins in men (abstract) (PDF) 
Mahabadi,Vahid; Amory,John K.; Swerdloff,Ronald S.; Bremner,William J.; Page,Stephanie T.; Sitruk-Ware,Regine; Christensen,Peter D.; Kumar,Narender; Tsong,Yun-yen; Blithe,Diana; Wang,Christina
Journal of Clinical Endocrinology and Metabolism 94(7): 2313-2320
Publication date: 2009


Contraceptive research leads to an array of options (PDF) 
Population Briefs 15(3)
Publication date: 2009


Different cardiovascular effects of progestins according to structure and activity (abstract) (HTML) 
Nath,Anita; Sitruk-Ware,Regine
Climacteric 12(suppl 1): 96-101
Publication date: 2009


Distribution, metabolism and excretion of a synthetic androgen 7α-methyl-19-nortestosterone, a potential male-contraceptive (abstract) (HTML) 
Vishwanath Prasad,Pramod; Arumugam,Ramamani; Willman,Mark; Ge,Renshan; Sitruk-Ware,Regine; Kumar,Narender
Steroids 74(1): 121-131
Publication date: 2009


Effectiveness of medical abortion with mifepristone and buccal misoprostol through 59 gestational days (abstract) (HTML) 
Fjerstad,Mary; Sivin,Irving; Lichtenberg,E.Steve; Trussell,James; Cleland,Kelly; Cullins,Vanessa
Contraception 80(3): 282-286
Publication date: 2009


Meta-analysis of 200 or 600 mg mifepristone in association with two prostaglandins for termination of early pregnancy (abstract) (HTML) 
Lievre,Michel; Sitruk-Ware,Regine
Contraception 80(1): 95-100
Publication date: 2009


Methods for female contraception: A model for innovation in drug delivery systems (abstract) (HTML) 
Merkatz,Ruth B.; Tokay,Barbara A.; Sitruk-Ware,Regine
Clinical Pharmacology and Therapeutics 85(5): 553-557
Publication date: 2009


Mitogen-activated protein kinases in male reproductive function (abstract) (HTML) 
Li,Michelle W.M.; Mruk,Dolores D.; Cheng,Chuen-yan
Trends in Molecular Medicine 15(4): 159-168
Publication date: 2009


Parenteral administration of progestins for hormonal replacement therapy (abstract) (HTML) 
Nath,Anita; Sitruk-Ware,Regine
European Journal of Contraception and Reproductive Health Care 14(2): 88-96
Publication date: 2009


Pharmacology and clinical applications of selective estrogen receptor modulators (abstract) (HTML) 
Nath,Anita; Sitruk-Ware,Regine
Climacteric 12(3): 188-205
Publication date: 2009


RAB13 participates in ectoplasmic specialization dynamics in the rat testis (abstract) (PDF) (HTML) 
Mruk,Dolores D.; Lau,Ann S.N.
Biology of Reproduction 80(3): 590-601
Publication date: 2009


Rates of serious infection after changes in regimens for medical abortion (abstract) (HTML) 
Fjerstad,Mary; Trussell,James; Sivin,Irving; Lichtenberg,E.Steve; Cullins,Vanessa
New England Journal of Medicine 361(2): 145-151
Publication date: 2009


Testicular cell junction: A novel target for male contraception  (abstract) (HTML) 
Lee,Nikki P.Y.; Wong,Elissa W.P.; Mruk,Dolores D.; Cheng,Chuen-yan
Current Medicinal Chemistry 16(7): 906-915
Publication date: 2009


Unexpected heaping in reported gestational age for women undergoing medical abortion (abstract) (HTML) 
Sivin,Irving; Trussell,James; Lichtenberg,E.Steve; Fjerstad,Mary; Cleland,Kelly; Cullins,Vanessa
Contraception 80(3): 287-291
Publication date: 2009


"Construyendo sobre décadas de éxito: Lidereando la investigación sobre anticonceptivos y desarrollo de productos [Building on decades of success: Pioneering contraceptive research and products]," fact sheet (PDF) 
Publication date: 2008


An autocrine axis in the testis that coordinates spermiation and blood-testis barrier restructuring during spermatogenesis (abstract) (PDF) (HTML) 
Yan,Helen H.N.; Mruk,Dolores D.; Wong,Elissa W.P.; Lee,Will M.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 105(26): 8950-8955
Publication date: 2008


Anchoring junctions as drug targets: Role in contraceptive development (abstract) (PDF) (HTML) 
Mruk,Dolores D.; Silvestrini,Bruno; Cheng,Chuen-yan
Pharmacological Reviews 60(2): 146-180
Publication date: 2008


Comparative actions of progesterone, medroxyprogesterone acetate, drospirenone and nestorone on breast cancer cell migration and invasion (abstract) (PDF) 
Fu,Xiao-Dong; Giretti,Maria Silva; Goglia,Lorenzo; Flamini,Marina Ines; Matias Sanchez,Angel; Baldacci,Chiara; Garibaldi,Silvia; Sitruk-Ware,Regine; Genazzani,Andrea R.; Simoncini,Tommaso
BMC Cancer 8: 166-
Publication date: 2008


Delivering non-hormonal contraceptives to men: Advances and obstacles (abstract) (HTML) 
Mruk,Dolores D.; Cheng,Chuen-yan
Trends in Biotechnology 26(2): 90-99
Publication date: 2008


Determinants of the rate and extent of spermatogenic suppression during hormonal male contraception: An integrated analysis (abstract) (PDF) (HTML) 
Liu,Peter Y.; Swerdloff,Ronald S.; Anawalt,Bradley D.; Anderson,Richard A.; Bremner,William J.; Elliesen,Joerg; Gu,Yi-Qun; Kersemaekers,Wendy M.; McLachlan,Robert I.; Meriggiola,M.Christina; Nieschlag,Eberhard; Sitruk-Ware,Regine; Vogelsong,Kirsten M.; Wang,Xing-Hai; Wu,Frederick C.W.; Zitzmann,Michael; Handelsman,David J.; Wang,Christina
Journal of Clinical Endocrinology and Metabolism 93(5): 1774-1783
Publication date: 2008


Does estrogen therapy reduce coronary artery calcification in postmenopausal women? (HTML) 
Sitruk-Ware,Regine
Nature Clinical Practice Endocrinology and Metabolism 4(1): 12-13
Publication date: 2008


Efficacy of Carraguard-based microbicides in vivo despite variable in vitro activity (abstract) (PDF) 
Turville,Stuart G.; Aravantinou,Meropi; Miller,Todd; Kenney,Jessica; Teitelbaum,Aaron; Hu,Lieyu; Chudolij,Anne; Zydowsky,Thomas M.; Piatak Jr.,Michael; Bess Jr.,Julian W.; Lifson,Jeffrey D.; Blanchard,James; Gettie,Agegnehu; Robbiani,Melissa
PLoS ONE 3(9): e3162-
Publication date: 2008


IUDs: A beneficial, underused contraceptive technology (PDF) 
Population Briefs 14(1)
Publication date: 2008


Microbicide product development (abstract) (HTML) 
Maguire,Robin A.
Current Opinion in HIV and AIDS 3(5): 554-557
Publication date: 2008


Microbicides (HTML) 
Kaldor,John; Robbiani,Melissa
Current Opinion in HIV and AIDS 3(5)
Publication date: 2008


Microbicides: Chemistry, structure, and strategy (abstract) (HTML) 
Zydowsky,Thomas M.
Current Opinion in HIV and AIDS 3(5): 548-553
Publication date: 2008


New contraceptive developments (PDF) 
Momentum, December
Publication date: 2008


New perspectives in non-hormonal male contraception (abstract) (HTML) 
Mruk,Dolores D.
Trends in Endocrinology and Metabolism 19(2): 57-64
Publication date: 2008


New vistas in contraceptive technology (abstract) (PDF) 
RamaRao,Saumya; Sitruk-Ware,Regine; Townsend,John W.
Gender and Development 16(2): 327-344
Publication date: 2008


Progesterone and progestins: Neuroprotection and myelin repair (abstract) (HTML) 
Schumacher,Michael; Sitruk-Ware,Regine; De Nicola,Alejandro
Current Opinion in Pharmacology 8(6): 740-746
Publication date: 2008


Progesterone receptor modulator CDB-2914 induces extracellular matrix metalloproteinase inducer in cultured human uterine leiomyoma cells (abstract) (PDF) (HTML) 
Xu,Qin; Ohara,Noriyuki; Liu,Jin; Amano,Mariko; Sitruk-Ware,Regine; Yoshida,Shigeki; Maruo,Takeshi
Molecular Human Reproduction 14(3): 181-191
Publication date: 2008


