Development of new male contraceptive methods would be a valuable addition to the limited choices currently available to men, namely condoms, withdrawal, abstinence, and vasectomy. The Council's research on male reproduction and its male contraceptive R&D are unique because they examine men's reproductive health as a whole, rather than focusing exclusively on contraception.
Population Council focus
At the Population Council's Center for Biomedical Research in New York City, male reproductive health projects include:
- Developing subdermal contraceptive implants delivering the novel androgen MENT®, a synthetic steroid that resembles testosterone but does not stimulate prostate growth like testosterone can when used as a contraceptive. Council researchers are using MENT® acetate in contraceptive implants because it suppresses sperm cell development without reducing libido.
- Determining the additional potential of MENT® as a hormone therapy method (via transdermal gel or patch) to treat age-related symptoms associated with the natural decline of testosterone production in men.
- Investigating the biology and regulation of events that occur during Sertoli–Sertoli and Sertoli–germ cell communication during spermatogenesis, with the goal of developing safe, reversible male contraceptives. Currently, adjudin (1-[2,4-dichlorobenzyl]-1H-indazole-3-carbohydrazide) is the lead compound under investigation. Probing studies in male contraception revealed adjudin is capable of depleting germ cells by disrupting cell adhesion in the testis, thereby creating reversible contraception.
- Conducting translational studies to understand the underlying causes of male infertility associated with the arrest of sperm cell development and the absence of sperm (azoospermia). Identifying novel DNA binding proteins, which are critical to successful division in developing germ cells, may provide new lead compounds for therapeutic interventions and provide avenues for a new generation of small molecules for male contraception.
Population Council impact
The development of safe, effective male contraceptive technologies is a new frontier in reproductive health technology with exciting implications—particularly because of their potential to engage men more centrally in the pursuit of reproductive health and gender equity. When Council R&D is complete, these products will be valuable additions to the array of available contraceptive options. In addition:
- Such dedicated research into various formulations of MENT® has resulted in considerable progression of male subdermal implant technology.
- Basic and translational research has identified novel mechanisms of germ cell development in men and has led to greater understanding of DNA and chromosome modifications during human sperm production.
Future directions
- In the search for innovative methods of male contraception, the Council is exploring a novel approach using a molecule that prevents maturation of the sperm, making it unable to fertilize an egg.
- Researchers also are investigating the mechanism by which environmental toxicants—such as cadmium, xenostrogens like bisphenol A (BPA), and phthalates—disrupt spermatogenesis. (Some environmental toxicants can lower sperm count, resulting in male subfertility or infertility.)
Projects
Development and Physiology of Leydig Cells (more)
Testosterone production by Leydig cells in the testis is the critical factor ensuring adequate sperm production and male fertility. Council researchers are identifying components that affect testosterone secretion and may offer new avenues for contraception and male hormone therapy.
(1/1998 - ongoing)
United States
MENT® (more)
Council researchers are working to develop methods of contraception for men that contain MENT®, a synthetic steroid that resembles testosterone
(1/2005 - ongoing)
Chile, Dominican Republic, Germany, United Kingdom, United States
Physiology of Sertoli Cells (more)
The goal of Council research on Sertoli cells is the development of safe, reversible male contraceptives.
(1/1995 - ongoing)
United States
Probing Studies in Male Contraception (more)
Council researchers are undertaking research that may lead to novel contraceptive methods for men.
(1/1995 - ongoing)
United States
Subdermal Implants for Men (more)
Studies have found that men are interested in taking more responsibility for family planning; an implant for men is the Council's lead product in male contraception.
(1/2005 - ongoing)
Chile, Dominican Republic, Germany, United Kingdom, United States
Transdermal Delivery Systems for Men (more)
Council research has demonstrated that MENT permeates the skin significantly better than two other androgens and is safe for further development as a hormone therapy method for men.
