With a high proportion of pregnancies either ill-timed or unwanted, high levels of unmet need for birth spacing, and a growing market of both women and men demanding high-quality reproductive health services, research is needed on potential compounds and delivery systems in order to develop new products particularly suitable for use in developing countries.
Population Council focus
The Council’s reproductive health portfolio in basic biomedical research identifies leads for eventual product development. Scientists at the Council's Center for Biomedical Research also test new scientific technologies, including concepts, new molecules, delivery systems, and methods, to accelerate progress in research.
Population Council impact
- For women, the Council is conducting research on selective hormone receptors (e.g., ulipristal) to make contraceptive delivery systems safer and more effective in the prevention of unwanted pregnancy, and to contribute to breast health by arresting the potential emergence of tumor cells.
- For men, the Council is conducting research on mechanisms of androgen action, including work on MENT® in the identification of new male contraceptives, as well as identifying and understanding germ cell development and sperm function to identify nonhormonal targets, and the effects of environmental endocrine disruptors on testicular function (e.g., on Leydig cells which are affected by one such phthalate, DBP, a disruptor commonly found in plastics).
Projects
Action of Endocrine Disrupters on Leydig Cells (more)
Diethylhexylphthalate (DEHP) is a suspected endocrine-disrupting chemical that is a common constituent of flexible plastics; Council research is investigating the effect of DEHP on the function of Leydig cells, the cells responsible for making testosterone.
(4/1999 - ongoing)
United States
Development and Physiology of Leydig Cells (more)
Testosterone production by Leydig cells in the testis is the critical factor ensuring adequate sperm production and male fertility. Council researchers are identifying components that affect testosterone secretion and may offer new avenues for contraception and male hormone therapy.
(1/1998 - ongoing)
United States
Dual Health Benefits: Nestorone
Council scientists at the Center for Biomedical Research are developing safer and more effective long-acting contraceptives that have dual health benefits, using molecules with selective binding to hormone receptors, such as Nestorone®, a derivative of progesterone.
(1/2010 - ongoing)
France, United States
Dual Health Benefits: Ulipristal (more)
Council scientists at the Center for Biomedical Research are developing safer and more effective long-acting contraceptives that have dual health benefits, using molecules with selective binding to hormone receptors, such as ulipristal, a novel progesterone receptor modulator.
(1/2010 - ongoing)
United States
Germ Cell Dynamics (more)
Basic research at the Council's Center for Biomedical Research seeks to identify genetic mechanisms resulting in infertility in mice that might be used to develop new forms of male contraception.
(1/1998 - ongoing)
United States
In Search of Stem Leydig Cells: Identification, Isolation, and Development (more)
Leydig cells secrete the male hormone testosterone needed for fertility and formation of the male body plan; Council research seeks to understand the cellular controls of testostorone production in Leydig cells.
(1/1995 - ongoing)
United States
Physiology of Sertoli Cells (more)
The goal of Council research on Sertoli cells is the development of safe, reversible male contraceptives.
(1/1995 - ongoing)
United States
Sperm Maturation (more)
Council researchers are working to identify the switch that activates sperm so that it can be turned on in infertile men and turned off when contraception is desired.
(7/2002 - ongoing)
United States
Studies on the Function of the Annulus of the Sperm Tail (more)
The annulus on the sperm tail is critical for sperm function; Council research on the annulus may lead to the development of a novel, reversible male contraceptive
(1/2003 - ongoing)
United States
The Biology of Blood–Testis Barrier Dynamics (more)
Population Council researchers have been investigating innovative ways to regulate the blood–testis barrier in spermatogenesis, which will likely lead to the development of novel male contraceptives.
(2/2009 - 3/2014)
United States
Facilitating Regulatory Approval of Multipurpose Prevention Technologies for Reproductive Health (more)
The Population Council is playing a central role in the US Agency for International Development’s effort to clarify and inform regulatory pathways for multipurpose prevention technologies.
(10/2010 - 9/2013)
United States
Dual-protection Contraceptive Ring (more)
Council researchers are collaborating to develop a dual-protection contraceptive ring that protects against both pregnancy and HIV.
(10/2009 - 11/2010)
United States
Resources
Actin cross-linking protein palladin and spermatogenesis (abstract) (PDF)
Qian,Xiao-jing; Mruk,Dolores D.; Cheng,Yan Ho; Cheng,Chuen-yan
Spermatogenesis 3(1)
Publication date: 2013
Adjudin attenuates lipopolysaccharide (LPS)- and ischemia-induced microglial activation (abstract) (HTML)
Shao,Jiaxiang; Liu,Tengyuan; Xie,Qian Reuben; Zhang,Tingting; Yu,Hemei; Wang,Boshi; Ying,Weihai; Mruk,Dolores D.; Silvestrini,Bruno; Cheng,Chuen-yan; Xia,Weiliang
Journal of Neuroimmunology 254(1): 83-90
Publication date: 2013
c-Yes regulates cell adhesion at the apical ectoplasmic specialization-blood-testis barrier axis via its effects on protein recruitment and distribution (abstract) (HTML)
Xiao,Xiang; Mruk,Dolores D.; Cheng,Chuen-yan
American Journal of Physiology: Endocrinology and Metabolism (Translational Series) 304(2): E145-E159
Publication date: 2013
Intercellular adhesion molecule-2 is involved in apical ectoplasmic specialization dynamics during spermatogenesis in the rat (abstract) (HTML)
Xiao,Xiang; Cheng,Chuen-yan; Mruk,Dolores D.
Journal of Endocrinology 216(1): 73-86
Publication date: 2013
Intercellular adhesion molecules (ICAMs) and spermatogenesis (abstract) (HTML)
Xiao,Xiang; Mruk,Dolores D.; Cheng,Chuen-yan
Human Reproduction Update Published online ahead of print, 3 January
Publication date: 2013
Regulation of actin dynamics and protein trafficking during spermatogenesis--Insights into a complex process (abstract) (HTML)
Su,Wenhui; Mruk,Dolores D.; Cheng,Chuen-yan
Critical Reviews in Biochemistry and Molecular Biology Published online ahead of print, 23 January
Publication date: 2013
Regulation of blood-testis barrier (BTB) dynamics during spermatogenesis via the "yin" and "yang" effects of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2 (abstract) (HTML)
Mok,Ka-Wai; Mruk,Dolores D.; Cheng,Chuen-yan
International Review of Cell and Molecular Biology 301: 291-358
Publication date: 2013
Rictor/mTORC2 regulates blood-testis barrier dynamics via its effects on gap junction communications and actin filament network (abstract) (HTML)
Mok,Ka-Wai; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
FASEB Journal Published online ahead of print, 3 January
Publication date: 2013
Secreted Frizzled-related protein 1 (sFRP1) regulates spermatid adhesion in the testis via dephosphorylation of focal adhesion kinase and the nectin-3 adhesion protein complex (abstract) (HTML)
Wong,Elissa W.P.; Lee,Will M.; Cheng,Chuen-yan
FASEB Journal 27(2): 464-477
Publication date: 2013
Ulipristal blocks ovulation by inhibiting progesterone receptor-dependent pathways intrinsic to the ovary (abstract) (HTML)
Nallasamy,Shanmugasundaram; Kim,Jaeyeon; Sitruk-Ware,Regine; Bagchi,Milan K.; Bagchi,Indrani C.
Reproductive Sciences 20(4): 371-381
Publication date: 2013
"Building on decades of success: Pioneering contraceptive research and products," fact sheet (PDF)
Publication date: 2012
A peptide derived from laminin-y3 reversibly impairs spermatogenesis in rats (abstract) (HTML)
Su,Linlin; Mruk,Dolores D.; Lie,Pearl P.Y.; Silvestrini,Bruno; Cheng,Chuen-yan
Nature Communications 3(1185): doi:10.1038/ncomms2171-
Publication date: 2012
Drug transporters in spermatogenesis: A re-evaluation of recent data on P-glycoprotein (abstract) (PDF) (HTML)
Mruk,Dolores D.; Cheng,Chuen-yan
Spermatogenesis 2(2): 70-72
Publication date: 2012
Effects of a novel estrogen-free, progesterone receptor modulator-contraceptive vaginal ring on inhibition of ovulation, bleeding patterns and endometrium in normal women (abstract) (HTML)
Brache,Vivian; Sitruk-Ware,Regine; Williams,A.; Blithe,Diana; Croxatto,Horacio B.; Kumar,Narender; Kumar,Sushma; Tsong,Yun-yen; Sivin,Irving; Nath,Anita; Sussman,Heather; Cochon,Leila; Miranda,Maria Jose; Reyes,Veronica; Faundes,Anibal; Mishell,Daniel R.,Jr.
Contraception 85(5): 480-488
Publication date: 2012
Filamin A is a regulator of blood-testis barrier assembly during postnatal development in the rat testis (abstract) (HTML)
Su,Wenhui; Mruk,Dolores D.; Lie,Pearl P.Y.; Lui,Wing-Yee; Cheng,Chuen-yan
Endocrinology 153(10): 5023-5035
Publication date: 2012
Filamin A: A regulator of blood-testis barrier assembly during post-natal development (abstract) (PDF) (HTML)
Su,Wenhui; Mruk,Dolores D.; Cheng,Chuen-yan
Spermatogenesis 2(2): 73-78
Publication date: 2012
Focal adhesion kinase-Tyr407 and -Tyr397 exhibit antagonistic effects on blood-testis barrier dynamics in the rat (abstract) (PDF) (HTML)
Lie,Pearl P.Y.; Mruk,Dolores D.; Mok,Ka-Wai; Su,Linlin; Lee,Will M.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 109(31): 12562-12567
Publication date: 2012
Hormonal contraception and the risk of HIV acquisition among women in South Africa (abstract) (HTML)
Morrison,Charles S.; Skoler-Karpoff,Stephanie; Kwok,Cynthia; Chen,Pai-lien; van de Wijgert,Janneke; Gehret-Plagianos,Marlena; Patel,Smruti; Ahmed,Khatija; Ramjee,Gita; Friedland,Barbara A.; Lahteenmaki,Pekka
AIDS 26(4): 497-504
Publication date: 2012
In search of suitable in vitro models to study germ cell movement across the blood-testis barrier (abstract) (PDF) (HTML)
Mruk,Dolores D.; Cheng,Chuen-yan
Spermatogenesis 2(1): 6-10
Publication date: 2012
Increased impact of a contraceptive vaginal ring with ethinyl estradiol and nestorone on C-reactive protein (abstract) (HTML)
Rad,Mandana; Burggraaf,Jacobus; Sitruk-Ware,Regine; de Kam,Marieke L.; Cohen,Adam F.; Kluft,Cornelius
Steroids 77(13): 1483-1486
Publication date: 2012
Microtubule affinity-regulating kinase 4 (MARK4) is a component of the ectoplasmic specialization in the rat testis (abstract) (PDF) (HTML)
Tang,Elizabeth I.; Xiao,Xiang; Mruk,Dolores D.; Qian,Xiao-jing; Mok,Ka-Wai; Jenardhanan,Pranitha; Lee,Will M.; Mathur,Premendu P.; Cheng,Chuen-yan
Spermatogenesis 2(2): 117-126
Publication date: 2012
Nonclinical development needs and regulatory requirements for multipurpose prevention technologies: A primer (PDF)
Romano,Joseph W.; Brady,Martha; Manning,Judy
Publication date: 2012
Progesterone receptors: A key for neuroprotection in experimental stroke (abstract) (PDF) (HTML)
Liu,Ailing; Margaill,Isabelle; Zhang,Shaodong; Labombarda,Florencia; Coqueran,Berard; Delespierre,Brigitte; Liere,Philippe; Marchand-Leroux,Catherine; O'Malley,Bert W.; Lydon,John P.; De Nicola,Alejandro; Sitruk-Ware,Regine; Mattern,Claudia; Plotkine,Michel; Schumacher,Michael; Guennoun,Rachida
Endocrinology 153(8): 3747-3757
Publication date: 2012
Regulation of drug transporters in the testis by environmental toxicant cadmium, steroids and cytokines (abstract) (PDF) (HTML)
Su,Linlin; Mruk,Dolores D.; Cheng,Chuen-yan
Spermatogenesis 2(4): 285-293
Publication date: 2012
Regulation of the blood-testis barrier by coxsackievirus and adenovirus receptor (abstract) (HTML)
Su,Linlin; Mruk,Dolores D.; Cheng,Chuen-yan
American Journal of Physiology: Cell Physiology 303(8): C843-C853
Publication date: 2012
rpS6 regulates blood-testis barrier dynamics by affecting F-actin organization and protein recruitment (abstract) (HTML)
Mok,Ka-Wai; Mruk,Dolores D.; Silvestrini,Bruno; Cheng,Chuen-yan
Endocrinology 153(10): 5036-5048
Publication date: 2012
Spermatogonial stem cells alone are not sufficient to re-initiate spermatogenesis in the rat testis following adjudin-induced infertility (abstract) (PDF) (HTML)
Mok,Ka-Wai; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
International Journal of Andrology 35(1): 86-101
Publication date: 2012
The biology of interleukin-1: Emerging concepts in the regulation of the actin cytoskeleton and cell junction dynamics (abstract) (HTML)
Lie,Pearl P.Y.; Cheng,Chuen-yan; Mruk,Dolores D.
Cellular and Molecular Life Sciences 69(4): 487-500
Publication date: 2012
The blood-testis barrier and its implications for male contraception (abstract) (PDF) (HTML)
Cheng,Chuen-yan; Mruk,Dolores D.
Pharmacological Reviews 64(1): 16-64
Publication date: 2012
The Scribble/Lgl/Dlg polarity protein complex is a regulator of blood-testis barrier dynamics and spermatid polarity during spermatogenesis (abstract) (HTML)
Su,Wenhui; Wong,Elissa W.P.; Mruk,Dolores D.; Cheng,Chuen-yan
Endocrinology 153(12): 6041-6053
Publication date: 2012
Tumor necrosis factor α-mediated restructuring of the Sertoli cell barrier in vitro involves matrix metalloprotease 9 (MMP9), membrane-bound intercellular adhesion molecule-1 (ICAM-1) and the actin cytoskeleton (abstract) (PDF) (HTML)
Lydka,Marta; Bilinska,Barbara; Cheng,Chuen-yan; Mruk,Dolores D.
Spermatogenesis 2(4): 294-303
Publication date: 2012
Users' and providers' perspectives on MPTs: What do we know, and what do we need to know? (PDF)
Presentation at Multipurpose Prevention Technologies for Reproductive Health, New Delhi, India, 11-12 December
Brady,Martha
Publication date: 2012
What have we learned from other reproductive health technologies? (PDF)
Presentation at Multipurpose Prevention Technologies for Reproductive Health, New Delhi, India, 11-12 December
Brady,Martha
Publication date: 2012
7α-methyl-19-nortestosterone vs. testosterone implants for hypogonadal osteoporosis: A preclinical study in the aged male orchidectomized rat model (abstract) (HTML)
Sinnasael,M.; Callewaert,F.; Morreels,M.; Kumar,Narender; Sitruk-Ware,Regine; Van Proeyen,K.; Hespel,P.; Boonen,Steven; Claessens,F.; Vanderschueren,Dirk
International Journal of Andrology 34(6 pt 2): 601-611
Publication date: 2011
A study to assess the assembly of a functional blood-testis barrier in developing rat testes (abstract) (PDF)
Mok,Ka-Wai; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Spermatogenesis 1(3): 270-280
Publication date: 2011
Actin-binding protein drebrin E is involved in junction dynamics during spermatogenesis (abstract) (PDF)
Li,Michelle W.M.; Xiao,Xiang; Mruk,Dolores D.; Lam,Yee-ling; Lee,Will M.; Lui,Wing-Yee; Bonanomi,Michele; Silvestrini,Bruno; Cheng,Chuen-yan
Spermatogenesis 1(2): 123-136
Publication date: 2011
Adjudin disrupts spermatogenesis via the action of some unlikely partners: Eps8, Arp2/3 complex, drebrin E, PAR6 and 14-3-3 (abstract) (PDF)
Cheng,Chuen-yan; Lie,Pearl P.Y.; Wong,Elissa W.P.; Mruk,Dolores D.; Silvestrini,Bruno
Spermatogenesis 1(4): 291-291
Publication date: 2011
Adjudin, a potential male contraceptive, exerts its effects locally in the seminiferous epithelium of mammalian testes (abstract) (HTML)
Mok,Ka-Wai; Mruk,Dolores D.; Lie,Pearl P.Y.; Lui,Wing-Yee; Cheng,Chuen-yan
Reproduction 141(5): 571-580
Publication date: 2011
An in vitro system to study Sertoli cell blood-testis barrier dynamics (abstract) (HTML)
Mruk,Dolores D.; Cheng,Chuen-yan
Methods in Molecular Biology 763: 237-252
Publication date: 2011
Cancer/testis (CT) antigens, carcinogenesis and spermatogenesis (abstract) (PDF)
Cheng,Yan Ho; Wong,Elissa W.P.; Cheng,Chuen-yan
Spermatogenesis 1(3): 209-220
Publication date: 2011
Characterization and functionality of proliferative human Sertoli cells (abstract) (HTML)
Chui,Kitty; Trivedi,Alpa; Cheng,Chuen-yan; Cherbavaz,Diana B.; Dazin,Paul F.; Huynh,Ai Lam Thu; Mitchell,James B.; Rabinovitch,Gabriel A.; Noble-Haeusslein,Linda J.; John,Constance M.
Cell Transplantation 20(5): 619-635
Publication date: 2011
c-Yes regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization in the seminiferous epithelium of rat testes (abstract) (HTML)
Xiao,Xiang; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
International Journal of Biochemistry and Cell Biology 43(4): 651-665
Publication date: 2011
Day of dialogue on multipurpose prevention technologies: Toward clarity in nomenclature (PDF)
Brady,Martha; McGrory,C.Elizabeth
Meeting notes
Publication date: 2011
Desmosomes in the testis: Moving into an unchartered territory (abstract) (HTML)
Mruk,Dolores D.; Cheng,Chuen-yan
Spermatogenesis 1(1): 47-51
Publication date: 2011
Drug transporters and blood-testis barrier function (abstract) (PDF) (HTML)
Su,Linlin; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Journal of Endocrinology 209(3): 337-351
Publication date: 2011
Drug transporters, the blood-testis barrier, and spermatogenesis (abstract) (HTML)
Su,Linlin; Mruk,Dolores D.; Cheng,Chuen-yan
Journal of Endocrinology 208(3): 207-223
Publication date: 2011
Effects of methoxychlor and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 3ß-hydroxysteroid dehydrogenase and 17ß-hydroxysteroid dehydrogenase-3 activities in human and rat testes (abstract) (HTML)
Hu,Guo-Xin; Zhao,Binghai; Chu,Yanhui; Li,X.H.; Akingbemi,Benson T.; Zheng,Zhi-Qiang; Ge,Renshan
International Journal of Andrology 34(2): 138-144
Publication date: 2011
Emerging role for drug transporters at the blood-testis barrier (abstract) (HTML)
Mruk,Dolores D.; Su,Linlin; Cheng,Chuen-yan
Trends in Pharmacological Science 32(2): 99-106
Publication date: 2011
Enhanced chemiluminescence (ECL) for routine immunoblotting. An inexpensive alternative to commercially available kits (abstract) (PDF)
Mruk,Dolores D.; Cheng,Chuen-yan
Spermatogenesis 1(2): 121-122
Publication date: 2011
Environmental contaminants: Is male reproductive health at risk? (abstract) (PDF)
Mruk,Dolores D.; Cheng,Chuen-yan
Spermatogenesis 1(4): 283-290
Publication date: 2011
Environmental inhibitors of 11ß-hydroxysteroid dehydrogenase type 2 (abstract) (HTML)
Ma,Xue; Lian,Qing-Quan; Dong,Qiang; Ge,Renshan
Toxicology 285(3): 83-89
Publication date: 2011
Environmental toxicants and male reproductive function (abstract) (HTML)
Cheng,Chuen-yan; Wong,Elissa W.P.; Lie,Pearl P.Y.; Li,Michelle W.M.; Su,Linlin; Siu,Erica R.; Yan,Helen H.N.; Mannu,J.; Mathur,Premendu P.; Bonanomi,Michele; Silvestrini,Bruno; Mruk,Dolores D.
Spermatogenesis 1(1): 2-13
Publication date: 2011
Facilitating regulatory approval of multipurpose prevention technologies for sexual and reproductive health (PDF)
Brady,Martha
Brief
Publication date: 2011
Hormonal influences in multiple sclerosis: New therapeutic benefits for steroids (abstract) (HTML)
El-Etr,Martine; Ghoumari,Abdel M.; Sitruk-Ware,Regine; Schumacher,Michael
Maturitas 68(1): 47-51
Publication date: 2011
Impacts of environmental toxicants on male reproductive dysfunction (abstract) (HTML)
Wong,Elissa W.P.; Cheng,Chuen-yan
Trends in Pharmacological Science 32(5): 290-299
Publication date: 2011
Interleukin-1α is a regulator of the blood-testis barrier (abstract) (PDF) (HTML)
Lie,Pearl P.Y.; Cheng,Chuen-yan; Mruk,Dolores D.
FASEB Journal 25(4): 1244-1253
Publication date: 2011
Metabolic effects of contraceptive steroids (abstract) (HTML)
Sitruk-Ware,Regine; Nath,Anita
Reviews in Endocrine and Metabolic Disorders 12(2): 63-75
Publication date: 2011
Microsurgical spermatocelectomy: Technique and outcomes of a novel surgical approach (abstract) (HTML)
Kauffman,Eric C.; Kim,Howard H.; Tanrikut,Cigdem; Goldstein,Marc
Journal of Urology 185(1): 238-242
Publication date: 2011
Mifepristone in combination with prostaglandins for termination of 10-16 weeks' gestation: A systematic review (abstract) (HTML)
Chen,Qiu-ju; Hou,Shu-ping; Meads,Catherine; Huang,Yong-mei; Hong,Qing-qing; Zhu,Hao-ping; Cheng,Li-nan
European Journal of Obstetrics & Gynecology and Reproductive Biology 159(2): 247-254
Publication date: 2011
Perinatal exposure to di-(2-ethylhexyl) phthalate leads to restricted growth and delayed lung maturation in newborn rats (abstract) (HTML)
Chen,Shang-Qin; Chen,Jin-Ni; Cai,Xiao-Hong; Chen,Guo-Rong; Gao,Yuan; Ge,Renshan; Wu,Hai-Shan; Lin,Zhen-Lang; Lin,Jing
Journal of Perinatal Medicine 38(5): 515-521
Publication date: 2011
P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK) (abstract) (PDF) (HTML)
Su,Linlin; Mruk,Dolores D.; Lui,Wing-Yee; Lee,William M.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 108(49): 19623-19628
Publication date: 2011
Polarity proteins and actin regulatory proteins are unlikely partners that regulate cell adhesion in the seminiferous epithelium during spermatogenesis (abstract) (HTML)
Cheng,Chuen-yan; Wong,Elissa W.P.; Lie,Pearl P.Y.; Mruk,Dolores D.; Xiao,Xiang; Li,Michelle W.M.; Lui,Wing-Yee; Lee,Will M.
Histology and Histopathology 26(11): 1465-1474
Publication date: 2011
Progesterone and nestorone facilitate axon remyelination: A role for progesterone receptors (abstract) (PDF)
Hussain,Rashad; El-Etr,Martine; Gaci,O.; Rakotomamonjy,J.; Macklin,Wendy B.; Kumar,Narender; Sitruk-Ware,Regine; Schumacher,Michael; Ghoumari,Abdel M.
Endocrinology 152(10): 3820-3831
Publication date: 2011
Regulation of spermiogenesis, spermiation and blood-testis barrier dynamics: Novel insights from studies on Eps8 and Arp3 (abstract) (HTML)
Cheng,Chuen-yan; Mruk,Dolores D.