Rectal microbicides (abstract) (HTML) 
McGowan,Ian; Anton,Peter
Current Opinion in HIV and AIDS 3(5): 593-598
Publication date: 2008


A seamless trespass: Germ cell migration across the seminiferous epithelium during spermatogenesis (abstract) (PDF) (HTML) 
Wang,Claire Q.F.; Cheng,Chuen-yan
Journal of Cell Biology 178(4): 549-556
Publication date: 2007


An initial pharmacokinetic study with a Metered Dose Transdermal System® for delivery of the progestogen Nestorone® as a possible future contraceptive (abstract) (HTML) 
Fraser,Ian S.; Weisberg,Edith; Kumar,Narender; Kumar,Sushma; Humberstone,Andrew J.; McCrossin,Louise; Shaw,Deborah; Tsong,Yun-yen; Sitruk-Ware,Regine
Contraception 76(6): 432-438
Publication date: 2007


Chemical postmaster helps deliver contraceptive to testis (PDF) 
Population Briefs 13(1)
Publication date: 2007


Comparison of the impact of vaginal and oral administration of combined hormonal contraceptives on hepatic proteins sensitive to estrogen (abstract) (HTML) 
Sitruk-Ware,Regine; Menard,Joel; Rad,Mandana; Burggraaf,Jacobus; de Kam,Marieke L.; Tokay,Barbara A.; Sivin,Irving; Kluft,Cornelius
Contraception 75(6): 430-437
Publication date: 2007


C-type natriuretic peptide regulates blood-testis barrier dynamics in adult rat testes (abstract) (PDF) (HTML) 
Xia,Weiliang; Mruk,Dolores D.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 104(10): 3841-3846
Publication date: 2007


Effects of estradiol with oral or intravaginal progesterone on risk markers for breast cancer in a postmenopausal monkey model (abstract) (HTML) 
Wood,Charles E.; Sitruk-Ware,Regine; Tsong,Yun-yen; Register,Thomas C.; Lees,Cynthia J.; Cline,J.Mark
Menopause 14(4): 1-9
Publication date: 2007


Effects of levonorgestrel-releasing IUS and progesterone receptor modulator PRM CDB-2914 on uterine leiomyomas (abstract) (HTML) 
Maruo,Takeshi; Ohara,Noriyuki; Matsuo,Hiroya; Xu,Qin; Chen,Wei; Sitruk-Ware,Regine; Johansson,Elof D.B.
Contraception 75(6S): S99-S103
Publication date: 2007


Effects of oral and transvaginal ethinyl estradiol on hemostatic factors and hepatic proteins in a randomized, cross-over study (abstract) (PDF) (HTML) 
Sitruk-Ware,Regine; Plu-Bureau,Genevieve; Menard,Joel; Conard,Jacqueline; Kumar,Sushma; Thalaband,Jean-Christophe; Tokay,Barbara A.; Bouchard,Philippe
Journal of Clinical Endocrinology and Metabolism 92(6): 2074-2079
Publication date: 2007


Hormone therapy effects on social behavior and activity levels of surgically postmenopausal cynomolgus monkeys (abstract) (HTML) 
Shively,Carol A.; Wood,Charles E.; Register,Thomas C.; Willard,Stephanie L.; Lees,Cynthia J.; Chen,Haiying; Sitruk-Ware,Regine; Tsong,Yun-yen; Cline,J.Mark
Psychoneuroendocrinology 32(8-10): 981-990
Publication date: 2007


Junction restructuring and spermatogenesis: The biology, regulation, and implication in male contraceptive development (abstract) (HTML) 
Yan,Helen H.N.; Mruk,Dolores D.; Cheng,Chuen-yan
Current Topics in Developmental Biology 80: 57-92
Publication date: 2007


Pharmacokinetic study to compare the absorption and tolerability of two doses of levonorgestrel following single vaginal administration of levonorgestrel in Carraguard® gel: A new formulation for 'dual protection' contraception (abstract) (HTML) 
Sitruk-Ware,Regine; Brache,Vivian; Maguire,Robin A.; Croxatto,Horacio B.; Kumar,Narender; Kumar,Sushma; Montero,Juan Carlos; Salvatierra,Ana Maria; Phillips,David M.; Faundes,Anibal
Contraception 75(6): 454-460
Publication date: 2007


Preclinical and clinical properties of trimegestone: A potent and selective progestin (abstract) (HTML) 
Sitruk-Ware,Regine; Bossemeyer,Ronald; Bouchard,Philippe
Gynecological Endocrinology 23(6): 310-319
Publication date: 2007


Rab4A GTPase-catenin interactions are involved in cell junction dynamics in the testis (abstract) (PDF) (HTML) 
Mruk,Dolores D.; Lau,Ann S.N.; Sarkar,Oli; Xia,Weiliang
Journal of Andrology 28(5): 742-754
Publication date: 2007


Routes of delivery for progesterone and progestins (abstract) (HTML) 
Sitruk-Ware,Regine
Maturitas 57(1): 77-80
Publication date: 2007


Special issue on intrauterine devices and systems (abstract) (HTML) 
Sitruk-Ware,Regine; Donaldson,Peter J.
Contraception 75(6S): S1-
Publication date: 2007


The changing position of IUDs in reproductive health services in developing countries: Opportunities and challenges (abstract) (HTML) 
Townsend,John W.; Jacobstein,Roy
Contraception 75(6S): S35-S40
Publication date: 2007


The levonorgestrel intrauterine system for use in peri- and postmenopausal women (abstract) (HTML) 
Sitruk-Ware,Regine
Contraception 75(6S): S155-S160
Publication date: 2007


Utility and drawbacks of continuous use of a copper T IUD for 20 years (abstract) (HTML) 
Sivin,Irving
Contraception 75(6S): S70-S75
Publication date: 2007


"The one-year contraceptive ring: A technology in development," brochure (PDF) 
Publication date: 2006


A male contraceptive targeting germ cell adhesion (abstract) (HTML) 
Mruk,Dolores D.; Wong,Ching-hang; Silvestrini,Bruno; Cheng,Chuen-yan
Nature Medicine 12(11): 1323-1328
Publication date: 2006


A novel pathway involving progesterone receptor, endothelin-2, and endothelin receptor B controls ovulation in mice (abstract) (PDF) (HTML) 
Palanisamy,Gopinath S.; Cheon,Yong-Pil; Kim,Jaeyeon; Kannan,Athilakshmi; Li,Quanxi; Sato,Marcey; Mantena,Srinivasa R.; Sitruk-Ware,Regine; Bagchi,Milan K.; Bagchi,Indrani C.
Molecular Endocrinology 20(11): 2784-2795
Publication date: 2006


Adjudin-mediated junction restructuring in the seminiferous epithelium leads to displacement of soluble guanylate cyclase from adherens junctions (abstract) (HTML) 
Sarkar,Oli; Xia,Weiliang; Mruk,Dolores D.
Journal of Cellular Physiology 208(1): 175-187
Publication date: 2006


CDB-2914 may be an effective fibroid treatment (PDF) 
Population Briefs 12(3)
Publication date: 2006


Comparative effects of a contraceptive vaginal ring delivering a nonandrogenic progestin and continuous ethinyl estradiol and a combined oral contraceptive containing levonorgestrel on hemostasis variables (abstract) (HTML) 
Rad,Mandana; Kluft,Cornelius; Menard,Joel; Burggraaf,Jacobus; de Kam,Marieke L.; Meijer,Piet; Sivin,Irving; Sitruk-Ware,Regine
American Journal of Obstetrics and Gynecology 195(1): 72-77
Publication date: 2006


Contraception: An international perspective (abstract) (HTML) 
Sitruk-Ware,Regine
Contraception 73(3): 215-222
Publication date: 2006


Delineating the role of estrogen in regulating epididymal gene expression 
Deshpande,Shayu; Hardy,Matthew P.; Rao,A.Jagannadha; Gupta,S.K.; Koyama,K.
from Gamete Biology, Society of Reproduction and Fertility
Publication date: 2006


Differential interactions between transforming growth factor-β3/TβR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion (abstract) (PDF) (HTML) 
Xia,Weiliang; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Journal of Biological Chemistry 281(24): 16799-16813
Publication date: 2006


Emergency contraception: A method every woman should know (abstract) 
Khan,M.E.; Sebastian,Mary Philip
Total Health 1(7): 16-
Publication date: 2006


Laminin α3 forms a complex with β3 and γ3 chains that serves as the ligand for α 6β1-integrin at the apical ectoplasmic specialization in adult rat testes (abstract) (PDF) (HTML) 
Yan,Helen H.N.; Cheng,Chuen-yan
Journal of Biological Chemistry 281(25): 17286-17303
Publication date: 2006