(1/2005 - ongoing)
Chile, United States
Resources
7a-methyl-19-nortestosterone (MENT®): The Population Council's contribution to research on male contraception and treatment of hypogonadism (abstract) (HTML)
Nieschlag,Eberhard; Kumar,Narender; Sitruk-Ware,Regine
Contraception 87(3): 288-295
Publication date: 2013
A new combination of testosterone and nestorone transdermal gels for male hormonal contraception (abstract) (HTML)
Ilani,Niloufar; Roth,Mara Y.; Amory,John K.; Swerdloff,Ronald S.; Dart,Clint; Page,Stephanie T.; Bremner,William J.; Sitruk-Ware,Regine; Kumar,Narender; Blithe,Diana; Wang,Christina
Journal of Clinical Endocrinology and Metabolism 97(10): 3476-3486
Publication date: 2012
The blood-testis barrier and its implications for male contraception (abstract) (PDF) (HTML)
Cheng,Chuen-yan; Mruk,Dolores D.
Pharmacological Reviews 64(1): 16-64
Publication date: 2012
An in vitro system to study Sertoli cell blood-testis barrier dynamics (abstract) (HTML)
Mruk,Dolores D.; Cheng,Chuen-yan
Methods in Molecular Biology 763: 237-252
Publication date: 2011
P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK) (abstract) (PDF) (HTML)
Su,Linlin; Mruk,Dolores D.; Lui,Wing-Yee; Lee,William M.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 108(49): 19623-19628
Publication date: 2011
New frontiers in nonhormonal male contraception (abstract) (HTML)
Cheng,Chuen-yan; Mruk,Dolores D.
Contraception 82(5): 476-482
Publication date: 2010
Adjudin targeting rabbit germ cell adhesion as a male contraceptive: A pharmacokinetics study (abstract) (PDF) (HTML)
Hu,Guo-Xin; Hu,Lu-Feng; Yang,Dai-Zheng; Li,Jun-Wei; Chen,Guo-Rong; Chen,Bing-Bing; Mruk,Dolores D.; Bonanomi,Michele; Silvestrini,Bruno; Cheng,Chuen-yan; Ge,Renshan
Journal of Andrology 30(1): 87-93
Publication date: 2009
Cadmium-induced testicular injury (abstract) (HTML)
Siu,Erica R.; Mruk,Dolores D.; Porto,Catarina S.; Cheng,Chuen-yan
Toxicology and Applied Pharmacology 238(3): 240-249
Publication date: 2009
Combined transdermal testosterone gel and the progestin Nestorone suppresses serum gonadotropins in men (abstract) (PDF)
Mahabadi,Vahid; Amory,John K.; Swerdloff,Ronald S.; Bremner,William J.; Page,Stephanie T.; Sitruk-Ware,Regine; Christensen,Peter D.; Kumar,Narender; Tsong,Yun-yen; Blithe,Diana; Wang,Christina
Journal of Clinical Endocrinology and Metabolism 94(7): 2313-2320
Publication date: 2009
Mitogen-activated protein kinases in male reproductive function (abstract) (HTML)
Li,Michelle W.M.; Mruk,Dolores D.; Cheng,Chuen-yan
Trends in Molecular Medicine 15(4): 159-168
Publication date: 2009
RAB13 participates in ectoplasmic specialization dynamics in the rat testis (abstract) (PDF) (HTML)
Mruk,Dolores D.; Lau,Ann S.N.