Biochemical Journal 435(3): 553-562
Publication date: 2011
Role of 11ß-OH-C and C steroids in the coupling of 11ß-HSD1 and 17ß-HSD3 in regulation of testosterone biosynthesis in rat Leydig cells (abstract) (HTML)
Latif,Syed A.; Shen,Mae; Ge,Renshan; Sottas,Chantal M.; Hardy,Matthew P.; Morris,David J.
Steroids 76(7): 682-689
Publication date: 2011
Termination of second-trimester pregnancy by mifepristone combined with misoprostol versus intra-amniotic injection of ethacridine lactate (Rivanol®): A systematic review of Chinese trials (abstract) (HTML)
Hou,Shu-ping; Fang,Ai-hua; Chen,Qin-fang; Huang,Yong-mei; Chen,Qiu-ju; Cheng,Li-nan
Contraception 84(3): 214-223
Publication date: 2011
Testin and actin are key molecular targets of adjudin, an anti-spermatogenic agent, in the testis (abstract) (PDF)
Mruk,Dolores D.; Cheng,Chuen-yan
Spermatogenesis 1(2): 137-146
Publication date: 2011
The biology of the desmosome-like junction a versatile anchoring junction and signal transducer in the seminiferous epithelium (abstract) (HTML)
Lie,Pearl P.Y.; Cheng,Chuen-yan; Mruk,Dolores D.
International Review of Cell and Molecular Biology 286: 223-269
Publication date: 2011
The inhibition of human and rat 11ß-hydroxysteroid dehydrogenase 2 by perfluoroalkylated substances (abstract) (HTML)
Zhao,Binghai; Lian,Qing-Quan; Chu,Yanhui; Hardy,Dianne O.; Li,Xiao-Kun; Ge,Renshan
Journal of Steroid Biochemistry and Molecular Biology 125(1-2): 143-147
Publication date: 2011
The myotubularin family of lipid phosphatases in disease and in spermatogenesis (abstract) (PDF)
Mruk,Dolores D.; Cheng,Chuen-yan
Biochemical Journal 433(2): 253-262
Publication date: 2011
The ß1-integrin-p-FAK-p130Cas-DOCK180-RhoA-vinculin is a novel regulatory protein complex at the apical ectoplasmic specialization in adult rat testes (abstract) (HTML)
Siu,Michelle K.Y.; Wong,Ching-hang; Xia,Weiliang; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Spermatogenesis 1(1): 73-86
Publication date: 2011
What regulatory guidance exists for multipurpose prevention technologies (MPTs)? A review of key guidance documents and their applicability to MPTs (PDF)
Brady,Martha; Park,Heeyoung
Publication date: 2011
7α-hydroxytestosterone affects 11ß-hydroxysteroid dehydrogenase 1 direction in rat Leydig cells (abstract) (PDF) (HTML)
Hu,Guo-Xin; Lian,Qing-Quan; Chen,Bing-Bing; Vishwanath Prasad,Pramod; Kumar,Narender; Zheng,Zhi-Qiang; Ge,Renshan
Endocrinology 151(2): 748-754
Publication date: 2010
A Baby At Last! The Couples' Complete Guide to Getting Pregnant -- from Cutting-Edge Treatments to Commonsense Wisdom (PDF)
Rosenwaks,Zev R.; Goldstein,Marc; Fuerst,Mark L.
Publication date: 2010
A local autocrine axis in the testes that regulates spermatogenesis (HTML)
Cheng,Chuen-yan; Mruk,Dolores D.
Nature Reviews Endocrinology 6(7): 380-395
Publication date: 2010
Activation of the AMP activated protein kinase by short-chain fatty acids is the main mechanism underlying the beneficial effect of a high fiber diet on the metabolic syndrome (abstract) (HTML)
Hu,Guo-Xin; Chen,Guo-Rong; Hui,Xu; Ge,Renshan; Lin,Jing
Medical Hypotheses 74(1): 123-126
Publication date: 2010
Adjudin-mediated Sertoli-germ cell junction disassembly affects, Sertoli cell barrier function in vitro and in vivo (abstract) (HTML)
Su,Linlin; Cheng,Chuen-yan; Mruk,Dolores D.
International Journal of Biochemistry and Cell Biology 42(11): 1864-1875
Publication date: 2010
Cell junctions in the testis as targets for toxicants
Wong,Elissa W.P.; Yan,Helen H.N.; Li,Michelle W.M.; Lie,Pearl P.Y.; Mruk,Dolores D.; Cheng,Chuen-yan; Richburg,J.H.; Hoyer,P.; McQueen,Charlene
Comprehensive Toxicology 11, pp. 167-188
Publication date: 2010
Claudin and occludin expression and function in the seminiferous epithelium (abstract) (PDF) (HTML)
Morrow,C.M.; Mruk,Dolores D.; Cheng,Chuen-yan; Hess,R.A.
Philosophical Transactions of the Royal Society of London, Series B, Biological Sciences 365(1546): 1679-1696
Publication date: 2010
Clinically relevant progestins regulate neurogenic and neuroprotective responses in vitro and in vivo (abstract) (PDF)
Liu,Lifei; Zhao,Ligin; She,Hongyun; Chen,Shuhua; Ming Wang,Jun; Wong,Charisse; McClure,Kelsey; Sitruk-Ware,Regine; Diaz Brinton,Roberta
Endocrinology 151(12): 5782-5794
Publication date: 2010
Connexin 43 is critical to maintain the homeostasis of the blood-testis barrier via its effects on tight junction reassembly (abstract) (PDF) (HTML)
Li,Michelle W.M.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 107(42): 17998-18003
Publication date: 2010
Curcumin derivatives inhibit testicular 17ß-hydroxysteroid dehydrogenase 3 (abstract) (HTML)
Hu,Guo-Xin; Liang,Guang; Chu,Yanhui; Li,Xiao-Kun; Lian,Qing-Quan; Lin,Han; He,Yi; Huang,Yadong; Hardy,Dianne O.; Ge,Renshan
Bioorganic and Medicinal Chemistry Letters 20(8): 2549-2551
Publication date: 2010
Cytoskeletal dynamics and spermatogenesis (abstract) (PDF) (HTML)
Lie,Pearl P.Y.; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Philosophical Transactions of the Royal Society of London, Series B, Biological Sciences 365(1546): 1581-1592
Publication date: 2010
Deletion of the Igf1 gene: Suppressive effects on adult Leydig cell development (abstract) (PDF) (HTML)
Hu,Guo-Xin; Lin,Han; Chen,Guo-Rong; Chen,Bing-Bing; Lian,Qing-Quan; Hardy,Dianne O.; Zirkin,Barry R.; Ge,Renshan
Journal of Andrology 31(4): 379-387
Publication date: 2010
Differential effects of testosterone and TGF-ß3 on endocytic vesicle-mediated protein trafficking events at the blood-testis barrier (abstract) (HTML)
Su,Linlin; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Experimental Cell Research 316(17): 2945-2960
Publication date: 2010
Endometrial effect of progesterone delivered by vaginal rings in estrogen-treated postmenopausal women (abstract) (HTML)
Noe,Gabriela; Sitruk-Ware,Regine; Zegers-Hochschild,F.; Variano,B.; Montero,Juan Carlos; Arriagada,P.; Li,A.; Stanczyk,Frank Z.; Felix,J.C.; Mishell,Daniel R.,Jr.; Croxatto,Horacio B.
Climacteric 13(5): 433-441
Publication date: 2010
Glucocorticoid suppresses steroidogenesis in rat progenitor Leydig cells (abstract) (PDF) (HTML)
Xiao,Ye-Chen; Huang,Ya-Dong; Hardy,Dianne O.; Li,Xiao-Kun; Ge,Renshan
Journal of Andrology 31(4): 365-371
Publication date: 2010
Infertility: The male
Kim,Howard H.; Schlegel,Peter N.; Goldstein,Marc; Legato,Marianne J.
from Principles of Gender-Specific Medicine, pp. 366-380
Publication date: 2010
Inhibition of 3ß- and 17ß-hydroxysteroid dehydrogenase activities in rat Leydig cells by perfluorooctane acid (abstract) (HTML)
Zhao,Binghai; Chu,Yanhui; Hardy,Dianne O.; Li,Xiao-Kun; Ge,Renshan
Journal of Steroid Biochemistry and Molecular Biology 118(1-2): 13-17
Publication date: 2010
Inhibition of LH-stimulated androgen production in rat immature Leydig cells: Effects on nuclear receptor steroidogenic factor 1 by FGF2 (abstract) (HTML)
Xiao,Ye-Chen; Hardy,Dianne O.; Sottas,Chantal M.; Li,Xiao-Kun; Ge,Renshan
Growth Factors 28(1): 1-9
Publication date: 2010
Intrauterine administration of CDB-2914 (Ulipristal) suppresses the endometrium of rhesus macaques (abstract) (HTML)
Brenner,Robert M.; Slayden,Ov D.; Nath,Anita; Tsong,Yun-yen; Sitruk-Ware,Regine
Contraception 81(4): 336-342
Publication date: 2010
Male circumcision: Africa and beyond? (abstract) (HTML)
Kim,Howard H.; Li,Philip S.; Goldstein,Marc
Current Opinion in Urology 20(6): 515-519
Publication date: 2010
No-needle local anesthesia for adult male circumcision (abstract) (HTML)
Peng,Yifeng; Masson,Puneet; Li,Philip S.; Chang,Yue; Tian,Long; Lee,Richard; Kim,Howard H.; Sokal,David C.; Goldstein,Marc
Journal of Urology 184(3): 978-983
Publication date: 2010
Regulation of blood-testis barrier dynamics by TGF-ß3 is a Cdc42-dependent protein trafficking event (abstract) (PDF) (HTML)
Wong,Elissa W.P.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 107(25): 11399-11404
Publication date: 2010
Regulation of spermatogenesis in the microenvironment of the seminiferous epithelium: New insights and advances (abstract) (HTML)
Cheng,Chuen-yan; Wong,Elissa W.P.; Yan,Helen H.N.; Mruk,Dolores D.
Molecular and Cellular Endocrinology 315(1-2): 49-56
Publication date: 2010
Restricted Arp3 expression in the testis prevents blood-testis barrier disruption during junction restructuring at spermatogenesis (abstract) (PDF) (HTML)
Lie,Pearl P.Y.; Chan,Apple Y.N.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 107(25): 11411-11416
Publication date: 2010
Sertoli-germ cell junctions in the testis: A review of recent data (abstract) (PDF) (HTML)
Kopera,Ilona A.; Bilinska,Barbara; Cheng,Chuen-yan; Mruk,Dolores D.
Philosophical Transactions of the Royal Society of London, Series B, Biological Sciences 365(1546): 1593-1605
Publication date: 2010
Single-dose Pharmacokinetics of Nestorone, a potential female-contraceptive (abstract) (HTML)
Vishwanath Prasad,Pramod; Bashir,Mohammad; Sitruk-Ware,Regine; Kumar,Narender
Steroids 75(3): 252-264
Publication date: 2010
Sperm structure acts as protein gate (PDF)
Population Briefs 16(1)
Publication date: 2010
Structure-dependent inhibition of human and rat 11ß-hydroxysteroid dehydrogenase 2 activities by phthalates (abstract) (HTML)
Zhao,Binghai; Chu,Yanhui; Huang,Ya-Dong; Hardy,Dianne O.; Lin,Shaoqiang; Ge,Renshan
Chemico-Biological Interactions 183(1): 79-84
Publication date: 2010
Surgery for male infertility - Varicocelectomy and its alternatives
Kim,Howard H.; Goldstein,Marc
from Clinical Andrology: EAU/ESAU Course Guidelines, pp. 105-115
Publication date: 2010
The biology of spermatogenesis: The past, present and future (abstract) (HTML)
Cheng,Chuen-yan; Mruk,Dolores D.
Philosophical Transactions of the Royal Society of London, Series B, Biological Sciences 365(1546): 1459-1463
Publication date: 2010
Tight junctions in the testis: New perspectives (abstract) (PDF) (HTML)
Mruk,Dolores D.; Cheng,Chuen-yan
Philosophical Transactions of the Royal Society of London, Series B, Biological Sciences 365(1546): 1621-1635
Publication date: 2010
Varicocele repair for treatment of androgen deficiency (abstract) (HTML)
Tanrikut,Cigdem; Goldstein,Marc
Current Opinion in Urology 20(6): 500-502
Publication date: 2010
14-3-3 and its binding partners are regulators of protein-protein interactions during spermatogenesis (abstract) (PDF) (HTML)
Sun,Shengyi; Wong,Elissa W.P.; Li,Michelle W.M.; Lee,Will M.; Cheng,Chuen-yan
Journal of Endocrinology 202(3): 327-336
Publication date: 2009
14-3-3 protein regulates cell adhesion in the seminiferous epithelium of rat testes (abstract) (PDF) (HTML)
Wong,Elissa W.P.; Sun,Shengyi; Li,Michelle W.M.; Lee,Will M.; Cheng,Chuen-yan
Endocrinology 150(10): 4713-4723
Publication date: 2009
A decision analysis of treatments for nonobstructive azoospermia associated with varicocele (abstract) (HTML)
Lee,Richard; Li,Philip S.; Goldstein,Marc; Schattman,Glenn; Schlegel,Peter N.
Fertility and Sterility 92(1): 188-196
Publication date: 2009
A review of the pharmacokinetic and pharmacological properties of a once-yearly administered histrelin acetate implant in the treatment of prostate cancer (PDF)
Schlegel,Peter N.
BJU International 103(s2): 7-13
Publication date: 2009
Activins regulate 17ß-hydroxysteroid dehydrogenase type I transcription in murine gonadotrope cells (abstract) (PDF) (HTML)
Bak,Beata; Carpio,Laura; Kipp,Jinjing L.; Lamba,Pankaj; Wang,Ying; Ge,Renshan; Hardy,Matthew P.; Mayo,Kelly E.; Bernard,Daniel J.
Journal of Endocrinology 201(1): 89-104
Publication date: 2009
Adjudin targeting rabbit germ cell adhesion as a male contraceptive: A pharmacokinetics study (abstract) (PDF) (HTML)
Hu,Guo-Xin; Hu,Lu-Feng; Yang,Dai-Zheng; Li,Jun-Wei; Chen,Guo-Rong; Chen,Bing-Bing; Mruk,Dolores D.; Bonanomi,Michele; Silvestrini,Bruno; Cheng,Chuen-yan; Ge,Renshan
Journal of Andrology 30(1): 87-93
Publication date: 2009
Adverse effect of paroxetine on sperm (abstract) (HTML)
Tanrikut,Cigdem; Feldman,Adam S.; Altemus,Margaret; Paduch,Darius A.; Schlegel,Peter N.
Fertility and Sterility 94(3): 1021-1026
Publication date: 2009
An in vivo study on adjudin and blood-testis barrier dynamics (abstract) (PDF) (HTML)
Kopera,Ilona A.; Su,Linlin; Bilinska,Barbara; Cheng,Chuen-yan; Mruk,Dolores D.
Endocrinology 150(10): 4724-4733
Publication date: 2009
An intracellular trafficking pathway in the seminiferous epithelium regulating spermatogenesis: A biochemical and molecular perspective (abstract) (PDF) (HTML)
Cheng,Chuen-yan; Mruk,Dolores D.
Critical Reviews in Biochemistry and Molecular Biology 44(5): 245-263
Publication date: 2009
An occludin-focal adhesion kinase protein complex at the blood-testis barrier: A study using the cadmium model (abstract) (PDF) (HTML)
Siu,Erica R.; Wong,Elissa W.P.; Mruk,Dolores D.; Sze,K.L.; Porto,Catarina S.; Cheng,Chuen-yan
Endocrinology 150(7): 3336-3344
Publication date: 2009
Cadmium-induced testicular injury (abstract) (HTML)
Siu,Erica R.; Mruk,Dolores D.; Porto,Catarina S.; Cheng,Chuen-yan
Toxicology and Applied Pharmacology 238(3): 240-249
Publication date: 2009
Central modifications of allopregnanolone and ß-endorphin following subcutaneous administration of Nestorone (abstract) (HTML)
Lenzi,E.; Pluchino,N.; Begliuomini,S.; Casarosa,E.; Merlini,S.; Giannini,A.; Luisi,M.; Kumar,Narender; Sitruk-Ware,Regine; Genazzani,Andrea R.
Journal of Steroid Biochemistry and Molecular Biology 116(1-2): 15-20
Publication date: 2009
Characterization of a novel gain of function glucocorticoid receptor knock-in mouse (abstract) (PDF) (HTML)
Zhang,Junhui; Ge,Renshan; Matte-Martone,Catherine; Goodwin,Julie; Shlomchik,Warren D.; Mamula,Mark J.; Kooshkabadi,Ali; Hardy,Matthew P.; Geller,David
Journal of Biological Chemistry 284(10): 6249-6259
Publication date: 2009
Connexin 43 and plakophilin-2 as a protein complex that regulates blood-testis barrier dynamics (abstract) (PDF) (HTML)
Li,Michelle W.M.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 106(25): 10213-10218
Publication date: 2009
Coordinating cellular events during spermatogenesis: A biochemical model (abstract) (HTML)
Lie,Pearl P.Y.; Cheng,Chuen-yan; Mruk,Dolores D.
Trends in Biochemical Sciences 34(7): 366-373
Publication date: 2009
Cytokines and junction restructuring events during spermatogenesis in the testis: An emerging concept of regulation (abstract) (HTML)
Li,Michelle W.M.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Cytokine and Growth Factor Reviews 20(4): 329-338
Publication date: 2009
Deprival of testicular innervation induces apoptosis of Leydig cells via caspase-8-dependent signaling: A novel survival pathway revealed (abstract) (HTML)
Gong,Yong-Guang; Wang,Yi-Qiu; Gu,Min; Feng,Ming-Ming; Zhang,Wei; Ge,Renshan
Biochemical and Biophysical Research Communication 382(1): 165-170
Publication date: 2009
Disruption of the blood-testis barrier integrity by bisphenol A in vitro: Is this a suitable model for studying blood-testis barrier dynamics? (abstract) (HTML)
Li,Michelle W.M.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
International Journal of Biochemistry and Cell Biology 41(11): 2302-2314
Publication date: 2009
Distribution, metabolism and excretion of a synthetic androgen 7α-methyl-19-nortestosterone, a potential male-contraceptive (abstract) (HTML)
Vishwanath Prasad,Pramod; Arumugam,Ramamani; Willman,Mark; Ge,Renshan; Sitruk-Ware,Regine; Kumar,Narender
Steroids 74(1): 121-131
Publication date: 2009
Drug transporter, P-glycoprotein (MDR1), is an integrated component of the mammalian blood-testis barrier (abstract) (HTML)
Su,Linlin; Cheng,Chuen-yan; Mruk,Dolores D.
International Journal of Biochemistry and Cell Biology 41(12): 2578-2587
Publication date: 2009
Epidermal growth factor receptor pathway substrate 8 (Eps8) is a novel regulator of cell adhesion and the blood-testis barrier integrity in the seminiferous epithelium (abstract) (PDF) (HTML)
Lie,Pearl P.Y.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
FASEB Journal 23(8): 2555-2567
Publication date: 2009
Evaluation of male infertility (abstract) (HTML)
Schlegel,Peter N.
Minerva Ginecologica 61(4): 261-283
Publication date: 2009
Extracellular matrix and its role in spermatogenesis (abstract) (HTML)
Siu,Michelle K.Y.; Cheng,Chuen-yan
Advances in Experimental Medicine and Biology 636: 74-91
Publication date: 2009
Focal adhesion kinase is a blood-testis barrier regulator (abstract) (PDF) (HTML)
Siu,Erica R.; Wong,Elissa W.P.; Mruk,Dolores D.; Porto,Catarina S.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 106(23): 9298-9303
Publication date: 2009
High serum FSH levels in men with nonobstructive azoospermia does not affect success of microdissection testicular sperm extraction (abstract) (HTML)
Ramasamy,Ranjith; Lin,Kathleen; Veeck Gosden,Lucinda; Rosenwaks,Zev R.; Palermo,Gianpiero D.; Schlegel,Peter N.
Fertility and Sterility 92(2): 590-593
Publication date: 2009
In utero and lactational exposures to diethylhexyl-phthalate affect two populations of Leydig cells in male Long-Evans rats (abstract) (PDF) (HTML)
Lin,Han; Lian,Qing-Quan; Hu,Guo-Xin; Jin,Yuan; Zhang,Yunhui; Hardy,Dianne O.; Chen,Guo-Rong; Lu,Zhong-Qiu; Sottas,Chantal M.; Hardy,Matthew P.; Ge,Renshan
Biology of Reproduction 80(5): 882-888
Publication date: 2009
Increased proliferation but decreased steroidogenic capacity in Leydig cells from mice lacking cyclin-dependent kinase inhibitor 1B (abstract) (PDF) (HTML)
Lin,Han; Hu,Guo-Xin; Dong,Lei; Dong,Qiang; Mukai,Motoko; Chen,Bing-Bing; Holsberger,Denise R.; Sottas,Chantal M.; Cooke,Paul S.; Lian,Qing-Quan; Li,Xiao-Kun; Ge,Renshan
Biology of Reproduction 80(6): 1232-1238
Publication date: 2009
Leydig cells: From stem cells to aging (abstract) (HTML)
Chen,Haolin; Ge,Renshan; Zirkin,Barry R.
Molecular and Cellular Endocrinology 306(1-2): 9-16
Publication date: 2009
Male infertility in the era of ART: Why treat; how to treat (HTML)
Goldstein,Marc; Rosenwaks,Zev R.
Seminars in Reproductive Medicine 27(2): 107-108
Publication date: 2009
Methods for female contraception: A model for innovation in drug delivery systems (abstract) (HTML)
Merkatz,Ruth B.; Tokay,Barbara A.; Sitruk-Ware,Regine
Clinical Pharmacology and Therapeutics 85(5): 553-557
Publication date: 2009
Mitogen-activated protein kinases in male reproductive function (abstract) (HTML)
Li,Michelle W.M.; Mruk,Dolores D.; Cheng,Chuen-yan
Trends in Molecular Medicine 15(4): 159-168
Publication date: 2009
Mono-(2-ethylhexyl) phthalate (MEHP) regulates glucocorticoid metabolism through 11ß-hydroxysteroid dehydrogenase 2 in murine gonadotrope cells (abstract) (HTML)
Hong,Dun; Li,Xing-Wang; Lian,Qing-Quan; Lamba,Pankaj; Bernard,Daniel J.; Hardy,Dianne O.; Chen,Hai-Xiao; Ge,Renshan
Biochemical and Biophysical Research Communication 389(2): 305-309
Publication date: 2009
Nitric oxide and cyclic nucleotides: their roles in junction dynamics and spermatogenesis (abstract) (HTML)
Lee,Nikki P.Y.; Cheng,Chuen-yan
Advances in Experimental Medicine and Biology 636: 172-185
Publication date: 2009
Nonobstructive azoospermia: A revolutionary surgical approach and results (abstract) (HTML)
Schlegel,Peter N.
Seminars in Reproductive Medicine 27(2): 165-170
Publication date: 2009
Normal responses to restraint stress in mice lacking the gene for neuronal nitric oxide synthase (abstract) (PDF) (HTML)
Weissman,Ben-Avi; Sottas,Chantal M.; Holmes,Michael; Zhou,Ping; Iadecola,Costantino; Hardy,Dianne O.; Ge,Renshan; Hardy,Matthew P.