Long-term administration of mifepristone (RU486): Clinical tolerance during extended treatment of meningioma (abstract) (HTML) 
Grunberg,Steven M.; Weiss,Martin H.; Russell,Christy A.; Spitz,Irving M.; Ahmadi,Jamshid; Sadun,Alfredo; Sitruk-Ware,Regine
Cancer Investigation 24(8): 727-733
Publication date: 2006


New progestagens for contraceptive use (abstract) (PDF) 
Sitruk-Ware,Regine
Human Reproduction Update 12(2): 169-178
Publication date: 2006


Progesterone receptor modulator CDB-2914 down-regulates vascular endothelial growth factor, adrenomedullin and their receptors and modulates progesterone receptor content in cultured human uterine leiomyoma cells (abstract) (PDF) (HTML) 
Xu,Qin; Ohara,Noriyuki; Chen,Wei; Liu,Jin; Sasaki,Hiroko; Morikawa,Akira; Sitruk-Ware,Regine; Johansson,Elof D.B.; Maruo,Takeshi
Human Reproduction 21(9): 2408-2416
Publication date: 2006


Progestins and the brain, affects on sexuality and quality of life 
Sitruk-Ware,Regine; Kumar,Narender
Proceedings of the 6th International Menopause Society (IMS) Workshop, Pisa, Italy
Publication date: 2006


The levonorgestrel-releasing intrauterine system (Mirena®) (HTML) 
Sitruk-Ware,Regine
Gynaecology Forum 11(2): 1-32
Publication date: 2006


The Sertoli-spermatid junctional complex adhesion strength is affected in vitro by adjudin (abstract) (PDF) (HTML) 
Wolski,Katja M.; Mruk,Dolores D.; Cameron,Don F.
Journal of Andrology 27(6): 790-794
Publication date: 2006


Transition from Norplant to Jadelle in a clinic with extensive experience providing contraceptive implants (abstract) (HTML) 
Brache,Vivian; Faundes,Anibal; Alvarez-Sanchez,Francisco; Garcia,Ana-Gloria
Contraception 73(4): 364-367
Publication date: 2006


Tumor necrosis factor reversibly disrupts the blood-testis barrier and impairs Sertoli-germ cell adhesion in the seminiferous epithelium of adult rat testes (abstract) (PDF) (HTML) 
Li,Michelle W.M.; Xia,Weiliang; Mruk,Dolores D.; Wang,Claire Q.F.; Yan,Helen H.N.; Siu,Michelle K.Y.; Lui,Wing-Yee; Lee,Will M.; Cheng,Chuen-yan
Journal of Endocrinology 190(2): 313-329
Publication date: 2006


Blood-testis barrier dynamics are regulated by α2-macroglobulin via the c-Jun N-terminal protein kinase pathway (abstract) (PDF) (HTML) 
Wong,Ching-hang; Mruk,Dolores D.; Siu,Michelle K.Y.; Cheng,Chuen-yan
Endocrinology 146(4): 1893-1908
Publication date: 2005


Bone and muscle protective potential of the prostate-sparing synthetic androgen 7α-methyl-19-nortestosterone: Evidence from the aged orchidectomized male rat model (abstract) (HTML) 
Venken,Katrien; Boonen,Steven; Van Herck,Erik; Vandenput,Liesbeth; Kumar,Narender; Sitruk-Ware,Regine; Sundaram,Kalyan; Bouillon,Roger; Vanderschueren,Dirk
Bone 36(4): 663-670
Publication date: 2005


Clinical performance and menstrual bleeding patterns with three dosage combinations of a Nestorone® progestogen/ethinyl estradiol contraceptive vaginal ring used on a bleeding-signaled regimen (abstract) (HTML) 
Weisberg,Edith; Brache,Vivian; Alvarez,Francisco; Massai,Rebeca; Mishell,Daniel R.,Jr.; Apter,Dan; Gale,Judi; Sivin,Irving; Tsong,Yun-yen; Fraser,Ian S.
Contraception 72(1): 46-52
Publication date: 2005


Contraceptive vaginal rings releasing Nestorone® and ethinylestradiol: A 1-year dose-finding trial (abstract) (HTML) 
Sivin,Irving; Mishell,Daniel R.,Jr.; Alvarez,Francisco; Brache,Vivian; Elomaa,Kaisa; Lahteenmaki,Pekka; Massai,Rebeca; Miranda,Patricia; Croxatto,Horacio B.; Dean,Catherine; Small,Margaret; Nash,Harold A.; Jackanicz,Theodore M.
Contraception 71(2): 122-129
Publication date: 2005


Delivery options for contraceptives (abstract) (HTML) 
Sitruk-Ware,Regine
Drug Discovery Today 10(14): 977-985
Publication date: 2005


Effect of a levonorgestrel intrauterine system on women with type 1 diabetes: A randomized trial (abstract) (HTML) 
Rogovskaya,Svetlana; Rivera,Roberto; Grimes,David A.; Chen,Pai-lien; Pierre-Louis,Bosny; Prilepskaya,Vera; Kulakov,Vladimir
Obstetrics and Gynecology 105(4): 811-815
Publication date: 2005


Emergency contraception's mode of action clarified (PDF) 
Population Briefs 11(2)
Publication date: 2005


Estrogen and progestogens: Different routes of administration (editorial) (HTML) 
Sitruk-Ware,Regine
Climacteric 8(suppl 1): 1-2
Publication date: 2005


Immune complex deposition in adult male Sprague-Dawley rats chronically immunized with GnRH (abstract) (PDF) 
Vargas,Louis A.; Sewell,Richard; Marshall,Aileen; Galatioto,Josephine; Tsong,Yun-yen; Catterall,James F.; Hunnicutt,Gary R.
American Journal of Reproductive Immunology 54(5): 292-310
Publication date: 2005


Interactions among IQGAP1, Cdc42, and the cadherin/catenin protein complex regulate Sertoli-germ cell adherens junction dynamics in the testis (abstract) (HTML) 
Lui,Wing-Yee; Mruk,Dolores D.; Cheng,Chuen-yan
Journal of Cellular Physiology 202(1): 49-66
Publication date: 2005


Management of patients receiving long-term treatment with mifepristone (abstract) (HTML) 
Spitz,Irving M.; Grunberg,Steven M.; Chabbert-Buffet,Nathalie; Lindenberg,Tzina; Gelber,Hadassa; Sitruk-Ware,Regine
Fertility and Sterility 84(6): 1719-1726
Publication date: 2005


Myotubularin phosphoinositide phosphatases, protein phosphatases, and kinases: Their roles in junction dynamics and spermatogenesis (abstract) (HTML) 
Zhang,Jiayi; Mruk,Dolores D.; Cheng,Chuen-yan
Journal of Cellular Physiology 204(2): 470-483
Publication date: 2005


Pharmacology of different progestogens: The special case of drospirenone (abstract) (HTML) 
Sitruk-Ware,Regine
Climacteric 8(suppl 3): 4-12
Publication date: 2005


Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells (abstract) (PDF) (HTML) 
Xu,Qin; Takekida,Shigeki; Ohara,Noriyuki; Chen,Wei; Sitruk-Ware,Regine; Johansson,Elof D.B.; Maruo,Takeshi
Journal of Clinical Endocrinology and Metabolism 90(2): 953-961
Publication date: 2005


Protein kinases and adherens junction dynamics in the seminiferous epithelium of the rat testis (abstract) (HTML) 
Lee,Nikki P.Y.; Cheng,Chuen-yan
Journal of Cellular Physiology 202(2): 344-360
Publication date: 2005


Regulation of ectoplasmic specialization dynamics in the seminiferous epithelium by focal adhesion-associated proteins in testosterone-suppressed rat testes (abstract) (PDF) (HTML) 
Wong,Ching-hang; Xia,Weiliang; Lee,Nikki P.Y.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Endocrinology 146(3): 1192-1204
Publication date: 2005


Regulation of Sertoli-germ cell adherens junction dynamics via changes in protein-protein interactions of the N-cadherin-ß-catenin protein complex which are possibly mediated by c-Src and myotubularin-related protein 2: An in vivo study using an androgen suppression model (abstract) (PDF) (HTML) 
Zhang,Jiayi; Wong,Ching-hang; Xia,Weiliang; Mruk,Dolores D.; Lee,Nikki P.Y.; Lee,Will M.; Cheng,Chuen-yan
Endocrinology 146(3): 1268-1284
Publication date: 2005