Biology of Reproduction 80(3): 590-601
Publication date: 2009
Testicular cell junction: A novel target for male contraception
(abstract) (HTML)
Lee,Nikki P.Y.; Wong,Elissa W.P.; Mruk,Dolores D.; Cheng,Chuen-yan
Current Medicinal Chemistry 16(7): 906-915
Publication date: 2009
An autocrine axis in the testis that coordinates spermiation and blood-testis barrier restructuring during spermatogenesis (abstract) (PDF) (HTML)
Yan,Helen H.N.; Mruk,Dolores D.; Wong,Elissa W.P.; Lee,Will M.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 105(26): 8950-8955
Publication date: 2008
Anchoring junctions as drug targets: Role in contraceptive development (abstract) (PDF) (HTML)
Mruk,Dolores D.; Silvestrini,Bruno; Cheng,Chuen-yan
Pharmacological Reviews 60(2): 146-180
Publication date: 2008
Delivering non-hormonal contraceptives to men: Advances and obstacles (abstract) (HTML)
Mruk,Dolores D.; Cheng,Chuen-yan
Trends in Biotechnology 26(2): 90-99
Publication date: 2008
Determinants of the rate and extent of spermatogenic suppression during hormonal male contraception: An integrated analysis (abstract) (PDF) (HTML)
Liu,Peter Y.; Swerdloff,Ronald S.; Anawalt,Bradley D.; Anderson,Richard A.; Bremner,William J.; Elliesen,Joerg; Gu,Yi-Qun; Kersemaekers,Wendy M.; McLachlan,Robert I.; Meriggiola,M.Christina; Nieschlag,Eberhard; Sitruk-Ware,Regine; Vogelsong,Kirsten M.; Wang,Xing-Hai; Wu,Frederick C.W.; Zitzmann,Michael; Handelsman,David J.; Wang,Christina
Journal of Clinical Endocrinology and Metabolism 93(5): 1774-1783
Publication date: 2008
New perspectives in non-hormonal male contraception (abstract) (HTML)
Mruk,Dolores D.
Trends in Endocrinology and Metabolism 19(2): 57-64
Publication date: 2008
A seamless trespass: Germ cell migration across the seminiferous epithelium during spermatogenesis (abstract) (PDF) (HTML)
Wang,Claire Q.F.; Cheng,Chuen-yan
Journal of Cell Biology 178(4): 549-556
Publication date: 2007
An initial pharmacokinetic study with a Metered Dose Transdermal System® for delivery of the progestogen Nestorone® as a possible future contraceptive (abstract) (HTML)
Fraser,Ian S.; Weisberg,Edith; Kumar,Narender; Kumar,Sushma; Humberstone,Andrew J.; McCrossin,Louise; Shaw,Deborah; Tsong,Yun-yen; Sitruk-Ware,Regine
Contraception 76(6): 432-438
Publication date: 2007
Chemical postmaster helps deliver contraceptive to testis (PDF)
Population Briefs 13(1)
Publication date: 2007
C-type natriuretic peptide regulates blood-testis barrier dynamics in adult rat testes (abstract) (PDF) (HTML)
Xia,Weiliang; Mruk,Dolores D.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 104(10): 3841-3846
Publication date: 2007
Junction restructuring and spermatogenesis: The biology, regulation, and implication in male contraceptive development (abstract) (HTML)
Yan,Helen H.N.; Mruk,Dolores D.; Cheng,Chuen-yan
Current Topics in Developmental Biology 80: 57-92
Publication date: 2007
Rab4A GTPase-catenin interactions are involved in cell junction dynamics in the testis (abstract) (PDF) (HTML)
Mruk,Dolores D.; Lau,Ann S.N.; Sarkar,Oli; Xia,Weiliang
Journal of Andrology 28(5): 742-754
Publication date: 2007
A male contraceptive targeting germ cell adhesion (abstract) (HTML)
Mruk,Dolores D.; Wong,Ching-hang; Silvestrini,Bruno; Cheng,Chuen-yan
Nature Medicine 12(11): 1323-1328
Publication date: 2006
Adjudin-mediated junction restructuring in the seminiferous epithelium leads to displacement of soluble guanylate cyclase from adherens junctions (abstract) (HTML)
Sarkar,Oli; Xia,Weiliang; Mruk,Dolores D.
Journal of Cellular Physiology 208(1): 175-187
Publication date: 2006
Delineating the role of estrogen in regulating epididymal gene expression
Deshpande,Shayu; Hardy,Matthew P.; Rao,A.Jagannadha; Gupta,S.K.; Koyama,K.
from Gamete Biology, Society of Reproduction and Fertility
Publication date: 2006
Differential interactions between transforming growth factor-β3/TβR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion (abstract) (PDF) (HTML)
Xia,Weiliang; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Journal of Biological Chemistry 281(24): 16799-16813
Publication date: 2006
Laminin α3 forms a complex with β3 and γ3 chains that serves as the ligand for α 6β1-integrin at the apical ectoplasmic specialization in adult rat testes (abstract) (PDF) (HTML)
Yan,Helen H.N.; Cheng,Chuen-yan
Journal of Biological Chemistry 281(25): 17286-17303
Publication date: 2006
The Sertoli-spermatid junctional complex adhesion strength is affected in vitro by adjudin (abstract) (PDF) (HTML)
Wolski,Katja M.; Mruk,Dolores D.; Cameron,Don F.