Journal of Andrology 30(5): 614-620
Publication date: 2009
Obstructive azoospermia: A microsurgical success story (abstract) (HTML)
Tanrikut,Cigdem; Goldstein,Marc
Seminars in Reproductive Medicine 27(2): 159-164
Publication date: 2009
Parenteral administration of progestins for hormonal replacement therapy (abstract) (HTML)
Nath,Anita; Sitruk-Ware,Regine
European Journal of Contraception and Reproductive Health Care 14(2): 88-96
Publication date: 2009
Peptidergic not monoaminergic fibers profusely innervate the young adult human testis (abstract) (PDF) (HTML)
Gong,Yong-Guang; Feng,Ming-Ming; Hu,Xiang-Nong; Wang,Yi-Qiu; Gu,Min; Zhang,Wei; Ge,Renshan
Journal of Anatomy 214(3): 330-338
Publication date: 2009
Pharmacology and clinical applications of selective estrogen receptor modulators (abstract) (HTML)
Nath,Anita; Sitruk-Ware,Regine
Climacteric 12(3): 188-205
Publication date: 2009
Phthalate levels and low birth weight: A nested case-control study of Chinese newborns (abstract) (PDF) (HTML)
Zhang,Yunhui; Lin,Ling; Cao,Yang; Chen,Bingheng; Zheng,Lixing; Ge,Renshan
Journal of Pediatrics 155(4): 500-504
Publication date: 2009
Phthalate-induced testicular dysgenesis syndrome: Leydig cell influence (abstract) (HTML)
Hu,Guo-Xin; Lian,Qing-Quan; Ge,Renshan; Hardy,Dianne O.; Li,Xiao-Kun
Trends in Endocrinology and Metabolism 20(3): 139-145
Publication date: 2009
Polarity proteins and cell-cell interactions in the testis (abstract) (HTML)
Wong,Elissa W.P.; Cheng,Chuen-yan
International Review of Cell and Molecular Biology 278: 309-353
Publication date: 2009
RAB13 participates in ectoplasmic specialization dynamics in the rat testis (abstract) (PDF) (HTML)
Mruk,Dolores D.; Lau,Ann S.N.
Biology of Reproduction 80(3): 590-601
Publication date: 2009
Regulation of blood-testis barrier dynamics by focal adhesion kinase (FAK): An unexpected turn of events (abstract) (PDF)
Cheng,Chuen-yan; Mruk,Dolores D.
Cell Cycle 8(21): 3493-3499
Publication date: 2009
Study finds link between phthalates and low birth weight (PDF)
Population Briefs 15(1)
Publication date: 2009
Successful fertility treatment for Klinefelter's syndrome (abstract) (HTML)
Ramasamy,Ranjith; Ricci,Joseph A.; Palermo,Gianpiero D.; Veeck Gosden,Lucinda; Rosenwaks,Zev R.; Schlegel,Peter N.
Journal of Urology 182(3): 1108-1113
Publication date: 2009
Testicular cell junction: A novel target for male contraception
(abstract) (HTML)
Lee,Nikki P.Y.; Wong,Elissa W.P.; Mruk,Dolores D.; Cheng,Chuen-yan
Current Medicinal Chemistry 16(7): 906-915
Publication date: 2009
TGF-ß3 and TNFα perturb blood-testis barrier (BTB) dynamics by accelerating the clathrin-mediated endocytosis of integral membrane proteins: A new concept of BTB regulation during spermatogenesis (abstract) (PDF) (HTML)
Xia,Weiliang; Wong,Elissa W.P.; Mruk,Dolores D.; Cheng,Chuen-yan
Developmental Biology 327(1): 48-61
Publication date: 2009
The (+)- and (-)-gossypols potently inhibit human and rat 11ß-hydroxysteroid dehydrogenase type 2 (abstract) (HTML)
Chen,Bing-Bing; Lin,Han; Hu,Guo-Xin; Su,Ying; Zhou,Hong-Yu; Lian,Qing-Quan; Cai,Hui; Hardy,Dianne O.; Gu,Ding-Ying; Ge,Renshan
Journal of Steroid Biochemistry and Molecular Biology 113(3-5): 177-181
Publication date: 2009
The annulus of the mouse sperm tail is required to establish a membrane diffusion barrier that is engaged during the late steps of spermiogenesis (abstract) (PDF) (HTML)
Kwitny,Susanna; Klaus,Angela V.; Hunnicutt,Gary R.
Biology of Reproduction 82(4): 669-678
Publication date: 2009
Transcription regulation in spermatogenesis (abstract) (HTML)
Lui,Wing-Yee; Cheng,Chuen-yan
Advances in Experimental Medicine and Biology 636: 115-132
Publication date: 2009
Value of serum antisperm antibodies in diagnosing obstructive azoospermia (abstract) (HTML)
Lee,Richard; Goldstein,Marc; Ullery,Brant W.; Ehrlich,Joshua; Soares,Marc; Razzano,Renee A.; Herman,Michael; Callahan,Mark A.; Li,Philip S.; Schlegel,Peter N.; Witkin,Steve S.
Journal of Urology 181(1): 264-269
Publication date: 2009
"Construyendo sobre décadas de éxito: Lidereando la investigación sobre anticonceptivos y desarrollo de productos [Building on decades of success: Pioneering contraceptive research and products]," fact sheet (PDF)
Publication date: 2008
Adult varicocele (abstract) (HTML)
Kim,Howard H.; Goldstein,Marc
Current Opinion in Urology 18(6): 608-612
Publication date: 2008
An autocrine axis in the testis that coordinates spermiation and blood-testis barrier restructuring during spermatogenesis (abstract) (PDF) (HTML)
Yan,Helen H.N.; Mruk,Dolores D.; Wong,Elissa W.P.; Lee,Will M.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 105(26): 8950-8955
Publication date: 2008
Anchoring junctions as drug targets: Role in contraceptive development (abstract) (PDF) (HTML)
Mruk,Dolores D.; Silvestrini,Bruno; Cheng,Chuen-yan
Pharmacological Reviews 60(2): 146-180
Publication date: 2008
Biology and regulation of ectoplasmic specialization, an atypical adherens junction type, in the testis (abstract) (HTML)
Wong,Elissa W.P.; Mruk,Dolores D.; Cheng,Chuen-yan
Biochimica et Biophysica Acta--Biomembranes 1778(3): 692-708
Publication date: 2008
Blood-testis barrier dynamics are regulated by testosterone and cytokines via their differential effects on the kinetics of protein endocytosis and recycling in Sertoli cells (abstract) (PDF) (HTML)
Yan,Helen H.N.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
FASEB Journal 22(6): 1945-1959
Publication date: 2008
Comparative actions of progesterone, medroxyprogesterone acetate, drospirenone and nestorone on breast cancer cell migration and invasion (abstract) (PDF)
Fu,Xiao-Dong; Giretti,Maria Silva; Goglia,Lorenzo; Flamini,Marina Ines; Matias Sanchez,Angel; Baldacci,Chiara; Garibaldi,Silvia; Sitruk-Ware,Regine; Genazzani,Andrea R.; Simoncini,Tommaso
BMC Cancer 8: 166-
Publication date: 2008
Cross-talk between tight and anchoring junctions: Lesson from the testis (abstract) (HTML)
Yan,Helen H.N.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Advances in Experimental Medicine and Biology 636: 234-254
Publication date: 2008
Cyclic 3',5'-AMP causes ADAM1/ADAM2 to rapidly diffuse within the plasma membrane of guinea pig sperm (abstract) (PDF) (HTML)
Hunnicutt,Gary R.; Koppel,Dennis E.; Kwitny,Susanna; Cowan,Ann E.
Biology of Reproduction 79(5): 999-1007
Publication date: 2008
Delivering non-hormonal contraceptives to men: Advances and obstacles (abstract) (HTML)
Mruk,Dolores D.; Cheng,Chuen-yan
Trends in Biotechnology 26(2): 90-99
Publication date: 2008
Determinants of the rate and extent of spermatogenic suppression during hormonal male contraception: An integrated analysis (abstract) (PDF) (HTML)
Liu,Peter Y.; Swerdloff,Ronald S.; Anawalt,Bradley D.; Anderson,Richard A.; Bremner,William J.; Elliesen,Joerg; Gu,Yi-Qun; Kersemaekers,Wendy M.; McLachlan,Robert I.; Meriggiola,M.Christina; Nieschlag,Eberhard; Sitruk-Ware,Regine; Vogelsong,Kirsten M.; Wang,Xing-Hai; Wu,Frederick C.W.; Zitzmann,Michael; Handelsman,David J.; Wang,Christina
Journal of Clinical Endocrinology and Metabolism 93(5): 1774-1783
Publication date: 2008
Do sperm DNA integrity tests predict pregnancy with in vitro fertilization? (abstract) (HTML)
Collins,John; Barnhart,Kurt T.; Schlegel,Peter N.
Fertility and Sterility 89(4): 823-831
Publication date: 2008
Does estrogen therapy reduce coronary artery calcification in postmenopausal women? (HTML)
Sitruk-Ware,Regine
Nature Clinical Practice Endocrinology and Metabolism 4(1): 12-13
Publication date: 2008
Efficacy of Carraguard-based microbicides in vivo despite variable in vitro activity (abstract) (PDF)
Turville,Stuart G.; Aravantinou,Meropi; Miller,Todd; Kenney,Jessica; Teitelbaum,Aaron; Hu,Lieyu; Chudolij,Anne; Zydowsky,Thomas M.; Piatak Jr.,Michael; Bess Jr.,Julian W.; Lifson,Jeffrey D.; Blanchard,James; Gettie,Agegnehu; Robbiani,Melissa
PLoS ONE 3(9): e3162-
Publication date: 2008
Endocrine manipulation in male infertility (abstract) (HTML)
Kim,Howard H.; Schlegel,Peter N.
Urologic Clinics of North America 35(2): 303-318
Publication date: 2008
Identification and characterization of the minimal androgen-regulated kidney-specific kidney androgen-regulated protein gene promoter (abstract) (PDF) (HTML)
Fan,Liqiang; Hardy,Dianne O.; Catterall,James F.; Zhao,Jian; Li,Suxia
Acta Biochimica et Biophysica Sinica 40(12): 979-988
Publication date: 2008
Illuminating the mechanisms of sperm maturation (PDF)
Population Briefs 14(2)
Publication date: 2008
Incidental testicular lesions found during infertility evaluation are usually benign and may be managed conservatively (abstract) (HTML)
Eifler Jr.,John B.; King,Peggy; Schlegel,Peter N.
Journal of Urology 180(1): 261-265
Publication date: 2008
Inhibition of 11ß-hydroxysteroid dehydrogenase enzymatic activities by glycyrrhetinic acid in vivo supports direct glucocorticoid-mediated suppression of steroidogenesis in Leydig cells (abstract) (PDF) (HTML)
Hu,Guo-Xin; Lin,Han; Sottas,Chantal M.; Morris,David J.; Hardy,Matthew P.; Ge,Renshan
Journal of Andrology 29(3): 345-351
Publication date: 2008
Interleukin 1 Alpha (IL1A) is a novel regulator of the blood-testis barrier in the rat (abstract) (PDF) (HTML)
Sarkar,Oli; Mathur,Premendu P.; Cheng,Chuen-yan; Mruk,Dolores D.
Biology of Reproduction 78(3): 445-454
Publication date: 2008
Involvement of testicular growth factors in fetal Leydig cell aggregation after exposure to phthalate in utero (abstract) (PDF) (HTML)
Lin,Han; Ge,Renshan; Chen,Guo-Rong; Hu,Guo-Xin; Dong,Lei; Lian,Qing-Quan; Hardy,Dianne O.; Sottas,Chantal M.; Li,Xiao-Kun; Hardy,Matthew P.
Proceedings of the National Academy of Sciences of the United States of America 105(20): 7218-7222
Publication date: 2008
IUDs: A beneficial, underused contraceptive technology (PDF)
Population Briefs 14(1)
Publication date: 2008
Microbicide product development (abstract) (HTML)
Maguire,Robin A.
Current Opinion in HIV and AIDS 3(5): 554-557
Publication date: 2008
Microbicides (HTML)
Kaldor,John; Robbiani,Melissa
Current Opinion in HIV and AIDS 3(5)
Publication date: 2008
Microbicides: Chemistry, structure, and strategy (abstract) (HTML)
Zydowsky,Thomas M.
Current Opinion in HIV and AIDS 3(5): 548-553
Publication date: 2008
Modulation of 11ß-hydroxysteroid dehydrogenase expression by bombesin: A possible mechanism for glucocorticoid resistance in androgen independent prostate cancer (abstract) (HTML)
Lee,J.G.; Ge,Renshan; Hardy,Dianne O.; Leong,K.; Nanus,D.M.; Hardy,Matthew P.; Shen,R.
Hormone and Metabolic Research 40(11): 772-778
Publication date: 2008
Mono-(2-ethylhexyl) phthalate increases spermatocyte mitochondrial peroxiredoxin 3 and cyclooxygenase 2 (abstract) (PDF) (HTML)
Onorato,Thomas M.; Brown,Petrice W.; Morris,Patricia L.
Journal of Andrology 29(3): 293-303
Publication date: 2008
New contraceptive developments (PDF)
Momentum, December
Publication date: 2008
New perspectives in non-hormonal male contraception (abstract) (HTML)
Mruk,Dolores D.
Trends in Endocrinology and Metabolism 19(2): 57-64
Publication date: 2008
New vistas in contraceptive technology (abstract) (PDF)
RamaRao,Saumya; Sitruk-Ware,Regine; Townsend,John W.
Gender and Development 16(2): 327-344
Publication date: 2008
Par3/Par6 polarity complex coordinates apical ectoplasmic specialization and blood-testis barrier restructuring during spermatogenesis (abstract) (PDF) (HTML)
Wong,Elissa W.P.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 105(28): 9657-9662
Publication date: 2008
Progesterone and progestins: Neuroprotection and myelin repair (abstract) (HTML)
Schumacher,Michael; Sitruk-Ware,Regine; De Nicola,Alejandro
Current Opinion in Pharmacology 8(6): 740-746
Publication date: 2008
Progesterone receptor modulator CDB-2914 induces extracellular matrix metalloproteinase inducer in cultured human uterine leiomyoma cells (abstract) (PDF) (HTML)
Xu,Qin; Ohara,Noriyuki; Liu,Jin; Amano,Mariko; Sitruk-Ware,Regine; Yoshida,Shigeki; Maruo,Takeshi
Molecular Human Reproduction 14(3): 181-191
Publication date: 2008
Rapid mechanisms of glucocorticoid signaling in the Leydig cell (abstract) (HTML)
Hu,Guo-Xin; Lian,Qing-Quan; Lin,Han; Latif,Syed A.; Morris,David J.; Hardy,Matthew P.; Ge,Renshan
Steroids 73(9-10): 1018-1024
Publication date: 2008
Reassessing reconstruction in the management of obstructive azoospermia: Reconstruction or sperm acquisition? (abstract) (HTML)
Lee,Richard; Li,Philip S.; Schlegel,Peter N.; Goldstein,Marc
Urologic Clinics of North America 35(2): 289-301
Publication date: 2008
Rectal microbicides (abstract) (HTML)
McGowan,Ian; Anton,Peter
Current Opinion in HIV and AIDS 3(5): 593-598
Publication date: 2008
Resolution of de novo
HIV production and trafficking in immature dendritic cells (abstract) (HTML)
Turville,Stuart G.; Aravantinou,Meropi; Stoessel,Hella; Romani,Nikolaus; Robbiani,Melissa
Nature Methods 5(1): 75-85
Publication date: 2008
Small ubiquitin-related modifier (SUMO)-1, SUMO-2/3 and SUMOylation are involved with centromeric heterochromatin of chromosomes 9 and 1 and proteins of the synaptonemal complex during meiosis in men (abstract) (PDF)
Brown,Petrice W.; Hwang,KeumSil; Schlegel,Peter N.; Morris,Patricia L.
Human Reproduction 23(12): 2850-2857
Publication date: 2008
The outcome of intracytoplasmic sperm injection using occasional spermatozoa in the ejaculate of men with spermatogenic failure (abstract) (HTML)
Bendikson,Kristin A.; Neri,Queenie V.; Takeuchi,Takumi; Toschi,Marco; Schlegel,Peter N.; Rosenwaks,Zev R.; Palermo,Gianpiero D.
Journal of Urology 180(3): 1060-1064
Publication date: 2008
A seamless trespass: Germ cell migration across the seminiferous epithelium during spermatogenesis (abstract) (PDF) (HTML)
Wang,Claire Q.F.; Cheng,Chuen-yan
Journal of Cell Biology 178(4): 549-556
Publication date: 2007
An initial pharmacokinetic study with a Metered Dose Transdermal System® for delivery of the progestogen Nestorone® as a possible future contraceptive (abstract) (HTML)
Fraser,Ian S.; Weisberg,Edith; Kumar,Narender; Kumar,Sushma; Humberstone,Andrew J.; McCrossin,Louise; Shaw,Deborah; Tsong,Yun-yen; Sitruk-Ware,Regine
Contraception 76(6): 432-438
Publication date: 2007
Biphasic effects of postnatal exposure to diethylhexylphthalate on the timing of puberty in male rats (abstract) (PDF) (HTML)
Ge,Renshan; Chen,Guo-Rong; Dong,Qiang; Akingbemi,Benson T.; Sottas,Chantal M.; Santos,Michelle; Sealfon,Stuart C.; Bernard,Daniel J.; Hardy,Matthew P.
Journal of Andrology 28(4): 513-520
Publication date: 2007
Cellular localization of sphingomyelin synthase 2 in the seminiferous epithelium of adult rat testes (abstract) (PDF) (HTML)
Lee,Nikki P.Y.; Mruk,Dolores D.; Xia,Weiliang; Cheng,Chuen-yan
Journal of Endocrinology 192(1): 17-32
Publication date: 2007
Chemical postmaster helps deliver contraceptive to testis (PDF)
Population Briefs 13(1)
Publication date: 2007
Comparison of the impact of vaginal and oral administration of combined hormonal contraceptives on hepatic proteins sensitive to estrogen (abstract) (HTML)
Sitruk-Ware,Regine; Menard,Joel; Rad,Mandana; Burggraaf,Jacobus; de Kam,Marieke L.; Tokay,Barbara A.; Sivin,Irving; Kluft,Cornelius
Contraception 75(6): 430-437
Publication date: 2007
Coxsackie and adenovirus receptor (CAR) is a product of Sertoli and germ cells in rat testes which is localized at the Sertoli-Sertoli and Sertoli-germ cell interface (abstract) (HTML)
Wang,Claire Q.F.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Experimental Cell Research 313(7): 1373-1392
Publication date: 2007
C-type natriuretic peptide regulates blood-testis barrier dynamics in adult rat testes (abstract) (PDF) (HTML)
Xia,Weiliang; Mruk,Dolores D.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 104(10): 3841-3846
Publication date: 2007
Development of a cryopreservation protocol for Leydig cells (abstract) (PDF) (HTML)
Chen,Guo-Rong; Ge,Renshan; Lin,Han; Dong,Lei; Sottas,Chantal M.; Hardy,Matthew P.
Human Reproduction 22(8): 2160-2168
Publication date: 2007
Ectoplasmic specialization: A friend or a foe of spermatogenesis? (abstract) (HTML)
Yan,Helen H.N.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
BioEssays 29(1): 36-48
Publication date: 2007
Effects of estradiol with oral or intravaginal progesterone on risk markers for breast cancer in a postmenopausal monkey model (abstract) (HTML)
Wood,Charles E.; Sitruk-Ware,Regine; Tsong,Yun-yen; Register,Thomas C.; Lees,Cynthia J.; Cline,J.Mark
Menopause 14(4): 1-9
Publication date: 2007
Effects of levonorgestrel-releasing IUS and progesterone receptor modulator PRM CDB-2914 on uterine leiomyomas (abstract) (HTML)
Maruo,Takeshi; Ohara,Noriyuki; Matsuo,Hiroya; Xu,Qin; Chen,Wei; Sitruk-Ware,Regine; Johansson,Elof D.B.
Contraception 75(6S): S99-S103
Publication date: 2007
Effects of oral and transvaginal ethinyl estradiol on hemostatic factors and hepatic proteins in a randomized, cross-over study (abstract) (PDF) (HTML)
Sitruk-Ware,Regine; Plu-Bureau,Genevieve; Menard,Joel; Conard,Jacqueline; Kumar,Sushma; Thalaband,Jean-Christophe; Tokay,Barbara A.; Bouchard,Philippe
Journal of Clinical Endocrinology and Metabolism 92(6): 2074-2079
Publication date: 2007
G dynamics as a marker for membrane changes associated with the process of capacitation in murine and bovine spermatozoa (abstract) (PDF) (HTML)
Selvaraj,Vimal; Buttke,Danielle E.; Asano,Atsushi; McElwee,John L.; Wolff,Collin A.; Nelson,Jacquelyn L.; Klaus,Angela V.; Hunnicutt,Gary R.; Travis,Alexander J.
Journal of Andrology 28(4): 588-599
Publication date: 2007
Gene expression during development of fetal and adult Leydig cells (abstract) (HTML)
Dong,Lei; Jelinsky,Scott A.; Finger,Joshua N.; Johnston,Daniel S.; Kopf,Gregory S.; Sottas,Chantal M.; Hardy,Matthew P.; Ge,Renshan
Annals of the New York Academy of Sciences 1120: 16-35
Publication date: 2007
Hormone therapy effects on social behavior and activity levels of surgically postmenopausal cynomolgus monkeys (abstract) (HTML)
Shively,Carol A.; Wood,Charles E.; Register,Thomas C.; Willard,Stephanie L.; Lees,Cynthia J.; Chen,Haiying; Sitruk-Ware,Regine; Tsong,Yun-yen; Cline,J.Mark
Psychoneuroendocrinology 32(8-10): 981-990
Publication date: 2007
Innovative single-armed suture technique for microsurgical vasoepididymostomy (abstract) (HTML)
Monoski,Mara A.; Schiff,Jonathan D.; Li,Philip S.; Chan,Peter T.K.; Goldstein,Marc
Urology 69(4): 800-804
Publication date: 2007
Junction restructuring and spermatogenesis: The biology, regulation, and implication in male contraceptive development (abstract) (HTML)
Yan,Helen H.N.; Mruk,Dolores D.; Cheng,Chuen-yan
Current Topics in Developmental Biology 80: 57-92
Publication date: 2007
Pharmacokinetic study to compare the absorption and tolerability of two doses of levonorgestrel following single vaginal administration of levonorgestrel in Carraguard® gel: A new formulation for 'dual protection' contraception (abstract) (HTML)
Sitruk-Ware,Regine; Brache,Vivian; Maguire,Robin A.; Croxatto,Horacio B.; Kumar,Narender; Kumar,Sushma; Montero,Juan Carlos; Salvatierra,Ana Maria; Phillips,David M.; Faundes,Anibal
Contraception 75(6): 454-460
Publication date: 2007
Phthalate ester toxicity in Leydig cells: Developmental timing and dosage considerations (abstract) (HTML)
Ge,Renshan; Chen,Guo-Rong; Tanrikut,Cigdem; Hardy,Matthew P.
Reproductive Toxicology 23(3): 366-373
Publication date: 2007
Phthalates toxic to testosterone-producing cells (PDF)
Population Briefs 13(3)
Publication date: 2007
Preclinical and clinical properties of trimegestone: A potent and selective progestin (abstract) (HTML)
Sitruk-Ware,Regine; Bossemeyer,Ronald; Bouchard,Philippe
Gynecological Endocrinology 23(6): 310-319
Publication date: 2007
Rab4A GTPase-catenin interactions are involved in cell junction dynamics in the testis (abstract) (PDF) (HTML)
Mruk,Dolores D.; Lau,Ann S.N.; Sarkar,Oli; Xia,Weiliang
Journal of Andrology 28(5): 742-754
Publication date: 2007
Regulation of Leydig cells during pubertal development
Ge,Renshan; Hardy,Matthew P.; Payne,Anita H.
from The Leydig Cell in Health and Disease
Publication date: 2007
Routes of delivery for progesterone and progestins (abstract) (HTML)
Sitruk-Ware,Regine
Maturitas 57(1): 77-80
Publication date: 2007
Simultaneous vasectomy and varicocelectomy: Indications and technique (abstract) (HTML)
Lee,Richard; Li,Philip S.; Goldstein,Marc
Urology 70(2): 362-365
Publication date: 2007
Special issue on intrauterine devices and systems (abstract) (HTML)
Sitruk-Ware,Regine; Donaldson,Peter J.