Sertoli-germ cell anchoring junction dynamics in the testis are regulated by an interplay of lipid and protein kinases (abstract) (PDF) (HTML) 
Siu,Michelle K.Y.; Wong,Ching-hang; Lee,Will M.; Cheng,Chuen-yan
Journal of Biological Chemistry 280(26): 25029-25047
Publication date: 2005


Serum Nestorone® and ethinyl estradiol levels, and ovulation inhibition in women using three different dosage combinations of a Nestorone progestogen-ethinyl estradiol contraceptive vaginal ring on a bleeding-signaled regimen (abstract) (HTML) 
Fraser,Ian S.; Weisberg,Edith; Brache,Vivian; Alvarez,Francisco; Massai,Rebeca; Mishell,Daniel R.,Jr.; Apter,Dan; Gale,Judi; Tsong,Yun-yen; Sivin,Irving
Contraception 72(1): 40-45
Publication date: 2005


Sperm with bent tails point to possible male contraceptive (PDF) 
Population Briefs 11(2)
Publication date: 2005


TGF-ß3 regulates anchoring junction dynamics in the seminiferous epithelium of the rat testis via the Ras/ERK signaling pathway: An in vivo study (abstract) (PDF) (HTML) 
Xia,Weiliang; Cheng,Chuen-yan
Developmental Biology 280(2): 321-343
Publication date: 2005


The levonorgestrel intrauterine system: Long-term contraception and therapeutic effects (abstract) (PDF) 
Sitruk-Ware,Regine; Inki,Pirjo
Women's Health 1(2): 171-182
Publication date: 2005


Vaginal delivery of contraceptives (abstract) (HTML) 
Sitruk-Ware,Regine
Expert Opinion on Drug Delivery 2(4): 729-736
Publication date: 2005


α-macroglobulin expression in the liver in response to inflammation is mediated by the testis (abstract) (PDF) 
Lui,Wing-Yee; Cheng,Yan Ho; Mruk,Dolores D.; Cheng,Chin Ho; Mo,Meng-Yun; Lee,Will M.; Cheng,Chuen-yan
Journal of Endocrinology 185(3): 497-505
Publication date: 2005


Adaptors, junction dynamics, and spermatogenesis (abstract) (PDF) (HTML) 
Lee,Nikki P.Y.; Cheng,Chuen-yan
Biology of Reproduction 71(2): 392-404
Publication date: 2004


Assay for establishing whether microbicide applicators have been exposed to the vagina (abstract) (HTML) 
Wallace,Andrea R.; Thorn,Mitchell; Maguire,Robin A.; Sudol,Kristin M.; Phillips,David M.
Sexually Transmitted Diseases 31(8): 465-468
Publication date: 2004


Cell-cell interactions at the ectoplasmic specialization in the testis (abstract) (HTML) 
Mruk,Dolores D.; Cheng,Chuen-yan
Trends in Endocrinology and Metabolism 15(9): 439-447
Publication date: 2004


Disruption of Mtmr2 produces CMT4B1-like neuropathy with myelin outfolding and impaired spermatogenesis (abstract) (PDF) (HTML) 
Bolino,Alessandra; Bolis,Annalisa; Previtali,Stefano Carlo; Dina,Giorgia; Bussini,Simona; Dati,Gabriele; Amadio,Stefano; Del Carro,Ubaldo; Mruk,Dolores D.; Feltri,Maria Laura; Cheng,Chuen-yan; Quattrini,Angelo; Wrabetz,Lawrence
Journal of Cell Biology 167(4): 711-721
Publication date: 2004


Dynamic cross-talk between cells and the extracellular matrix in the testis (abstract) (HTML) 
Siu,Michelle K.Y.; Cheng,Chuen-yan
BioEssays 26(9): 978-992
Publication date: 2004


Ectoplasmic specialization, a testis-specific cell-cell actin-based adherens junction type: Is this a potential target for male contraceptive development? (abstract) (PDF) (HTML) 
Lee,Nikki P.Y.; Cheng,Chuen-yan
Human Reproduction Update 10(4): 349-369
Publication date: 2004


Exogenous progestagens and the human breast (abstract) (HTML) 
Sitruk-Ware,Regine; Plu-Bureau,Genevieve
Maturitas 49(1): 58-66
Publication date: 2004


Extracellular matrix: Recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis (abstract) (HTML) 
Siu,Michelle K.Y.; Cheng,Chuen-yan
Biology of Reproduction 71(2): 375-391
Publication date: 2004


Future developments in hormonal contraception (abstract) (HTML) 
Johansson,Elof D.B.
American Journal of Obstetrics and Gynecology 190(suppl 1): S69-S71
Publication date: 2004


Interactions of proteases, protease inhibitors, and the β1 integrin/laminin γ3 protein complex in the regulation of ectoplasmic specialization dynamics in the rat testis (abstract) (HTML) 
Siu,Michelle K.Y.; Cheng,Chuen-yan
Biology of Reproduction 70(4): 945-964
Publication date: 2004


Lubricants containing N-9 may enhance rectal transmission of HIV and other STIs (abstract) (HTML) 
Phillips,David M.; Sudol,Kristin M.; Taylor,Clark L.; Guichard,Laura; Elsen,Robert; Maguire,Robin A.
Contraception 70(2): 107-110
Publication date: 2004


Mifepristone does not induce cervical softening in non-pregnant women (abstract) (HTML) 
Ben-Chetrit,Avraham; Eldar-Geva,Talia; Lindenberg,Tzina; Farhat,Morshed; Shimonovitz,Shlomo; Zacut,David; Gelber,Hadassa; Sitruk-Ware,Regine; Spitz,Irving M.
Human Reproduction 19(10): 2372-2376
Publication date: 2004


New delivery systems in contraception: Vaginal rings (abstract) (HTML) 
Johansson,Elof D.B.; Sitruk-Ware,Regine
American Journal of Obstetrics and Gynecology 190(suppl 1): S54-S59
Publication date: 2004


New progestogens: A review of their effects in perimenopausal and postmenopausal women (abstract) (HTML) 
Sitruk-Ware,Regine
Drugs and Aging 21(13): 865-883
Publication date: 2004


Nitric oxide/nitric oxide synthase, spermatogenesis, and tight junction dynamics (abstract) (PDF) (HTML) 
Lee,Nikki P.Y.; Cheng,Chuen-yan
Biology of Reproduction 70(2): 267-276
Publication date: 2004


Pharmacological profile of progestins (abstract) (HTML) 
Sitruk-Ware,Regine
Maturitas 47(4): 277-283
Publication date: 2004


Potential long-acting male contraceptive studied (PDF) 
Population Briefs 10(3)
Publication date: 2004


Regulation of blood-testis barrier dynamics: An in vivo study (abstract) (HTML) 
Wong,Ching-hang; Mruk,Dolores D.; Lui,Wing-Yee; Cheng,Chuen-yan
Journal of Cell Science 117(5): 783-798
Publication date: 2004


Release-modulating factors strongly affecting steroid diffusion from silicone elastomer (abstract) (HTML) 
Nash,Harold A.; Robertson,Dale N.; Evans,Simone J.
Journal of Pharmaceutical Sciences 93(10): 2420-2430
Publication date: 2004


Role of progestins with partial antiandrogenic effects (abstract) (HTML) 
Sitruk-Ware,Regine; Husmann,F.; Skouby,S.O.; Thijssen,J.H.H.; Fruzzetti,F.; Hanker,J.; Huber,J.; Druckmann,R.
Climacteric 7(3): 238-254
Publication date: 2004


Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis (abstract) (PDF) (HTML) 
Mruk,Dolores D.; Cheng,Chuen-yan
Endocrine Reviews 25(5): 747-806
Publication date: 2004


Two-year performance of a Nestorone-releasing contraceptive implant: A three-center study of 300 women (abstract) (HTML) 
Sivin,Irving; Croxatto,Horacio B.; Bahamondes,Luis; Brache,Vivian; Alvarez-Sanchez,Francisco; Massai,Rebeca; Schechter,Janet; Ranta,Sirpa; Kumar,Narender; Wu,Esther; Tejada,Ana-Sofia; Reyes,Veronica; Travers,Elaine; Allen,Arthur; Moo-Young,Alfred J.
Contraception 69(2): 137-144
Publication date: 2004


Zyxin, axin, and Wiskott-Aldrich syndrome protein are adaptors that link the cadherin/catenin protein complex to the cytoskeleton at adherens junctions in the seminiferous epithelium of the rat testis (abstract) (PDF) (HTML) 
Lee,Nikki P.Y.; Mruk,Dolores D.; Conway,Anne M.; Cheng,Chuen-yan
Journal of Andrology 25(2): 200-215
Publication date: 2004