Journal of Andrology 27(6): 790-794
Publication date: 2006
Tumor necrosis factor reversibly disrupts the blood-testis barrier and impairs Sertoli-germ cell adhesion in the seminiferous epithelium of adult rat testes (abstract) (PDF) (HTML)
Li,Michelle W.M.; Xia,Weiliang; Mruk,Dolores D.; Wang,Claire Q.F.; Yan,Helen H.N.; Siu,Michelle K.Y.; Lui,Wing-Yee; Lee,Will M.; Cheng,Chuen-yan
Journal of Endocrinology 190(2): 313-329
Publication date: 2006
Blood-testis barrier dynamics are regulated by α2-macroglobulin via the c-Jun N-terminal protein kinase pathway (abstract) (PDF) (HTML)
Wong,Ching-hang; Mruk,Dolores D.; Siu,Michelle K.Y.; Cheng,Chuen-yan
Endocrinology 146(4): 1893-1908
Publication date: 2005
Interactions among IQGAP1, Cdc42, and the cadherin/catenin protein complex regulate Sertoli-germ cell adherens junction dynamics in the testis (abstract) (HTML)
Lui,Wing-Yee; Mruk,Dolores D.; Cheng,Chuen-yan
Journal of Cellular Physiology 202(1): 49-66
Publication date: 2005
Myotubularin phosphoinositide phosphatases, protein phosphatases, and kinases: Their roles in junction dynamics and spermatogenesis (abstract) (HTML)
Zhang,Jiayi; Mruk,Dolores D.; Cheng,Chuen-yan
Journal of Cellular Physiology 204(2): 470-483
Publication date: 2005
Protein kinases and adherens junction dynamics in the seminiferous epithelium of the rat testis (abstract) (HTML)
Lee,Nikki P.Y.; Cheng,Chuen-yan
Journal of Cellular Physiology 202(2): 344-360
Publication date: 2005
Regulation of ectoplasmic specialization dynamics in the seminiferous epithelium by focal adhesion-associated proteins in testosterone-suppressed rat testes (abstract) (PDF) (HTML)
Wong,Ching-hang; Xia,Weiliang; Lee,Nikki P.Y.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Endocrinology 146(3): 1192-1204
Publication date: 2005
Regulation of Sertoli-germ cell adherens junction dynamics via changes in protein-protein interactions of the N-cadherin-ß-catenin protein complex which are possibly mediated by c-Src and myotubularin-related protein 2: An in vivo study using an androgen suppression model (abstract) (PDF) (HTML)
Zhang,Jiayi; Wong,Ching-hang; Xia,Weiliang; Mruk,Dolores D.; Lee,Nikki P.Y.; Lee,Will M.; Cheng,Chuen-yan
Endocrinology 146(3): 1268-1284
Publication date: 2005
Sertoli-germ cell anchoring junction dynamics in the testis are regulated by an interplay of lipid and protein kinases (abstract) (PDF) (HTML)
Siu,Michelle K.Y.; Wong,Ching-hang; Lee,Will M.; Cheng,Chuen-yan
Journal of Biological Chemistry 280(26): 25029-25047
Publication date: 2005
Sperm with bent tails point to possible male contraceptive (PDF)
Population Briefs 11(2)
Publication date: 2005
TGF-ß3 regulates anchoring junction dynamics in the seminiferous epithelium of the rat testis via the Ras/ERK signaling pathway: An in vivo study (abstract) (PDF) (HTML)
Xia,Weiliang; Cheng,Chuen-yan
Developmental Biology 280(2): 321-343
Publication date: 2005
α-macroglobulin expression in the liver in response to inflammation is mediated by the testis (abstract) (PDF)
Lui,Wing-Yee; Cheng,Yan Ho; Mruk,Dolores D.; Cheng,Chin Ho; Mo,Meng-Yun; Lee,Will M.; Cheng,Chuen-yan
Journal of Endocrinology 185(3): 497-505
Publication date: 2005
Adaptors, junction dynamics, and spermatogenesis (abstract) (PDF) (HTML)
Lee,Nikki P.Y.; Cheng,Chuen-yan
Biology of Reproduction 71(2): 392-404
Publication date: 2004
Cell-cell interactions at the ectoplasmic specialization in the testis (abstract) (HTML)
Mruk,Dolores D.; Cheng,Chuen-yan
Trends in Endocrinology and Metabolism 15(9): 439-447