Contraception 75(6S): S1-
Publication date: 2007
Targeted and reversible disruption of the blood-testis barrier by an FSH mutant-occludin peptide conjugate (abstract) (PDF) (HTML)
Wong,Ching-hang; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
FASEB Journal 21(2): 438-448
Publication date: 2007
Testosterone production in mice lacking inducible nitric oxide synthase expression is sensitive to restraint stress (abstract) (PDF) (HTML)
Weissman,Ben-Avi; Sottas,Chantal M.; Zhou,Ping; Iadecola,Costantino; Hardy,Matthew P.
American Journal of Physiology: Endocrinology and Metabolism (Translational Series) 292(2): E615-E620
Publication date: 2007
The changing position of IUDs in reproductive health services in developing countries: Opportunities and challenges (abstract) (HTML)
Townsend,John W.; Jacobstein,Roy
Contraception 75(6S): S35-S40
Publication date: 2007
The levonorgestrel intrauterine system for use in peri- and postmenopausal women (abstract) (HTML)
Sitruk-Ware,Regine
Contraception 75(6S): S155-S160
Publication date: 2007
The Leydig Cell in Health and Disease
Publication date: 2007
Unraveling the molecular targets pertinent to junction restructuring events during spermatogenesis using the Adjudin-induced germ cell depletion model (abstract) (PDF) (HTML)
Xia,Weiliang; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Journal of Endocrinology 192(3): 563-583
Publication date: 2007
Utility and drawbacks of continuous use of a copper T IUD for 20 years (abstract) (HTML)
Sivin,Irving
Contraception 75(6S): S70-S75
Publication date: 2007
"The one-year contraceptive ring: A technology in development," brochure (PDF)
Publication date: 2006
A male contraceptive targeting germ cell adhesion (abstract) (HTML)
Mruk,Dolores D.; Wong,Ching-hang; Silvestrini,Bruno; Cheng,Chuen-yan
Nature Medicine 12(11): 1323-1328
Publication date: 2006
A multistep kinase-based Sertoli cell autocrine-amplifying loop regulates prostaglandins, their receptors, and cytokines (abstract) (PDF) (HTML)
Ishikawa,Tomomoto; Morris,Patricia L.
Endocrinology 147(4): 1706-1716
Publication date: 2006
A novel class of small RNAs bind to MILI protein in mouse testes (abstract) (HTML)
Aravin,Alexei; Gaidatzis,Dimos; Pfeffer,Sebastien; Lagos-Quintana,Mariana; Landgraf,Pablo; Iovino,Nicola; Morris,Patricia L.; Brownstein,Michael J.; Kuramochi-Miyagawa,Satomi; Nakano,Toru; Chien,Minchen; Russo,James J.; Ju,Jingyue; Sheridan,Robert; Sander,Chris; Zavolan,Mihaela; Tuschl,Thomas
Nature 442(7099): 203-207
Publication date: 2006
A novel pathway involving progesterone receptor, endothelin-2, and endothelin receptor B controls ovulation in mice (abstract) (PDF) (HTML)
Palanisamy,Gopinath S.; Cheon,Yong-Pil; Kim,Jaeyeon; Kannan,Athilakshmi; Li,Quanxi; Sato,Marcey; Mantena,Srinivasa R.; Sitruk-Ware,Regine; Bagchi,Milan K.; Bagchi,Indrani C.
Molecular Endocrinology 20(11): 2784-2795
Publication date: 2006
Adjudin-mediated junction restructuring in the seminiferous epithelium leads to displacement of soluble guanylate cyclase from adherens junctions (abstract) (HTML)
Sarkar,Oli; Xia,Weiliang; Mruk,Dolores D.
Journal of Cellular Physiology 208(1): 175-187
Publication date: 2006
CDB-2914 may be an effective fibroid treatment (PDF)
Population Briefs 12(3)
Publication date: 2006
Comparative effects of a contraceptive vaginal ring delivering a nonandrogenic progestin and continuous ethinyl estradiol and a combined oral contraceptive containing levonorgestrel on hemostasis variables (abstract) (HTML)
Rad,Mandana; Kluft,Cornelius; Menard,Joel; Burggraaf,Jacobus; de Kam,Marieke L.; Meijer,Piet; Sivin,Irving; Sitruk-Ware,Regine
American Journal of Obstetrics and Gynecology 195(1): 72-77
Publication date: 2006
Contraception: An international perspective (abstract) (HTML)
Sitruk-Ware,Regine
Contraception 73(3): 215-222
Publication date: 2006
Correlation of ultrasound-measured venous size and reversal of flow with Valsalva with improvement in semen-analysis parameters after varicocelectomy (abstract) (HTML)
Schiff,Jonathan D.; Li,Philip S.; Goldstein,Marc
Fertility and Sterility 86(1): 250-252
Publication date: 2006
Council biologist discovers stem Leydig cells (PDF)
Population Briefs 12(2)
Publication date: 2006
Council researchers wrestle with SUMO (PDF)
Population Briefs 12(1)
Publication date: 2006
Cyclical mastalgia and breast cancer risk: Results of a French cohort study (abstract) (PDF) (HTML)
Plu-Bureau,Genevieve; Le,Monique G.; Sitruk-Ware,Regine; Thalaband,Jean-Christophe
Cancer Epidemiology Biomarkers & Prevention 15(6): 1229-1231
Publication date: 2006
Day of Dialogue on Public Sector Pricing of Pharmaceutical Products (PDF)
Duclayan,Gina
Report of a meeting
Publication date: 2006
Delineating the role of estrogen in regulating epididymal gene expression
Deshpande,Shayu; Hardy,Matthew P.; Rao,A.Jagannadha; Gupta,S.K.; Koyama,K.
from Gamete Biology, Society of Reproduction and Fertility
Publication date: 2006
Differential interactions between transforming growth factor-β3/TβR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion (abstract) (PDF) (HTML)
Xia,Weiliang; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Journal of Biological Chemistry 281(24): 16799-16813
Publication date: 2006
Dynamin II interacts with the cadherin- and occludin-based protein complexes at the blood-testis barrier in adult rat testes (abstract) (PDF) (HTML)
Lie,Pearl P.Y.; Xia,Weiliang; Wang,Claire Q.F.; Mruk,Dolores D.; Yan,Helen H.N.; Wong,Ching-hang; Lee,Will M.; Cheng,Chuen-yan
Journal of Endocrinology 191(3): 571-586
Publication date: 2006
Emergency contraception: A method every woman should know (abstract)
Khan,M.E.; Sebastian,Mary Philip
Total Health 1(7): 16-
Publication date: 2006
Haploinsufficiency at the protein kinase A RIα Gene Locus leads to fertility defects in male mice and men (abstract) (PDF) (HTML)
Burton,Kimberly A.; McDermott,Deborah A.; Wilkes,David; Poulsen,Melissa N.; Nolan,Michael A.; Goldstein,Marc; Basson,Craig T.; McKnight,G.Stanley
Molecular Endocrinology 20(10): 2504-2513
Publication date: 2006
In search of rat stem Leydig cells: Identification, isolation, and lineage-specific development (abstract) (PDF)
Ge,Renshan; Dong,Qiang; Sottas,Chantal M.; Papadopoulos,Vassilios; Zirkin,Barry R.; Hardy,Matthew P.
Proceedings of the National Academy of Sciences of the United States of America 103(8): 2719-2724
Publication date: 2006
Interleukin-1β signals through a c-Jun N-terminal kinase-dependent inducible nitric oxide synthase and nitric oxide production pathway in Sertoli epithelial cells (abstract) (PDF) (HTML)
Ishikawa,Tomomoto; Morris,Patricia L.
Endocrinology 147(11): 5424-5430
Publication date: 2006
Laminin α3 forms a complex with β3 and γ3 chains that serves as the ligand for α 6β1-integrin at the apical ectoplasmic specialization in adult rat testes (abstract) (PDF) (HTML)
Yan,Helen H.N.; Cheng,Chuen-yan
Journal of Biological Chemistry 281(25): 17286-17303
Publication date: 2006
Long-term administration of mifepristone (RU486): Clinical tolerance during extended treatment of meningioma (abstract) (HTML)
Grunberg,Steven M.; Weiss,Martin H.; Russell,Christy A.; Spitz,Irving M.; Ahmadi,Jamshid; Sadun,Alfredo; Sitruk-Ware,Regine
Cancer Investigation 24(8): 727-733
Publication date: 2006
Meeting explores pricing of pharmaceutical products (PDF)
Population Briefs 12(2)
Publication date: 2006
Microsurgical reconstruction of iatrogenic injuries to the epididymis from hydrocelectomy (abstract) (HTML)
Hopps,Carin V.; Goldstein,Marc
Journal of Urology 176(5): 2077-2080
Publication date: 2006
Mifepristone and misoprostol sequential regimen side effects, complications and safety (abstract) (HTML)
Sitruk-Ware,Regine
Contraception 74(1): 48-55
Publication date: 2006
New developments in the evaluation and management of the infertile male
Paduch,Darius A.; Goldstein,Marc; Rosenwaks,Zev R.; Oehninger,Sergio C.; Kruger,Thinus F.
from Male Infertility: Diagnosis and Treatment, pp. 453-460
Publication date: 2006
New progestagens for contraceptive use (abstract) (PDF)
Sitruk-Ware,Regine
Human Reproduction Update 12(2): 169-178
Publication date: 2006
No-scalpel, no-needle vasectomy (abstract) (HTML)
Monoski,Mara A.; Li,Philip S.; Baum,Neil D.; Goldstein,Marc
Urology 68(1): 9-14
Publication date: 2006
Progesterone receptor modulator CDB-2914 down-regulates vascular endothelial growth factor, adrenomedullin and their receptors and modulates progesterone receptor content in cultured human uterine leiomyoma cells (abstract) (PDF) (HTML)
Xu,Qin; Ohara,Noriyuki; Chen,Wei; Liu,Jin; Sasaki,Hiroko; Morikawa,Akira; Sitruk-Ware,Regine; Johansson,Elof D.B.; Maruo,Takeshi
Human Reproduction 21(9): 2408-2416
Publication date: 2006
Progestins and the brain, affects on sexuality and quality of life
Sitruk-Ware,Regine; Kumar,Narender
Proceedings of the 6th International Menopause Society (IMS) Workshop, Pisa, Italy
Publication date: 2006
SUMO-1, human male germ cell development and the androgen receptor in the testis of men with normal and abnormal spermatogenesis (abstract) (PDF) (HTML)
Vigodner,Margarita; Ishikawa,Tomomoto; Schlegel,Peter N.; Morris,Patricia L.
American Journal of Physiology: Endocrinology and Metabolism (Translational Series) 290(5): E1022-E1033
Publication date: 2006
Testicular cell dynamics and endocrine signaling (HTML)
Hardy,Matthew P.; Griswold,Michael D.
Annals of the New York Academy of Sciences 1061
Publication date: 2006
The levonorgestrel-releasing intrauterine system (Mirena®) (HTML)
Sitruk-Ware,Regine
Gynaecology Forum 11(2): 1-32
Publication date: 2006
The Sertoli-spermatid junctional complex adhesion strength is affected in vitro by adjudin (abstract) (PDF) (HTML)
Wolski,Katja M.; Mruk,Dolores D.; Cameron,Don F.
Journal of Andrology 27(6): 790-794
Publication date: 2006
Transition from Norplant to Jadelle in a clinic with extensive experience providing contraceptive implants (abstract) (HTML)
Brache,Vivian; Faundes,Anibal; Alvarez-Sanchez,Francisco; Garcia,Ana-Gloria
Contraception 73(4): 364-367
Publication date: 2006
Tumor necrosis factor reversibly disrupts the blood-testis barrier and impairs Sertoli-germ cell adhesion in the seminiferous epithelium of adult rat testes (abstract) (PDF) (HTML)
Li,Michelle W.M.; Xia,Weiliang; Mruk,Dolores D.; Wang,Claire Q.F.; Yan,Helen H.N.; Siu,Michelle K.Y.; Lui,Wing-Yee; Lee,Will M.; Cheng,Chuen-yan
Journal of Endocrinology 190(2): 313-329
Publication date: 2006
Varicocele: Size does matter (HTML)
Tanrikut,Cigdem; Goldstein,Marc
Journal of Urology 176(5): 1912-1913
Publication date: 2006
Visualization of Gwith cholera toxin B in live epididymal versus ejaculated bull, mouse, and human spermatozoa (abstract) (PDF) (HTML)
Buttke,Danielle E.; Nelson,Jacquelyn L.; Schlegel,Peter N.; Hunnicutt,Gary R.; Travis,Alexander J.
Biology of Reproduction 74(5): 889-895
Publication date: 2006
11β-hydroxysteroid dehydrogenase 2 in rat Leydig cells: Its role in blunting glucocorticoid action at physiological levels of substrate (abstract) (PDF) (HTML)
Ge,Renshan; Dong,Qiang; Niu,Enmei; Sottas,Chantal M.; Hardy,Dianne O.; Catterall,James F.; Latif,Syed A.; Morris,David J.; Hardy,Matthew P.
Endocrinology 146(6): 2657-2664
Publication date: 2005
AF-2364 [1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide] is a potential male contraceptive: A review of recent data (abstract) (HTML)
Cheng,Chuen-yan; Mruk,Dolores D.; Silvestrini,Bruno; Bonanomi,Michele; Wong,Ching-hang; Siu,Michelle K.Y.; Lee,Nikki P.Y.; Lui,Wing-Yee; Mo,Meng-Yun
Contraception 72(4): 251-261
Publication date: 2005
Altered prostatic epithelial proliferation and apoptosis, prostatic development and serum testosterone in mice lacking cyclin-dependent kinase inhibitors (abstract) (PDF) (HTML)
Mukai,Motoko; Dong,Qiang; Hardy,Matthew P.; Kiyokawa,Hiroaki; Peterson,Richard E.; Cooke,Paul S.
Biology of Reproduction 73(5): 951-958
Publication date: 2005
Blood-testis barrier dynamics are regulated by an engagement/disengagement mechanism between tight and adherens junctions via peripheral adaptors (abstract) (PDF) (HTML)
Yan,Helen H.N.; Cheng,Chuen-yan
Proceedings of the National Academy of Sciences of the United States of America 102(33): 11722-11727
Publication date: 2005
Blood-testis barrier dynamics are regulated by α2-macroglobulin via the c-Jun N-terminal protein kinase pathway (abstract) (PDF) (HTML)
Wong,Ching-hang; Mruk,Dolores D.; Siu,Michelle K.Y.; Cheng,Chuen-yan
Endocrinology 146(4): 1893-1908
Publication date: 2005
Bone and muscle protective potential of the prostate-sparing synthetic androgen 7α-methyl-19-nortestosterone: Evidence from the aged orchidectomized male rat model (abstract) (HTML)
Venken,Katrien; Boonen,Steven; Van Herck,Erik; Vandenput,Liesbeth; Kumar,Narender; Sitruk-Ware,Regine; Sundaram,Kalyan; Bouillon,Roger; Vanderschueren,Dirk
Bone 36(4): 663-670
Publication date: 2005
Clinical performance and menstrual bleeding patterns with three dosage combinations of a Nestorone® progestogen/ethinyl estradiol contraceptive vaginal ring used on a bleeding-signaled regimen (abstract) (HTML)
Weisberg,Edith; Brache,Vivian; Alvarez,Francisco; Massai,Rebeca; Mishell,Daniel R.,Jr.; Apter,Dan; Gale,Judi; Sivin,Irving; Tsong,Yun-yen; Fraser,Ian S.
Contraception 72(1): 46-52
Publication date: 2005
Contraceptive vaginal rings releasing Nestorone® and ethinylestradiol: A 1-year dose-finding trial (abstract) (HTML)
Sivin,Irving; Mishell,Daniel R.,Jr.; Alvarez,Francisco; Brache,Vivian; Elomaa,Kaisa; Lahteenmaki,Pekka; Massai,Rebeca; Miranda,Patricia; Croxatto,Horacio B.; Dean,Catherine; Small,Margaret; Nash,Harold A.; Jackanicz,Theodore M.
Contraception 71(2): 122-129
Publication date: 2005
Cytokines and junction restructuring during spermatogenesis: A lesson to learn from the testis (abstract) (HTML)
Xia,Weiliang; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Cytokine and Growth Factor Reviews 16(4-5): 469-493
Publication date: 2005
Delivery options for contraceptives (abstract) (HTML)
Sitruk-Ware,Regine
Drug Discovery Today 10(14): 977-985
Publication date: 2005
Disruption of Sertoli-germ cell adhesion function in the seminiferous epithelium of the rat testis can be limited to adherens junctions without affecting the blood-testis barrier integrity: An in vivo study using an androgen suppression model (abstract) (HTML)
Xia,Weiliang; Wong,Ching-hang; Lee,Nikki P.Y.; Lee,Will M.; Cheng,Chuen-yan
Journal of Cellular Physiology 205(1): 141-157
Publication date: 2005
Effect of a levonorgestrel intrauterine system on women with type 1 diabetes: A randomized trial (abstract) (HTML)
Rogovskaya,Svetlana; Rivera,Roberto; Grimes,David A.; Chen,Pai-lien; Pierre-Louis,Bosny; Prilepskaya,Vera; Kulakov,Vladimir
Obstetrics and Gynecology 105(4): 811-815
Publication date: 2005
Emergency contraception's mode of action clarified (PDF)
Population Briefs 11(2)
Publication date: 2005
Endogenous selective inhibitors of 11ß-hydroxysteroid dehydrogenase isoforms 1 and 2 of adrenal origin (abstract) (HTML)
Latif,Syed A.; Pardo,Hector A.; Hardy,Matthew P.; Morris,David J.
Molecular and Cellular Endocrinology 243(1-2): 43-50
Publication date: 2005
Estrogen and progestogens: Different routes of administration (editorial) (HTML)
Sitruk-Ware,Regine
Climacteric 8(suppl 1): 1-2
Publication date: 2005
Gene expression in rat Leydig cells during development from the progenitor to adult stage: A cluster analysis (abstract) (PDF) (HTML)
Ge,Renshan; Dong,Qiang; Sottas,Chantal M.; Chen,Haolin; Zirkin,Barry R.; Hardy,Matthew P.
Biology of Reproduction 72(6): 1405-1415
Publication date: 2005
Immune complex deposition in adult male Sprague-Dawley rats chronically immunized with GnRH (abstract) (PDF)
Vargas,Louis A.; Sewell,Richard; Marshall,Aileen; Galatioto,Josephine; Tsong,Yun-yen; Catterall,James F.; Hunnicutt,Gary R.
American Journal of Reproductive Immunology 54(5): 292-310
Publication date: 2005
Interactions among IQGAP1, Cdc42, and the cadherin/catenin protein complex regulate Sertoli-germ cell adherens junction dynamics in the testis (abstract) (HTML)
Lui,Wing-Yee; Mruk,Dolores D.; Cheng,Chuen-yan
Journal of Cellular Physiology 202(1): 49-66
Publication date: 2005
Low chemical exposure may speed male puberty (PDF)
Population Briefs 11(3)
Publication date: 2005
Maintenance of spermatogenesis requires TAF4b, a gonad-specific subunit of TFIID (abstract) (PDF) (HTML)
Falender,Allison E.; Freiman,Richard N.; Geles,Kenneth G.; Lo,Kirk C.; Hwang,KeumSil; Lamb,Dolores J.; Morris,Patricia L.; Tijan,Robert; Richards,JoAnne S.
Genes and Development 19(7): 794-803
Publication date: 2005
Management of patients receiving long-term treatment with mifepristone (abstract) (HTML)
Spitz,Irving M.; Grunberg,Steven M.; Chabbert-Buffet,Nathalie; Lindenberg,Tzina; Gelber,Hadassa; Sitruk-Ware,Regine
Fertility and Sterility 84(6): 1719-1726
Publication date: 2005
Mitogen-activated protein kinases, adherens junction dynamics, and spermatogenesis: A review of recent data (abstract) (PDF) (HTML)
Wong,Ching-hang; Cheng,Chuen-yan
Developmental Biology 286(1): 1-15
Publication date: 2005
Myotubularin phosphoinositide phosphatases, protein phosphatases, and kinases: Their roles in junction dynamics and spermatogenesis (abstract) (HTML)
Zhang,Jiayi; Mruk,Dolores D.; Cheng,Chuen-yan
Journal of Cellular Physiology 204(2): 470-483
Publication date: 2005
Paracrine modulation of androgen synthesis in rat Leydig cells by nitric oxide (abstract) (PDF) (HTML)
Weissman,Ben-Avi; Niu,Enmei; Ge,Renshan; Sottas,Chantal M.; Holmes,Michael; Hutson,James C.; Hardy,Matthew P.
Journal of Andrology 26(3): 369-378
Publication date: 2005
Pharmacology of different progestogens: The special case of drospirenone (abstract) (HTML)
Sitruk-Ware,Regine
Climacteric 8(suppl 3): 4-12
Publication date: 2005
Population Council contributions toward the development and advances in reproductive biomedicine and population sciences in Asian nations (1952-2002) (HTML)
Koide,Samuel S.
Journal of Obstetrics and Gynaecology Research 31(1): 2-11
Publication date: 2005
Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells (abstract) (PDF) (HTML)
Xu,Qin; Takekida,Shigeki; Ohara,Noriyuki; Chen,Wei; Sitruk-Ware,Regine; Johansson,Elof D.B.; Maruo,Takeshi
Journal of Clinical Endocrinology and Metabolism 90(2): 953-961
Publication date: 2005
Protein kinases and adherens junction dynamics in the seminiferous epithelium of the rat testis (abstract) (HTML)
Lee,Nikki P.Y.; Cheng,Chuen-yan
Journal of Cellular Physiology 202(2): 344-360
Publication date: 2005
Regulation of ectoplasmic specialization dynamics in the seminiferous epithelium by focal adhesion-associated proteins in testosterone-suppressed rat testes (abstract) (PDF) (HTML)
Wong,Ching-hang; Xia,Weiliang; Lee,Nikki P.Y.; Mruk,Dolores D.; Lee,Will M.; Cheng,Chuen-yan
Endocrinology 146(3): 1192-1204
Publication date: 2005
Regulation of Sertoli-germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/beta-catenin (CATNB) signaling pathway: An in vitro and in vivo study (abstract) (PDF) (HTML)
Lee,Nikki P.Y.; Mruk,Dolores D.; Wong,Ching-hang; Cheng,Chuen-yan
Biology of Reproduction 73(3): 458-471
Publication date: 2005
Regulation of Sertoli-germ cell adherens junction dynamics via changes in protein-protein interactions of the N-cadherin-ß-catenin protein complex which are possibly mediated by c-Src and myotubularin-related protein 2: An in vivo study using an androgen suppression model (abstract) (PDF) (HTML)
Zhang,Jiayi; Wong,Ching-hang; Xia,Weiliang; Mruk,Dolores D.; Lee,Nikki P.Y.; Lee,Will M.; Cheng,Chuen-yan
Endocrinology 146(3): 1268-1284
Publication date: 2005
Se esclarece mecanismo de acción de la anticoncepción de emergencia [Emergency contraception's mode of action clarified] (PDF)
Population Briefs 11(2)
Publication date: 2005
Sertoli cell expression of steroidogenic acute regulatory protein-related lipid transfer 1 and 5 domain-containing proteins and sterol regulatory element binding protein-1 are interleukin-1beta regulated by activation of c-Jun N-terminal kinase and cyclooxygenase-2 and cytokine induction (abstract) (PDF) (HTML)
Ishikawa,Tomomoto; Hwang,KeumSil; Lazzarino,Deborah; Morris,Patricia L.