A clinical trial of 7α-methyl-19-nortestosterone implants for possible use as a long-acting contraceptive for men (abstract) (PDF) (HTML) 
von Eckardstein,Sigrid; Noe,Gabriela; Brache,Vivian; Nieschlag,Eberhard; Croxatto,Horacio B.; Alvarez-Sanchez,Francisco; Moo-Young,Alfred J.; Sivin,Irving; Kumar,Narender; Small,Margaret; Sundaram,Kalyan; Population Council International Committee for Contraception Research
Journal of Clinical Endocrinology and Metabolism 88(11): 5232-5239
Publication date: 2003


Adherens junction dynamics in the testis and spermatogenesis (PDF) (HTML) 
Lui,Wing-Yee; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Journal of Andrology 24(1): 1-14
Publication date: 2003


Adhering junction dynamics in the testis are regulated by an interplay of β 1-integrin and focal adhesion complex-associated proteins (abstract) (PDF) (HTML) 
Siu,Michelle K.Y.; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Endocrinology 144(5): 2141-2163
Publication date: 2003


Alternatives for optimal hormone replacement therapy (abstract) 
Sitruk-Ware,Regine
Climacteric 6(suppl 2): 11-16
Publication date: 2003


Effects of levonorgestrel-releasing intra-uterine system on the expression of vascular endothelial growth factor and adrenomedullin in the endometrium in adenomyosis (abstract) (PDF) (HTML) 
Laoag-Fernandez,Jovelle B.; Maruo,Takeshi; Pakarinen,Paivi; Spitz,Irving M.; Johansson,Elof D.B.
Human Reproduction 18(4): 694-699
Publication date: 2003


Estradiol/progesterone-releasing vaginal rings for hormone replacement therapy in postmenopausal women (abstract) (HTML) 
Hamada,Anna Lissa; Maruo,Takeshi; Samoto,Takashi; Yoshida,Shigeki; Nash,Harold A.; Spitz,Irving M.; Johansson,Elof D.B.
Gynecological Endocrinology 17(3): 247-254
Publication date: 2003


Estradiol-progesterone interaction during the preparation of vaginal rings (abstract) (HTML) 
Saleh,Saleh I.; Khidr,Sayed H.; Ahmed,Sayed M.; Jackanicz,Theodore M.; Nash,Harold A.
Journal of Pharmaceutical Sciences 92(2): 258-265
Publication date: 2003


Evidence for tissue selectivity of the synthetic androgen 7α-methyl-19-nortestosterone in hypogonadal men (abstract) (PDF) 
Anderson,Richard A.; Wallace,A.Michael; Sattar,Naveed; Kumar,Narender; Sundaram,Kalyan
Journal of Clinical Endocrinology and Metabolism 88(6): 2784-2793
Publication date: 2003


Fer kinase/FerT and adherens junction dynamics in the testis: An in vitro and in vivo study (abstract) (PDF) (HTML) 
Chen,Yong-Mei; Lee,Nikki P.Y.; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Biology of Reproduction 69(2): 656-672
Publication date: 2003


Hormone choice may reduce risks of menopause therapy (PDF) 
Population Briefs 9(2)
Publication date: 2003


Hormone therapy and the cardiovascular system: The critical role of progestins (abstract) 
Sitruk-Ware,Regine
Climacteric 6(suppl 3): 21-28
Publication date: 2003


Hormone Use in Menopause and Male Andropause: A Choice for Women and Men 
Segal,Sheldon J.; Mastroianni,Luigi,Jr.
Publication date: 2003


Is the cadherin/catenin complex a functional unit of cell-cell actin-based adherens junctions in the rat testis? (abstract) (PDF) (HTML) 
Lee,Nikki P.Y.; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Biology of Reproduction 68(2): 489-508
Publication date: 2003


Nestorone®: Clinical applications for contraception and HRT (abstract) (HTML) 
Sitruk-Ware,Regine; Small,Margaret; Kumar,Narender; Tsong,Yun-yen; Sundaram,Kalyan; Jackanicz,Theodore M.
Steroids 68(10-13): 907-913
Publication date: 2003


Pharmacological properties of mifepristone: Toxicology and safety in animal and human studies (abstract) (HTML) 
Sitruk-Ware,Regine; Spitz,Irving M.
Contraception 68(6): 409-420
Publication date: 2003


Progestins in hormonal replacement therapy (HRT): New molecules, risks and benefits 
Sitruk-Ware,Regine
Annales d'Endocrinologie 64(2): 178-178
Publication date: 2003


Progestins in hormonal therapy (HT) today, tomorrow and the next day: A roundtable discussion (HTML) 
Sitruk-Ware,Regine
Steroids 68(10-13): 973-979
Publication date: 2003


Regulation of Sertoli cell tight junction dynamics in the rat testis via the nitric oxide synthase/soluble guanylate cyclase/3',5'-cyclic guanosine monophosphate/protein kinase G signaling pathway: An in vitro study (abstract) (PDF) (HTML) 
Lee,Nikki P.Y.; Cheng,Chuen-yan
Endocrinology 144(7): 3114-3129
Publication date: 2003


Rho GTPases and spermatogenesis (abstract) (HTML) 
Lui,Wing-Yee; Lee,William M.; Cheng,Chuen-yan
Biochimica et Biophysica Acta 1593(2-3): 121-129
Publication date: 2003


Risks and benefits, advantages and disadvantages of levonorgestrel-releasing contraceptive implants (abstract) (HTML) 
Sivin,Irving
Drug Safety 26(5): 303-335
Publication date: 2003


Role of progestogen in hormone therapy for postmenopausal women: Position statement of The North American Menopause Society (abstract) (HTML) 
Menopause 10(2): 113-132
Publication date: 2003


Role of tissue inhibitor of metalloproteases-1 in junction dynamics in the testis (abstract) (PDF) (HTML) 
Mruk,Dolores D.; Siu,Michelle K.Y.; Conway,Anne M.; Lee,Nikki P.Y.; Lau,Ann S.N.; Cheng,Chuen-yan
Journal of Andrology 24(4): 510-523
Publication date: 2003


Sertoli cell tight junction dynamics: Their regulation during spermatogenesis (abstract) (PDF) (HTML) 
Lui,Wing-Yee; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Biology of Reproduction 68(4): 1087-1097
Publication date: 2003


Sertoli-germ cell adherens junction dynamics in the testis are regulated by RhoB GTPase via the ROCK/LIMK signaling pathway (abstract) (HTML) 
Lui,Wing-Yee; Lee,William M.; Cheng,Chuen-yan
Biology of Reproduction 68(6): 2189-2206
Publication date: 2003


Subdermal progestin implant (Nestorone®) in the treatment of endometriosis: Clinical response to various doses (abstract) (HTML) 
Ylanen,Kaija; Laatikainen,Timo; Lahteenmaki,Pekka; Moo-Young,Alfred J.
Acta Obstetricia et Gynecologica Scandinavica 82(2): 167-172
Publication date: 2003


TGF-β3 regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: An in vivo study (abstract) (PDF) (HTML) 
Lui,Wing-Yee; Wong,Daria C.H.; Mruk,Dolores D.; Cheng,Chuen-yan
Endocrinology 144(4): 1139-1142
Publication date: 2003


TGF-βs: Their role in testicular function and Sertoli cell tight junction dynamics (abstract) (HTML) 
Lui,Wing-Yee; Lee,William M.; Cheng,Chuen-yan
International Journal of Andrology 26(3): 147-160
Publication date: 2003


The interplay of collagen IV, tumor necrosis factor-α, gelatinase B (matrix metalloprotease-9), and tissue inhibitor of metalloproteases-1 in the basal lamina regulates Sertoli cell-tight junction dynamics in the rat testis (abstract) (PDF) (HTML) 
Siu,Michelle K.Y.; Lee,William M.; Cheng,Chuen-yan
Endocrinology 144(1): 371-387
Publication date: 2003


The pharmacokinetics of mifepristone in humans reveal insights into differential mechanisms of antiprogestin action (abstract) (HTML) 
Heikinheimo,Oskari; Kekkonen,Raimo; Lahteenmaki,Pekka
Contraception 68(6): 421-426
Publication date: 2003


Transforming growth factor β3 regulates the dynamics of Sertoli cell tight junctions via the p38 mitogen-activated protein kinase pathway (abstract) (PDF) (HTML) 
Lui,Wing-Yee; Lee,William M.; Cheng,Chuen-yan
Biology of Reproduction 68(5): 1597-1612
Publication date: 2003