Publication date: 2004
Disruption of Mtmr2 produces CMT4B1-like neuropathy with myelin outfolding and impaired spermatogenesis (abstract) (PDF) (HTML)
Bolino,Alessandra; Bolis,Annalisa; Previtali,Stefano Carlo; Dina,Giorgia; Bussini,Simona; Dati,Gabriele; Amadio,Stefano; Del Carro,Ubaldo; Mruk,Dolores D.; Feltri,Maria Laura; Cheng,Chuen-yan; Quattrini,Angelo; Wrabetz,Lawrence
Journal of Cell Biology 167(4): 711-721
Publication date: 2004
Dynamic cross-talk between cells and the extracellular matrix in the testis (abstract) (HTML)
Siu,Michelle K.Y.; Cheng,Chuen-yan
BioEssays 26(9): 978-992
Publication date: 2004
Ectoplasmic specialization, a testis-specific cell-cell actin-based adherens junction type: Is this a potential target for male contraceptive development? (abstract) (PDF) (HTML)
Lee,Nikki P.Y.; Cheng,Chuen-yan
Human Reproduction Update 10(4): 349-369
Publication date: 2004
Extracellular matrix: Recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis (abstract) (HTML)
Siu,Michelle K.Y.; Cheng,Chuen-yan
Biology of Reproduction 71(2): 375-391
Publication date: 2004
Interactions of proteases, protease inhibitors, and the β1 integrin/laminin γ3 protein complex in the regulation of ectoplasmic specialization dynamics in the rat testis (abstract) (HTML)
Siu,Michelle K.Y.; Cheng,Chuen-yan
Biology of Reproduction 70(4): 945-964
Publication date: 2004
Nitric oxide/nitric oxide synthase, spermatogenesis, and tight junction dynamics (abstract) (PDF) (HTML)
Lee,Nikki P.Y.; Cheng,Chuen-yan
Biology of Reproduction 70(2): 267-276
Publication date: 2004
Potential long-acting male contraceptive studied (PDF)
Population Briefs 10(3)
Publication date: 2004
Regulation of blood-testis barrier dynamics: An in vivo study (abstract) (HTML)
Wong,Ching-hang; Mruk,Dolores D.; Lui,Wing-Yee; Cheng,Chuen-yan
Journal of Cell Science 117(5): 783-798
Publication date: 2004
Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis (abstract) (PDF) (HTML)
Mruk,Dolores D.; Cheng,Chuen-yan
Endocrine Reviews 25(5): 747-806
Publication date: 2004
Zyxin, axin, and Wiskott-Aldrich syndrome protein are adaptors that link the cadherin/catenin protein complex to the cytoskeleton at adherens junctions in the seminiferous epithelium of the rat testis (abstract) (PDF) (HTML)
Lee,Nikki P.Y.; Mruk,Dolores D.; Conway,Anne M.; Cheng,Chuen-yan
Journal of Andrology 25(2): 200-215
Publication date: 2004
A clinical trial of 7α-methyl-19-nortestosterone implants for possible use as a long-acting contraceptive for men (abstract) (PDF) (HTML)
von Eckardstein,Sigrid; Noe,Gabriela; Brache,Vivian; Nieschlag,Eberhard; Croxatto,Horacio B.; Alvarez-Sanchez,Francisco; Moo-Young,Alfred J.; Sivin,Irving; Kumar,Narender; Small,Margaret; Sundaram,Kalyan; Population Council International Committee for Contraception Research
Journal of Clinical Endocrinology and Metabolism 88(11): 5232-5239
Publication date: 2003
Adherens junction dynamics in the testis and spermatogenesis (PDF) (HTML)
Lui,Wing-Yee; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Journal of Andrology 24(1): 1-14
Publication date: 2003
Adhering junction dynamics in the testis are regulated by an interplay of β 1-integrin and focal adhesion complex-associated proteins (abstract) (PDF) (HTML)
Siu,Michelle K.Y.; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Endocrinology 144(5): 2141-2163
Publication date: 2003
Evidence for tissue selectivity of the synthetic androgen 7α-methyl-19-nortestosterone in hypogonadal men (abstract) (PDF)