Endocrinology 146(12): 5100-5111
Publication date: 2005
Sertoli-germ cell anchoring junction dynamics in the testis are regulated by an interplay of lipid and protein kinases (abstract) (PDF) (HTML)
Siu,Michelle K.Y.; Wong,Ching-hang; Lee,Will M.; Cheng,Chuen-yan
Journal of Biological Chemistry 280(26): 25029-25047
Publication date: 2005
Serum Nestorone® and ethinyl estradiol levels, and ovulation inhibition in women using three different dosage combinations of a Nestorone progestogen-ethinyl estradiol contraceptive vaginal ring on a bleeding-signaled regimen (abstract) (HTML)
Fraser,Ian S.; Weisberg,Edith; Brache,Vivian; Alvarez,Francisco; Massai,Rebeca; Mishell,Daniel R.,Jr.; Apter,Dan; Gale,Judi; Tsong,Yun-yen; Sivin,Irving
Contraception 72(1): 40-45
Publication date: 2005
Sperm with bent tails point to possible male contraceptive (PDF)
Population Briefs 11(2)
Publication date: 2005
Stimulation of testosterone production in rat Leydig cells by aldosterone is mineralocorticoid receptor mediated (abstract) (HTML)
Ge,Renshan; Dong,Qiang; Sottas,Chantal M.; Latif,Syed A.; Morris,David J.; Hardy,Matthew P.
Molecular and Cellular Endocrinology 243(1-2): 35-42
Publication date: 2005
Stress hormone and male reproductive function (abstract) (HTML)
Hardy,Matthew P.; Gao,Hui-Bao; Dong,Qiang; Ge,Renshan; Wang,Qian; Chai,Wei Ran; Feng,Xing; Sottas,Chantal M.
Cell and Tissue Research 322(1): 147-153
Publication date: 2005
Testicular expression of small ubiquitin-related modifier- 1 (SUMO-1) supports multiple roles in spermatogenesis: Silencing of sex chromosomes in spermatocytes, spermatid microtubule nucleation, and nuclear reshaping (abstract) (PDF) (HTML)
Vigodner,Margarita; Morris,Patricia L.
Developmental Biology 282(2): 480-492
Publication date: 2005
TGF-ß3 regulates anchoring junction dynamics in the seminiferous epithelium of the rat testis via the Ras/ERK signaling pathway: An in vivo study (abstract) (PDF) (HTML)
Xia,Weiliang; Cheng,Chuen-yan
Developmental Biology 280(2): 321-343
Publication date: 2005
The Sept4 septin locus is required for sperm terminal differentiation in mice (abstract) (PDF) (HTML)
Kissel,Holger; Georgescu,Maria-Magdalena; Larisch,Sarit; Manova,Katia; Hunnicutt,Gary R.; Steller,Hermann
Developmental Cell 8(3): 353-364
Publication date: 2005
The blood-testis barrier: Its biology, regulation, and physiological role in spermatogenesis (abstract) (HTML)
Wong,Ching-hang; Cheng,Chuen-yan
Current Topics in Developmental Biology 71: 263-296
Publication date: 2005
The levonorgestrel intrauterine system: Long-term contraception and therapeutic effects (abstract) (PDF)
Sitruk-Ware,Regine; Inki,Pirjo
Women's Health 1(2): 171-182
Publication date: 2005
Vaginal delivery of contraceptives (abstract) (HTML)
Sitruk-Ware,Regine
Expert Opinion on Drug Delivery 2(4): 729-736
Publication date: 2005
α-macroglobulin expression in the liver in response to inflammation is mediated by the testis (abstract) (PDF)
Lui,Wing-Yee; Cheng,Yan Ho; Mruk,Dolores D.; Cheng,Chin Ho; Mo,Meng-Yun; Lee,Will M.; Cheng,Chuen-yan
Journal of Endocrinology 185(3): 497-505
Publication date: 2005
A practical approach to male infertility
Hopps,Carin V.; Schlegel,Peter N.; Goldstein,Marc
from Principles of Gender-Specific Medicine, pp. 538-549
Publication date: 2004
Adaptors, junction dynamics, and spermatogenesis (abstract) (PDF) (HTML)
Lee,Nikki P.Y.; Cheng,Chuen-yan
Biology of Reproduction 71(2): 392-404
Publication date: 2004
Assay for establishing whether microbicide applicators have been exposed to the vagina (abstract) (HTML)
Wallace,Andrea R.; Thorn,Mitchell; Maguire,Robin A.; Sudol,Kristin M.; Phillips,David M.
Sexually Transmitted Diseases 31(8): 465-468
Publication date: 2004
Both SMAD2 and SMAD3 mediate activin-stimulated expression of the follicle-stimulating hormone β subunit in mouse gonadotrope cells (abstract) (PDF) (HTML)
Bernard,Daniel J.
Molecular Endocrinology 18(3): 606-623
Publication date: 2004
Cell-cell interactions at the ectoplasmic specialization in the testis (abstract) (HTML)
Mruk,Dolores D.; Cheng,Chuen-yan
Trends in Endocrinology and Metabolism 15(9): 439-447
Publication date: 2004
Cloning and characterization of rat spermatid protein SSP411: A thioredoxin-like protein (abstract) (PDF)
Shi,Hui-Juan; Wu,Ai Zhen; Santos,Michelle; Feng,Zong-Ming; Huang,Li; Chen,Yong-Mei; Zhu,Kai; Chen,Ching-Ling C.
Journal of Andrology 25(4): 479-493
Publication date: 2004
Cloning of a novel inhibin alpha cDNA from rhesus monkey testis (abstract) (PDF) (HTML)
Bernard,Daniel J.; Woodruff,Teresa K.; Plant,Tony M.
Reproductive Biology and Endocrinology 2: 71-
Publication date: 2004
Development of Leydig cells in the insulin-like growth factor-I (IGF-I) knockout mouse: Effects of IGF-I replacement and gonadotropic stimulation (abstract) (HTML)
Wang,Gui-Min; Hardy,Matthew P.
Biology of Reproduction 70(3): 632-639
Publication date: 2004
Disruption of Mtmr2 produces CMT4B1-like neuropathy with myelin outfolding and impaired spermatogenesis (abstract) (PDF) (HTML)
Bolino,Alessandra; Bolis,Annalisa; Previtali,Stefano Carlo; Dina,Giorgia; Bussini,Simona; Dati,Gabriele; Amadio,Stefano; Del Carro,Ubaldo; Mruk,Dolores D.; Feltri,Maria Laura; Cheng,Chuen-yan; Quattrini,Angelo; Wrabetz,Lawrence
Journal of Cell Biology 167(4): 711-721
Publication date: 2004
Dynamic cross-talk between cells and the extracellular matrix in the testis (abstract) (HTML)
Siu,Michelle K.Y.; Cheng,Chuen-yan
BioEssays 26(9): 978-992
Publication date: 2004
Ectoplasmic specialization, a testis-specific cell-cell actin-based adherens junction type: Is this a potential target for male contraceptive development? (abstract) (PDF) (HTML)
Lee,Nikki P.Y.; Cheng,Chuen-yan
Human Reproduction Update 10(4): 349-369
Publication date: 2004
Effect of chenodeoxycholic acid on 11β-hydroxysteroid dehydrogenase in various target tissues (abstract) (HTML)
Morris,David J.; Souness,Graham W.; Latif,Syed A.; Hardy,Matthew P.; Brem,Andrew S.
Metabolism 53(6): 811-816
Publication date: 2004
Exogenous progestagens and the human breast (abstract) (HTML)
Sitruk-Ware,Regine; Plu-Bureau,Genevieve
Maturitas 49(1): 58-66
Publication date: 2004
Extracellular matrix: Recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis (abstract) (HTML)
Siu,Michelle K.Y.; Cheng,Chuen-yan
Biology of Reproduction 71(2): 375-391
Publication date: 2004
Future developments in hormonal contraception (abstract) (HTML)
Johansson,Elof D.B.
American Journal of Obstetrics and Gynecology 190(suppl 1): S69-S71
Publication date: 2004
Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells (abstract) (PDF)
Akingbemi,Benson T.; Sottas,Chantal M.; Koulova,Anna I.; Klinefelter,Gary R.; Hardy,Matthew P.
Endocrinology 145(2): 592-603
Publication date: 2004
Interactions of proteases, protease inhibitors, and the β1 integrin/laminin γ3 protein complex in the regulation of ectoplasmic specialization dynamics in the rat testis (abstract) (HTML)
Siu,Michelle K.Y.; Cheng,Chuen-yan
Biology of Reproduction 70(4): 945-964
Publication date: 2004
Leydig cell function in man
Dong,Qiang; Hardy,Matthew P.; Winters,S.
from Contemporary Endocrinology-Hypogonadism: Basic, Clinical and Therapeutic Principles, pp. 23-44
Publication date: 2004
Lubricants containing N-9 may enhance rectal transmission of HIV and other STIs (abstract) (HTML)
Phillips,David M.; Sudol,Kristin M.; Taylor,Clark L.; Guichard,Laura; Elsen,Robert; Maguire,Robin A.
Contraception 70(2): 107-110
Publication date: 2004
Mifepristone does not induce cervical softening in non-pregnant women (abstract) (HTML)
Ben-Chetrit,Avraham; Eldar-Geva,Talia; Lindenberg,Tzina; Farhat,Morshed; Shimonovitz,Shlomo; Zacut,David; Gelber,Hadassa; Sitruk-Ware,Regine; Spitz,Irving M.
Human Reproduction 19(10): 2372-2376
Publication date: 2004
Müllerian-inhibiting substance inhibits rat Leydig cell regeneration after ethylene dimethanesulphonate ablation (abstract) (PDF)
Salva,Antonio; Hardy,Matthew P.; Wu,Xiu-feng; Sottas,Chantal M.; MacLaughlin,David T.; Donahoe,Patricia K.; Lee,Mary M.
Biology of Reproduction 70(3): 600-607
Publication date: 2004
New delivery systems in contraception: Vaginal rings (abstract) (HTML)
Johansson,Elof D.B.; Sitruk-Ware,Regine
American Journal of Obstetrics and Gynecology 190(suppl 1): S54-S59
Publication date: 2004
New progestogens: A review of their effects in perimenopausal and postmenopausal women (abstract) (HTML)
Sitruk-Ware,Regine
Drugs and Aging 21(13): 865-883
Publication date: 2004
Nitric oxide/nitric oxide synthase, spermatogenesis, and tight junction dynamics (abstract) (PDF) (HTML)
Lee,Nikki P.Y.; Cheng,Chuen-yan
Biology of Reproduction 70(2): 267-276
Publication date: 2004
Pharmacological profile of progestins (abstract) (HTML)
Sitruk-Ware,Regine
Maturitas 47(4): 277-283
Publication date: 2004
Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances (abstract) (PDF)
Akingbemi,Benson T.; Ge,Renshan; Klinefelter,Gary R.; Zirkin,Barry R.; Hardy,Matthew P.
Proceedings of the National Academy of Sciences of the United States of America 101(3): 775-780
Publication date: 2004
Physiology of the testis and epididymis
Robaire,Bernard; Hardy,Matthew P.; Chan,Peter T.K.; Goldstein,Marc; Rosenwaks,Zev R.
from Reproductive Medicine Secrets, pp. 15-22
Publication date: 2004
Potential long-acting male contraceptive studied (PDF)
Population Briefs 10(3)
Publication date: 2004
Rapid glucocorticoid mediation of suppressed testosterone biosynthesis in male mice subjected to immobilization stress (abstract) (PDF) (HTML)
Dong,Qiang; Salva,Antonio; Sottas,Chantal M.; Niu,Enmei; Holmes,Michael; Hardy,Matthew P.
Journal of Andrology 25(6): 973-981
Publication date: 2004
Regulation of blood-testis barrier dynamics: An in vivo study (abstract) (HTML)
Wong,Ching-hang; Mruk,Dolores D.; Lui,Wing-Yee; Cheng,Chuen-yan
Journal of Cell Science 117(5): 783-798
Publication date: 2004
Release-modulating factors strongly affecting steroid diffusion from silicone elastomer (abstract) (HTML)
Nash,Harold A.; Robertson,Dale N.; Evans,Simone J.
Journal of Pharmaceutical Sciences 93(10): 2420-2430
Publication date: 2004
Robotic microsurgical vasovasostomy and vasoepididymostomy: A prospective randomized study in a rat model (abstract) (HTML)
Schiff,Jonathan D.; Li,Philip S.; Goldstein,Marc
Journal of Urology 171(4): 1720-1725
Publication date: 2004
Role of progestins with partial antiandrogenic effects (abstract) (HTML)
Sitruk-Ware,Regine; Husmann,F.; Skouby,S.O.; Thijssen,J.H.H.; Fruzzetti,F.; Hanker,J.; Huber,J.; Druckmann,R.
Climacteric 7(3): 238-254
Publication date: 2004
Role of varicocelectomy in men with nonobstructive azoospermia (abstract) (HTML)
Schlegel,Peter N.; Kaufmann,Jeremy
Fertility and Sterility 81(6): 1585-1588
Publication date: 2004
Seasonal plasticity in the song control system: Multiple brain sites of steroid hormone action and the importance of variation in song behavior (abstract) (HTML)
Ball,Gregory F.; Auger,Catherine J.; Bernard,Daniel J.; Charlier,Thierry D.; Sartor,Jennifer J.; Riters,Lauren V.; Balthazart,Jacques
Annals of the New York Academy of Sciences 1016: 586-610
Publication date: 2004
Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis (abstract) (PDF) (HTML)
Mruk,Dolores D.; Cheng,Chuen-yan
Endocrine Reviews 25(5): 747-806
Publication date: 2004
The 25th volume: Did you see the latest? (PDF)
Hardy,Matthew P.; Schlegel,Peter N.
Journal of Andrology 25(2): 177-
Publication date: 2004
Two-year performance of a Nestorone-releasing contraceptive implant: A three-center study of 300 women (abstract) (HTML)
Sivin,Irving; Croxatto,Horacio B.; Bahamondes,Luis; Brache,Vivian; Alvarez-Sanchez,Francisco; Massai,Rebeca; Schechter,Janet; Ranta,Sirpa; Kumar,Narender; Wu,Esther; Tejada,Ana-Sofia; Reyes,Veronica; Travers,Elaine; Allen,Arthur; Moo-Young,Alfred J.
Contraception 69(2): 137-144
Publication date: 2004
Zyxin, axin, and Wiskott-Aldrich syndrome protein are adaptors that link the cadherin/catenin protein complex to the cytoskeleton at adherens junctions in the seminiferous epithelium of the rat testis (abstract) (PDF) (HTML)
Lee,Nikki P.Y.; Mruk,Dolores D.; Conway,Anne M.; Cheng,Chuen-yan
Journal of Andrology 25(2): 200-215
Publication date: 2004
A clinical trial of 7α-methyl-19-nortestosterone implants for possible use as a long-acting contraceptive for men (abstract) (PDF) (HTML)
von Eckardstein,Sigrid; Noe,Gabriela; Brache,Vivian; Nieschlag,Eberhard; Croxatto,Horacio B.; Alvarez-Sanchez,Francisco; Moo-Young,Alfred J.; Sivin,Irving; Kumar,Narender; Small,Margaret; Sundaram,Kalyan; Population Council International Committee for Contraception Research
Journal of Clinical Endocrinology and Metabolism 88(11): 5232-5239
Publication date: 2003
A role for kit receptor signaling in Leydig cell steroidogenesis (abstract) (PDF) (HTML)
Rothschild,Gerson; Sottas,Chantal M.; Kissel,Holger; Agosti,Valter; Manova,Katia; Hardy,Matthew P.; Besmer,Peter
Biology of Reproduction 69(3): 925-932
Publication date: 2003
Adherens junction dynamics in the testis and spermatogenesis (PDF) (HTML)
Lui,Wing-Yee; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Journal of Andrology 24(1): 1-14
Publication date: 2003
Adhering junction dynamics in the testis are regulated by an interplay of β 1-integrin and focal adhesion complex-associated proteins (abstract) (PDF) (HTML)
Siu,Michelle K.Y.; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Endocrinology 144(5): 2141-2163
Publication date: 2003
Alternatives for optimal hormone replacement therapy (abstract)
Sitruk-Ware,Regine
Climacteric 6(suppl 2): 11-16
Publication date: 2003
Editorial commentary: SMAD expression in the testis predicts age- and cell-specific responses to activin and TGFβ (HTML)
Bernard,Daniel J.
Journal of Andrology 24(2): 201-203
Publication date: 2003
Effects of insulin-like growth factor I on steroidogenic enzyme expression levels in mouse Leydig cells (abstract) (PDF) (HTML)
Wang,Gui-Min; O'Shaughnessy,Peter J.; Chubb,Curtis; Robaire,Bernard; Hardy,Matthew P.
Endocrinology 144(11): 5058-5064
Publication date: 2003
Effects of levonorgestrel-releasing intra-uterine system on the expression of vascular endothelial growth factor and adrenomedullin in the endometrium in adenomyosis (abstract) (PDF) (HTML)
Laoag-Fernandez,Jovelle B.; Maruo,Takeshi; Pakarinen,Paivi; Spitz,Irving M.; Johansson,Elof D.B.
Human Reproduction 18(4): 694-699
Publication date: 2003
Enlarged ovarian follicles in users of a levonorgestrel-releasing intrauterine system and contraceptive implant (abstract) (HTML)
Bahamondes,Luis; Hidalgo,Margarete; Petta,Carlos; Diaz,Juan; Espejo-Arce,Ximena; Monteiro-Dantas,Cecilia
Journal of Reproductive Medicine 48(8): 637-640
Publication date: 2003
Estradiol/progesterone-releasing vaginal rings for hormone replacement therapy in postmenopausal women (abstract) (HTML)
Hamada,Anna Lissa; Maruo,Takeshi; Samoto,Takashi; Yoshida,Shigeki; Nash,Harold A.; Spitz,Irving M.; Johansson,Elof D.B.
Gynecological Endocrinology 17(3): 247-254
Publication date: 2003
Estradiol-progesterone interaction during the preparation of vaginal rings (abstract) (HTML)
Saleh,Saleh I.; Khidr,Sayed H.; Ahmed,Sayed M.; Jackanicz,Theodore M.; Nash,Harold A.
Journal of Pharmaceutical Sciences 92(2): 258-265
Publication date: 2003
Estrogen receptor-α gene deficiency enhances androgen biosynthesis in the mouse Leydig cell (abstract) (HTML)
Akingbemi,Benson T.; Ge,Renshan; Rosenfeld,Cheryl S.; Newton,Leslie G.; Hardy,Dianne O.; Catterall,James F.; Lubahn,Dennis B.; Korach,Kenneth S.; Hardy,Matthew P.
Endocrinology 144(1): 84-93
Publication date: 2003
Evidence for tissue selectivity of the synthetic androgen 7α-methyl-19-nortestosterone in hypogonadal men (abstract) (PDF)
Anderson,Richard A.; Wallace,A.Michael; Sattar,Naveed; Kumar,Narender; Sundaram,Kalyan
Journal of Clinical Endocrinology and Metabolism 88(6): 2784-2793
Publication date: 2003
Fer kinase/FerT and adherens junction dynamics in the testis: An in vitro and in vivo study (abstract) (PDF) (HTML)
Chen,Yong-Mei; Lee,Nikki P.Y.; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Biology of Reproduction 69(2): 656-672
Publication date: 2003
Gestational exposure to ethane dimethanesulfonate permanently alters reproductive competence in the CD-1 mouse (abstract) (PDF) (HTML)
Tarka-Leeds,Dana K.; Suarez,Juan D.; Roberts,Naomi L.; Rogers,John M.; Hardy,Matthew P.; Klinefelter,Gary R.
Biology of Reproduction 69(3): 959-967
Publication date: 2003
Hormone choice may reduce risks of menopause therapy (PDF)
Population Briefs 9(2)
Publication date: 2003
Hormone therapy and the cardiovascular system: The critical role of progestins (abstract)
Sitruk-Ware,Regine
Climacteric 6(suppl 3): 21-28
Publication date: 2003
Hormone Use in Menopause and Male Andropause: A Choice for Women and Men
Segal,Sheldon J.; Mastroianni,Luigi,Jr.
Publication date: 2003
Inhibin receptor signaling
Bernard,Daniel J.; Henry,Helen L.; Norman,Anthony W.
from Encyclopedia of Hormones, pp. 297-303
Publication date: 2003
Is the cadherin/catenin complex a functional unit of cell-cell actin-based adherens junctions in the rat testis? (abstract) (PDF) (HTML)
Lee,Nikki P.Y.; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Biology of Reproduction 68(2): 489-508
Publication date: 2003
Mechanisms of glucocorticoid-induced Leydig cell apoptosis (abstract) (HTML)
Gao,Hui-Bao; Tong,Ming-Han; Hu,Yan-Qin; You,Hai-Yan; Guo,Qiang-Su; Ge,Renshan; Hardy,Matthew P.
Molecular and Cellular Endocrinology 199(1-2): 153-163
Publication date: 2003
Mirena®-induced drop in menstrual bleeding studied (PDF)
Population Briefs 9(1)
Publication date: 2003
Nestorone®: Clinical applications for contraception and HRT (abstract) (HTML)
Sitruk-Ware,Regine; Small,Margaret; Kumar,Narender; Tsong,Yun-yen; Sundaram,Kalyan; Jackanicz,Theodore M.
Steroids 68(10-13): 907-913
Publication date: 2003
Normal reproductive function in InhBP/p120-deficient mice (abstract) (HTML)
Bernard,Daniel J.; Burns,Kathleen H.; Haupt,Bisong; Matzuk,Martin M.; Woodruff,Teresa K.
Molecular and Cellular Biology 23(14): 4882-4891
Publication date: 2003
Pharmacological properties of mifepristone: Toxicology and safety in animal and human studies (abstract) (HTML)
Sitruk-Ware,Regine; Spitz,Irving M.
Contraception 68(6): 409-420
Publication date: 2003
Progestins in hormonal replacement therapy (HRT): New molecules, risks and benefits
Sitruk-Ware,Regine
Annales d'Endocrinologie 64(2): 178-178
Publication date: 2003
Progestins in hormonal therapy (HT) today, tomorrow and the next day: A roundtable discussion (HTML)
Sitruk-Ware,Regine
Steroids 68(10-13): 973-979
Publication date: 2003
Prostaglandin (PG) FP and EP1 receptors mediate PDF2α and PGE2 regulation of interleukin-1β expression in Leydig cell progenitors (abstract) (HTML)
Walch,Laurence; Clavarino,Emanuela; Morris,Patricia L.
Endocrinology 144(4): 1284-1291
Publication date: 2003
Rab8B GTPase and junction dynamics in the testis (abstract) (HTML)
Lau,Ann S.N.; Mruk,Dolores D.