A critical review of the toxicological effects of Carrageenan and processed eucheuma seaweed on the gastrointestinal tract (abstract) (HTML) 
Cohen,Samuel M.; Ito,Nobuyuki
Critical Reviews in Toxicology 32(5): 413-444
Publication date: 2002


Antiandrogenic progestogens in hormone replacement therapy (HTML) 
Sitruk-Ware,Regine
Gynaecology Forum 7(2): 8-11
Publication date: 2002


Antioxidant superoxide dismutase--A review: Its function, regulation in the testis, and role in male fertility (abstract) (HTML) 
Mruk,Dolores D.; Silvestrini,Bruno; Mo,Meng-Yun; Cheng,Chuen-yan
Contraception 65(4): 305-311
Publication date: 2002


Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development (abstract) (PDF) (HTML) 
Cheng,Chuen-yan; Mruk,Dolores D.
Physiological Reviews 82(4): 825-874
Publication date: 2002


Effect of chronic administration of 7α-methyl-19-nortestosterone on serum testosterone, number of spermatozoa and fertility in adult male bonnet monkeys (Macaca radiata) (abstract) (PDF) (HTML) 
Ramachandra,S.G.; Ramesh,V.; Krishnamurthy,H.N.; Kumar,Narender; Sundaram,Kalyan; Hardy,Matthew P.; Rao,A.Jagannadha
Reproduction 124(2): 301-309
Publication date: 2002


Effects of levonorgestrel-releasing intrauterine system on the endometrium and the relevance to the management of menorrhagia caused by uterine myoma and adenomyosis 
Maruo,Takeshi; Laoag-Fernandez,Jovelle B.; Matsuo,Hiroya; Samoto,Takashi; Kurachi,Osamu; Takeuchi,S.; Spitz,Irving M.; Pakarinen,Paivi; Lahteenmaki,Pekka; Johansson,Elof D.B.; Barlow,David; Mardon,Helen; Kennedy,Stephen
from Cell and Molecular Biology of Endometrium in Health and Disease, pp. 193-207
Publication date: 2002


Hormonal replacement therapy (HTML) 
Sitruk-Ware,Regine
Reviews in Endocrine and Metabolic Disorders 3(3): 243-256
Publication date: 2002


Indazole carboxylic acids in male contraception (abstract) (HTML) 
Cheng,Chuen-yan; Mo,Meng-Yun; Grima,Josephine; Saso,Luciano; Tita,Beatrice; Mruk,Dolores D.; Silvestrini,Bruno
Contraception 65(4): 265-268
Publication date: 2002


Investigating nonhormonal male contraceptives 
Population Council Annual Report 2002
Publication date: 2002


Jadelle® Levonorgestrel Rod Implants: A Summary of Scientific Data and Lessons Learned from Programmatic Experience (PDF) 
Sivin,Irving; Nash,Harold A.; Waldman,Sandra N.
Publication date: 2002


New methods of progestin delivery 
Sitruk-Ware,Regine; Small,Margaret
Contemporary Clinical Gynecology and Obstetrics 2(4): 287-298
Publication date: 2002


Pharmacokinetic study of different dosing regimens of levonorgestrel for emergency contraception in healthy women (abstract) (PDF) (HTML) 
Johansson,Elof D.B.; Brache,Vivian; Alvarez-Sanchez,Francisco; Faundes,Anibal; Cochon,Leila; Ranta,Sirpa; Lovern,Mark; Kumar,Narender
Human Reproduction 17(6): 1472-1476
Publication date: 2002


Progestins and breast cancer risk: State of the controversy 
Sitruk-Ware,Regine; Plu-Bureau,Genevieve; Neves-e-Castro,Manuel; Wren,Barry G.
from Menopause: Hormones and Cancer, pp. 123-128
Publication date: 2002


Progestogens in hormonal replacement therapy: New molecules, risks, and benefits (abstract) (HTML) 
Sitruk-Ware,Regine
Menopause 9(1): 6-15
Publication date: 2002


Recent developments in contraceptive implants at the Population Council (abstract) (HTML) 
Sivin,Irving; Moo-Young,Alfred J.
Contraception 65(1): 113-119
Publication date: 2002


Unraveling Mirena's molecular mystery 
Population Council Annual Report 2002
Publication date: 2002


Vaginal rings delivering progesterone and estradiol may be a new method of hormone replacement therapy (abstract) (HTML) 
Maruo,Takeshi; Mishell,Daniel R.,Jr.; Ben-Chetrit,Avraham; Hochner-Celnikier,Drorith; Hamada,Anna Lissa; Nash,Harold A.
Fertility and Sterility 78(5): 1010-1016
Publication date: 2002


A male contraceptive pill by 2000? 
Segal,Sheldon J.
from Toward a New Partnership: Encouraging the Positive Involvement of Men as Supportive Partners in Reproductive Health, pp. 3-4
Publication date: 2001


Contraceptive efficacy and clinical performance of Nestorone implants in postpartum women (abstract) (HTML) 
Massai,Rebeca; Diaz,Soledad; Quintero,E.; Reyes,Veronica; Herreros,C.; Zepeda,Ana; Croxatto,Horacio B.; Moo-Young,Alfred J.
Contraception 64(6): 369-376
Publication date: 2001


Current approaches to systemic male contraception 
Bremner,William J.; Cheng,Chuen-yan; Cuasnicu,Patricia S.; Habenicht,Ursula F.; Colvard,Douglas S.; Doncel,Gustavo F.; Coutinho,Elsimar M.; Spinola,Paulo
from Current Knowledge in Reproductive Medicine, pp. 315-331
Publication date: 2001


Effective long-term androgen suppression in men with prostate cancer using a hydrogel implant with the GnRH agonist histrelin (abstract) (HTML) 
Schlegel,Peter N.; Kuzma,Petr; Frick,Julian; Farkas,Amicur; Gomahr,Andreas; Spitz,Irving M.; Chertin,Boris; Mack,Doris; Jungwirth,Andreas; King,Peggy; Nash,Harold A.; Bardin,C.Wayne; Moo-Young,Alfred J.
Urology 58(4): 578-582
Publication date: 2001


Effects of the levonorgestrel-releasing intrauterine system on proliferation and apoptosis in the endometrium (abstract) (PDF) (HTML) 
Maruo,Takeshi; Laoag-Fernandez,Jovelle B.; Pakarinen,Paivi; Murakoshi,H.; Spitz,Irving M.; Johansson,Elof D.B.
Human Reproduction 16(10): 2103-2108
Publication date: 2001


Evidence for the binding of a human sperm component with diaphanous protein (abstract) (HTML) 
Zhang,Si-Ming; Miao,Shiying; Wang,Linfang; Koide,Samuel S.
Archives of Andrology 46(1): 29-35
Publication date: 2001


Immediate postabortal contraception with the levonorgestrel intrauterine device, Norplant, and traditional methods (abstract) (HTML) 
Ortayli,Nuriye; Bulat,Aysen; Sahin,Tulay; Sivin,Irving
Contraception 63(6): 309-314
Publication date: 2001


Levonorgestrel concentrations during 7 years of continuous use of Jadelle contraceptive implants (abstract) (HTML) 
Sivin,Irving; Wan,Livia; Ranta,Sirpa; Alvarez,Francisco; Brache,Vivian; Mishell,Daniel R.,Jr.; Darney,Philip; Biswas,Arijit; Diaz,Soledad; Kiriwat,Orawan; Anant,Manee Piya; Klaisle,Cynthia; Pavez,Margarita; Schechter,Janet
Contraception 64(1): 43-49
Publication date: 2001


Post-marketing surveillance of Norplant contraceptive implants: I. Contraceptive efficacy and reproductive health (abstract) (HTML) 
Meirik,Olav; Farley,Timothy M.M.; Sivin,Irving; Diaz,Soledad
Contraception 63(4): 167-186
Publication date: 2001


Post-marketing surveillance of Norplant contraceptive implants: II. Non-reproductive health (abstract) (HTML) 
Meirik,Olav; Farley,Timothy M.M.; Sivin,Irving; Diaz,Soledad; Collins,John
Contraception 63(4): 187-209
Publication date: 2001


Reversible inhibition of spermatogenesis in rats using a new male contraceptive, 1-(2,4-dichlorobenzyl)-indazole-3-carbohydrazide (abstract) (PDF) (HTML) 
Grima,Josephine; Silvestrini,Bruno; Cheng,Chuen-yan
Biology of Reproduction 64(5): 1500-1508
Publication date: 2001


Safety and efficacy of levonorgestrel implant, intrauterine device, and sterilization (abstract) (HTML) 
Meirik,Olav; Farley,Timothy M.M.; Sivin,Irving
Obstetrics and Gynecology 97(4): 539-547
Publication date: 2001