Anderson,Richard A.; Wallace,A.Michael; Sattar,Naveed; Kumar,Narender; Sundaram,Kalyan
Journal of Clinical Endocrinology and Metabolism 88(6): 2784-2793
Publication date: 2003
Fer kinase/FerT and adherens junction dynamics in the testis: An in vitro and in vivo study (abstract) (PDF) (HTML)
Chen,Yong-Mei; Lee,Nikki P.Y.; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Biology of Reproduction 69(2): 656-672
Publication date: 2003
Hormone Use in Menopause and Male Andropause: A Choice for Women and Men
Segal,Sheldon J.; Mastroianni,Luigi,Jr.
Publication date: 2003
Is the cadherin/catenin complex a functional unit of cell-cell actin-based adherens junctions in the rat testis? (abstract) (PDF) (HTML)
Lee,Nikki P.Y.; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Biology of Reproduction 68(2): 489-508
Publication date: 2003
Regulation of Sertoli cell tight junction dynamics in the rat testis via the nitric oxide synthase/soluble guanylate cyclase/3',5'-cyclic guanosine monophosphate/protein kinase G signaling pathway: An in vitro study (abstract) (PDF) (HTML)
Lee,Nikki P.Y.; Cheng,Chuen-yan
Endocrinology 144(7): 3114-3129
Publication date: 2003
Rho GTPases and spermatogenesis (abstract) (HTML)
Lui,Wing-Yee; Lee,William M.; Cheng,Chuen-yan
Biochimica et Biophysica Acta 1593(2-3): 121-129
Publication date: 2003
Role of tissue inhibitor of metalloproteases-1 in junction dynamics in the testis (abstract) (PDF) (HTML)
Mruk,Dolores D.; Siu,Michelle K.Y.; Conway,Anne M.; Lee,Nikki P.Y.; Lau,Ann S.N.; Cheng,Chuen-yan
Journal of Andrology 24(4): 510-523
Publication date: 2003
Sertoli cell tight junction dynamics: Their regulation during spermatogenesis (abstract) (PDF) (HTML)
Lui,Wing-Yee; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Biology of Reproduction 68(4): 1087-1097
Publication date: 2003
Sertoli-germ cell adherens junction dynamics in the testis are regulated by RhoB GTPase via the ROCK/LIMK signaling pathway (abstract) (HTML)
Lui,Wing-Yee; Lee,William M.; Cheng,Chuen-yan
Biology of Reproduction 68(6): 2189-2206
Publication date: 2003
TGF-β3 regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: An in vivo study (abstract) (PDF) (HTML)
Lui,Wing-Yee; Wong,Daria C.H.; Mruk,Dolores D.; Cheng,Chuen-yan
Endocrinology 144(4): 1139-1142
Publication date: 2003
TGF-βs: Their role in testicular function and Sertoli cell tight junction dynamics (abstract) (HTML)
Lui,Wing-Yee; Lee,William M.; Cheng,Chuen-yan
International Journal of Andrology 26(3): 147-160
Publication date: 2003
The interplay of collagen IV, tumor necrosis factor-α, gelatinase B (matrix metalloprotease-9), and tissue inhibitor of metalloproteases-1 in the basal lamina regulates Sertoli cell-tight junction dynamics in the rat testis (abstract) (PDF) (HTML)
Siu,Michelle K.Y.; Lee,William M.; Cheng,Chuen-yan
Endocrinology 144(1): 371-387
Publication date: 2003
Transforming growth factor β3 regulates the dynamics of Sertoli cell tight junctions via the p38 mitogen-activated protein kinase pathway (abstract) (PDF) (HTML)
Lui,Wing-Yee; Lee,William M.; Cheng,Chuen-yan
Biology of Reproduction 68(5): 1597-1612
Publication date: 2003
Antioxidant superoxide dismutase--A review: Its function, regulation in the testis, and role in male fertility (abstract) (HTML)
Mruk,Dolores D.; Silvestrini,Bruno; Mo,Meng-Yun; Cheng,Chuen-yan
Contraception 65(4): 305-311
Publication date: 2002
Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development (abstract) (PDF) (HTML)
Cheng,Chuen-yan; Mruk,Dolores D.