Endocrinology 144(4): 1549-1563
Publication date: 2003
Regulation of Sertoli cell tight junction dynamics in the rat testis via the nitric oxide synthase/soluble guanylate cyclase/3',5'-cyclic guanosine monophosphate/protein kinase G signaling pathway: An in vitro study (abstract) (PDF) (HTML)
Lee,Nikki P.Y.; Cheng,Chuen-yan
Endocrinology 144(7): 3114-3129
Publication date: 2003
Rho GTPases and spermatogenesis (abstract) (HTML)
Lui,Wing-Yee; Lee,William M.; Cheng,Chuen-yan
Biochimica et Biophysica Acta 1593(2-3): 121-129
Publication date: 2003
Risks and benefits, advantages and disadvantages of levonorgestrel-releasing contraceptive implants (abstract) (HTML)
Sivin,Irving
Drug Safety 26(5): 303-335
Publication date: 2003
Role of progestogen in hormone therapy for postmenopausal women: Position statement of The North American Menopause Society (abstract) (HTML)
Menopause 10(2): 113-132
Publication date: 2003
Role of tissue inhibitor of metalloproteases-1 in junction dynamics in the testis (abstract) (PDF) (HTML)
Mruk,Dolores D.; Siu,Michelle K.Y.; Conway,Anne M.; Lee,Nikki P.Y.; Lau,Ann S.N.; Cheng,Chuen-yan
Journal of Andrology 24(4): 510-523
Publication date: 2003
Sertoli cell tight junction dynamics: Their regulation during spermatogenesis (abstract) (PDF) (HTML)
Lui,Wing-Yee; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Biology of Reproduction 68(4): 1087-1097
Publication date: 2003
Sertoli-germ cell adherens junction dynamics in the testis are regulated by RhoB GTPase via the ROCK/LIMK signaling pathway (abstract) (HTML)
Lui,Wing-Yee; Lee,William M.; Cheng,Chuen-yan
Biology of Reproduction 68(6): 2189-2206
Publication date: 2003
Subdermal progestin implant (Nestorone®) in the treatment of endometriosis: Clinical response to various doses (abstract) (HTML)
Ylanen,Kaija; Laatikainen,Timo; Lahteenmaki,Pekka; Moo-Young,Alfred J.
Acta Obstetricia et Gynecologica Scandinavica 82(2): 167-172
Publication date: 2003
TGF-β3 regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: An in vivo study (abstract) (PDF) (HTML)
Lui,Wing-Yee; Wong,Daria C.H.; Mruk,Dolores D.; Cheng,Chuen-yan
Endocrinology 144(4): 1139-1142
Publication date: 2003
TGF-βs: Their role in testicular function and Sertoli cell tight junction dynamics (abstract) (HTML)
Lui,Wing-Yee; Lee,William M.; Cheng,Chuen-yan
International Journal of Andrology 26(3): 147-160
Publication date: 2003
The functional roles of 11 β-HSD1: Vascular tissue, testis and brain (abstract) (HTML)
Morris,David J.; Brem,Andrew S.; Ge,Renshan; Jellinck,P.Harry; Sakai,Randall R.; Hardy,Matthew P.
Molecular and Cellular Endocrinology 203(1-2): 1-12
Publication date: 2003
The interplay of collagen IV, tumor necrosis factor-α, gelatinase B (matrix metalloprotease-9), and tissue inhibitor of metalloproteases-1 in the basal lamina regulates Sertoli cell-tight junction dynamics in the rat testis (abstract) (PDF) (HTML)
Siu,Michelle K.Y.; Lee,William M.; Cheng,Chuen-yan
Endocrinology 144(1): 371-387
Publication date: 2003
The pharmacokinetics of mifepristone in humans reveal insights into differential mechanisms of antiprogestin action (abstract) (HTML)
Heikinheimo,Oskari; Kekkonen,Raimo; Lahteenmaki,Pekka
Contraception 68(6): 421-426
Publication date: 2003
Transforming growth factor β3 regulates the dynamics of Sertoli cell tight junctions via the p38 mitogen-activated protein kinase pathway (abstract) (PDF) (HTML)
Lui,Wing-Yee; Lee,William M.; Cheng,Chuen-yan
Biology of Reproduction 68(5): 1597-1612
Publication date: 2003
Unlocking the mechanism of androgen action (PDF)
Population Briefs 9(3)
Publication date: 2003
A critical review of the toxicological effects of Carrageenan and processed eucheuma seaweed on the gastrointestinal tract (abstract) (HTML)
Cohen,Samuel M.; Ito,Nobuyuki
Critical Reviews in Toxicology 32(5): 413-444
Publication date: 2002
Age-related decreases in Leydig cell testosterone production are not restored by exposure to LH in vitro (abstract) (PDF) (HTML)
Chen,Haolin; Hardy,Matthew P.; Zirkin,Barry R.
Endocrinology 143(5): 1637-1642
Publication date: 2002
Altering cell bonds in testis may yield contraceptive (PDF)
Population Briefs 8(2)
Publication date: 2002
Antiandrogenic progestogens in hormone replacement therapy (HTML)
Sitruk-Ware,Regine
Gynaecology Forum 7(2): 8-11
Publication date: 2002
Antioxidant superoxide dismutase--A review: Its function, regulation in the testis, and role in male fertility (abstract) (HTML)
Mruk,Dolores D.; Silvestrini,Bruno; Mo,Meng-Yun; Cheng,Chuen-yan
Contraception 65(4): 305-311
Publication date: 2002
Biphasic effect of GABA on rat sperm acrosome reaction: Involvement of GABA(A) and GABA(B) receptors (abstract) (HTML)
Hu,Jing Hua; He,Xiao Bing; Wu,Qi; Yan,Yuan Chang; Koide,Samuel S.
Archives of Andrology 48(5): 369-378
Publication date: 2002
Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development (abstract) (PDF) (HTML)
Cheng,Chuen-yan; Mruk,Dolores D.
Physiological Reviews 82(4): 825-874
Publication date: 2002
Characterization and potential function of a novel testis-specific nucleoporin BS-63 (abstract) (HTML)
Cai,Ying; Gao,Ying; Sheng,Qi; Miao,Shiying; Cui,Xiuyun; Wang,Linfang; Zong,Shudong; Koide,Samuel S.
Molecular Reproduction and Development 61(1): 126-134
Publication date: 2002
Cyclooxygenase 2 pathway mediates IL-1β regulation of IL-1α, -1β, and IL-6 mRNA levels in Leydig cell progenitors (abstract) (PDF) (HTML)
Walch,Laurence; Morris,Patricia L.
Endocrinology 143(9): 3276-3283
Publication date: 2002
Effect of chronic administration of 7α-methyl-19-nortestosterone on serum testosterone, number of spermatozoa and fertility in adult male bonnet monkeys (Macaca radiata) (abstract) (PDF) (HTML)
Ramachandra,S.G.; Ramesh,V.; Krishnamurthy,H.N.; Kumar,Narender; Sundaram,Kalyan; Hardy,Matthew P.; Rao,A.Jagannadha
Reproduction 124(2): 301-309
Publication date: 2002
Effects of levonorgestrel-releasing intrauterine system on the endometrium and the relevance to the management of menorrhagia caused by uterine myoma and adenomyosis
Maruo,Takeshi; Laoag-Fernandez,Jovelle B.; Matsuo,Hiroya; Samoto,Takashi; Kurachi,Osamu; Takeuchi,S.; Spitz,Irving M.; Pakarinen,Paivi; Lahteenmaki,Pekka; Johansson,Elof D.B.; Barlow,David; Mardon,Helen; Kennedy,Stephen
from Cell and Molecular Biology of Endometrium in Health and Disease, pp. 193-207
Publication date: 2002
Effects of social stress on hormones, brain, and behavior
Blanchard,D.Caroline; McKittrick,Christina R.; Hardy,Matthew P.; Blanchard,Robert J.; Pfaff,Donald W.; Arnold,Arthur P.; Etgen,Anne M.; Fahrbach,Susan E.; Rubin,Robert T.
from Hormones, Brain, and Behavior, pp. 735-763
Publication date: 2002
Expression of 11β-hydroxylase in rat Leydig cells (abstract) (PDF) (HTML)
Wang,Gui-Min; Ge,Renshan; Latif,Syed A.; Morris,David J.; Hardy,Matthew P.
Endocrinology 143(2): 621-626
Publication date: 2002
Glucocorticoid induces apoptosis in rat Leydig cells (abstract) (PDF) (HTML)
Gao,Hui-Bao; Tong,Ming-Han; Hu,Yan-Qin; Guo,Qiang-Su; Ge,Renshan; Hardy,Matthew P.
Endocrinology 143(1): 130-138
Publication date: 2002
Gonadotropins, via cAMP, negatively regulate GATA-1 gene expression in testicular cells (abstract) (PDF) (HTML)
Zhang,Zhifang; Wu,Ai Zhen; Feng,Zong-Ming; Mruk,Dolores D.; Cheng,Chuen-yan; Chen,Ching-Ling C.
Endocrinology 143(3): 829-836
Publication date: 2002
Hormonal replacement therapy (HTML)
Sitruk-Ware,Regine
Reviews in Endocrine and Metabolic Disorders 3(3): 243-256
Publication date: 2002
Hormone-specific regulation of the kidney androgen-regulated gene promoter in cultured mouse renal proximal-tubule cells (abstract) (PDF) (HTML)
Soler,Montse; Tornavaca,Olga; Sole,Esther; Menoyo,Anna; Hardy,Dianne O.; Catterall,James F.; Vandewalle,Alain; Meseguer,Anna
Biochemical Journal 366(3): 757-766
Publication date: 2002
Illuminating the role of inhibins and activins in fertility (PDF)
Population Briefs 8(1)
Publication date: 2002
Indazole carboxylic acids in male contraception (abstract) (HTML)
Cheng,Chuen-yan; Mo,Meng-Yun; Grima,Josephine; Saso,Luciano; Tita,Beatrice; Mruk,Dolores D.; Silvestrini,Bruno
Contraception 65(4): 265-268
Publication date: 2002
Influence of acetazolamide on AQP1 gene expression in testis and on sperm count/motility in epididymis of rats (abstract) (HTML)
Yu,Heming; Sun,B.M.; Bai,Q.; Koide,Samuel S.; Li,Xuejun
Archives of Andrology 48(4): 281-294
Publication date: 2002
Inhibin binding protein (InhBP/p120), beta-glycan, and the continuing search for the inhibin receptor (abstract) (PDF) (HTML)
Bernard,Daniel J.; Chapman,Stacey C.; Woodruff,Teresa K.
Molecular Endocrinology 16(2): 207-212
Publication date: 2002
Inhibition of recovery of spermatogenesis in irradiated rats by different androgens (abstract) (PDF) (HTML)
Shetty,Gunapala; Wilson,Gene; Hardy,Matthew P.; Niu,Enmei; Huhtaniemi,Ilpo; Meistrich,Marvin L.
Endocrinology 143(9): 3385-3396
Publication date: 2002
Investigating nonhormonal male contraceptives
Population Council Annual Report 2002
Publication date: 2002
Jadelle® Levonorgestrel Rod Implants: A Summary of Scientific Data and Lessons Learned from Programmatic Experience (PDF)
Sivin,Irving; Nash,Harold A.; Waldman,Sandra N.
Publication date: 2002
Male reproductive biology
Schlegel,Peter N.; Hardy,Matthew P.; Walsh,Patrick C.; Retik,Alan B.; Vaughan,E.Darracott,Jr.; Wein,Alan J.; Kavoussi,Louis R.; Novick,Andrew C.; Partin,Alan W.; Peters,Craig A.
from Campbell's Urology, 8th Edition, pp. 1437-1474
Publication date: 2002
Men with nonobstructive azoospermia have Leydig cell hypertrophy but not hyperplasia (abstract) (HTML)
Tash,Jennifer A.; McCallum,Stewart; Hardy,Matthew P.; Knudsen,Beatrice; Schlegel,Peter N.
Journal of Urology 168(3): 1068-1070
Publication date: 2002
New methods of progestin delivery
Sitruk-Ware,Regine; Small,Margaret
Contemporary Clinical Gynecology and Obstetrics 2(4): 287-298
Publication date: 2002
Pharmacokinetic study of different dosing regimens of levonorgestrel for emergency contraception in healthy women (abstract) (PDF) (HTML)
Johansson,Elof D.B.; Brache,Vivian; Alvarez-Sanchez,Francisco; Faundes,Anibal; Cochon,Leila; Ranta,Sirpa; Lovern,Mark; Kumar,Narender
Human Reproduction 17(6): 1472-1476
Publication date: 2002
Photoperiod-dependent regulation of inhibin in Siberian hamsters: I. Ovarian inhibin production and secretion (abstract) (PDF) (HTML)
Kenny,Hilary A.; Bernard,Daniel J.; Horton,Teresa H.; Woodruff,Teresa K.
Journal of Endocrinology 174(1): 71-83
Publication date: 2002
Photoperiod-dependent regulation of inhibin in Siberian hamsters: II. Regulation of inhibin production and secretion by pregnant mare serum gonadotropin (abstract) (PDF) (HTML)
Kenny,Hilary A.; Bernard,Daniel J.; Horton,Teresa H.; Woodruff,Teresa K.
Journal of Endocrinology 174(1): 85-94
Publication date: 2002
Progestins and breast cancer risk: State of the controversy
Sitruk-Ware,Regine; Plu-Bureau,Genevieve; Neves-e-Castro,Manuel; Wren,Barry G.
from Menopause: Hormones and Cancer, pp. 123-128
Publication date: 2002
Progestogens in hormonal replacement therapy: New molecules, risks, and benefits (abstract) (HTML)
Sitruk-Ware,Regine
Menopause 9(1): 6-15
Publication date: 2002
Protein kinase C increases 11β-hydroxysteroid dehydrogenase oxidation and inhibits reduction in rat Leydig cells (abstract) (PDF) (HTML)
Ge,Renshan; Hardy,Matthew P.
Journal of Andrology 23(1): 135-143
Publication date: 2002
Recent developments in contraceptive implants at the Population Council (abstract) (HTML)
Sivin,Irving; Moo-Young,Alfred J.
Contraception 65(1): 113-119
Publication date: 2002
Role of systemic and local IGF-I in the effects of estrogen on growth and epithelial proliferation of mouse uterus (abstract) (PDF) (HTML)
Sato,Tomomi; Wang,Gui-Min; Hardy,Matthew P.; Kurita,Takeshi; Cunha,Gerald R.; Cooke,Paul S.
Endocrinology 143(7): 2673-2679
Publication date: 2002
Subunit composition and function of GABAA receptors of rat spermatozoa (abstract) (HTML)
Hu,Jing Hua; He,Xiao Bing; Wu,Qi; Yan,Yuan Chang; Koide,Samuel S.
Neurochemical Research 27(3): 195-199
Publication date: 2002
Trends of reproductive hormones in male rats during psychosocial stress: Role of glucocorticoid metabolism in behavioral dominance (abstract) (PDF) (HTML)
Hardy,Matthew P.; Sottas,Chantal M.; Ge,Renshan; McKittrick,Christina R.; Tamashiro,Kellie L.; McEwen,Bruce S.; Haider,Syed G.; Markham,Christopher M.; Blanchard,Robert J.; Blanchard,D.Caroline; Sakai,Randall R.
Biology of Reproduction 67(6): 1750-1755
Publication date: 2002
Unraveling Mirena's molecular mystery
Population Council Annual Report 2002
Publication date: 2002
Vaginal rings delivering progesterone and estradiol may be a new method of hormone replacement therapy (abstract) (HTML)
Maruo,Takeshi; Mishell,Daniel R.,Jr.; Ben-Chetrit,Avraham; Hochner-Celnikier,Drorith; Hamada,Anna Lissa; Nash,Harold A.
Fertility and Sterility 78(5): 1010-1016
Publication date: 2002
A male contraceptive pill by 2000?
Segal,Sheldon J.
from Toward a New Partnership: Encouraging the Positive Involvement of Men as Supportive Partners in Reproductive Health, pp. 3-4
Publication date: 2001
An emerging role for co-receptors in inhibin signal transduction (abstract) (HTML)
Bernard,Daniel J.; Chapman,Stacey C.; Woodruff,Teresa K.
Molecular and Cellular Endocrinology 180(1-2): 55-62
Publication date: 2001
Cell- and stage-specific high-level expression of TBP-related factor 2 (TRF2) during mouse spermatogenesis (abstract) (HTML)
Zhang,Di; Penttila,Tarja-Leena; Morris,Patricia L.; Roeder,Robert G.
Mechanisms of Development 106(1-2): 203-205
Publication date: 2001
Consequences of dendritic cell (DC)-immunodeficiency virus interactions: Chemically inactivated virus as a model for studying antigen presentation and virus transmission by primate DCs (abstract) (HTML)
Frank,Ines; Pope,Melissa
Immunobiology 204(5): 622-628
Publication date: 2001
Contraceptive efficacy and clinical performance of Nestorone implants in postpartum women (abstract) (HTML)
Massai,Rebeca; Diaz,Soledad; Quintero,E.; Reyes,Veronica; Herreros,C.; Zepeda,Ana; Croxatto,Horacio B.; Moo-Young,Alfred J.
Contraception 64(6): 369-376
Publication date: 2001
Current approaches to systemic male contraception
Bremner,William J.; Cheng,Chuen-yan; Cuasnicu,Patricia S.; Habenicht,Ursula F.; Colvard,Douglas S.; Doncel,Gustavo F.; Coutinho,Elsimar M.; Spinola,Paulo
from Current Knowledge in Reproductive Medicine, pp. 315-331
Publication date: 2001
Effective long-term androgen suppression in men with prostate cancer using a hydrogel implant with the GnRH agonist histrelin (abstract) (HTML)
Schlegel,Peter N.; Kuzma,Petr; Frick,Julian; Farkas,Amicur; Gomahr,Andreas; Spitz,Irving M.; Chertin,Boris; Mack,Doris; Jungwirth,Andreas; King,Peggy; Nash,Harold A.; Bardin,C.Wayne; Moo-Young,Alfred J.
Urology 58(4): 578-582
Publication date: 2001
Effects of the levonorgestrel-releasing intrauterine system on proliferation and apoptosis in the endometrium (abstract) (PDF) (HTML)
Maruo,Takeshi; Laoag-Fernandez,Jovelle B.; Pakarinen,Paivi; Murakoshi,H.; Spitz,Irving M.; Johansson,Elof D.B.
Human Reproduction 16(10): 2103-2108
Publication date: 2001
Evidence for the binding of a human sperm component with diaphanous protein (abstract) (HTML)
Zhang,Si-Ming; Miao,Shiying; Wang,Linfang; Koide,Samuel S.
Archives of Andrology 46(1): 29-35
Publication date: 2001
Expression and function of the HSD-3.8 gene encoding a testis-specific protein (abstract) (PDF) (HTML)
Lin,Wen; Zhou,Xuefeng; Zhang,Meilin; Li,Yan; Miao,Shiying; Wang,Linfang; Zong,Shudong; Koide,Samuel S.
Molecular Human Reproduction 7(9): 811-818
Publication date: 2001
Expression and localization of caveolin-1, and the presence of membrane rafts, in mouse and guinea pig spermatozoa (abstract) (PDF) (HTML)
Travis,Alexander J.; Merdiushev,Tanya; Vargas,Louis A.; Jones,Brian H.; Purdon,Marie A.; Nipper,Rick W.; Galatioto,Josephine; Moss,Stuart B.; Hunnicutt,Gary R.; Kopf,Gregory S.
Developmental Biology 240(2): 599-610
Publication date: 2001
Follicle-stimulating hormone and leukemia inhibitory factor regulate Sertoli cell retinol metabolism (abstract) (PDF) (HTML)
Guo,Xiajia; Morris,Patricia L.; Gudas,Lorraine J..
Endocrinology 142(3): 1024-1032
Publication date: 2001
Genetic approaches to the study of pituitary follicle-stimulating hormone regulation,
Bernard,Daniel J.; Woodruff,Teresa K.; Matzuk,Martin M.; Brown,Chester W.; Kumar,T.Rajendra
from Transgenics in Endocrinology, pp. 297-317
Publication date: 2001
Gonadal steroid receptor mRNA in catecholaminergic nuclei of the canary brainstem (abstract) (HTML)
Maney,Donna L.; Bernard,Daniel J.; Ball,Gregory F.
Neuroscience Letters 311(3): 189-192
Publication date: 2001
Guinea pig fertilin exhibits restricted lateral mobility in epididymal sperm and becomes freely diffusing during capacitation (abstract) (PDF) (HTML)
Cowan,Ann E.; Koppel,Dennis E.; Vargas,Louis A.; Hunnicutt,Gary R.
Developmental Biology 236(2): 502-509
Publication date: 2001
High deletion frequency of the complete AZFa sequence in men with Sertoli-cell-only syndrome (abstract) (HTML)
Kamp,Christine; Huellen,Karin; Fernandes,S.; Sousa,M.; Schlegel,Peter N.; Mielnik,Anna; Kleinman,S.; Yavetz,H.; Krause,W.; Kupker,Wolfgang; Johannisson,R.; Schulze,Wolfgang; Weidner,Wolfgang; Barros,A.; Vogt,Peter H.
Molecular Human Reproduction 7(10): 987-994
Publication date: 2001
Identification and implantation stage-specific expression of an interferon-a-regulated gene in human and rat endometrium (abstract) (PDF) (HTML)
Li,Quanxi; Zhang,Meilin; Kumar,Sushma; Zhu,Li-Ji; Chen,Dahu; Bagchi,Milan K.; Bagchi,Indrani C.
Endocrinology 142(6): 2390-2400
Publication date: 2001
Immediate postabortal contraception with the levonorgestrel intrauterine device, Norplant, and traditional methods (abstract) (HTML)
Ortayli,Nuriye; Bulat,Aysen; Sahin,Tulay; Sivin,Irving
Contraception 63(6): 309-314
Publication date: 2001
Inhibin binding protein in rats: Alternative transcripts and regulation in the pituitary across the estrous cycle (abstract) (PDF) (HTML)
Bernard,Daniel J.; Woodruff,Teresa K.
Molecular Endocrinology 15(4): 654-667
Publication date: 2001
Irradiation selectively inhibits expression from the androgen-dependent Pem homeobox gene promoter in Sertoli cells (abstract) (PDF) (HTML)
Maiti,Sourindra; Meistrich,Marvin L.; Wilson,Gene; Shetty,Gunapala; Marcelli,Marco; McPhaul,Michael J.; Morris,Patricia L.; Wilkinson,Miles F.
Endocrinology 142(4): 1567-1577
Publication date: 2001
Is cadmium chloride-induced inter-Sertoli tight junction permeability barrier disruption a suitable in vitro model to study the events of junction disassembly during spermatogenesis in the rat testis? (abstract) (PDF) (HTML)
Chung,Nancy P.Y.; Cheng,Chuen-yan
Endocrinology 142(5): 1878-1888
Publication date: 2001
Isolation of steroid-regulated genes from the uterus by mRNA differential display
Kumar,Sushma; Angervo,Maarit; Bagchi,Milan K.; Bagchi,Indrani C.; Lieberman,Benjamin A.
from Steroid Receptor Methods, Protocols and Assays, pp. 105-117
Publication date: 2001
Kap promoter analysis in vivo: A regulatory role for a truncated L1 repeat (abstract) (HTML)
Hardy,Dianne O.; Niu,Enmei; Catterall,James F.
Molecular and Cellular Endocrinology 181(1-2): 57-67
Publication date: 2001
Levonorgestrel concentrations during 7 years of continuous use of Jadelle contraceptive implants (abstract) (HTML)
Sivin,Irving; Wan,Livia; Ranta,Sirpa; Alvarez,Francisco; Brache,Vivian; Mishell,Daniel R.,Jr.; Darney,Philip; Biswas,Arijit; Diaz,Soledad; Kiriwat,Orawan; Anant,Manee Piya; Klaisle,Cynthia; Pavez,Margarita; Schechter,Janet
Contraception 64(1): 43-49
Publication date: 2001
Male infertility
Brandell,Roy A.; Schlegel,Peter N.; Weiss,Robert M.; George,Nicholas J.R.; O'Reilly,Patrick H.
from Comprehensive Urology, pp. 583-596
Publication date: 2001
Mechanisms of inhibin signal transduction (abstract) (PDF) (HTML)
Bernard,Daniel J.; Chapman,Stacey C.; Woodruff,Teresa K.
Recent Progress in Hormone Research 56(1): 417-450
Publication date: 2001
Messenger ribonucleic acid encoding interferon-inducible guanylate binding protein 1 is induced in human endometrium within the putative window of implantation (abstract) (PDF) (HTML)
Kumar,Sushma; Li,Quanxi; Dua,Anuradha; Ying,Yu-Kang; Bagchi,Milan K.; Bagchi,Indrani C.