The IUD and recovery of fertility (PDF) 
Sivin,Irving; Webb,Anne; Stedman,Yvonne
Family Planning Perspectives 33(5): 234-241
Publication date: 2001


The possible role of enterothepatic cycling on bioavailibility of noretisterone and gestodene in women using combined oral contraceptives (abstract) (HTML) 
Elomaa,Kaisa; Ranta,Sirpa; Tuominen,Juhani; Lahteenmaki,Pekka
Contraception 63(1): 13-18
Publication date: 2001


Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis (abstract) (PDF) (HTML) 
Cheng,Chuen-yan; Silvestrini,Bruno; Grima,Josephine; Mo,Meng-Yun; Zhu,Li-Ji; Johansson,Elof D.B.; Saso,Luciano; Leone,Maria Grazia; Palmery,Maura; Mruk,Dolores D.
Biology of Reproduction 65(2): 449-461
Publication date: 2001


A detailed analysis of menstrual blood loss in women using Norplant® and Nestorone® progestogen-only contraceptive implants or vaginal rings (abstract) (HTML) 
Fraser,Ian S.; Weisberg,Edith; Minehan,Ellen; Johansson,Elof D.B.
Contraception 61(4): 241-251
Publication date: 2000


Alterations in sex steroids and gonadotropins in post-menopausal women subsequent to long-term mifepristone administration (abstract) (HTML) 
Heikinheimo,Oskari; Ranta,Sirpa; Grunberg,Steven M.; Spitz,Irving M.
Steroids 65(10-11): 831-836
Publication date: 2000


An implant releasing the gonadotropin hormone-releasing hormone agonist histrelin maintains medical castration for up to 30 months in metastatic prostate cancer (abstract) (HTML) 
Chertin,Boris; Spitz,Irving M.; Lindenberg,Tzina; Algur,Nurit; Zer,Tami; Kuzma,Petr; Moo-Young,Alfred J.; Catane,Raphael; Farkas,Amicur
Journal of Urology 163(3): 838-844
Publication date: 2000


Biodegradable systems for long-acting Nestorone® 
Trantolo,Debra J.; Wise,Donald L.; Moo-Young,Alfred J.; Hsu,Yung-Yueh; Gresser,Joseph D.; Klibanov,Alexander; Langer,Robert; Mikos,Antonio; Brannon-Peppas,Lisa; Peppas,Nicholas A.; Wnek,Gary E.; Yaszemski,Michael J.
from Handbook of Pharmaceutical Controlled Release Technology, pp. 807-819
Publication date: 2000


Chronic toxicity and reversibility of antifertility effect of immunization against gonadotropin-releasing hormone in male rats and rabbits (abstract) (PDF) (HTML) 
Kumar,Narender; Savage,Toyin; DeJesus,William; Tsong,Yun-yen; Didolkar,Ashok K.; Sundaram,Kalyan
Toxicological Sciences 53(1): 92-99
Publication date: 2000


Effects of progesterone on uterine leiomyoma growth and apoptosis (abstract) (HTML) 
Maruo,Takeshi; Matsuo,Hiroya; Samoto,Takashi; Shimomura,Yosuke; Kurachi,Osamu; Gao,Zhijian; Wang,Yin; Spitz,Irving M.; Johansson,Elof D.B.
Steroids 65(10-11): 585-592
Publication date: 2000


Nestorone®: A progestin with a unique pharmacological profile (abstract) (HTML) 
Kumar,Narender; Koide,Samuel S.; Tsong,Yun-yen; Sundaram,Kalyan
Steroids 65(10-11): 629-636
Publication date: 2000


Ovarian function during use of Nestorone® subdermal implants (abstract) (HTML) 
Brache,Vivian; Massai,Rebeca; Mishell,Daniel R.,Jr.; Moo-Young,Alfred J.; Alvarez-Sanchez,Francisco; Salvatierra,Ana Maria; Cochon,Leila; Croxatto,Horacio B.; Robbins,Ann; Faundes,Anibal
Contraception 61(3): 199-204
Publication date: 2000


Progesterone receptor modulators and progesterone antagonists in women's health (abstract) (HTML) 
Spitz,Irving M.; Chwalisz,Kristof
Steroids 65(10-11): 807-815
Publication date: 2000


Progestin-only contraceptive rings (abstract) (HTML) 
Brache,Vivian; Alvarez-Sanchez,Francisco; Faundes,Anibal; Jackanicz,Theodore M.; Mishell,Daniel R.,Jr.; Lahteenmaki,Pekka
Steroids 65(10-11): 687-691
Publication date: 2000


Prolonged effectiveness of Norplant® capsule implants: A 7-year study (abstract) (HTML) 
Sivin,Irving; Mishell,Daniel R.,Jr.; Diaz,Soledad; Biswas,Arijit; Alvarez-Sanchez,Francisco; Darney,Philip; Holma,Pentti; Wan,Livia; Brache,Vivian; Kiriwat,Orawan; Abdalla,Kamal; Campodonico,Italo; Pasquale,Samuel; Pavez,Margarita; Schechter,Janet
Contraception 61(3): 187-194
Publication date: 2000


Safety of three formulations of nonoxynol-9-containing vaginal spermicides (HTML) 
Coggins,Christiana; Elias,Christopher J.; N-9 Formulation Preference Study Group Committee
International Journal of Gynecology and Obstetrics 68(3): 267-268
Publication date: 2000


The levonorgestrel intrauterine system in contraception (abstract) (HTML) 
Lahteenmaki,Pekka; Rauramo,Ilkka; Backman,Tiina
Steroids 65(10-11): 693-697
Publication date: 2000


The return of the pharmaceutical industry to the market of contraception (abstract) (HTML) 
Johansson,Elof D.B.
Steroids 65(10-11): 709-711
Publication date: 2000


Usefulness of estradiol/progesterone-releasing vaginal rings in long-term management of postmenopausal women 
Maruo,Takeshi; Samoto,Takashi; Yoshida,Shigeki; Hamada,Anna Lissa; Nash,Harold A.; Spitz,Irving M.; Johansson,Elof D.B.
Advances in Obstetrics and Gynecology 52(2): 266-271
Publication date: 2000


Vaginal epithelial surface appearances in women using vaginal rings for contraception (abstract) (HTML) 
Fraser,Ian S.; Lacarra,Maria; Mishell,Daniel R.,Jr.; Alvarez-Sanchez,Francisco; Brache,Vivian; Lahteenmaki,Pekka; Elomaa,Kaisa; Weisberg,Edith; Nash,Harold A.
Contraception 61(2): 131-138
Publication date: 2000


Vaginal rings for contraception in lactating women (abstract) (HTML) 
Massai,Rebeca; Diaz,Soledad; Jackanicz,Theodore M.; Croxatto,Horacio B.
Steroids 65(10-11): 703-707
Publication date: 2000


7a-methyl-19-nortestosterone maintains sexual behavior and mood in hypogonadal men (abstract) (PDF) (HTML) 
Anderson,Richard A.; Martin,C.W.; Kung,Annie W.C.; Everington,D.; Pun,T.C.; Tan,K.C.B.; Bancroft,John; Sundaram,Kalyan; Moo-Young,Alfred J.; Baird,David T.
Journal of Clinical Endocrinology and Metabolism 84(10): 3556-3562
Publication date: 1999


7α-methyl-19-nortestosterone, a synthetic androgen with high potency: Structure-activity comparisons with other androgens (abstract) (HTML) 
Kumar,Narender; Crozat,Anne; Li,F.; Catterall,James F.; Bardin,C.Wayne; Sundaram,Kalyan
Journal of Steroid Biochemistry and Molecular Biology 71(5-6): 213-222
Publication date: 1999


A comparative study of two contraceptive vaginal rings releasing norethindrone acetate and differing doses of ethinyl estradiol (abstract) (HTML) 
Weisberg,Edith; Fraser,Ian S.; Mishell,Daniel R.,Jr.; Lacarra,Maria; Darney,Philip; Jackanicz,Theodore M.
Contraception 59(5): 305-310
Publication date: 1999


Correlation of endocrine profiles with bleeding patterns during use of Nestorone® contraceptive implants (abstract) (PDF) 
Faundes,Anibal; Alvarez,Francisco; Brache,Vivian; Cochon,Leila; Tejada,Ana-Sofia; Moo-Young,Alfred J.
Human Reproduction 14(12): 3013-3017
Publication date: 1999


Efficacy, bleeding patterns, and side effects of a 1-year contraceptive vaginal ring (abstract) (HTML) 
Weisberg,Edith; Fraser,Ian S.; Lacarra,Maria; Mishell,Daniel R.,Jr.; Alvarez,Francisco; Brache,Vivian; Nash,Harold A.
Contraception 59(5): 311-318
Publication date: 1999