Physiological Reviews 82(4): 825-874
Publication date: 2002
Indazole carboxylic acids in male contraception (abstract) (HTML)
Cheng,Chuen-yan; Mo,Meng-Yun; Grima,Josephine; Saso,Luciano; Tita,Beatrice; Mruk,Dolores D.; Silvestrini,Bruno
Contraception 65(4): 265-268
Publication date: 2002
Investigating nonhormonal male contraceptives
Population Council Annual Report 2002
Publication date: 2002
A male contraceptive pill by 2000?
Segal,Sheldon J.
from Toward a New Partnership: Encouraging the Positive Involvement of Men as Supportive Partners in Reproductive Health, pp. 3-4
Publication date: 2001
Current approaches to systemic male contraception
Bremner,William J.; Cheng,Chuen-yan; Cuasnicu,Patricia S.; Habenicht,Ursula F.; Colvard,Douglas S.; Doncel,Gustavo F.; Coutinho,Elsimar M.; Spinola,Paulo
from Current Knowledge in Reproductive Medicine, pp. 315-331
Publication date: 2001
Evidence for the binding of a human sperm component with diaphanous protein (abstract) (HTML)
Zhang,Si-Ming; Miao,Shiying; Wang,Linfang; Koide,Samuel S.
Archives of Andrology 46(1): 29-35
Publication date: 2001
Reversible inhibition of spermatogenesis in rats using a new male contraceptive, 1-(2,4-dichlorobenzyl)-indazole-3-carbohydrazide (abstract) (PDF) (HTML)
Grima,Josephine; Silvestrini,Bruno; Cheng,Chuen-yan
Biology of Reproduction 64(5): 1500-1508
Publication date: 2001
Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis (abstract) (PDF) (HTML)
Cheng,Chuen-yan; Silvestrini,Bruno; Grima,Josephine; Mo,Meng-Yun; Zhu,Li-Ji; Johansson,Elof D.B.; Saso,Luciano; Leone,Maria Grazia; Palmery,Maura; Mruk,Dolores D.
Biology of Reproduction 65(2): 449-461
Publication date: 2001
An implant releasing the gonadotropin hormone-releasing hormone agonist histrelin maintains medical castration for up to 30 months in metastatic prostate cancer (abstract) (HTML)
Chertin,Boris; Spitz,Irving M.; Lindenberg,Tzina; Algur,Nurit; Zer,Tami; Kuzma,Petr; Moo-Young,Alfred J.; Catane,Raphael; Farkas,Amicur
Journal of Urology 163(3): 838-844
Publication date: 2000
Testin, a sensitive marker to monitor the integrity of Sertoli-germ cell junctions, can be used to screen potential male contraceptives
Grima,Josephine; Silvestrini,Bruno; Cheng,Chuen-yan; Coutinho,Elsimar M.; Spinola,Paulo
from Proceedings of the 10th World Congress on Human Reproduction, pp. 109-113
Publication date: 1999
Contraceptive update
Segal,Sheldon J.
New York University Review of Law and Social Change 23(3): 457-469
Publication date: 1997
Introduction
Segal,Sheldon J.
New York University Review of Law and Social Change 23(3): 329-337
Publication date: 1997
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