Journal of Clinical Endocrinology and Metabolism 86(6): 2420-2427
Publication date: 2001
Modulation of rat Leydig cell steroidogenic function by di(2-ethylhexyl) phthalate (abstract) (PDF) (HTML)
Akingbemi,Benson T.; Youker,Robert T.; Sottas,Chantal M.; Ge,Renshan; Katz,Emily; Klinefelter,Gary R.; Zirkin,Barry R.; Hardy,Matthew P.
Biology of Reproduction 65(4): 1252-1259
Publication date: 2001
Müllerian inhibiting substance inhibits testosterone synthesis in adult rats (abstract) (PDF) (HTML)
Sriraman,Venkataraman; Niu,Enmei; Matias,Jonathan R.; Donahoe,Patricia K.; MacLaughlin,David T.; Hardy,Matthew P.; Lee,Mary M.
Journal of Andrology 22(5): 750-758
Publication date: 2001
Nitric oxide synthase activity in human seminal plasma (abstract) (HTML)
Zini,Armand; O'Bryan,Moira K.; Schlegel,Peter N.
Urology 58(1): 85-89
Publication date: 2001
Oestrogenic and antiandrogenic chemicals in the environment: Effects on male reproductive health [review] (abstract) (HTML)
Akingbemi,Benson T.; Hardy,Matthew P.
Annals of Medicine 33(6): 391-403
Publication date: 2001
Post-marketing surveillance of Norplant contraceptive implants: I. Contraceptive efficacy and reproductive health (abstract) (HTML)
Meirik,Olav; Farley,Timothy M.M.; Sivin,Irving; Diaz,Soledad
Contraception 63(4): 167-186
Publication date: 2001
Post-marketing surveillance of Norplant contraceptive implants: II. Non-reproductive health (abstract) (HTML)
Meirik,Olav; Farley,Timothy M.M.; Sivin,Irving; Diaz,Soledad; Collins,John
Contraception 63(4): 187-209
Publication date: 2001
Prenatal exposure to dexamethasone alters Leydig cell steroidogenic capacity in immature and adult rats (abstract) (PDF) (HTML)
Page,Kathleen Creed; Sottas,Chantal M.; Hardy,Matthew P.
Journal of Andrology 22(6): 973-980
Publication date: 2001
Purification of rat Leydig cells: Increased yields after unit-gravity sedimentation of collagenase-dispersed interstitial cells (abstract) (PDF) (HTML)
Salva,Antonio; Klinefelter,Gary R.; Hardy,Matthew P.
Journal of Andrology 22(4): 665-671
Publication date: 2001
Regulation of Sertoli cell myotubularin (rMTM) expression by germ cells in vitro (abstract) (PDF) (HTML)
Li,Jonathan C.H.; Lee,William M.; Mruk,Dolores D.; Cheng,Chuen-yan
Journal of Andrology 22(2): 266-277
Publication date: 2001
Reversible inhibition of spermatogenesis in rats using a new male contraceptive, 1-(2,4-dichlorobenzyl)-indazole-3-carbohydrazide (abstract) (PDF) (HTML)
Grima,Josephine; Silvestrini,Bruno; Cheng,Chuen-yan
Biology of Reproduction 64(5): 1500-1508
Publication date: 2001
Safety and efficacy of levonorgestrel implant, intrauterine device, and sterilization (abstract) (HTML)
Meirik,Olav; Farley,Timothy M.M.; Sivin,Irving
Obstetrics and Gynecology 97(4): 539-547
Publication date: 2001
Self antigen prognostic for human immunodeficiency virus disease progression (abstract) (PDF) (HTML)
Bristow,Cynthia L.; Patel,Hirenkumar; Arnold,Roland R.
Clinical and Diagnostic Laboratory Immunology 8(5): 937-942
Publication date: 2001
Spermiogenesis deficiency in mice lacking the Trf2 gene (abstract) (HTML)
Zhang,Di; Penttila,Tarja-Leena; Morris,Patricia L.; Teichmann,Martin; Roeder,Robert G.
Science 292(5519): 1153-1155
Publication date: 2001
The development and regression of deciduosarcomas and other lesions caused by estrogens and progestins in rabbits (abstract) (PDF) (HTML)
Zook,Bernard C.; Janne,Olli A.; Abraham,Andrew A.; Nash,Harold A.
Toxicologic Pathology 29(4): 411-416
Publication date: 2001
The inter-Sertoli tight junction permeability barrier is regulated by the interplay of protein phosphatases and kinases: An in vitro study (abstract) (PDF) (HTML)
Li,Jonathan C.H.; Mruk,Dolores D.; Cheng,Chuen-yan
Journal of Andrology 22(5): 847-856
Publication date: 2001
The IUD and recovery of fertility (PDF)
Sivin,Irving; Webb,Anne; Stedman,Yvonne
Family Planning Perspectives 33(5): 234-241
Publication date: 2001
The possible role of enterothepatic cycling on bioavailibility of noretisterone and gestodene in women using combined oral contraceptives (abstract) (HTML)
Elomaa,Kaisa; Ranta,Sirpa; Tuominen,Juhani; Lahteenmaki,Pekka
Contraception 63(1): 13-18
Publication date: 2001
The roles of estrogen and progestin in producing deciduosarcoma and other lesions in the rabbit (abstract) (PDF) (HTML)
Janne,Olli A.; Zook,Bernard C.; Didolkar,Ashok K.; Sundaram,Kalyan; Nash,Harold A.
Toxicologic Pathology 29(4): 417-421
Publication date: 2001
Transforming growth factor β3 perturbs the inter-Sertoli tight junction permeability barrier in vitro possibly mediated via its effects on occludin, zonula occludens-1, and claudin-11 (abstract) (PDF) (HTML)
Lui,Wing-Yee; Lee,William M.; Cheng,Chuen-yan
Endocrinology 142(5): 1865-1877
Publication date: 2001
Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis (abstract) (PDF) (HTML)
Cheng,Chuen-yan; Silvestrini,Bruno; Grima,Josephine; Mo,Meng-Yun; Zhu,Li-Ji; Johansson,Elof D.B.; Saso,Luciano; Leone,Maria Grazia; Palmery,Maura; Mruk,Dolores D.
Biology of Reproduction 65(2): 449-461
Publication date: 2001
In vitro regulation of extracellular superoxide dismutase in Sertoli cells (abstract) (HTML)
Mruk,Dolores D.; Cheng,Chuen-yan
Life Sciences 67(2): 133-145
Publication date: 2000
A detailed analysis of menstrual blood loss in women using Norplant® and Nestorone® progestogen-only contraceptive implants or vaginal rings (abstract) (HTML)
Fraser,Ian S.; Weisberg,Edith; Minehan,Ellen; Johansson,Elof D.B.
Contraception 61(4): 241-251
Publication date: 2000
A metabolite of methoxychlor, 2,2-bis(p-hydroxyphenyl)-1,1, 1-trichloroethane, reduces testosterone biosynthesis in rat Leydig cells through suppression of steady-state messenger ribonucleic acid levels of the cholesterol side-chain cleavage enzyme (abstract) (HTML)
Akingbemi,Benson T.; Ge,Renshan; Klinefelter,Gary R.; Gunsalus,Glen L.; Hardy,Matthew P.
Biology of Reproduction 62(3): 571-578
Publication date: 2000
Alterations in sex steroids and gonadotropins in post-menopausal women subsequent to long-term mifepristone administration (abstract) (HTML)
Heikinheimo,Oskari; Ranta,Sirpa; Grunberg,Steven M.; Spitz,Irving M.
Steroids 65(10-11): 831-836
Publication date: 2000
An implant releasing the gonadotropin hormone-releasing hormone agonist histrelin maintains medical castration for up to 30 months in metastatic prostate cancer (abstract) (HTML)
Chertin,Boris; Spitz,Irving M.; Lindenberg,Tzina; Algur,Nurit; Zer,Tami; Kuzma,Petr; Moo-Young,Alfred J.; Catane,Raphael; Farkas,Amicur
Journal of Urology 163(3): 838-844
Publication date: 2000
Antisperm antibodies associated with infertility: Properties and encoding genes of target antigens (abstract) (HTML)
Koide,Samuel S.; Wang,Linfang; Kamada,Masaharu
Proceedings of the Society for Experimental Biology and Medicine 224(3): 123-132
Publication date: 2000
Biodegradable systems for long-acting Nestorone®
Trantolo,Debra J.; Wise,Donald L.; Moo-Young,Alfred J.; Hsu,Yung-Yueh; Gresser,Joseph D.; Klibanov,Alexander; Langer,Robert; Mikos,Antonio; Brannon-Peppas,Lisa; Peppas,Nicholas A.; Wnek,Gary E.; Yaszemski,Michael J.
from Handbook of Pharmaceutical Controlled Release Technology, pp. 807-819
Publication date: 2000
Changes in the expression of junctional and nonjunctional complex component genes when inter-Sertoli tight junctions are formed in vitro (abstract) (PDF) (HTML)
Wong,Connie C.S.; Chung,Sanny S.W.; Grima,Josephine; Zhu,Li-Ji; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Journal of Andrology 21(2): 227-237
Publication date: 2000
Chronic toxicity and reversibility of antifertility effect of immunization against gonadotropin-releasing hormone in male rats and rabbits (abstract) (PDF) (HTML)
Kumar,Narender; Savage,Toyin; DeJesus,William; Tsong,Yun-yen; Didolkar,Ashok K.; Sundaram,Kalyan
Toxicological Sciences 53(1): 92-99
Publication date: 2000
Dihydrotestosterone as a selective cellular/nuclear localization vector for anti-gene peptide nucleic acid in prostatic carcinoma cells (abstract) (PDF) (HTML)
Boffa,Lidia C.; Scarfi,Sonia; Mariani,Maria Rita; Damonte,Gianluca; Allfrey,Vincent G.; Benatti,Umberto; Morris,Patricia L.
Cancer Research 60(8): 2258-2262
Publication date: 2000
E1A-mediated repression of progesterone receptor-dependent transactivation involves inhibition of the assembly of a multisubunit coactivation complex (abstract) (PDF) (HTML)
Xu,Yue; Klein-Hitpass,Ludger; Bagchi,Milan K.
Molecular and Cellular Biology 20(6): 2138-2146
Publication date: 2000
Effects of lonidamine on testicular and epididymal proteins in the rat (abstract) (HTML)
Leone,Maria Grazia; Grippa,Eleanora; Guidolin,Diego; Tita,Beatrice; Abdel-Haq,Hanin; Gatto,Maria Teresa; Bordi,Federica; Cheng,Chuen-yan; Silvestrini,Bruno; Saso,Luciano
Reproductive Toxicology 14(3): 257-263
Publication date: 2000
Effects of progesterone on uterine leiomyoma growth and apoptosis (abstract) (HTML)
Maruo,Takeshi; Matsuo,Hiroya; Samoto,Takashi; Shimomura,Yosuke; Kurachi,Osamu; Gao,Zhijian; Wang,Yin; Spitz,Irving M.; Johansson,Elof D.B.
Steroids 65(10-11): 585-592
Publication date: 2000
Embryo implantation (PDF) (HTML)
Carson,Daniel D.; Bagchi,Indrani C.; Dey,Sudhandsu K.; Enders,Allen C.; Fazleabas,Asgerally T.; Lessey,Bruce A.; Yoshinaga,Koji
Developmental Biology 223(2): 217-237
Publication date: 2000
GATA-1 and GATA-4 transactivate inhibin/activin β-B-subunit gene transcription in testicular cells (abstract) (PDF) (HTML)
Feng,Zong-Ming; Wu,Ai Zhen; Zhang,Zhifang; Chen,Ching-Ling C.
Molecular Endocrinology 14(11): 1820-1835
Publication date: 2000
Hideyo Noguchi's last stand: The yellow fever commission in Accra, Africa (1927-8) (HTML)
Koide,Samuel S.
Journal of Medical Biography 8(2): 97-101
Publication date: 2000
Identification of the oxidative 3α-hydroxysteroid dehydrogenase activity of rat Leydig cells as Type II retinol dehydrogenase (abstract) (PDF) (HTML)
Hardy,Dianne O.; Ge,Renshan; Catterall,James F.; Hou,Yong-tai; Penning,Trevor M.; Hardy,Matthew P.
Endocrinology 141(5): 1608-1617
Publication date: 2000
Initial predominance of the oxidative activity of type I 11 β-hydroxysteroid dehydrogenase in primary rat Leydig cells and transfected cell lines (abstract) (PDF) (HTML)
Ge,Renshan; Hardy,Matthew P.
Journal of Andrology 21(2): 303-310
Publication date: 2000
Interleukin-6 regulation of kappa opioid receptor gene expression in primary Sertoli cells (abstract) (HTML)
Jenab,Shirzad; Morris,Patricia L.
Endocrine 13(1): 11-15
Publication date: 2000
Lonidamine and analogue AF2785 block the cyclic adenosine 3',5'-monophosphate-activated chloride current and chloride secretion in the rat epididymis (abstract) (PDF) (HTML)
Gong,Xiandi; Wong,Y.L.; Leung,George P.H.; Cheng,Chuen-yan; Silvestrini,Bruno; Wong,Patrick Y.D.
Biology of Reproduction 63(3): 833-838
Publication date: 2000
Nestorone®: A progestin with a unique pharmacological profile (abstract) (HTML)
Kumar,Narender; Koide,Samuel S.; Tsong,Yun-yen; Sundaram,Kalyan
Steroids 65(10-11): 629-636
Publication date: 2000
Ovarian function during use of Nestorone® subdermal implants (abstract) (HTML)
Brache,Vivian; Massai,Rebeca; Mishell,Daniel R.,Jr.; Moo-Young,Alfred J.; Alvarez-Sanchez,Francisco; Salvatierra,Ana Maria; Cochon,Leila; Croxatto,Horacio B.; Robbins,Ann; Faundes,Anibal
Contraception 61(3): 199-204
Publication date: 2000
Point mutation in Kit receptor tyrosine kinase reveals essential roles for Kit signaling in spermatogenesis and oogenesis without affecting other Kit responses (abstract) (PDF) (HTML)
Kissel,Holger; Timokhina,Inna; Hardy,Matthew P.; Rothschild,Gerson; Tajima,Youichi; Soares,Vera; Angeles,Michael; Whitlow,Scott R.; Manova,Katia; Besmer,Peter
EMBO Journal 19(6): 1312-1326
Publication date: 2000
Progesterone receptor modulators and progesterone antagonists in women's health (abstract) (HTML)
Spitz,Irving M.; Chwalisz,Kristof
Steroids 65(10-11): 807-815
Publication date: 2000
Progestin-only contraceptive rings (abstract) (HTML)
Brache,Vivian; Alvarez-Sanchez,Francisco; Faundes,Anibal; Jackanicz,Theodore M.; Mishell,Daniel R.,Jr.; Lahteenmaki,Pekka
Steroids 65(10-11): 687-691
Publication date: 2000
Progestins and Antiprogestins in Clinical Practice
Publication date: 2000
Prolonged effectiveness of Norplant® capsule implants: A 7-year study (abstract) (HTML)
Sivin,Irving; Mishell,Daniel R.,Jr.; Diaz,Soledad; Biswas,Arijit; Alvarez-Sanchez,Francisco; Darney,Philip; Holma,Pentti; Wan,Livia; Brache,Vivian; Kiriwat,Orawan; Abdalla,Kamal; Campodonico,Italo; Pasquale,Samuel; Pavez,Margarita; Schechter,Janet
Contraception 61(3): 187-194
Publication date: 2000
Protein profiles in various epididymal segments of normal and castrated rats (abstract) (HTML)
Mathur,Premendu P.; Marshall,Aileen; Cheng,Chuen-yan
Asian Journal of Andrology 2(1): 57-64
Publication date: 2000
Rat testicular myotubularin, a protein tyrosine phosphatase expressed by Sertoli and germ cells, is a potential marker for studying cell-cell interactions in the rat testis (abstract) (HTML)
Li,Jonathan C.H.; Samy,Eileen T.; Grima,Josephine; Chung,Sanny S.W.; Mruk,Dolores D.; Lee,William M.; Silvestrini,Bruno; Cheng,Chuen-yan
Journal of Cellular Physiology 185(3): 366-385
Publication date: 2000
Safety of three formulations of nonoxynol-9-containing vaginal spermicides (HTML)
Coggins,Christiana; Elias,Christopher J.; N-9 Formulation Preference Study Group Committee
International Journal of Gynecology and Obstetrics 68(3): 267-268
Publication date: 2000
Sertoli cell prostaglandin D synthetase is a multifunctional molecule: Its expression and regulation (abstract) (PDF) (HTML)
Samy,Eileen T.; Li,Jonathan C.H.; Grima,Josephine; Lee,William M.; Silvestrini,Bruno; Cheng,Chuen-yan
Endocrinology 141(2): 710-721
Publication date: 2000
Sertoli cell proteins in testicular paracriny
Mruk,Dolores D.; Cheng,Chuen-yan; Jegou,B.; Pineau,C.; Saez,J.
Ernst Schering Research Foundation Workshop Supplement 6, pp. 197-228
Publication date: 2000
Testin induction: The role of cyclic 3',5'-adenosine monophosphate/protein kinase A signaling in the regulation of basal and lonidamine-induced testin expression by rat Sertoli cells (abstract) (PDF) (HTML)
Grima,Josephine; Cheng,Chuen-yan
Biology of Reproduction 63(6): 1648-1660
Publication date: 2000
The effects of androgen on androgen receptor expression in rat testicular and epididymal cells: A quantitative immunohistochemical study (abstract) (PDF) (HTML)
Zhu,Li-Ji; Hardy,Matthew P.; Inigo,Ivan V.; Huhtaniemi,Ilpo; Bardin,C.Wayne; Moo-Young,Alfred J.
Biology of Reproduction 63(2): 368-376
Publication date: 2000
The levonorgestrel intrauterine system in contraception (abstract) (HTML)
Lahteenmaki,Pekka; Rauramo,Ilkka; Backman,Tiina
Steroids 65(10-11): 693-697
Publication date: 2000
The return of the pharmaceutical industry to the market of contraception (abstract) (HTML)
Johansson,Elof D.B.
Steroids 65(10-11): 709-711
Publication date: 2000
Usefulness of estradiol/progesterone-releasing vaginal rings in long-term management of postmenopausal women
Maruo,Takeshi; Samoto,Takashi; Yoshida,Shigeki; Hamada,Anna Lissa; Nash,Harold A.; Spitz,Irving M.; Johansson,Elof D.B.
Advances in Obstetrics and Gynecology 52(2): 266-271
Publication date: 2000
Vaginal epithelial surface appearances in women using vaginal rings for contraception (abstract) (HTML)
Fraser,Ian S.; Lacarra,Maria; Mishell,Daniel R.,Jr.; Alvarez-Sanchez,Francisco; Brache,Vivian; Lahteenmaki,Pekka; Elomaa,Kaisa; Weisberg,Edith; Nash,Harold A.
Contraception 61(2): 131-138
Publication date: 2000
Vaginal rings for contraception in lactating women (abstract) (HTML)
Massai,Rebeca; Diaz,Soledad; Jackanicz,Theodore M.; Croxatto,Horacio B.
Steroids 65(10-11): 703-707
Publication date: 2000
7a-methyl-19-nortestosterone maintains sexual behavior and mood in hypogonadal men (abstract) (PDF) (HTML)
Anderson,Richard A.; Martin,C.W.; Kung,Annie W.C.; Everington,D.; Pun,T.C.; Tan,K.C.B.; Bancroft,John; Sundaram,Kalyan; Moo-Young,Alfred J.; Baird,David T.
Journal of Clinical Endocrinology and Metabolism 84(10): 3556-3562
Publication date: 1999
7α-methyl-19-nortestosterone, a synthetic androgen with high potency: Structure-activity comparisons with other androgens (abstract) (HTML)
Kumar,Narender; Crozat,Anne; Li,F.; Catterall,James F.; Bardin,C.Wayne; Sundaram,Kalyan
Journal of Steroid Biochemistry and Molecular Biology 71(5-6): 213-222
Publication date: 1999
A comparative study of two contraceptive vaginal rings releasing norethindrone acetate and differing doses of ethinyl estradiol (abstract) (HTML)
Weisberg,Edith; Fraser,Ian S.; Mishell,Daniel R.,Jr.; Lacarra,Maria; Darney,Philip; Jackanicz,Theodore M.
Contraception 59(5): 305-310
Publication date: 1999
A novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice (abstract) (PDF) (HTML)
Davisson,Robin L.; Ding,Yueming; Stec,David E.; Catterall,James F.; Sigmund,Curt D.
Physiological Genomics 1(1): 3-9
Publication date: 1999
An investigation of the latency period between sperm oolemmal adhesion and oocyte penetration (abstract) (HTML)
Bronson,Richard A.; Bronson,S.K.; Oula,L.; Fusi,F.M.; Calzi,F.; Phillips,David M.
Molecular Reproduction and Development 52(3): 319-327
Publication date: 1999
Assignment of chromosomal locus and evidence for alternatively spliced mRNAs of a human sperm membrane protein (hSMP-1) (abstract) (HTML)
Wang,Hang; Miao,Shiying; Chen,Dahu; Wang,Linfang; Koide,Samuel S.
Biochimica et Biophysica Acta 1447(1): 119-124
Publication date: 1999
Cloning and uterus/oviduct-specific expression of a novel estrogen-regulated gene (ERG1) (abstract) (PDF) (HTML)
Chen,Dahu; Xu,Xueping; Zhu,Li-Ji; Angervo,Maarit; Li,Quanxi; Bagchi,Milan K.; Bagchi,Indrani C.
Journal of Biological Chemistry 274(45): 32215-32224
Publication date: 1999
Correlation of endocrine profiles with bleeding patterns during use of Nestorone® contraceptive implants (abstract) (PDF)
Faundes,Anibal; Alvarez,Francisco; Brache,Vivian; Cochon,Leila; Tejada,Ana-Sofia; Moo-Young,Alfred J.
Human Reproduction 14(12): 3013-3017
Publication date: 1999
Debate: Is ICSI a genetic time bomb? No: ICSI is safe and effective (PDF)
Schlegel,Peter N.; Lamb,Dolores J.
Journal of Andrology 20(1): 18-33
Publication date: 1999
Development of an enzyme-linked immunosorbent assay, using a monoclonal antibody against a2-macroglobulin, for the diagnosis of systemic lupus erythematosus (abstract) (HTML)
Cazzolla,Nicolas; Saso,Luciano; Grima,Josephine; Leone,Maria Grazia; Grippa,Eleanora; Cheng,Chuen-yan; Silvestrini,Bruno
Clinical Biochemistry 32(4): 249-255
Publication date: 1999
Effect of methylene blue, indigo carmine and renografin on human sperm motility (abstract) (HTML)
Sheynkin,Yefim R.; Stamm,Christopher; Li,Philip S.; Goldstein,Marc
Urology 53(1): 214-217
Publication date: 1999
Efficacy, bleeding patterns, and side effects of a 1-year contraceptive vaginal ring (abstract) (HTML)
Weisberg,Edith; Fraser,Ian S.; Lacarra,Maria; Mishell,Daniel R.,Jr.; Alvarez,Francisco; Brache,Vivian; Nash,Harold A.
Contraception 59(5): 311-318
Publication date: 1999
Eliciting an immune response by plasmid DNA encoding a human sperm protein (HSD-1) (abstract) (HTML)
Wu,Y.W.; Chen,Dahu; Miao,Shiying; Wang,Linfang; Zong,Shudong; Koide,Samuel S.
Archives of Andrology 42(3): 127-136
Publication date: 1999
Estradiol-delivering vaginal rings for hormone replacement therapy (abstract) (HTML)
Nash,Harold A.; Alvarez-Sanchez,Francisco; Mishell,Daniel R.,Jr.; Fraser,Ian S.; Maruo,Takeshi; Harmon,Troy M.