Estradiol-delivering vaginal rings for hormone replacement therapy (abstract) (HTML) 
Nash,Harold A.; Alvarez-Sanchez,Francisco; Mishell,Daniel R.,Jr.; Fraser,Ian S.; Maruo,Takeshi; Harmon,Troy M.
American Journal of Obstetrics and Gynecology 181(6): 1400-1406
Publication date: 1999


Gonadotrophin and testosterone suppression by 7a-methyl-19-nortestosterone acetate administered by subdermal implant to healthy men (abstract) (PDF) (HTML) 
Noe,Gabriela; Suvisaari,J.; Martin,C.W.; Moo-Young,Alfred J.; Sundaram,Kalyan; Saleh,Saleh I.; Quintero,E.; Croxatto,Horacio B.; Lahteenmaki,Pekka
Human Reproduction 14(9): 2200-2206
Publication date: 1999


Liability concerns in contraceptive research (abstract) (HTML) 
Segal,Sheldon J.
International Journal of Gynecology and Obstetrics 67(suppl 2): S141-S151
Publication date: 1999


Norplant® implants and progesterone vaginal rings do not affect maternal bone turnover and density during lactation and after weaning (abstract) (PDF) 
Diaz,Soledad; Reyes,M.V.; Zepeda,Ana; Gonzalez,G.B.; Lopez,J.M.; Campino,C.; Croxatto,Horacio B.
Human Reproduction 14(10): 2499-2505
Publication date: 1999


Overview: Contraceptive research accomplishments in the 20th century and present use of contraceptives 
Johansson,Elof D.B.; Coutinho,Elsimar M.; Spinola,Paulo
from Reproductive Medicine, A Millennium Review, pp. 92-99
Publication date: 1999


Parenteral administration of progestin Nestorone® to lactating cynomolgus monkeys: An ideal hormonal contraceptive at lactation? (abstract) (PDF) 
Heikinheimo,Oskari; Ranta,Sirpa; Moo-Young,Alfred J.; Lahteenmaki,Pekka; Gordon,K.
Human Reproduction 14(8): 1993-1997
Publication date: 1999


Preregistration study on the safety and contraceptive efficacy of a progesterone-releasing vaginal ring in Chilean nursing women (abstract) (HTML) 
Massai,Rebeca; Miranda,Patricia; Valdes,P; Lavin,P.; Zepeda,Ana; Casado,M.E.; Silva,M.A.; Fetis,G.; Bravo,C.; Chandia,O.; Peralta,O.; Croxatto,Horacio B.; Diaz,Soledad
Contraception 60(1): 9-14
Publication date: 1999


Testin, a sensitive marker to monitor the integrity of Sertoli-germ cell junctions, can be used to screen potential male contraceptives 
Grima,Josephine; Silvestrini,Bruno; Cheng,Chuen-yan; Coutinho,Elsimar M.; Spinola,Paulo
from Proceedings of the 10th World Congress on Human Reproduction, pp. 109-113
Publication date: 1999


Levonorgestrel capsule implants in the United States: A 5-year study (abstract) (HTML) 
Sivin,Irving; Mishell,Daniel R.,Jr.; Darney,Philip; Wan,Livia; Christ,M.
Obstetrics and Gynecology 92: 337-344
Publication date: 1998


Levonorgestrel-releasing implants: Norplant® capsules and LNG rod (Jadelle) implants 
Sivin,Irving; Teichmann,Alexander T.; Corbin,Alan
from Levonorgestrel, pp. 165-175
Publication date: 1998


Norplant® Consensus Statement and background review (HTML) 
Fraser,Ian S.; Tiitinen,Aila; Affandi,Biran; Brache,Vivian; Croxatto,Horacio B.; Diaz,Soledad; Ginsburg,Jean; Gu Sujuan; Holma,Pentti; Johansson,Elof D.B.; Meirik,Olav; Mishell,Daniel R.,Jr.; Nash,Harold A.; von Schoultz,B; Sivin,Irving
Contraception 57(1): 1-9
Publication date: 1998


Potential benefits in developing countries through use of the levonorgestrel-releasing intrauterine system (HTML) 
Sivin,Irving
Gynaecology Forum 3(3): 23-25
Publication date: 1998


Contraceptive update 
Segal,Sheldon J.
New York University Review of Law and Social Change 23(3): 457-469
Publication date: 1997


Contraceptives for lactating women: A comparative trial of a progesterone-releasing vaginal ring and the Copper T 380A IUD (abstract) (HTML) 
Sivin,Irving; Diaz,Soledad; Croxatto,Horacio B.; Miranda,Patricia; Shaaban,Mamdouh; Sayed,Ezzat H.; Xiao,Bilian; Wu,Shang-Chun; Du Ming-kun; Alvarez-Sanchez,Francisco; Brache,Vivian; Basnayake,Sriani; McCarthy,Terence; Lacarra,Maria; Mishell,Daniel R.,Jr.; Koetsawang,Suporn; Stern,Janet; Jackanicz,Theodore M.
Contraception 55(4): 225-232
Publication date: 1997


Fertility regulation in nursing women: IX. Contraceptive performance, duration of lactation, infant growth, and bleeding patterns during use of progesterone vaginal rings, progestin-only pills, Norplant implants, and Copper T 380-A intrauterine devices (abstract) (HTML) 
Diaz,Soledad; Zepeda,Ana; Maturana,X.; Reyes,M.V.; Miranda,Patricia; Casado,M.E.; Peralta,O.; Croxatto,Horacio B.
Contraception 56(4): 223-232
Publication date: 1997


Introduction 
Segal,Sheldon J.
New York University Review of Law and Social Change 23(3): 329-337
Publication date: 1997


Immediate postplacental insertion of GYNE-T 380 and GYNE-T 380 postpartum intrauterine contraceptive devices: Randomized study (abstract) (HTML) 
Tatum,Howard J.; Beltran,Renalto Saavedra; Ramos,Rebecca; Van Kets,Henry; Sivin,Irving; Schmidt,Frederick H.
American Journal of Obstetrics and Gynecology 175(5): 1231-1235
Publication date: 1996


IUD mechanisms of action 
Croxatto,Horacio B.; Ortiz,Maria Elena; Valdez,Enrique; Bardin,C.Wayne; Mishell,Daniel R.,Jr.
from Proceedings from the Fourth International Conference on IUDs, pp. 44-62
Publication date: 1994


The Copper T 380 IUD 
Schmidt,Frederick H.; Sivin,Irving; Waldman,Sandra N.; Bardin,C.Wayne; Mishell,Daniel R.,Jr.
from Proceedings from the Fourth International Conference on IUDs, pp. 298-307
Publication date: 1994


Contraception in lactating women (abstract) (HTML) 
Diaz,Soledad; Croxatto,Horacio B.
Current Opinion in Obstetrics and Gynecology 5(6): 815-822
Publication date: 1993


The Copper T 380 Intrauterine Device: A Summary of Scientific Data 
Sivin,Irving; Greenslade,Forrest; Schmidt,Frederick H.; Waldman,Sandra N.
Publication date: 1992


Progesterone vaginal rings for contraception during breastfeeding 
Croxatto,Horacio B.; Diaz,Soledad; Runnebaum,B.; Rabe,T.; Kiesel,L.
from Advances in Gynecological and Obstetric Research Series: Vol. 2: Female Contraception and Male Fertility Regulation (1st ed.), pp. 135-142
Publication date: 1991


IUDS are contraceptives, not abortifacients: A comment on research and belief (PDF) 
Sivin,Irving
Studies in Family Planning 20(6): 355-359
Publication date: 1989


Long-acting, more effective Copper T IUDs: A summary of U.S. experience, 1970-75 
Sivin,Irving; Stern,Janet
Studies in Family Planning 10(10): 263-281
Publication date: 1979


A comparison of the Copper T-200 and the Lippes Loop in four countries 
Sivin,Irving
Studies in Family Planning 7(4): 115-123
Publication date: 1977


Life-table analysis of IUDs: Problems and recommendations 
Jain,Anrudh K.; Sivin,Irving
Studies in Family Planning 8(2): 25-47
Publication date: 1977


The effectiveness of the Copper-T intrauterine device: A collaborative study in five countries 
Sivin,Irving
Studies in Family Planning 4(7): 162-170
Publication date: 1973


Evaluation of intrauterine devices: Ninth progress report of the cooperative statistical program 
Tietze,Christopher; Lewit,Sarah
Studies in Family Planning 1(55): 1-40
Publication date: 1970