American Journal of Obstetrics and Gynecology 181(6): 1400-1406
Publication date: 1999
Fertilization and pregnancy outcome with intracytoplasmic sperm injection for azoospermic men (abstract) (PDF) (HTML)
Palermo,Gianpiero D.; Schlegel,Peter N.; Hariprashad,June J.; Ergun,Berrin; Mielnik,Anna; Zaninovic,Nikica; Veeck,Lucinda L.; Rosenwaks,Zev R.
Human Reproduction 14(3): 741-748
Publication date: 1999
Function of stem cell factor (SCF) as a survival factor of spermatogonia and localization of messenger ribonucleic acid in the rat seminiferous epithelium (abstract) (PDF) (HTML)
Hakovirta,Harri; Yan,Wei; Kaleva,Marko; Zhang,Fuping; Vantinnen,Kateriina; Morris,Patricia L.; Soder,Molle; Parvinen,Martti; Toppari,Jorma
Endocrinology 140(3): 1492-1498
Publication date: 1999
Genetic/contraceptive immunization: Antifertility DNA vaccine in mice
Chen,Dahu; Wu,Y.W.; Miao,Shiying; Li,Yan; Zong,Shudong; Wang,Linfang; Koide,Samuel S.
Advances in Reproduction 3: 53-58
Publication date: 1999
Gonadotrophin and testosterone suppression by 7a-methyl-19-nortestosterone acetate administered by subdermal implant to healthy men (abstract) (PDF) (HTML)
Noe,Gabriela; Suvisaari,J.; Martin,C.W.; Moo-Young,Alfred J.; Sundaram,Kalyan; Saleh,Saleh I.; Quintero,E.; Croxatto,Horacio B.; Lahteenmaki,Pekka
Human Reproduction 14(9): 2200-2206
Publication date: 1999
Growth hormone regulates steroidogenic acute regulatory protein expression and steroidogenesis in Leydig cell progenitors (abstract) (PDF) (HTML)
Kanzaki,Masanori; Morris,Patricia L.
Endocrinology 140(4): 1681-1686
Publication date: 1999
Identification and purification of proteins from germ cell-conditioned medium (GCCM) (abstract) (PDF) (HTML)
Chung,Sanny S.W.; Mruk,Dolores D.; Lee,William M.; Cheng,Chuen-yan
Biochemistry and Molecular Biology International 47(3): 479-491
Publication date: 1999
Identification of an attenuating region in the bovine follicle-stimulating hormone b subunit mRNA that decreases its expression in E. coli (abstract) (HTML)
Samaddar,Mitali; Babu,P.Suresh; Catterall,James F.; Dighe,Rajan R.
Gene 228(1-2): 253-260
Publication date: 1999
Leydig cells
Akingbemi,Benson T.; Ge,Renshan; Hardy,Matthew P.; Knobil,Ernst; Neill,Jimmy D.
from Encyclopedia of Reproduction, pp. 1021-1033
Publication date: 1999
Liability concerns in contraceptive research (abstract) (HTML)
Segal,Sheldon J.
International Journal of Gynecology and Obstetrics 67(suppl 2): S141-S151
Publication date: 1999
Micropurification of b- and g-crystallins from rabbit aqueous humor (abstract) (HTML)
Leone,Maria Grazia; Saso,Luciano; Cheng,Chuen-yan; Silvestrini,Bruno
International Journal of Biological Macromolecules 26(2-3): 167-171
Publication date: 1999
Molecular cloning and characterization of a novel testis-specific nucleoporin-related gene (abstract) (HTML)
Wang,Linfang; Zhu,Haidong; Miao,Shiying; Cao,D.F.; Wu,Y.W.; Zong,Shudong; Koide,Samuel S.
Archives of Andrology 42(2): 71-84
Publication date: 1999
Müllerian inhibiting substance type II receptor expression and function in purified rat Leydig cells (abstract) (PDF) (HTML)
Lee,Mary M.; Seah,Ching Ching; Masiakos,Peter T.; Sottas,Chantal M.; Preffer,Frederic I.; Donahoe,Patricia K.; MacLaughlin,David T.; Hardy,Matthew P.
Endocrinology 140(6): 2819-2827
Publication date: 1999
Obstruction of the vas deferens alters protein secretion by the rat caput epididymal epithelium in vivo (abstract) (PDF) (HTML)
Turner,Terry T.; Riley,Tina A.; Mruk,Dolores D.; Cheng,Chuen-yan
Journal of Andrology 20(2): 289-297
Publication date: 1999
Opposing changes in 3a-hydroxysteroid dehydrogenase oxidative and reductive activities in rat Leydig cells during prepubertal development (abstract) (PDF) (HTML)
Ge,Renshan; Hardy,Dianne O.; Catterall,James F.; Hardy,Matthew P.
Biology of Reproduction 60: 855-860
Publication date: 1999
Overview: Contraceptive research accomplishments in the 20th century and present use of contraceptives
Johansson,Elof D.B.; Coutinho,Elsimar M.; Spinola,Paulo
from Reproductive Medicine, A Millennium Review, pp. 92-99
Publication date: 1999
Parenteral administration of progestin Nestorone® to lactating cynomolgus monkeys: An ideal hormonal contraceptive at lactation? (abstract) (PDF)
Heikinheimo,Oskari; Ranta,Sirpa; Moo-Young,Alfred J.; Lahteenmaki,Pekka; Gordon,K.
Human Reproduction 14(8): 1993-1997
Publication date: 1999
Potential regulation of membrane trafficking by estrogen receptor a via induction of Rab11 in uterine glands during implantation (abstract) (PDF) (HTML)
Chen,Dahu; Ganapathy,Padmaja; Zhu,Li-Ji; Xu,Xueping; Li,Quanxi; Bagchi,Indrani C.; Bagchi,Milan K.
Molecular Endocrinology 13(6): 993-1004
Publication date: 1999
Restoration of spermatogenesis after scrotal replacement of experimentally cryptorchid rat testis: Assessment of germ cell apoptosis and eNos expression (abstract) (HTML)
Zini,Armand; Abitbol,Joseph; Schulsinger,David; Goldstein,Marc; Schlegel,Peter N.
Urology 53(1): 223-227
Publication date: 1999
Sertolin is a novel gene marker of cell-cell interactions in the rat testis (abstract) (PDF) (HTML)
Mruk,Dolores D.; Cheng,Chuen-yan
Journal of Biological Chemistry 274(38): 27056-17068
Publication date: 1999
Study on the formation of specialized inter-Sertoli cell junctions in vitro (abstract) (HTML)
Chung,Sanny S.W.; Lee,William M.; Cheng,Chuen-yan
Journal of Cellular Physiology 181(2): 258-272
Publication date: 1999
TEMO is a novel testicular gene to study Sertoli-germ cell interactions: Its cDNA cloning and regulation
Cheng,Chuen-yan; Mo,Meng-Yun; Mruk,Dolores D.; Lee,William M.; Silvestrini,Bruno; Coutinho,Elsimar M.; Spinola,Paulo
from Proceedings of the 10th World Congress on Human Reproduction
Publication date: 1999
Testin, a sensitive marker to monitor the integrity of Sertoli-germ cell junctions, can be used to screen potential male contraceptives
Grima,Josephine; Silvestrini,Bruno; Cheng,Chuen-yan; Coutinho,Elsimar M.; Spinola,Paulo
from Proceedings of the 10th World Congress on Human Reproduction, pp. 109-113
Publication date: 1999
Varicocelectomy
Brandell,Roy A.; Li,Philip S.; Goldstein,Marc
from Atlas of Urologic Clinics of North America: Surgery for Male Infertility, pp. 145-154
Publication date: 1999
Vasovasostomy
Brandell,Roy A.; Li,Philip S.; Goldstein,Marc
from Atlas of Urologic Clinics of North America: Surgery for Male Infertility, pp. 45-64
Publication date: 1999
A nuclear receptor corepressor modulates transcriptional activity of antagonist-occupied steroid hormone receptor (abstract) (PDF) (HTML)
Zhang,Xun; Jeyakumar,M.; Petukhov,Sergei; Bagchi,Milan K.
Molecular Endocrinology 12(4): 513-524
Publication date: 1998
Attenuation of calcitonin gene expression in pregnant rat uterus leads to a block in embryonic implantation (abstract) (PDF) (HTML)
Zhu,Li-Ji; Bagchi,Milan K.; Bagchi,Indrani C.
Endocrinology 139(1): 330-339
Publication date: 1998
Calcitonin is a progesterone-regulated marker that forecasts the receptive state of endometrium during implantation (abstract) (PDF) (HTML)
Zhu,Li-Ji; Cullinan-Bove,Kathleen; Polihronis,Mary; Bagchi,Milan K.; Bagchi,Indrani C.
Endocrinology 139(9): 3923-3934
Publication date: 1998
Electron microscopy of cultured cells
Phillips,David M.; Mather,J.P.; Barnes,D.
from Methods in Cell Biology: Cell Culture for the Cell and Molecular Biologist, pp. 297-311
Publication date: 1998
Functional role of the c-Abl tyrosine kinase in meiosis I (abstract) (PDF) (HTML)
Kharbanda,Surender; Pandey,Pramrod; Morris,Patricia L.; Whang,Y.; Zhu,Li-Ji; Kumar,Narender; Yuan,Zhi-Min; Weichselbaum,Ralph; Sawyers,Charles L.; Pandita,T.; Kufe,Donald
Oncogene 16(14): 1773-1778
Publication date: 1998
Germ cell apoptosis and endothelial nitric oxide synthase (eNOS) expression following ischemia-reperfusion injury to the testis (abstract)
Zini,Armand; Abitbol,Joseph; Girardi,Sarah K.; Schulsinger,David; Goldstein,Marc; Schlegel,Peter N.
Archives of Andrology 41: 57-65
Publication date: 1998
Human sperm NADH and NADPH diaphorase cytochemistry: Correlation with sperm motility (abstract) (HTML)
Zini,Armand; O'Bryan,Moira K.; Israel,L.; Schlegel,Peter N.
Urology 51(3): 464-468
Publication date: 1998
Identification and regulation of testicular interferon gamma (IFN-y) receptor subunits: IFN-y enhances interferon regulatory factor-1 and interleukin-1b-converting enzyme expression (abstract) (PDF) (HTML)
Kanzaki,Masanori; Morris,Patricia L.
Endocrinology 139(5): 2636-2644
Publication date: 1998
Induction of spermatogenesis and achievement of pregnancy after microsurgical varicocelectomy in men with azoospermia and severe oligoasthenospermia (abstract) (HTML)
Matthews,Gerald J.; Matthews,E.D.; Goldstein,Marc
Fertility and Sterility 70(1): 71-75
Publication date: 1998
KzF-1, a novel rat KRAB zinc finger encoding gene, is expressed during rat spermatogenesis (abstract) (HTML)
Bellefroid,E.J.; Sahin,M.; Poncelet,D.A.; Riviere,M.; Martial,J.A.; Morris,Patricia L.; Pieler,T.; Szpirer,C.; Ward,D.C.
Biochimica et Biophysica Acta 1398(3): 321-329
Publication date: 1998
Lactogenic hormone-inducible phosphorylation and gamma-activated binding site binding activities of STAT5b in primary rat Leydig cells and MA-10 mouse Leydig tumor cells (abstract) (PDF) (HTML)
Kanzaki,Masanori; Morris,Patricia L.
Endocrinology 139(4): 1872-1882
Publication date: 1998
Levonorgestrel capsule implants in the United States: A 5-year study (abstract) (HTML)
Sivin,Irving; Mishell,Daniel R.,Jr.; Darney,Philip; Wan,Livia; Christ,M.
Obstetrics and Gynecology 92: 337-344
Publication date: 1998
Levonorgestrel-releasing implants: Norplant® capsules and LNG rod (Jadelle) implants
Sivin,Irving; Teichmann,Alexander T.; Corbin,Alan
from Levonorgestrel, pp. 165-175
Publication date: 1998
Lysergic acid diethylamide is a partial agonist of D2 dopaminergic receptors and it potentiates dopamine-mediated prolactin secretion in lactotrophs in vitro (abstract) (HTML)
Giacomelli,Sabrina; Palmery,Maura; Romanelli,Luca; Cheng,Chuen-yan; Silvestrini,Bruno
Life Sciences 63(3): 215-222
Publication date: 1998
Molecular mechanisms of nuclear receptor-mediated transcriptional activation and basal repression
Bagchi,Milan K.; Freedman,Leonard
from The Molecular Biology of Steroid and Nuclear Hormone Receptors, pp. 159-190
Publication date: 1998
Neural crest-specific and general expression of distinct metalloprotease-disintegrins in early Xenopus laevis development (abstract) (PDF) (HTML)
Cai,Hui; Kratzschmar,Jorn; Alfandari,Dominique; Hunnicutt,Gary R.; Blobel,Carl P.
Developmental Biology 204(2): 508-524
Publication date: 1998
Norplant® Consensus Statement and background review (HTML)
Fraser,Ian S.; Tiitinen,Aila; Affandi,Biran; Brache,Vivian; Croxatto,Horacio B.; Diaz,Soledad; Ginsburg,Jean; Gu Sujuan; Holma,Pentti; Johansson,Elof D.B.; Meirik,Olav; Mishell,Daniel R.,Jr.; Nash,Harold A.; von Schoultz,B; Sivin,Irving
Contraception 57(1): 1-9
Publication date: 1998
Physiology of male reproduction: The testis, epididymis and ductus deferens
Schlegel,Peter N.; Chang,T.S.K.; Walsh,Patrick C.; Retik,Alan B.; Vaughan,E.Darracott,Jr.; Wein,Alan J.
from Campbell's Urology, pp. 1254-1286
Publication date: 1998
Potential benefits in developing countries through use of the levonorgestrel-releasing intrauterine system (HTML)
Sivin,Irving
Gynaecology Forum 3(3): 23-25
Publication date: 1998
Rat testicular extracellular superoxide dismutase (SODEX): Its purification, characterization, and regulation (abstract) (PDF) (HTML)
Mruk,Dolores D.; Cheng,Chin Ho; Cheng,Yan Ho; Mo,Meng-Yun; Grima,Josephine; Silvestrini,Bruno; Lee,William M.; Cheng,Chuen-yan
Biology of Reproduction 59: 298-308
Publication date: 1998
Rat testicular N-cadherin: Its complementary deoxyribonucleic acid cloning and regulation (abstract) (PDF) (HTML)
Chung,Sanny S.W.; Mo,Meng-Yun; Silvestrini,Bruno; Lee,William M.; Cheng,Chuen-yan
Endocrinology 139(4): 1853-1862
Publication date: 1998
Regulation of a2-macroglobulin expression in Sertoli cells and hepatocytes in vitro by germ cells (abstract) (PDF) (HTML)
Braghiroli,L.; Silvestrini,Bruno; Sorrentino,J.; Grima,Josephine; Mruk,Dolores D.; Cheng,Chuen-yan
Biology of Reproduction 59: 111-123
Publication date: 1998
Surgical management of male infertility and other scrotal disorders
Goldstein,Marc; Walsh,Patrick C.; Retik,Alan B.; Vaughan,E.Darracott,Jr.; Wein,Alan J.
from Campbell's Urology, pp. 1331-1377
Publication date: 1998
Testicular GATA-1 factor upregulates the promoter activity of rat inhibin a-subunit gene in MA-10 Leydig tumor cells (abstract) (PDF) (HTML)
Feng,Zong-Ming; Wu,Ai Zhen; Chen,Ching-Ling C.
Molecular Endocrinology 12(3): 378-390
Publication date: 1998
Testicular leukemia inhibitory factor (LIF) and LIF receptor (LIFR) mediate phosphorylation of STAT-3 and STAT-1 proteins and induce c-fos transcription and AP-1 activation in rat Sertoli but not germ cells (abstract) (PDF) (HTML)
Jenab,Shirzad; Morris,Patricia L.
Endocrinology 139(4): 1883-1890
Publication date: 1998
Testin secreted by Sertoli cells is associated with cell surface and its expression correlates with the disruption of Sertoli-germ cell junctions but not the inter-Sertoli tight junction protein complex in the testis (abstract) (PDF) (HTML)
Grima,Josephine; Wong,Connie C.S.; Zhu,Li-Ji; Zong,Shudong; Cheng,Chuen-yan
Journal of Biological Chemistry 273(33): 21040-21053
Publication date: 1998
The localization of messenger ribonucleic acids for somatostatin receptors 1, 2, and 3 in rat testis (abstract) (PDF) (HTML)
Zhu,Li-Ji; Krempels,Krisztina; Bardin,C.Wayne; O'Carroll,Anne-Marie; Mezey,Eva
Endocrinology 139(1): 350-357
Publication date: 1998
The use of intracytoplasmic sperm injection with electroejaculates from anejaculatory men (abstract) (PDF) (HTML)
Chung,P.H.; Palermo,Gianpiero D.; Schlegel,Peter N.; Veeck,Lucinda L.; Eid,J.F.; Rosenwaks,Zev R.
Human Reproduction 13(7): 1854-1858
Publication date: 1998
Transcription and translation of estrogen receptor-β in the male reproductive tract of estrogen receptor-α knock-out and wild-type mice (abstract) (PDF) (HTML)
Rosenfeld,Cheryl S.; Ganjam,V.K.; Taylor,John A.; Yuan,X.H.; Stiehr,J.R.; Hardy,Matthew P.; Lubahn,Dennis B.
Endocrinology 139(6): 2982-2987
Publication date: 1998
Variation in the end products of androgen biosynthesis and metabolism during postnatal differentiation of rat Leydig cells (abstract) (PDF) (HTML)
Ge,Renshan; Hardy,Matthew P.
Endocrinology 139(9): 3787-3795
Publication date: 1998
Analysis of the process of localization of fertilin to the sperm posterior head plasma membrane domain during sperm maturation in the epididymis (abstract) (PDF) (HTML)
Hunnicutt,Gary R.; Koppel,Dennis E.; Myles,Diane G.
Developmental Biology 191(1): 146-159
Publication date: 1997
Contraceptive update
Segal,Sheldon J.
New York University Review of Law and Social Change 23(3): 457-469
Publication date: 1997
Contraceptives for lactating women: A comparative trial of a progesterone-releasing vaginal ring and the Copper T 380A IUD (abstract) (HTML)
Sivin,Irving; Diaz,Soledad; Croxatto,Horacio B.; Miranda,Patricia; Shaaban,Mamdouh; Sayed,Ezzat H.; Xiao,Bilian; Wu,Shang-Chun; Du Ming-kun; Alvarez-Sanchez,Francisco; Brache,Vivian; Basnayake,Sriani; McCarthy,Terence; Lacarra,Maria; Mishell,Daniel R.,Jr.; Koetsawang,Suporn; Stern,Janet; Jackanicz,Theodore M.
Contraception 55(4): 225-232
Publication date: 1997
Introduction
Segal,Sheldon J.
New York University Review of Law and Social Change 23(3): 329-337
Publication date: 1997
Transcriptional regulation of Sertoli cell immediate early genes by interleukin-6 and interferon-y is mediated through phosphorylation of STAT-3 and STAT-1 proteins (abstract) (PDF) (HTML)
Jenab,Shirzad; Morris,Patricia L.
Endocrinology 138(7): 2740-2746
Publication date: 1997
Bleeding complaints during the first year of Norplant® implants use and their impact on removal rate (abstract) (HTML)
Diaz,Juan; Faundes,Anibal; Olmos,Paulo; Diaz,Margarita
Contraception 53(2): 91-95
Publication date: 1996
Differential activation of signal transducer and activator of transcription (STAT)-3 and STAT-1 transcription factors and c-fos messenger ribonucleic acid by interleukin-6 and interferon-gamma in Sertoli cells (abstract) (HTML)
Jenab,Shirzad; Morris,Patricia L.
Endocrinology 137(11): 4738-4743
Publication date: 1996
Immediate postplacental insertion of GYNE-T 380 and GYNE-T 380 postpartum intrauterine contraceptive devices: Randomized study (abstract) (HTML)
Tatum,Howard J.; Beltran,Renalto Saavedra; Ramos,Rebecca; Van Kets,Henry; Sivin,Irving; Schmidt,Frederick H.
American Journal of Obstetrics and Gynecology 175(5): 1231-1235
Publication date: 1996
Sperm surface protein PH-20 is bifunctional: One activity is a hyaluronidase and a second, distinct activity is required in secondary sperm-zona binding (abstract) (PDF) (HTML)
Hunnicutt,Gary R.; Primakoff,Paul; Myles,Diane G.
Biology of Reproduction 55(1): 80-86
Publication date: 1996
Structural change of the endoplasmic reticulum during fertilization: Evidence for loss of membrane continuity using the green fluorescent protein (abstract) (PDF) (HTML)
Terasaki,Mark; Jaffe,Laurinda A.; Hunnicutt,Gary R.; Hammer,John A.,III
Developmental Biology 179(2): 320-328
Publication date: 1996
Structural relationship of sperm soluble hyaluronidase to the sperm membrane protein PH 20 (abstract) (PDF) (HTML)
Hunnicutt,Gary R.; Mahan,Kimberly; Lathrop,William F.; Ramarao,Chodavarapu S.; Myles,Diane G.; Primakoff,Paul
Biology of Reproduction 54(6): 1343-1349
Publication date: 1996
IUD mechanisms of action
Croxatto,Horacio B.; Ortiz,Maria Elena; Valdez,Enrique; Bardin,C.Wayne; Mishell,Daniel R.,Jr.
from Proceedings from the Fourth International Conference on IUDs, pp. 44-62
Publication date: 1994
The Copper T 380 IUD
Schmidt,Frederick H.; Sivin,Irving; Waldman,Sandra N.; Bardin,C.Wayne; Mishell,Daniel R.,Jr.
from Proceedings from the Fourth International Conference on IUDs, pp. 298-307
Publication date: 1994
The Copper T 380 Intrauterine Device: A Summary of Scientific Data
Sivin,Irving; Greenslade,Forrest; Schmidt,Frederick H.; Waldman,Sandra N.
Publication date: 1992
Rapid and slow mechanisms for loss of cell adhesiveness during fertilization in Chlamydomonas (abstract) (HTML)
Hunnicutt,Gary R.; Snell,William J.
Developmental Biology 147(1): 216-224
Publication date: 1991
Cell body and flagellar agglutinins in Chlamydomonas reinhardtii: The cell body plasma membrane is a reservoir for agglutinins whose migration to the flagella is regulated by a functional barrier (abstract) (PDF) (HTML)
Hunnicutt,Gary R.; Kosfiszer,M.G.; Snell,William J.
Journal of Cell Biology 111(4): 1605-1616
Publication date: 1990
IUDS are contraceptives, not abortifacients: A comment on research and belief (PDF)
Sivin,Irving
Studies in Family Planning 20(6): 355-359
Publication date: 1989
Long-acting, more effective Copper T IUDs: A summary of U.S. experience, 1970-75
Sivin,Irving; Stern,Janet
Studies in Family Planning 10(10): 263-281
Publication date: 1979
A comparison of the Copper T-200 and the Lippes Loop in four countries
Sivin,Irving
Studies in Family Planning 7(4): 115-123
Publication date: 1977
Life-table analysis of IUDs: Problems and recommendations
Jain,Anrudh K.; Sivin,Irving
Studies in Family Planning 8(2): 25-47
Publication date: 1977
The effectiveness of the Copper-T intrauterine device: A collaborative study in five countries
Sivin,Irving
Studies in Family Planning 4(7): 162-170
Publication date: 1973
Fertility decline and contraceptive use in the International Postpartum Family Planning Program
Sivin,Irving
Studies in Family Planning 2(12): 248-256
Publication date: 1971
Evaluation of intrauterine devices: Ninth progress report of the cooperative statistical program
Tietze,Christopher; Lewit,Sarah
Studies in Family Planning 1(55): 1-40
Publication date: 1970
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